Clinical trials: Metronidazole
Antibiotic Side Effect, Antibiotic-associated Diarrhea
Metagenomic and Metabolomic Reconstitution of Gut Microbiota After Broad Spectrum Antibiotic Therapy
In the United States, healthcare providers prescribe over 270 million antibiotic prescriptions each year. While antibiotics have transformed medicine and methods of treating life-threatening bacterial infection, broad spectrum…
- Conditions
- Antibiotic Side Effect, Antibiotic-associated Diarrhea, Antibiotic-induced Dysbiosis, Antibiotic-induced Epithelial Barrier Disintegrity
- Trial name
- NCT04171466
- Testing
- Ciprofloxacin + Metronidazole, SH-DS01
- Where
- Canada
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Seed Health
Suicide Risk
Telehealth to Improve Prevention of Suicide (TIPS)
The study will rigorously evaluate whether synchronous, within-visit telemental health evaluation and intervention services can successfully overcome poor access to behavioral health and substandard suicide-related care in…
- Trial name
- TIPS (NCT04800029)
- Testing
- TIPS Program, TIPS Program + ED-SAFE
- Where
- United States
- Volunteers
- 32,406 people
- Sponsor
- University of Massachusetts, Worcester
Metastatic Cancer, Solid Tumors
Phase I/II Trial Investigating the Safety, Tolerability, Pharmacokinetics, Immune and Clinical Activity of SX-682 in Combination With BinTrafusp Alfa (M7824 or TGF-beta "Trap"/PD-L1) With CV301 TRICOM in Advanced Solid Tumors (STAT)
Background: Combination immunotherapy techniques are being explored to improve responses and enhance benefits in people with cancer. Researchers want to see if this type of treatment can help people with advanced solid tumors.
- Trial name
- NCT04574583
- Testing
- SX-682, M7824, MVA-BN-CV301
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Cancer Institute (NCI)
ARDS (Acute Respiratory Distress Syndrome), VILI (Ventilator-induced Lung Injury)
Real-Time Algorithm-Driven Ventilation Feedback to Improve Lung-Protective Ventilation in Patients With ARDS (REALVENT-study)
The REALVENT trial is designed to evaluate whether a real-time, algorithm-driven ventilation feedback strategy can improve lung-protective ventilation (LPV) achievement rates in critically ill patients receiving invasive…
- Conditions
- ARDS (Acute Respiratory Distress Syndrome), VILI (Ventilator-induced Lung Injury), Respiratory Failure, Critical Illness
- Trial name
- REALVENT (NCT07307066)
- Testing
- REal-time Algorithm-driven Ventilation feedback to improve lung-protective ventilation in critically, Standard ICU care
- Where
- China
- Volunteers
- 208 people
- Sponsor
- Peking Union Medical College Hospital
Bacterial Vaginosis
Rwanda Vaginal Microbiota Restoration Study
A pilot randomized controlled clinical trial of intermittent use of two different vaginal lactobacilli-containing probiotics, and oral metronidazole, to prevent bacterial vaginosis recurrence.
- Trial name
- VMB (NCT02459665)
- Testing
- Vaginal multiple lactobacilli-containing probiotic for prevention of BV recurrence, Prophylactic use of metronidazole pills (500 mg), Vaginal Lcr35-containing probiotic for prevention of BV recurrence
- Volunteers
- 68 people
- Sponsor
- Janneke van de Wijgert
Schizophrenia
Randomized Clinical Trial of Intensive Computer-based Cognitive Remediation in Recent-onset Schizophrenia
The purpose of this study is to test a new computerized training program as well as to find out whether the computer training might help people who have schizophrenia.
- Trial name
- TARA (NCT01773239)
- Testing
- TARA computer-based exercises
- Where
- 2 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Posit Science Corporation
Healthy
Bioavailability of Metronidazole Vaginal Gel in Healthy Subjects
The primary object of this study was to evaluate the relative bioavailability of the test formulation of metronidazole vaginal gel with the already marketed reference formulation MetroGel-Vaginal Gel® in healthy adult female…
- Trial name
- NCT01020877
- Testing
- Metronidazole
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Teva Pharmaceuticals USA
Helicobatcer Pylori, First-Line Eradication
Efficacy And Safety of Bismuth-Tetracycline-Rabeprazole Triple For First-Line Eradication of Helicobacter Pylori Infection
Most international treatment guidelines currently recommend a 14-day bismuth quadruple therapy as the first-line treatment for Helicobacter pylori infection, especially in areas with high clarithromycin resistance.
- Trial name
- NCT07788053
- Testing
- Bismuth, Bismuth quadruple therapy
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- Chih-An Shih, MD
Bacterial Vaginosis, HIV Infections
Effect of Bacterial Vaginosis on HIV Susceptibility and Female Genital Immunology
A non-randomized, interventional, longitudinal clinical study to quantify the impact of bacterial vaginosis treatment on HIV susceptibility and genital immunology in Kenyan women.
- Trial name
- NCT02527941
- Testing
- Metronidazole
- Where
- Kenya
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Perianal Crohns'
Evaluation of the Pharmacokinetics of Metronidazole 10% Ointment Applied Peri Anally in Healthy Volunteers and Patients With Perianal Crohn's Disease
The purpose of this study is to evaluate the blood levels of Metronidazole after application to the peri anal area after a single dose and 6 or 7 days application.
