Clinical trials: Metformin, completed
Healthy
Bioequivalence and Drug - Drug Interaction Study of Metformin/Gliclazide in Healthy Participants
This study investigated the bioequivalence and drug-drug interaction of Metformin/Gliclazide fixed combination tablet compared to co-administration of individual tablets of Metformin and Gliclazide.
- Trial name
- NCT03467945
- Testing
- Metformin/Gliclazide Fixed Combination, Metformin, Gliclazide
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Merck KGaA, Darmstadt, Germany
Diabetes Mellitus
Observational Study to Assess Glycosylated Hemoglobin Changes After 6 Months of Treatment With Pioglitazone.
The purpose of this study is to asses changes in glycosylated hemoglobin, fasting blood lipids and genetic polymorphism's in peroxisomal proliferator activated receptors--gamma receptor after 6 months of pioglitazone, once daily…
- Trial name
- NCT00449553
- Testing
- Pioglitazone and sulphonylurea, Pioglitazone and metformin
- Where
- 4 sites in Denmark, Iceland and 2 more
- Volunteers
- 326 people
- Sponsor
- Takeda
Type 2 Diabetes Mellitus
Remission Evaluation of a Metabolic Intervention in Type 2 Diabetes With Forxiga
The purpose of the study is to determine whether in patients with early type 2 diabetes, a short-term intensive metabolic intervention comprising Forxiga, metformin, basal insulin glargine and lifestyle approaches will be…
- Trial name
- NCT02561130
- Testing
- insulin glargine, metformin, Forxiga
- Where
- 7 sites in Canada
- Volunteers
- 154 people
- Sponsor
- Population Health Research Institute
Healthy Volunteer
A Study to Evaluate Potential Cytochrome P450 and Transporter Protein Interactions With CC-99677
It is a phase 1, open-label, single-center, three-part study to assess the safety, tolerability, and pharmacokinetics of multiple doses of CC-99677 administered alone or in combination with either methotrexate and sulfasalazine…
- Trial name
- NCT04268394
- Testing
- CC-99677, Methotrexate, Sulfasalazine
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Celgene
Type 2 Diabetes
MiTy Kids (Metformin in Women With Type 2 Diabetes in Pregnancy Kids Trial)
The prevalence of diabetes in pregnancy is rising in all maternal age groups. There is increasing evidence that in-utero exposure to maternal diabetes is associated with an increased risk of obesity and type 2 diabetes in…
- Trial name
- NCT01832181
- Where
- Canada
- Volunteers
- 287 people
- Sponsor
- Mount Sinai Hospital, Canada
Hypothalamic Obesity
Hypothalamic Obesity Following Craniopharyngioma Surgery: A Pilot Trial of Combined Metformin and Diazoxide Therapy
To study the effect of combined diazoxide-metformin therapy on body weight in youth with hypothalamic obesity following treatment for craniopharyngioma.
- Trial name
- NCT00892073
- Testing
- Diazoxide, Metformin
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- The Hospital for Sick Children
Pre Diabetes, Type 2 Diabetes Mellitus
Personalised Medicine in Pre-diabetes and Early Type 2 Diabetes
Prediabetes is a common condition in overweight individuals affecting approximately 35% of American adults and 30% of Australian adults.
- Trial name
- PREDICT (NCT03558867)
- Testing
- Metformin + Healthy diet, Metformin + Personalized diet
- Where
- Australia
- Volunteers
- 138 people
- Sponsor
- Garvan Institute of Medical Research
Type 2 Diabetes Mellitus
Study To Compare Single Dose Of Three Modified Release Formulations Of PF-04937319 With Immediate Release Material-Sparing-Tablet (IR MST) Formulation Previously Studied In Adults With Type 2 Diabetes Mellitus.
Study B1621015 will characterize bioavailability, tolerability and pharmacodynamics of three modified release formulations of PF-04937319 compared with the immediate release material-sparing-tablet (IR MST) formulation in adults…
- Trial name
- NCT02206607
- Testing
- PF-04937319 IR MST, PF-04937319 MR 1, PF-04937319 MR 2
- Where
- 2 sites in United States
- Volunteers
- 39 people
- Sponsor
- Pfizer
Type 2 Diabetes Mellitus
Drug-Drug Interaction Study of Glucokinase Activator HMS5552 and Metformin in T2DM
This is a Phase 1, open-label, sequential, multiple-dose, drug-drug interaction study of GK activator HMS5552 and metformin in patients with type 2 diabetes mellitus (T2DM).
- Trial name
- NCT02597400
- Testing
- Metformin, HMS5552
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Hua Medicine Limited
Healthy
Bioequivalence of a Linagliptin / Metformin Fixed-dose Combination (FDC) Tablet Compared With Single Linagliptin and Metformin Tablets Administered Together in Healthy Volunteers
Study to demonstrate bioequivalence of a 2.5 mg linagliptin/1000 mg metformin fixed-dose combination (FDC) tablet compared with single tablets of linagliptin 2.5 mg and metformin 1000 mg administered together.
- Trial name
- NCT02221401
- Testing
- Linagliptin/Metformin FDC, Linagliptin, Metformin
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Polycystic Ovary Syndrome
Metformin in Pregnant PCOS Women
To investigate the effect of metformin on pregnancy complications and pregnancy outcome in the II. and III. trimester of pregnancy in women with polycystic ovary syndrome.
