Clinical trials: Methylphenidate, open to volunteers
Lactating Women on Select DOI, Breastfed Infants of Mothers on Select DOI
Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants
Over half of women in the US who are breastfeeding their infants take prescription drugs. You are being asked to participate in this study because you are breastfeeding your infant and are currently taking, as part of your…
- Trial name
- NCT03511118
- Testing
- Tranexamic acid (TXA), labetalol, metformin
- Where
- 22 sites in United States, Canada
- Volunteers
- 1,600 people
- Sponsor
- Duke University
Chronic Neuropathic Pain
Ecstasy to Alleviate SEvere Chronic Neuropathic Pain Trial
This is a Health Canada regulated internal pilot study designed to assess the feasibility, tolerability, and preliminary efficacy of 3, 4-methylenedioxymethamphetamine hydrochloride capsules-AT for chronic neuropathic pain to…
- Trial name
- EASEPain (NCT07301632)
- Testing
- 3,4-Methylenedioxymethamphetamine, Methylphenidate
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Unity Health Toronto
ADHD - Attention Deficit Disorder With Hyperactivity
Medication Treatment of ADHD in Pediatric Epilepsy
This is an observational study assessing the usage of stimulant medication for ADHD in the context of pediatric epilepsy.
- Trial name
- NCT07594652
- Testing
- methylphenidate hydrochloride (Jornay PM)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Clinical High Risk for Psychosis (CHR)
A Multimodal Imaging Study of Dopamine in Early Psychosis
The development of new treatments for psychosis, a psychiatric condition that is prevalent and highly disabling despite antipsychotic medications, has been limited, in part, by a lack of information from brain imaging studies…
- Trial name
- MISDEP (NCT06977308)
- Testing
- Methylphenidate (MPH), [11C]raclopride
- Volunteers
- 115 people
- Sponsor
- New York State Psychiatric Institute
ADHD
EEG Biomarkers for ADHD Stimulant Treatment
Pediatric attention deficit hyperactivity disorder (ADHD) affects up to 10% of children in the U.S. and more than 90% are prescribed stimulant medications according to clinical guidelines.
- Trial name
- NCT07650643
- Testing
- methylphenidate HCl, Mixed amphetamine salts extended release
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Boston Children's Hospital
Pregnancy Related, Narcolepsy
WAKIX® (Pitolisant) Pregnancy Registry
The WAKIX (pitolisant) Pregnancy Registry is a US-based, prospective, observational cohort study designed to evaluate the association between pitolisant exposure during pregnancy and subsequent maternal, fetal, and infant…
- Trial name
- NCT05536011
- Testing
- Pitolisant, Comparator Products
- Where
- United States
- Volunteers
- 1,329 people
- Sponsor
- Harmony Biosciences Management, Inc.
Chronic Pain
The Role of Brain Dopamine in Chronic Pain
Chronic pain is associated with plasticity in the brain limbic system composed mainly of the amygdala, hippocampus, ventral striatum, and cingulate cortex (ACC) /medial prefrontal cortex (mPFC).
- Trial name
- NCT05285683
- Testing
- Methylphenidate, carbidopa-levodopa
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Rochester
Attention-deficit/Hyperactivity Disorder
An Open-Label Treatment With Randomization Observation, Investigator-Initiated Study, on the Duration and Efficacy of Jornay PM (Methylphenidate Hydrochloride Extended-Release Capsules) on Adult ADHD Symptoms and Executive Function and Emotional Regulation Throughout the Day Into Early Evening
The goal of this study is to extend the efficacy evidence of sustained release methylphenidate compound (JornayPM) in adults with Attention-deficit/hyperactivity disorder (ADHD).
- Trial name
- NCT06577779
- Testing
- Methylphenidate Hydrochloride Extended Release Capsule
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- NYU Langone Health
Epilepsy
Methylphenidate for the Treatment of Epilepsy-related Cognitive Deficits
Methylphenidate (MPH) is a stimulant, FDA-approved for the treatment of attention deficit hyperactivity disorder (ADHD). It is unknown, however, if stimulants would be of benefit for memory and thinking problems due to epilepsy.
- Trial name
- NCT04419272
- Testing
- Methylphenidate
- Where
- 4 sites in United States
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Alzheimer Disease, Apathy in Dementia
rTMS for Apathy Clinical Trial
Apathy is a common, early, and disabling symptom in dementias and mild behavioural impairment such as Alzheimer's disease (AD) and is characterized by lack of interest and enthusiasm.
