Clinical trials: Methylphenidate
Healthy Volunteers
A PET Study Examining Pharmacokinetics and Dopamine Transporter Receptor Occupancy Of Two Long-Acting Formulations of Methylphenidate in Adults
The specific aim of this study is to document the pharmacokinetics of dopamine transporter DAT receptor occupancy of OROS MPH and Metadate CD using PET scanning with C-11 Altropane as the ligand.
- Trial name
- NCT00301639
- Testing
- OROS methylphenidate hydrochloride, methylphenidate hydrochloride
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Multiple Sclerosis
Methylphenidate to Improve Balance and Walking in MS
Methylphenidate is an amphetamine-like psychomotor stimulant drug currently approved for the treatment of attention-deficit hyperactivity disorder (ADHD), postural orthostasis tachycardia syndrome and narcolepsy.
- Trial name
- NCT01896700
- Testing
- Methylphenidate
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Oregon Health and Science University
Attention Deficit Hyperactivity Disorder
Carnitine as an Adjunct to Methylphenidate for the Treatment of Attention Deficit Hyperactivity Disorder
Attention-deficit hyperactivity disorder (ADHD) is the most common neurobehavioural disorder of childhood. The investigators hypothesized that carnitine would be beneficial for treatment of ADHD, and this could be evaluated in a…
- Trial name
- NCT01099072
- Testing
- methylphenidate+carnitine
- Where
- Iran
- Volunteers
- 40 people
- Sponsor
- Tehran University of Medical Sciences
Posttraumatic Stress Disorder (PTSD)
Methylphenidate for the Treatment of PTSD With Associated Neurocognitive Complaints
Posttraumatic stress disorder (PTSD) is frequently accompanied by difficulty concentrating, poor memory, and inability to keep up with tasks, which negatively impacts a person's ability to function at work and in relationships.
- Trial name
- IMPACT (NCT05776056)
- Testing
- Methylphenidate
- Where
- 3 sites in United States
- Volunteers
- 70 people
- Sponsor
- VA Office of Research and Development
Alzheimer Disease, Apathy in Dementia
rTMS for Apathy Clinical Trial
Apathy is a common, early, and disabling symptom in dementias and mild behavioural impairment such as Alzheimer's disease (AD) and is characterized by lack of interest and enthusiasm.
- Conditions
- Alzheimer Disease, Apathy in Dementia, Dementia, Mild Behavioural Impairment
- Trial name
- REACT (NCT05561205)
- Testing
- rTMS, methylphenidate
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Sunnybrook Health Sciences Centre
ADHD, Trichotillomania
Methylphenidate in ADHD With Trichotillomania
This study will evaluate the safety and effectiveness of methylphenidate in treating attention deficit hyperactivity disorder (ADHD) in children with both ADHD and trichotillomania.
- Trial name
- NCT00552266
- Testing
- Methylphenidate
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Geha Mental Health Center
Attention Deficit Hyperactivity Disorder
The COMACS Study: A Comparison of Methylphenidates in an Analog Classroom Setting
This study was designed to compare Concerta Extended Release tablets with Metadate CD capsules in children with ADHD who were between 6 and 12 years old.
- Trial name
- NCT00381758
- Testing
- Methylphenidate Extended Release Capsules
- Volunteers
- 184 people
- Sponsor
- UCB Pharma
Healthy
A Study of Repeat Dosing of OROS® Methylphenidate Hydrochloride (CONCERTA®) and Immediate Release Methylphenidate Hydrochloride in Healthy Adults
This is a double-blind, randomized, placebo-controlled, five-period crossover study to examine the likability of a repeated administration of immediate release methylphenidate hydrochloride (IR-MPH 40 mg) and OROS®-MPH (CONCERTA®…
- Trial name
- NCT00302458
- Testing
- OROS-Methylphenidate, Immediate Release Methylphenidate
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Cognitively Healthy Subjects Influenced by Psychoactive Drugs
Cognitive Hyper-performance - Effects of Stimulating Substances in Chess-players
Effects of caffeine, methylphenidate, modafinil and placebo on cognitive performance of chess players in chess games and neuropsychiatric standardized tests.
- Trial name
- CHESS (NCT01834547)
- Testing
- Drugs use: methylphenidate, Drug use: modafinil, caffeine
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- K. Lieb
ADHD
Stimulant Drug Treatment of Attention-Deficit Hyperactivity Disorder (AD/HD), Inattentive Type
The purpose of this study is to compare the response to methylphenidate treatment of children with two different subtypes of ADHD.