- Trial name
- PregMet (NCT00159536)
- Testing
- Metformin
- Where
- 10 sites in Norway
- Volunteers
- 257 people
- Sponsor
- Norwegian University of Science and Technology
Renal Insufficiency
Assessing the Behavior of Met DR in Subjects With Kidney Dysfunction
This study evaluated how a single dose of delayed-release metformin (Met DR) behaves in subjects with normal kidney function, mild kidney dysfunction, moderate kidney dysfunction, or severe kidney dysfunction.
- Trial name
- NCT01658514
- Testing
- Met DR, Met XR
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Elcelyx Therapeutics, Inc.
Ischemia Reperfusion Injury, Endothelial Function
The Metformin-FMD Trial
In acute myocardial infarction early restoration of coronary blood flow is the most effective strategy to limit infarct-size. Paradoxically, reperfusion itself also aggravates myocardial injury and contributes to final infarct…
- Trial name
- MetFMD (NCT01610401)
- Testing
- Metformin, Pretreatment with metformin in combination of infusion of caffeine., No pretreatment with metformin in combination with infusion of caffeine
- Where
- Netherlands
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Type 2 Diabetes Mellitus
Efficacy and Safety of Alogliptin vs. Acarbose in Chinese Type 2 Diabetes Mellitus (T2DM) Patients With High CV Risk or CHD Treated With Aspirin and Inadequately Controlled With Metformin Monotherapy or Drug Naive
Primary Objectives: To assess efficacy in terms of change from baseline in Hemoglobin A1c (HbA1c) at the end of study between the two drugs.
- Trial name
- ACADEMIC (NCT03794336)
- Testing
- Alogliptin, Acarbose, Metformin
- Where
- China
- Volunteers
- 1,293 people
- Sponsor
- Sanofi
Type 2 Diabetes Mellitus
Incretin-based Drugs and the Risk of Heart Failure
The purpose of this study is to determine whether incretin-based drugs (used to treat type 2 diabetes) taken either alone or in combination with other anti-diabetic drugs are associated with an increased risk of heart failure…
- Trial name
- NCT02456428
- Testing
- DPP-4 inhibitors, GLP-1 analogs, Insulins
- Where
- Canada
- Volunteers
- 1,499,650 people
- Sponsor
- Canadian Network for Observational Drug Effect Studies, CNODES
Diabetes Mellitus, Type 2
Remote Study Collecting Blood Glucose Values and Activity Data in Patients With Type 2 Diabetes on Different Treatments
Earlier protocol ID was NN1250-4630, protocol ID is changed to NN1535-7774. The purpose of this study is to collect blood glucose values and activity data in patients with type 2 diabetes for approximately 12 weeks using…
- Trial name
- NCT04809311
- Testing
- Oral antidiabetetic drugs, Basal insulin, Glucagon-like peptide-1 (GLP-1)
- Where
- Denmark
- Volunteers
- 156 people
- Sponsor
- Novo Nordisk A/S
Diabetes, Diabetes Mellitus, Type 2
Efficacy and Safety of Semaglutide Once Weekly Versus Insulin Glargine Once Daily as add-on to Metformin With or Without Sulphonylurea in Insulin-naïve Subjects With Type 2 Diabetes
This trial is conducted in Africa, North and South America, Asia and Europe. The purpose of the trial is to compare the effect of once-weekly dosing of two dose levels of semaglutide versus insulin glargine once-daily on…
- Trial name
- SUSTAIN™ 4 (NCT02128932)
- Testing
- semaglutide, insulin glargine
- Where
- 231 sites in United States, Argentina and 13 more
- Volunteers
- 1,089 people
- Sponsor
- Novo Nordisk A/S
Type 2 Diabetes Mellitus
Assessing the Effect of Met DR on Plasma Glucose and PK in Subjects With T2DM
This study compared the effects of delayed-release metformin (Met DR, EFB0027) administered once daily in the morning (qAM), administered once daily in the evening (qPM), and administered twice daily (BID) on circulating glucose…
- Trial name
- NCT01804842
- Testing
- Met DR
- Volunteers
- 26 people
- Sponsor
- Elcelyx Therapeutics, Inc.
Hyperlipidemia, Diabetes
Clinical Trial to Investigate the Pharmacokinetics Drug Interaction Between Metformin and Rosuvastatin
The purpose of this study is to investigate the pharmacokinetic drug interaction between Metformin and Rosuvastatin in healthy male volunteers.
- Trial name
- NCT02186483
- Testing
- Metformin, Rosuvastatin, Metformin and Rosuvastatin
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Jeil Pharmaceutical Co., Ltd.
Diabetes Mellitus, Type 2
Safety and Efficacy of Vildagliptin vs. Thiazolidinedione as add-on Therapy to Metformin in Patients With Type 2 Diabetes Not Controlled With Metformin Alone
This study is designed to evaluate, in a primary care setting, the safety and efficacy of vildaglipgtin as add on therapy to metformin relative to TZD added to metformin in patients with type 2 diabetes inadequately controlled by…
- Trial name
- NCT00396227
- Testing
- vildagliptin, thiazolidinedione (TZD)
- Where
- United States
- Volunteers
- 2,665 people
- Sponsor
- Novartis Pharmaceuticals
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