Clinical trials: Methylphenidate
ADHD, Substance Abuse
Attention Deficit Hyperactivity Disorder (ADHD) in Adolescents With Substance Use Disorders (SUD)
The purpose of this study is to determine the efficacy of osmotic-release methylphenidate (OROS-MPH) versus placebo for the treatment of ADHD in adolescents with SUD.
- Trial name
- NCT00264797
- Testing
- Methylphenidate (OROS-MPH)
- Where
- 12 sites in United States
- Volunteers
- 303 people
- Sponsor
- University of Cincinnati
Adult ADHD
Efficacy of Concerta in Treating ADHD in Mothers of Children With ADHD
This study involves a 7 week dose-response trial of Concerta™ methylphenidate for mothers of children with ADHD who have ADHD themselves.
- Trial name
- NCT00318981
- Testing
- Concerta
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Maryland, College Park
Attention Deficit Hyperactivity Disorder (ADHD)
Effectiveness of Methylphenidate Late Formula to Reduce Cannabis Use in Young Cannabis-Related Patients and Attention Deficit Disorder Hyperactivity
Abuse of psychoactive substances is a behavior belonging to the field of risk behaviors that begins and takes place during adolescence. These risk behaviors are a major public health problem in France and worldwide.
- Trial name
- METHACAN (NCT03481959)
- Testing
- Methylphenidate
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Attention-Deficit/Hyperactivity Disorder
Pharmacokinetic Study of Methylphenidate HCl Extended-Release Capsules in Children 4 to Under 6 Years of Age With ADHD
To assess the pharmacokinetics of a single dose of Aptensio XR® (methylphenidate hydrochloride extended-release) capsules under fed conditions in male or female children 4 to under 6 years of age with ADHD.
- Trial name
- PK003 (NCT02470234)
- Testing
- Methylphenidate HCl ER Capsules, 10 mg, Methylphenidate HCl ER Capsules, 15 mg, Methylphenidate HCl ER Capsules, 20 mg
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Rhodes Pharmaceuticals, L.P.
Drug Binding to DAT Receptors
Study of Dopamine Transporter Receptor Occupancy With Long-acting Dex-methylphenidate
The objectives of this study are to document the pharmacokinetics of the adequacy of DAT receptor occupancy d-MPH formulation in three doses (20 mg, 30 mg, and 40 mg) using PET scanning with C-11 Altropane as the ligand across a…
- Trial name
- NCT00593138
- Testing
- dex-methylphenidate
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Adhd
Psychostimulants Effects on Brain Functional Connectivity in Youth With Attention Deficit Hyperactivity Disorder
In the current study, we will administer three widely administered cognitive tasks while simultaneously measuring electroencephalography (EEG) in ADHD patients before and after methylphenidate immediate release (IR) treatment…
- Trial name
- NCT02318017
- Testing
- Methylphenidate
- Where
- Israel
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
ADHD
EEG Biomarkers for ADHD Stimulant Treatment
Pediatric attention deficit hyperactivity disorder (ADHD) affects up to 10% of children in the U.S. and more than 90% are prescribed stimulant medications according to clinical guidelines.
- Trial name
- NCT07650643
- Testing
- methylphenidate HCl, Mixed amphetamine salts extended release
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Boston Children's Hospital
Attention Deficit Hyperactivity Disorder
Methylphenidate Treatment Response Study of Genetic Polymorphism in Attention Deficit Hyperactivity Disorder(ADHD)
The purpose of this study is to determine whether norepinephrine gene polymorphism affect to treatment response in ADHD
- Trial name
- NCT00862108
- Testing
- Methylphenidate
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
Attention Deficit Hyperactivity Disorder
Multi Neuro-functional Biomarkers for Monitoring the Effects of Treatments in ADHD Children
MIMOSA study aims to characterize from behavioral, neurophysiological and neurocognitive perspectives children and adolescents with attention deficit hyperactivity disorder (ADHD), in order to identify a possible biomarker of…
- Trial name
- MIMOSA (NCT04272021)
- Testing
- Methylphenidate
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS Eugenio Medea
Attention Deficit Hyperactivity Disorder
Added Value of the Oculomotor and Cognitive Examination in the Management of Patients With ADHD
ADHD is a neurodevelopmental disorder characterized by symptoms of inattention and / or hyperactivity-impulsivity that affects nearly 6% of school-aged children and persists into adulthood.
- Trial name
- NCT03411434
- Testing
- Methylphenidate Oral Tablet
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Centre Hospitalier Rouffach
ADHD - Inattentive Type, ADHD - Combined Type
Attention Deficit Disorder Medication Response Study
This study evaluates how children with Attention Deficit Disorder without Hyperactivity (ADD) respond to medication, and if their response is different from children who have problems with both hyperactivity and inattention.
