Clinical trials: Metformin, completed
Diabetes
Life Style Modifications Prevents Type 2 Diabetes in Asian Indians
Three year prospective randomised controlled trial in IGT subjects to study the effect of metformin and lifestyle modification in preventing the conversion to diabetes
- Trial name
- NCT00279240
- Testing
- Metformin
- Where
- India
- Volunteers
- healthy volunteers welcome
- Sponsor
- M.V. Hospital for Diabetes
Endometrial Cancer
Preoperative Window Study of Metformin for the Treatment of Endometrial Cancer
The overall goal of this proposal is to investigate the potential benefit of metformin as a novel therapy for the treatment of endometrial cancer.
- Trial name
- NCT01911247
- Testing
- Metformin
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Metabolic Disturbance, Hyperprolactinemia
Clinical Efficacy and Adverse Reactions of Antipsychotic Treatment
The goal of this clinical trial is to explore the potential of metformin in managing olanzapine-induced metabolic disturbance and hyperprolactinemia in patients with schizophrenia. The main questions it aims to answer are: 1.
- Conditions
- Metabolic Disturbance, Hyperprolactinemia, Schizophrenia
- Trial name
- NCT06326840
- Testing
- Metformin
- Where
- Taiwan
- Volunteers
- 42 people
- Sponsor
- Taipei Medical University Hospital
Atherosclerosis, Diabetes
Effects on Re-endothelialisation With Bydureon Treatment in Type 2 Diabetes Subjects
The aim of the study is to use Exenatide long-acting release (LAR) [Bydureon] to minimize vascular remodeling and neointima formation after Percutaneous Coronary Intervention (PCI) and to accelerate stent endothelialisation.
- Conditions
- Atherosclerosis, Diabetes, Restenosis
- Trial name
- Rebuild (NCT02621489)
- Testing
- Bydureon, Humulin kwickpen, Metformin
- Where
- Sweden
- Volunteers
- 38 people
- Sponsor
- Karolinska Institutet
Type 2 Diabetes Mellitus
Efficacy and Safety of Alogliptin Plus Metformin Compared to Glipizide Plus Metformin in Patients With Type 2 Diabetes Mellitus
The purpose of this study is to determine the safety and effectiveness of adding alogliptin, once daily (QD), compared to glipizide with metformin in diabetic patients.
- Trial name
- ENDURE (NCT00856284)
- Testing
- Alogliptin, Metformin, Glipizide
- Where
- 261 sites in United States, Argentina and 30 more
- Volunteers
- 2,639 people
- Sponsor
- Takeda
Diabetes, Diabetes Mellitus, Type 2
Efficacy and Safety of Biphasic Insulin Aspart 30 With Metformin in Type 2 Diabetes
This trial is conducted in Africa. The aim of this trial is to evaluate the efficacy and safety of biphasic insulin aspart plus OAD compared to biphasic insulin aspart alone on blood glucose control in type 2 diabetes.
- Trial name
- NCT00624364
- Testing
- biphasic insulin aspart, metformin
- Where
- 15 sites in South Africa
- Volunteers
- 140 people
- Sponsor
- Novo Nordisk A/S
Healthy Volunteer
A Study to Assess the Bioequivalence of Fixed Dose Combination of Dapagliflozin/Metformin XR Relative to Co-administration of the Individual Components in Healthy Chinese Subjects.
To assess the bioequivalence between dapagliflozin/metformin XR FDC tablet and co-administration of dapagliflozin and metformin XR tablets.
- Trial name
- NCT04856007
- Testing
- Dapagliflozin/metformin XR FDC 5/500 mg, Dapagliflozin/metformin XR FDC 10/1000 mg, Dapagliflozin 5 mg + Metformin 500 mg XR
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Diabetes Mellitus, Type 1
Protective Effects of Saxagliptin (And Vitamin D3) on β Cell Function in Adult-onset Latent Autoimmune Diabetes
The main purpose of this study is to evaluate whether saxagliptin or (and vitamin D3) with metformin (and insulin) therapy can better protect islet β cell function than metformin(and insulin) .
- Trial name
- NCT02407899
- Testing
- Saxagliptin, Vitamin D3, Insulin
- Where
- 39 sites in China
- Volunteers
- 300 people
- Sponsor
- Second Xiangya Hospital of Central South University
T2DM (Type 2 Diabetes Mellitus)
PRKAA2 Genetic Polymorphisms and Its Susceptibility to Chinese Type 2 Diabetes Mellitus and Diabetic Nephropathy
Metformin is a classical oral antidiabetic drug, often recommended to be the first-choice treatment of type 2 diabetes mellitus (T2DM).
