Clinical trials: Metformin, completed
Healthy
Bioequivalence and Drug - Drug Interaction Study of Metformin/Gliclazide in Healthy Participants
This study investigated the bioequivalence and drug-drug interaction of Metformin/Gliclazide fixed combination tablet compared to co-administration of individual tablets of Metformin and Gliclazide.
- Trial name
- NCT03467945
- Testing
- Metformin/Gliclazide Fixed Combination, Metformin, Gliclazide
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Merck KGaA, Darmstadt, Germany
Polycystic Ovary Syndrome
Empagliflozin vs Metformin in PCOS
This a randomised open-label parallel study involving women with polycystic ovary syndrome (PCOS). The patients will be randomised either to metformin 1500mg or empagliflozin 25mg daily for three months.
- Trial name
- NCT03008551
- Testing
- Empagliflozin, Metformin
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Healthy
Glucophage Immediate Release (GIR) China Bioequivalence Study
The study will assess the bioequivalence between single doses of glucophage immediate release (GIR) test tablets and GIR reference tablets under fed and fasted state in healthy subjects.
- Trial name
- NCT03393208
- Testing
- Test GIR, Reference GIR
- Where
- China
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Merck KGaA, Darmstadt, Germany
Prediabetic State, Insulin Resistance
Effect of Linagliptin + Metformin vs Metformin Alone in Patients With Prediabetes
Type 2 diabetes is a worldwide epidemic disease, and preventive strategies are needed to face this health problem. The goal of this clinical trial is to evaluate the effect of linagliptin + metformin vs metformin alone on…
- Trial name
- PRELLIM (NCT03004612)
- Testing
- Linagliptin + metformin, Metformin
- Where
- Mexico
- Volunteers
- 144 people
- Sponsor
- Universidad de Guanajuato
Healthy
A Study to Assess the Food Effect on Bioavailability of Metformin/Gliclazide in Healthy Participants
This study will assess the food effect on bioavailability of Metformin/Gliclazide fixed dose combination tablet in fed and fasted state.
- Trial name
- NCT03467971
- Testing
- Metformin/Gliclazide Fixed Combination
- Where
- Mexico
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Merck KGaA, Darmstadt, Germany
PCOS, Vitamin D Deficiency
Vitamin D for Polycystic Ovary Syndrome Clomiphene Resistant Women
This study is determining the therapeutic effect of Vitamin D supplements to Pcos clomiphene resistant polycystic ovarian syndrome Women. Half of patients will receive Vitamin D with metformin while other half metformin only.
- Trial name
- NCT04010942
- Testing
- Vit D, Metformin, Clomiphene
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Ain Shams University
Diabetes Mellitus, Type 1
REducing With MetfOrmin Vascular Adverse Lesions in Type 1 Diabetes (REMOVAL)
The trial is conducted in the United Kingdom (UK), Australia, Canada, Denmark and the Netherlands. The aim is to test whether 3 years treatment with metformin added to titrated insulin therapy (towards target HbA1c 7.0%/53…
- Trial name
- REMOVAL (NCT01483560)
- Testing
- Metformin
- Where
- 24 sites in Australia, Canada and 3 more
- Volunteers
- 493 people
- Sponsor
- University of Glasgow
Diabetes Prevention in Women After GDM Who Are at High-risk
Dapagliflozin and Metformin,Alone and in Combination, in Overweight/Obese Prior GDM Women
Women with a history of gestational diabetes (GDM) are at substantially increased risk of type 2 diabetes mellitus (T2DM). Compared with the general population, these women are more likely to be overweight or obese.
- Trial name
- DAPA-GDM (NCT02338193)
- Testing
- DAPA/MET XR, DAPA, MET XR
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Woman's
Type 2 Diabetes, Overweight
Effect of Liraglutide on Epicardial Fat in Subjects With Type 2 Diabetes
The purpose of this research study is to learn about the effect of Liraglutide, (Victoza®), on the fat surrounding the heart.Excessive amount of the fat around the heart is common in people with type 2 diabetes and can be…
- Conditions
- Type 2 Diabetes, Overweight, Obesity
- Trial name
- NCT02014740
- Testing
- Liraglutide, Metformin
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Miami
Polycystic Ovary Syndrome, Vitamin D Deficiency/Insufficiency
The Effect of Calcium and Vitamin D Supplements on Metabolic and Hormonal Disturbances in Polycystic Ovary Syndrome Patients
The aim of this study is to investigate the safety and metabolic-hormonal efficiency of supplementation vitamin D deficient/insufficient PCOS women with (calcium +vitamin D + metformin) for 8 weeks compared to (placebo+…
- Trial name
- NCT03792984
- Testing
- Vitamin D3, Calcium Carbonate, Metformin
- Where
- 2 sites in Syria
- Volunteers
- 40 people
- Sponsor
- Damascus University
Delirium, Anesthesia; Adverse Effect
Assessment of Immediate Postoperative Delirium (IPD) in Adult Patients: Incidence and Etiologic Factors
Delirium is considered to be acute failure of central nervous system. It is acute confusional state characterized by decline from baseline mental level, attention deficit and disorganized thinking.