- Trial name
- NCT00774969
- Testing
- Metronidazole
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- S.L.A. Pharma AG
Antibiotic, Bowel Cancer
Mechanical Bowel Preparation With or Without Oral Antibiotics for Colorectal Cancer Surgery
Investigation of the role of adding oral antibiotics to preoperative mechanical bowel preparation before colorectal surgery for cancer.
- Conditions
- Antibiotic, Bowel Cancer, Colorectal Cancer, Surgical Site Infection
- Trial name
- MECCA (NCT03563586)
- Testing
- Bowel Preparation plus antibiotics, Bowel Preparation
- Where
- Greece
- Volunteers
- 210 people
- Sponsor
- National and Kapodistrian University of Athens
Obesity, Obesity, Morbid
Effects of Differences in Body Composition on Retina and Choroid
The goal of this observational study is to examine the effects of body composition differences on retinal and choroidal structures.
- Conditions
- Obesity, Obesity, Morbid, Body Composition
- Trial name
- NCT06888765
- Testing
- Optical Coherence Tomography (OCT) and Body Composition Analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 261 people, healthy volunteers welcome
- Sponsor
- Bayram Meydan
Cerebral Autoregulation Mapping
Non-Invasive Mapping of Cerebral Autoregulation Using Near Infrared Spectroscopy
The investigators propose to employ advanced multi-channel near non-invasive near infrared spectroscopy (NIRS) system married with entirely non-invasive continuous arterial blood pressure (niABP) monitor to create a new wearable…
- Trial name
- NCT05433129
- Testing
- Transient hyperemic response, Orthostatic challenge, Vascular chemo-reactivity
- Where
- Canada
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Atrial Fibrillation
Verily Watch Cardio (AF and ECG) Study
This study is designed to evaluate the performance of the Verily Watch Cardio for recording electrocardiogram (ECG) and photoplethysmography (PPG) signals and detecting suspected atrial fibrillation (AF) episodes, in a…
- Trial name
- NCT06041373
- Testing
- Verily Watch Cardio, iRhythm Zio monitor, Schiller CARDIOVIT FT-1
- Where
- 3 sites in United States
- Sponsor
- Verily Life Sciences LLC
Peritonsillar Abscess
Penicillin and Metronidazole in Treatment of Peritonsillar Abscess
Treatment of peritonsillar abscess varies. To study whether broad spectrum antibiotics are required in addition to abscess drainage, a prospective, double blind, placebo-controlled, randomized study on 200 adult patients with…
- Trial name
- NCT01255670
- Testing
- penicillin and metronidazole in peritonsillar abscess
- Where
- Finland
- Volunteers
- 200 people
- Sponsor
- Helsinki University Central Hospital
Helicobacter Pylori Infection, Eradication Treatments
Prospective Randomised Trial of First and Second Line Treatments of RCT of First and Second Line H Pylori Treatments in Slovenia
Study is prospective randomised multicentric. The primary objective of the study is to compare the efficacy of two first-line therapy regimens and two second-line therapy regimens (ie, after failure of first-line treatment) in…
- Trial name
- NCT04359966
- Testing
- Esomeprazole 40mg, Clarithromycin 500 mg, Metronidazole 400 mg,, Esomeprazole 40mg, Bismuth subcitrate 120 mg, Amoxicillin 500 mg, Metronidazole 400 mg, Esomeprazole 40mg, Amoxicillin 500 mg, Levofloxacin 500 mg
- Where
- 3 sites in Slovenia
- Volunteers
- 560 people
- Sponsor
- Slovenian Society for Gastroenterology and Hepatology
Blastocystis Hominis Infections
Is it Effective to Treat Patients With Blastocystis Hominis Infection?
The objective of this study is to determine whether in the setting of primary health care it is effective to treat with metronidazole returning travellers with gastrointestinal symptoms and B. hominis in the stool or not.
- Trial name
- NCT01521403
- Testing
- Metronidazole
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University of Lausanne Hospitals
Vaginal Infection
Multi-Center Study of New Medications to Treat Vaginal Infections
The purpose of this study is to evaluate the safety and efficacy of terconazole gel in the treatment of vaginal infections
- Trial name
- SMART GIVES (NCT02308046)
- Testing
- Terconazole
- Where
- 41 sites in United States
- Volunteers
- 212 people
- Sponsor
- Curatek Pharmaceuticals, LLC
Impacted Mandibular Third Molar Extraction, Post Operative Complications
A Comparison of Recovery After Impacted Wisdom Tooth Removal
Justification of the Study There is a high prevalence of impacted third molars, often accompanied by a range of postoperative complications.
- Trial name
- CESE-3M (NCT07304882)
- Testing
- serratiopeptidase, Escin, Conventional drugs
- Where
- Yemen
- Volunteers
- 24 people
- Sponsor
- University of Science and Technology, Yemen
Pain, Symptomatic Irreversible Pulpitis
The Effectiveness of Single Antibiotic Paste Nitrofurantoin Versus Double Antibiotic Paste
In our study, we used nitrofurantoin as a root canal medication in patients suffering from symptomatic irreversible pulpitis in alleviating pain compared with double antibiotic paste.
- Trial name
- NCT05600023
- Testing
- Nitrofurantoin, Double Antibiotic
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Altamash Institute of Dental Medicine
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