Clinical trials: Methylphenidate
Normal Physiology
Dopaminergic Modulation of Brain Activation Using Simultaneous PET/Pharmacological MRI
Background: Dopamine (DA) is a chemical signal in the brain linked to learning, memory, and habits. Stimulant drugs like methylphenidate can increase DA in the brain. Researchers want to measure DA with and without this drug.
- Trial name
- NCT03326245
- Testing
- Methylphenidate Pill, Intravenous methylphenidate
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Stress
Differences by Sex and Genotype in the Effects of Stress on Executive Functions
The aim of this project is to test the effects of an environmental factor (mild stress) on prefrontal cortex (PFC) and the cognitive functions that depend on PFC (collectively called executive functions [EFs]), and to test our…
- Trial name
- NCT04273880
- Testing
- Methylphenidate, Vitamin C
- Where
- Canada
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Decision Making, Healthy
Studying the Role of Brain Molecules for Decision Making
The aim of the present project is to elucidate the neuropharmacological mechanisms underlying value (choice preference) and attention (choice randomness) processing in humans.
- Trial name
- NCT04384562
- Testing
- Methylphenidate, Reboxetine, Nicotine gum
- Where
- Switzerland
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Pain
Neural Correlates of Acute Pain Dynamics
This work aims to study the neural correlates and determinants of pain dynamics related to changes in a noxious stimulus.
- Trial name
- NCT05669924
- Testing
- Methylphenidate
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Attention Deficit Hyperactivity Disorder
The Neuroprotective Effects of Methylphenidate and Atomoxetine in Children With ADHD: A Lipidomic Study
1. To identify the difference in the lipidomic profiles between ADHD and controls; 2. To examine the effects of methylphenidate and atomoxetine on the lipidomic profiles in ADHD, and the relationship between medication-related…
- Trial name
- NCT03936491
- Testing
- Methylphenidate, Atomoxetine
- Where
- Taiwan
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Methylphenidate, Metabolomics
Metabolic Mechanisms of the Electrophysiological Biomarkers for Response to Methylphenidate Treatment in Children With ADHD
To explore the relationship of treatment-related changes in electrophysiology and those in metabolomics for identification of the underlying metabolic mechanisms for the electrophysiological effects of methylphenidate in children…
- Trial name
- NCT06073470
- Testing
- methylphenidate
- Where
- Taiwan
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
ADHD
Multimodal Brain Imaging of Methylphenidate in Children and Adolescents With ADHD
The goal of this proposal is to develop brain imaging tools to measure the effects of methylphenidate in children and adolescents with attention deficit hyperactivity disorder (ADHD).
- Trial name
- NCT06077669
- Testing
- Methylphenidate
- Where
- United States
- Sponsor
- Johns Hopkins University
Adult ADHD
Efficacy of Concerta in Treating ADHD in Mothers of Children With ADHD
This study involves a 7 week dose-response trial of Concerta™ methylphenidate for mothers of children with ADHD who have ADHD themselves.
- Trial name
- NCT00318981
- Testing
- Concerta
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Maryland, College Park
ADHD
The Effects of ADHD Medication (TEAM) Study
This study evaluates the effects of receiving and then discontinuing methylphenidate (MPH) in children with ADHD. After receiving MPH for 8 weeks, participants will be randomized to either discontinue MPH (and receive placebo) OR…
- Trial name
- TEAM (NCT02293655)
- Testing
- OROS-Methylphenidate (MPH)
- Where
- 2 sites in United States
- Volunteers
- 204 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
ADHD
The Effects of a Single Dose of Methylphenidate on Motor Performance
Aim: To evaluate the effects of MPH on young adults diagnosed with ADHD on different exercise performance tests. Hypothesis: MPH will have positive effects on motor tests requiring concentration.
- Trial name
- NCT04283604
- Testing
- MPH
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Loewenstein Hospital
Attention Deficit/Hyperactivity Disorder Combined Type, ADHD Predominantly Inattentive Type
The Effect of Methylphenidate Treatment in Familial Attention Deficit/Hyperactivity Disorder (ADHD)
The purpose of this study is to investigate the familial response to Methylphenidate treatment (Ritalin IR) in two aspects: ADHD symptom's improvement and side-effects development.
- Conditions
- Attention Deficit/Hyperactivity Disorder Combined Type, ADHD Predominantly Inattentive Type, ADHD Predominantly Hyperactivity Type, ADHD-not Other Specified
- Trial name
- NCT01554046
- Testing
- Methylphenidate- Ritalin IR (Immediate Release)
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center
Attention Deficit Hyperactivity Disorder, Generalized Anxiety Disorder
A 14 Week, Randomized, Placebo-Controlled Cross-Over Study of Methylphenidate Hydrochloride Controlled Release Capsules in Adult ADHD With and Without Anxiety Disorder Comorbidity
Other psychiatric disorders, including anxiety, often co-occur with adult ADHD; with 85% of ADHD patients having at least one other psychiatric condition.