- Trial name
- AIPDAP (NCT03967496)
- Testing
- Types of Anesthesia, Access of Surgery, Comorbidities
- Where
- Oman
- Volunteers
- 402 people
- Sponsor
- Sultan Qaboos University
Cushing's Disease, Acromegaly
Study of Management of Pasireotide-induced Hyperglycemia in Adult Patients With Cushing's Disease or Acromegaly
The study was designed to investigate the optimal management of hyperglycemia developed during pasireotide treatment in participants with Cushing's disease or Acromegaly, which was not manageable with metformin.
- Trial name
- NCT02060383
- Testing
- Pasireotide s.c., Sitagliptin, Liraglutide
- Where
- 43 sites in United States, Belgium and 10 more
- Volunteers
- 249 people
- Sponsor
- Novartis Pharmaceuticals
Polycystic Ovary Syndrome (PCOS), Insulin Resistance
PCOS Treatment Using DLBS3233, Metformin, and Combination of Both
This is a 3-arm, randomized, double-blind, double-dummy, and controlled clinical study over 6 months of treatment to evaluate the metabolic and clinical efficacy as well as the safety of DLBS3233 alone, metformin and combination…
- Trial name
- POSITIF (NCT01999686)
- Testing
- DLBS3233, Metformin XR
- Where
- 7 sites in Indonesia
- Volunteers
- 186 people
- Sponsor
- Dexa Medica Group
Insulin Resistance, Postmenopause
Insulin Resistance and Testosterone in Women
The purpose of this research study is to determine if a relationship between insulin resistance (IR) and testosterone (T) exists in women who have already gone through menopause.
- Trial name
- NCT00123110
- Testing
- metformin, leuprolide injection
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Physical Activity
Milk Protein Feeding After Aerobic Exercise in Older Adults With Pre-diabetes Taking the Biguanide Metformin
The investigators propose that post-exercise milk protein feeding will enhance the mitochondrial protein synthesis (biogenesis) response to an exercise-training program.
- Trial name
- NCT02552355
- Testing
- Metformin, Carbohydrate Beverage, Protein Beverage
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Healthy
Pharmacokinetic Characteristics of GLH1SM Extended Release Tablets in Healthy Volunteers
Crossover study to compare the pharmacokinetic characteristics of GLH1SM sustained release tablet and Janumet XR tablet in fasting condition
- Trial name
- NCT03851341
- Testing
- Janumet XR tablet 100/1000 mg, GLH1SM tablet 100/1000 mg
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- GL Pharm Tech Corporation
Breast Neoplasms, Lung Neoplasms
A Pharmacodynamic Study of Sirolimus and Metformin in Patients With Advanced Solid Tumors
Given the role of mTOR signaling and probable synergistic activity of combining sirolimus and metformin in patients with advanced solid tumors, the investigators hypothesize that: 1.
- Conditions
- Breast Neoplasms, Lung Neoplasms, Cancer of Liver, Lymphoma
- Trial name
- NCT02145559
- Testing
- Metformin XR, Delayed Metformin, Sirolimus
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Chicago
Thyroid Nodule, Insulin Resistance
Insulin Resistance and Metformin Use on Volume of Benign Thyroid Nodules
It has been shown that insulin might be involved in the pathogenesis of thyroid growth. Objective To evaluate the impact of IR and metformin use on the volume of benign thyroid nodules (TNs).
- Trial name
- NCT03183752
- Testing
- Metformin
- Where
- Brazil
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Hospital Universitário Clementino Fraga Filho
Iatrogenic Cushing Disease
Prevention of Metabolic Complications of Glucocorticoid Excess
According to current estimates, nearly 1% of the general population is treated with long-term glucocorticoids. Chronic hypercortisolism leads to a phenotype that resembles the metabolic syndrome.
- Trial name
- NCT01319994
- Testing
- Metformin
- Where
- United Kingdom
- Volunteers
- 57 people
- Sponsor
- Barts & The London NHS Trust
Left Ventricular Hypertrophy, Insulin Resistance
MetfoRmin and Its Effects on Left Ventricular Hypertrophy in Normotensive Patients With Coronary Artery Disease
Thickening of the heart muscle (left ventricle) known medically as Left Ventricular Hypertrophy (LVH) is very common in patients with heart disease. This increases risk of cerebrovascular/cardiovascular event.
- Conditions
- Left Ventricular Hypertrophy, Insulin Resistance, Coronary Artery Disease, PreDiabetes
- Trial name
- MET-REMODEL (NCT02226510)
- Testing
- Metformin XL
- Where
- United Kingdom
- Volunteers
- 68 people
- Sponsor
- University of Dundee