- Trial name
- NCT01727414
- Where
- United States
- Volunteers
- 171 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Chronic Neuropathic Pain
Ecstasy to Alleviate SEvere Chronic Neuropathic Pain Trial
This is a Health Canada regulated internal pilot study designed to assess the feasibility, tolerability, and preliminary efficacy of 3, 4-methylenedioxymethamphetamine hydrochloride capsules-AT for chronic neuropathic pain to…
- Trial name
- EASEPain (NCT07301632)
- Testing
- 3,4-Methylenedioxymethamphetamine, Methylphenidate
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Unity Health Toronto
ADHD, Attention Deficit Hyperactivity Disorder
Carboxylesterase 1 Genetic Variation and Methylphenidate in ADHD
The study team will determine the association between d,l-methylphenidate (MPH) therapeutic outcomes in ADHD patients and genetic variants of CES1 and reveal key associations between CES1 genotypes and the PK and PD of MPH.
- Trial name
- NCT03781752
- Testing
- Methylphenidate
- Where
- 4 sites in United States
- Volunteers
- 500 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Alzheimer Dementia
A Pilot of Methylphenidate in Mild Cognitive Impairment and Dementia Participants.
Investigators are doing this research study to find out if methylphenidate (MPH) can help people with Mild Cognitive Impairment (MCI) or mild dementia likely due to Alzheimer's Disease (AD) and related disorders (ADRD).
- Trial name
- NCT03811847
- Testing
- Methylphenidate Extended Release Oral Capsule
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Massachusetts General Hospital
Attention Deficit Disorder With Hyperactivity, Developmental Coordination Disorder
Co Morbid Attention Deficit and Hyperactivity Disorder(ADHD) and Developmental Co Ordination Disorder (DCD)
This study aims to establish and present the prevalence figures and demographics of the co-morbidity of ADHD and DCD. It further aims to design an exercise intervention, to be utilised in the management of the symptoms of both…
- Trial name
- NCT03595826
- Testing
- Neurostimulant pharmaceutical drugs
- Where
- South Africa
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- University of KwaZulu
Translational Electrophysiology
Novel Cross-Species Neurophysiological Assays of Reward and Cognitive Domains
The overarching goal of this multi-disciplinary research program is to develop and optimize new cross-species translational assessments of reward and cognition that will not only be assessed in parallel in humans and rats, but…
- Trial name
- NCT02855229
- Testing
- Methylphenidate
- Where
- United States
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Attention-Deficit/Hyperactivity Disorder, Drop-out
Treatment Drop-out and Missed Appointments Among Adults With ADHD
The investigators knowledge of factors associated with treatment drop-out and missed appointments among adults with Attention-Deficit/Hyperactivity Disorder (ADHD) within a naturalistic, clinical setting is very limited.
- Conditions
- Attention-Deficit/Hyperactivity Disorder, Drop-out, Non-adherence
- Trial name
- NCT02226445
- Testing
- Combined ADHD medication and psychosocial counseling
- Where
- Denmark
- Volunteers
- 153 people
- Sponsor
- University of Aarhus
Attention Deficit Hyperactivity Disorder
Gene-environment Interactions and Brain Functional Connectivity in Attention Deficit Hyperactivity Disorder
The aims of the current study are to examine gene-environment interactions associated with norepinephrine (NE) system genes (ADRA2A, SLC6A2) in ADHD, and to evaluate whether genetic changes in norepinephrine pathway are…
- Trial name
- NCT01912352
- Testing
- Methylphenidate
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Seoul National University
Attention-deficit/Hyperactivity Disorder
Cost-Effectiveness Study Of The Treatment Of Attention Deficit/Hyperactivity Disorder In Brazil
This study is an open-label, 6 month trial, of immediate release methylphenidate (MPH-IR) for children with ADHD aimed at assessing whether the observable behavioral changes seen during treatment are associated with potentially…
- Trial name
- NCT01228604
- Testing
- methylphenidate (Ritalin®)
- Where
- Brazil
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Attention Deficit Hyperactivity Disorder, Anxiety, Separation
Treatment of Youth With ADHD and Anxiety
The purpose of this NIMH-sponsored pilot study is to collect information on the efficacy and safety of drug treatments for children and adolescents who suffer from both ADHD and anxiety disorders.
- Conditions
- Attention Deficit Hyperactivity Disorder, Anxiety, Separation, Social Phobia, Generalized Anxiety Disorder
- Trial name
- NCT00012584
- Testing
- methylphenidate, fluvoxamine
- Where
- 5 sites in United States
- Volunteers
- 120 people
- Sponsor
- National Institute of Mental Health (NIMH)