- Conditions
- Alzheimer Disease, Apathy in Dementia, Dementia, Mild Behavioural Impairment
- Trial name
- REACT (NCT05561205)
- Testing
- rTMS, methylphenidate
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Sunnybrook Health Sciences Centre
Velocardiofacial Syndrome, Williams Syndrome
The Psychiatric and Cognitive Phenotypes in Velocardiofacial Syndrome
The purpose of this study is to investigate the Psychiatric and Cognitive Phenotypes in Velocardiofacial Syndrome (VCFS), Williams Syndrome (WS)and Fragile X Syndrome Characterization, Treatment and Examining the Connection to…
- Conditions
- Velocardiofacial Syndrome, Williams Syndrome, Fragile X Syndrome
- Trial name
- VCFS (NCT00768820)
- Testing
- methylphenidate, fluoxetin, risperidone
- Where
- Israel
- Volunteers
- 400 people
- Sponsor
- The Chaim Sheba Medical Center
Intellectual Disability, Fragile X Syndrome
Sensitivity of the NIH Toolbox to Stimulant Treatment in Intellectual Disabilities
This study is a randomized, double-blind, placebo-controlled, crossover trial of extended-release liquid methylphenidate (XRMPH) to evaluate the sensitivity of the NIH Toolbox Cognition Battery (NIHTB-CB) to changes in cognition…
- Conditions
- Intellectual Disability, Fragile X Syndrome, Down Syndrome, Attention Deficit Hyperactivity Disorder
- Trial name
- NCT05301361
- Testing
- Methylphenidate Oral Solution
- Where
- 3 sites in United States
- Volunteers
- 68 people
- Sponsor
- University of California, Davis
Alzheimer s Disease, Alzheimer Dementia (AD)
Combined Brain Stimulation and Methylphenidate Treatment for Apathy in Dementia
This study evaluates whether the combined treatment of methylphenidate and non-invasive brain stimulation, called intermittent theta burst stimulation, can effectively treat apathy in individuals with Alzheimer's disease or mixed…
- Conditions
- Alzheimer s Disease, Alzheimer Dementia (AD), Alzheimer Dementia, Alzheimer Disease
- Trial name
- PRIME (NCT07279740)
- Testing
- intermittent theta burst stimulation (iTBS), Methylphenidate (MPH)
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Sunnybrook Health Sciences Centre
Major Depressive Disorder, Depression
Precision Care for Major Depressive Disorder
This study aims to assess whether phenotyping-guided intervention selection is superior to intervention selection without phenotyping guidance (i.e., routine clinician and patient judgment regarding treatment selection) for…
- Conditions
- Major Depressive Disorder, Depression, Depressive Disorder, Major
- Trial name
- NCT06580041
- Testing
- Pramipexole, Methylphenidate, Phenelzine
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of California, San Francisco
Attention Deficit Hyperactivity Disorder (ADHD), Obesity (Body Mass Index &Amp;Amp;gt;30 kg/m2)
PHArmaCokinetics of methYLphenidate in Adult Patients With Attention-Deficit /Hyperactivity Disorder
PHACYLOB PHArmaCokinetics of methYLphenidate in adult patients with Attention-Deficit Hyperactivity Disorder (ADHD) : comparison between patients with and without OBesity.
- Conditions
- Attention Deficit Hyperactivity Disorder (ADHD), Obesity (Body Mass Index &Amp;Amp;gt;30 kg/m2), Methylphenidate, Obesity &Amp; Overweight
- Trial name
- PHACYLOB (NCT07121621)
- Testing
- PHArmacoKinetics of methYLphenidate in adult patients with ADHD: comparison between patients with and without OBesity.
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Tours
Fatigue
The Role of the Brain in Mental and Physical Fatigue
The goal of this clinical trial is to determine the role of brain neurotransmission in the onset of fatigue, identify the brain areas involved, and determine how brain activity and neuromuscular efficiency changes during onset of…
- Trial name
- NCT05880342
- Testing
- Reboxetine Pill, Methylphenidate Oral Product
- Where
- Belgium
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Attention Deficit Disorder With Hyperactivity, Executive Function Disorder
Neurofeedback-Based Digital Therapeutics for the Diagnosis and Treatment of ADHD in Children.
A multi-center, randomized controlled trial is being conducted to investigate the efficacy of a novel digital therapeutics (DTx) program that utilizes a cross-training approach between neurofeedback training and executive…
- Trial name
- ADHD (NCT06369714)
- Testing
- Concerta, Digital therapeutics
- Where
- 2 sites in China
- Volunteers
- 210 people
- Sponsor
- Lei Lei, MD
Attention Deficit Hyperactivity Disorder, Problem Behavior
Stimulant Effects on Disruptive Behavior
The goal of this study is to determine the effects of stimulant medication on disruptive behavior, function, preference and choice; however, it is primarily methodological and will add to current research by establishing an…
- Trial name
- NCT03420339
- Testing
- Stimulant
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Matthew J O'Brien, PhD, BCBA-D
Borderline Personality Disorder
The Effects of Methylphenidate on Symptomatology in Individuals With Borderline Personality Disorder
This study aims to investigate the effects of methylphenidate on symptomatology in individuals with borderline personality disorder.
- Trial name
- NCT06759298
- Testing
- methylphenidate
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tanta University
Attention Deficit Disorder with Hyperactivity, Diabetes Mellitus, Type 1
Lisdexamphetamine Vs Methylphenidate for Pediatric Patients with ADHD and Type 1 Diabetes
This clinical trial aims to evaluate the safety and effectiveness of an intervention involving parental training in behaviour management and medication in children with both Type 1 Diabetes (T1D) and Attention Deficit Disorder…
- Trial name
- LAMAinDiab (NCT05957055)
- Testing
- parental training in behavior management, Lisdexamfetamine, Methylphenidate
- Where
- Poland
- Volunteers
- 150 people
- Sponsor
- Medical University of Lodz