- Conditions
- Attention Deficit Hyperactivity Disorder, Generalized Anxiety Disorder, Social Anxiety Disorder, Panic Disorder
- Trial name
- NCT03785223
- Testing
- Methylphenidate Hydrochloride Controlled-Release Capsules
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- McMaster University
Attention Deficit Disorder With Hyperactivity (ADHD)
ADHD Medication and Predictors of Treatment Outcome
ADHD medication of children and adolescents is becoming increasingly common. Clinical experience and scientific studies have proven that approximately 30% of children/adolescents with ADHD do not benefit from this treatment.
- Trial name
- ADAPT (NCT02136147)
- Testing
- methylphenidate medication, atomoxetine medication, lisdexamphetamine medication
- Where
- Sweden
- Volunteers
- 632 people
- Sponsor
- Karolinska Institutet
ADHD
Acoustic and Vestibular Noise as Possible Non-pharmacological Treatment of ADHD in School Children
Noise benefit in ADHD Auditory noise benefit: The original findings from our research group, that auditory noise enhances cognitive performance in inattentive children without diagnosis as well as children with an ADHD diagnosis…
- Trial name
- NCT03425669
- Testing
- Stochastic Vestibular Stimulation, Active medication
- Where
- Sweden
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Lund University
Attention Deficit Hyperactivity Disorder
Long Acting Stimulant Treatment of Attention Deficit Hyperactivity Disorder (ADHD) in Young Children
This is a pilot study evaluating the effectiveness, safety, and tolerability of Ritalin LA in treating Attention Deficit Hyperactivity Disorder (ADHD) in 4 and 5 year old children.
- Trial name
- NCT00754208
- Testing
- methylphenidate
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Nebraska
Irritable Mood, ADHD
Irritability in Children With ADHD and Emotion Dysregulation
Objective: Emotion dysregulation is common among children with ADHD and associated with a broad range of adult psychopathology, which is similar to the longitudinal outcomes of childhood irritability.
- Trial name
- NCT05974241
- Testing
- Methylphenidate, aripiprazole, and combination
- Where
- Taiwan
- Volunteers
- 36 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Attention-Deficit/Hyperactivity Disorder
Real-World Evidence of Duration of Effect of Adhansia XR (Extended-Release) for Treatment of Attention-Deficit/Hyperactivity Disorder (ADHD)
The purpose of this study is to investigate the treatment effectiveness of Adhansia XR at month-2 after initiation, and the effectiveness of Adhansia XR overall and when compared with the active comparator group (Concerta) over…
- Trial name
- RE-DAX (NCT04507204)
- Testing
- Adhansia XR, Concerta
- Where
- 35 sites in United States
- Volunteers
- 267 people
- Sponsor
- Purdue Pharma LP
Fatigue, Unspecified Adult Solid Tumor, Protocol Specific
Methylphenidate in Treating Patients With Melanoma
RATIONALE: Methylphenidate may relieve some of the side effects of chemotherapy in patients with melanoma. It is not known whether receiving methylphenidate is more effective than receiving no further therapy in treating patients…
- Trial name
- NCT00003266
- Testing
- methylphenidate hydrochloride, quality-of-life assessment
- Where
- 59 sites in United States, Puerto Rico and 1 more
- Volunteers
- 200 people
- Sponsor
- Eastern Cooperative Oncology Group
Apathy, Alzheimer's Disease
Apathy in Dementia Methylphenidate Trial 2
Apathy in Dementia Methylphenidate Trial 2 (ADMET 2) is a Phase III, placebo-controlled, masked, 6 month, multi-center randomized clinical trial sponsored by National Institutes of Aging involving 200 participants with…
- Trial name
- ADMET2 (NCT02346201)
- Testing
- Methylphenidate
- Where
- 10 sites in United States, Canada
- Volunteers
- 200 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Alzheimer Dementia
A Pilot of Methylphenidate in Mild Cognitive Impairment and Dementia Participants.
Investigators are doing this research study to find out if methylphenidate (MPH) can help people with Mild Cognitive Impairment (MCI) or mild dementia likely due to Alzheimer's Disease (AD) and related disorders (ADRD).
- Trial name
- NCT03811847
- Testing
- Methylphenidate Extended Release Oral Capsule
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Massachusetts General Hospital