Clinical trials: Methotrexate, open to volunteers
GVHD,Acute, Acute Leukemia
Trial of 2 Step ATG for Acute GVHD Prevention Post Myeloablative Allogeneic Stem Cell Transplant
The purpose of this study is to test whether the combination of the drugs called tacrolimus (Tac), methotrexate (MTX) and new dosing strategy of another drug called (rabbit Anti-thymocyte Globulin [ATG]) will help prevent the…
- Conditions
- GVHD,Acute, Acute Leukemia, Myelodysplastic Syndromes, Myeloproliferative Disorders
- Trial name
- NCT06315309
- Testing
- ATG Combined with Tacrolimus and Mini Methotrexate
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Alabama at Birmingham
Psoriatic Arthritis (PsA)
Preventing Structural Damage in Early Psoriatic Arthritis
Investigators hypothesize that TNFi is superior to SC MTX in preventing structural damage in early, treatment-naïve PsA, assessed using HR-pQCT.
- Trial name
- NCT07486843
- Testing
- Amgevita 40Mg Solution for Injection, Methotrexate (Metoject® prefilled pen)
- Where
- Hong Kong
- Volunteers
- 108 people
- Sponsor
- Chinese University of Hong Kong
Plaque Psoriasis
Outcomes With Treatment and Withdraw of Ixekizumab in Patients With Plaque Psoriasis
Psoriasis (PsO) is a systemic immune disease that affect 2-4% of the population worldwide. PsO causes tremendous burden in terms of quality of life, psychological impact, disability and work productivity of affected individuals.
- Trial name
- NCT04537689
- Testing
- Ixekizumab, Methotrexate, Cyclosporin A
- Where
- Singapore
- Volunteers
- 40 people
- Sponsor
- Singapore General Hospital
Lymphoblastic Leukemia
TINI 2: Total Therapy for Infants With Acute Lymphoblastic Leukemia II
The purpose of this study is to improve upon the TINI study treatment. The study will test the ability of a type of immunotherapy called blinatumomab to clear persistent leukemia.
- Trial name
- NCT05848687
- Testing
- Dexamethasone, Mitoxantrone, PEG asparaginase
- Where
- 24 sites in United States, Canada
- Volunteers
- 90 people
- Sponsor
- Tanja Andrea Gruber
Alopecia Areata
Topical Methotrexate vs Minoxidil for Localized Alopecia Areata
Alopecia areata is an autoimmune disorder characterized by well-defined, non-scarring patches of hair loss on the scalp and other hair-bearing areas.
- Trial name
- MTX-MNX-AA (NCT07459933)
- Testing
- Methotrexate 1% Topical Gel, Minoxidil 5% Topical Spray
- Volunteers
- 268 people
- Sponsor
- Jinnah Postgraduate Medical Centre
Primary Central Nervous System (CNS) Lymphoma
R-PMDT Regimen in Newly Diagnosed PCNSL
A total of six cycles of the R-PMDT regimen (rituximab, pirtobrutinib, high-dose methotrexate, dexamethasone, and thiotepa) will be administered to patients with newly diagnosed primary central nervous system lymphoma (PCNSL).
- Trial name
- NCT07604987
- Testing
- R-PMDT
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Zou Dehui
Acute Lymphoblastic Leukemia, in Relapse, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent
HEM-iSMART-C: Ruxolitinib + Venetoclax + Dexamethasone + Cyclophosphamide and Cytarabine in Pediatric Patients With Relapsed or Refractory Hematological Malignancies
HEM-iSMART is a master protocol which investigates multiple investigational medicinal products in children, adolescents and young adults (AYA) with relapsed/refractory (R/R) ALL and LBL.
- Conditions
- Acute Lymphoblastic Leukemia, in Relapse, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Refractory
- Trial name
- HEM-iSMART C (NCT05745714)
- Testing
- Ruxolitinib, Venetoclax, Dexamethasone
- Where
- 33 sites in Austria, Belgium and 12 more
- Volunteers
- 26 people
- Sponsor
- Princess Maxima Center for Pediatric Oncology
Refractory Acute Myeloid Leukemia, Relapsed Acute Myeloid Leukemia
Study of Revumenib, Azacitidine, and Venetoclax in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia
This is a research study to find out if adding a new study drug called revumenib to commonly used chemotherapy drugs is safe and if they have beneficial effects in treating patients with acute myeloid leukemia (AML) or acute…
- Conditions
- Refractory Acute Myeloid Leukemia, Relapsed Acute Myeloid Leukemia, Acute Leukemia of Ambiguous Lineage
- Trial name
- NCT06177067
- Testing
- Revumenib, Venetoclax, Azacitidine
- Where
- 10 sites in United States
- Volunteers
- 24 people
- Sponsor
- St. Jude Children's Research Hospital
Active Rheumatoid Arthritis
A Study to Assess the Safety and Efficacy of Different Doses of ELV001 to Treat Active Rheumatoid Arthritis in Patients With an Inadequate Response to Methotrexate and Tumor Necrosis Factor Inhibition (START SYNERGY)
This is a Phase 2 randomized, double-blind, placebo-controlled study with a total duration of 32 weeks from Screening to End-of-Study (EOS) Visit. Approximately 180 participants are planned to be enrolled.
- Trial name
- NCT07409103
- Testing
- ELV001 25 mg, ELV001 75 mg, ELV001 125 mg
- Where
- 34 sites in United States, Serbia and 1 more
- Volunteers
- 180 people
- Sponsor
- Elevara Medicines Limited
Acute Leukemia, Lymphoblastic Leukemia
A Study to Investigate LP-118, Ponatinib, Vincristine and Dexamethasone in Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LBL)
The purpose of this study is to learn more about LP-118 (an experimental drug) and its side effects and decide on acceptable doses.