- Trial name
- NCT03155087
- Testing
- Metformin
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- People's Hospital of Zhengzhou University
Type 2 Diabetes
Antidiabetic Effects of Adding a DPP-4 Inhibitor to Pre-Existing Treatment With an Incretin Mimetic in Patients With T2D
Objectives: To quantify differences in control of glycemia (primary objective) and the secretion of endogenous incretin hormones (secondary objective) comparing sitagliptin or placebo added to pre-existing therapy with…
- Trial name
- NCT01937598
- Testing
- Mixed meal test, Liraglutide, Sitagliptin
- Where
- Germany
- Volunteers
- 16 people
- Sponsor
- Michael A. Nauck
Type 2 Diabetes Mellitus
Sitagliptin Comparative Study in Patients With Type 2 Diabetes (0431-049)
A study to evaluate the efficacy and safety of sitagliptin in comparison to a commonly used medication in patients with type 2 diabetes
- Trial name
- NCT00449930
- Testing
- sitagliptin phosphate, Comparator: metformin hydrochloride
- Volunteers
- 1,050 people
- Sponsor
- Merck Sharp & Dohme LLC
Diabetes Mellitus, Type 2
Empagliflozin (BI 10773) Comprehensive add-on Study in Japanese Subjects With Type 2 Diabetes Mellitus
The objective of the study is to investigate the long-term safety and efficacy of BI 10773 given for 52 weeks as add-on therapy to one oral antidiabetic drug in patients with type 2 diabetes mellitus with insufficient glycaemic…
- Trial name
- NCT01368081
- Testing
- Metformin, BI 10773
- Where
- 87 sites in Japan
- Volunteers
- 1,162 people
- Sponsor
- Boehringer Ingelheim
Healthy
Fasting Study of Metformin Hydrochloride ER Tablets 500 mg and Glucophage® XR Tablets 500 mg
The objective of this study is to investigate the bioequivalence of Mylan metformin hydrochloride ER tablets to Glucophage® XR tablets following a single, oral 500 mg (1 x 500 mg) dose administration under fasting conditions.
- Trial name
- NCT00650312
- Testing
- Metformin Hydrochloride ER Tablets 500 mg, Glucophage® XR Tablets 500 mg
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mylan Pharmaceuticals Inc
Diabetes Mellitus, Type 2
Intensive Insulin Glulisine Therapy in Patients With Type 2 Diabetes Inadequately Controlled With Basal Insulin and Oral Glucose-lowering Drugs
Primary Objective: To evaluate the efficacy of an intensive insulin regimen with insulin glargine and insulin glulisine in terms of change in Hemoglobin A1c (HbA1c) level from week 12 (visit 7) to week 24 (visit 10).
- Trial name
- CHANGING (NCT01203111)
- Testing
- INSULIN GLARGINE, INSULIN GLULISINE
- Where
- 10 sites in Algeria, Brazil and 8 more
- Volunteers
- 207 people
- Sponsor
- Sanofi
Type 2 Diabetes Mellitus
A Study of the Efficacy and Safety of Ertugliflozin Monotherapy in the Treatment of Participants With Type 2 Diabetes Mellitus and Inadequate Glycemic Control Despite Diet and Exercise (MK-8835-003, VERTIS MONO)
This trial will evaluate the efficacy and safety of ertugliflozin monotherapy in the treatment of participants with type 2 diabetes mellitus (T2DM) and inadequate glycemic control on diet and exercise.
- Trial name
- NCT01958671
- Testing
- Ertugliflozin 5 mg, Ertugliflozin 10 mg, Metformin
- Volunteers
- 461 people
- Sponsor
- Merck Sharp & Dohme LLC
Healthy
A Relative Bioavailability Study of Glyburide/Metformin HCl 5 mg/500 mg Tablets Under Fasting Conditions
The purpose of this study is compare the relative bioavailability of 5 mg Glyburide/500 mg Metformin Hydrochloride Tablets by Alpharma with that of 5 mg/500 mg CLUCOVANCE® Tablets by Bristol-Myers Squibb Company following a…
- Trial name
- NCT00865436
- Testing
- Glyburide and Metformin Hydrochloride Tablets 5 mg/500 mg, CLUCOVANCE® 5 mg/500 mg Tablets, single dose
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Actavis Inc.
Type 2 Diabetes Mellitus
A Phase 3 Study of Ranolazine in Subjects With Type 2 Diabetes Who Are Inadequately Controlled on Metformin Alone
This is a randomized, double-blind, placebo-controlled, parallel-group, multicenter study to determine the effect of ranolazine when added to metformin on glycemic control in adults with type 2 diabetes mellitus (T2DM) who are…
- Trial name
- NCT01555164
- Testing
- Ranolazine, Metformin, Diet
- Where
- 146 sites in United States, Canada and 9 more
- Volunteers
- 442 people
- Sponsor
- Gilead Sciences
T2DM With Inadequate Glycemic Control
CS02 vs Placebo With Metformin in Type 2 Diabetes Mellitus (T2DM)
The objective of the study is to compare the efficacy and safety of 3 doses CS02 Tablet in combination with a stable dose of metformin monotherapy against CS02 PTM (placebo) Tablet in combination with a stable dose of metformin…
- Trial name
- NCT03317028
- Where
- 13 sites in United States, Taiwan
- Volunteers
- 201 people
- Sponsor
- Center Laboratories, Inc.
Type 2 Diabetes
Myocardial Perfusion in Type 2 Diabetes
The investigators aimed to evaluate microvascular circulation with novel method: real-time myocardial contrast echocardiography in patients with type 2 diabetes and normal coronary arteries.
- Trial name
- NCT01043965
- Testing
- Metformin
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Type 2 Diabetes Mellitus
Effect of Moringa Oleifera on Metformin Plasma Level in Type 2 Diabetes Mellitus Patients
Type 2 diabetes mellitus (T2DM) patients from our previous survey tend to co-administer various herbs with their oral hypoglycemic agents (OHA). Some of these herbs are known to possess antidiabetic activities.
- Trial name
- NCT03189407
- Testing
- Moringa oleifera tea
- Volunteers
- 25 people
- Sponsor
- Titilayo O Fakeye
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