- Trial name
- NCT00824317
- Testing
- methylphenidate
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
ALL, Childhood, Leukemia, Lymphoblastic
Effects of Methylphenidate on Attention Deficits in Childhood Cancer Survivors
While neurocognitive impairments in attention, memory and executive functioning are commonly reported sequelae of childhood leukemia and brain tumors, studies have only recently begun to examine the treatment of attention…
- Conditions
- ALL, Childhood, Leukemia, Lymphoblastic, Leukemia, Lymphoblastic, Acute, Leukemia, Lymphoblastic, Acute, L1
- Trial name
- NCT01100658
- Testing
- Methylphenidate
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Minnesota
Attention Deficit Hyperactivity Disorder
Psychometric Validation of the Competitive Attention Test
This project aims at validating a new neuropsychological test to measure voluntary and involuntary attention for clinical use to diagnose attentional deficits.
- Trial name
- CAT (NCT03942835)
- Testing
- experience 1 : Competitive attention test in healthy participants, experience 2 : Competitive attention test in patients with ADHD with no treatment, experience 3 :Competitive attention test in patients with ADHD with psychostimulant treatment
- Where
- France
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Asthenia, Neoplasms
Ritalin: Antiasthenic Effect of Methylphenidate (Ritalin) in Palliative Care in Cancer Patients
The aim/objective of this study is to evaluate the antiasthenic effect of methylphenidate with a visual analogical scale (VAS) after 7 days of treatment, in cancer patients, in palliative care, i.e.
- Trial name
- Ritaline (NCT00273741)
- Testing
- methylphenidate
- Where
- 13 sites in France
- Volunteers
- 39 people
- Sponsor
- University Hospital, Grenoble
Bipolar Disorder, Attention Deficit Hyperactivity Disorder
Aripiprazole Associated With Methylphenidate in Children and Adolescents With Bipolar Disorder and ADHD
There is a scarcity of clinical trials assessing the effects of medications in children with bipolar disorder. This study aims to assess the efficacy of Aripiprazole associated with Methylphenidate (MPH)for the treatment of…
- Trial name
- NCT00305370
- Testing
- Aripiprazole
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Federal University of Rio Grande do Sul
Healthy Volunteers
Stimulant Effects on Brain Activity
The aim of this study is to investigate the effects of Methylphenidate on neural activity underlying inhibitory control and error monitoring in healthy adults.
- Trial name
- NCT02453698
- Testing
- Methylphenidate
- Where
- Canada
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Dementia, Alzheimer Disease
Apathy Associated With Alzheimer's Disease
Apathy, or lack of motivation, affects up to 80% of Alzheimer's disease (AD) patients. These amotivational symptoms increase patient reliance on caregivers, increase caregiver burden and distress, and increase the risk of patient…
- Trial name
- NCT00254033
- Testing
- Dextroamphetamine, Methylphenidate
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Sunnybrook Health Sciences Centre
Attention Deficit Disorder With Hyperactivity
Treatment of Severe Childhood Aggression (The TOSCA Study)
This study will determine the safety and effectiveness of two medications for treating aggression in children with attention deficit hyperactivity disorder (ADHD).
- Trial name
- NCT00796302
- Testing
- Methylphenidate HCl, Risperidone, Parent Management Training (PMT)
- Where
- 4 sites in United States
- Volunteers
- 168 people
- Sponsor
- Michael Aman
Healthy
Methylphenidate in Healthy Young Adults
Background: There is a paucity of data as to the effect of methylphenidate (MPH) on young adults who do not have attention deficit hyperactivity disorder (ADHD).
- Trial name
- NCT00815841
- Testing
- METHYLPHENIDATE
- Volunteers
- 50 people
- Sponsor
- Shaare Zedek Medical Center
Parkinson's Disease, Gait Disorders, Neurologic
Study of Methylphenidate to Treat Gait Disorders And Attention Deficit In Parkinson's Disease (PARKGAIT-II)
Therapeutic management of gait disorders in very advanced Parkinson's disease (PD) patients can sometimes be disappointing, since dopaminergic drug treatments and subthalamic nucleus (STN) stimulation are more effective for…
- Conditions
- Parkinson's Disease, Gait Disorders, Neurologic, Dementia
- Trial name
- PARKGAIT-II (NCT00914095)
- Testing
- methylphenidate
- Where
- France
- Volunteers
- 69 people
- Sponsor
- University Hospital, Lille
Delirium
Methylphenidate, Rivastigmine or Haloperidol in Hypoactive Delirium in Intensive Care Patients
The purpose of this pilot-trial is the feasibility of a large randomized, placebo controlled, doubleblind clinical trial to investigate the use of methylphenidate, rivastigmine or haloperidol in hypoactive ICU-delirium.
- Trial name
- NCT00599287
- Testing
- Haloperidol, Methylphenidate, Rivastigmine
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- UMC Utrecht