- Conditions
- Acute Leukemia, Lymphoblastic Leukemia, Lymphoblastic Lymphoma
- Trial name
- NCT06207123
- Testing
- LP-118, Ponatinib, Vincristine
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- University of Chicago
Acute Lymphoblastic Leukemia (ALL) in Complete Remission, Acute Myeloid Leukemia (AML) in Remission
Comparing Post-Transplant Cyclophosphamide As GVHD Prophylaxis to Standard of Care for Acute Leukemia Patients
This randomized clinical trial will evaluate two approaches of GvHD prophylaxis; the standard of care GVHD prophylaxis regimen (methotrexate/calcineurin inhibitors) and post-transplant cyclophosphamide with calcineurin inhibitors…
- Trial name
- PTCy-PMAT (NCT04314219)
- Testing
- Cyclophosphamide 50mg, Methotrexate
- Where
- Saudi Arabia
- Volunteers
- 264 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Rheumatoid Arthritis
Baricitinib Effects on Procoagulant State in Rheumatoid Arthritis
This prospective interventional study aims to evaluate the effects of baricitinib on disease activity, lipid profile, atherogenic index, and procoagulant biomarkers including monocyte-derived human tissue factor and D-dimer in…
- Trial name
- BAR-RA (NCT07357649)
- Testing
- Baricitinib
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tanta University
SLE - Systemic Lupus Erythematosus
The Primary Objective of the Trial is to Evaluate the Effect of the Addition of Belantamab Mafodotin to Standard of Care Therapy on the Titres of Serum Anti-dsDNA Antibodies in Patients With Previously Treated SLE.
The primary objective of the trial is to evaluate the effect of the addition of belantamab mafodotin to standard of care therapy on the titres of serum anti-dsDNA antibodies in patients with previously treated SLE.
- Trial name
- Bela-SLE (NCT07844200)
- Testing
- belantamab mafodotin to the existing stable standard background therapy
- Volunteers
- 12 people
- Sponsor
- Medical Association for the Study of Cancer Biology and Treatment
Breast Cancer
A Randomized Trial of Chemotherapy in Surgical Patients With Infiltrating Ductal Carcinoma of Breast
The overarching purpose of this study is to determine if the mainstay chemotherapeutic regimens represented by several genotoxic agents including but not limited to Cyclophosphamide, Doxorubicin, Epirubicin, Fluorouracil and…
- Trial name
- COC-IDCB (NCT02897700)
- Testing
- Single agent of cyclophosphamide, doxorubicin, epirubicin, fluorouracil and methotrexate, cyclophosphamide, doxorubicin, epirubicin, fluorouracil and methotrexate (CDEFM)
- Where
- 3 sites in China
- Volunteers
- 300 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Muscle Invasive Bladder Urothelial Carcinoma
Drug Screening Using IMD in Bladder Cancer
This research study involves implanting up to 4 microdevices, each small enough to fit inside the tip of a needle, into a tumor.
- Trial name
- NCT06204614
- Testing
- Implantable Micro-Device, Methotrexate, Carboplatin
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Desmoid Tumor
Cryoablation Versus Medical Therapy in Desmoid Tumors Progressing After Watchful Waiting
"Wait \& see" is currently the standard of care of recently diagnosed desmoid tumors (DT). In case of progression or symptomatic disease, medical therapy is nowadays widely used including chemotherapy.
- Trial name
- CRYODESMO-02 (NCT06081400)
- Testing
- Cryoablation, Chemotherapy drug
- Where
- 13 sites in France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Strasbourg, France
Primary Central Nervous System Lymphoma, Diffuse Large B-Cell Lymphoma
R-MA-PD-1 Versus R-MA in Treatment-naive Primary CNS Lymphoma
This is a prospective, open-label, multicenter, randomized controlled study in treatment-naive patients with primary central nervous system lymphoma (PCNSL, DLBCL type).
- Trial name
- RM-MA-PD1 (NCT07764601)
- Testing
- Penpulimab, Rituximab, Methotrexate
- Where
- 5 sites in China
- Volunteers
- 58 people
- Sponsor
- WEI XU
Immunoclassification, Psoriasis
Immunoclassification of Psoriasis: a Strategy for Precision Medicine
Through the combination of clinical manifestations and omics, the investigators aim to explore the skin cell atlas in different stages of psoriasis lesions, establish a clinical classification standard for psoriasis, and guide…
- Trial name
- NCT05503875
- Testing
- adalimumab, secukinumab, ixekizumab, guselkumab, Jak inhibitors, methotrexate
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Renal Pelvis and Ureter Urothelial Carcinoma
Testing the Addition of MEDI4736 (Durvalumab) to Chemotherapy Before Surgery for Patients With High-Grade Upper Urinary Tract Cancer
This phase II/III trial compares the effect of adding durvalumab to chemotherapy versus chemotherapy alone before surgery in treating patients with upper urinary tract cancer.
- Trial name
- NCT04628767
- Testing
- Biopsy Procedure, Biospecimen Collection, Cisplatin
- Where
- 258 sites in United States
- Volunteers
- 131 people
- Sponsor
- National Cancer Institute (NCI)
B Acute Lymphoblastic Leukemia
Inotuzumab Ozogamicin and Frontline Chemotherapy in Treating Young Adults With Newly Diagnosed B Acute Lymphoblastic Leukemia
This phase III trial studies the side effects of inotuzumab ozogamicin and how well it works when given with frontline chemotherapy in treating patients with newly diagnosed B acute lymphoblastic leukemia.
- Trial name
- NCT03150693
- Testing
- Allopurinol, Cytarabine, Daunorubicin Hydrochloride
- Where
- 460 sites in United States, Canada
- Volunteers
- 303 people
- Sponsor
- Alliance for Clinical Trials in Oncology