Clinical trials: Metronidazole
Respiratory Failure, Mechanical Ventilation
Personalized Ultrasound-Guided External Diaphragm Pacing to Improve Outcomes in Invasive Mechanically Ventilated Patients
This study aims to explore whether personalized external diaphragm pacing (EDP) guided by real-time diaphragm ultrasound (DU) can improve outcomes for patients on invasive mechanical ventilation.
- Trial name
- NCT06609577
- Testing
- Diaphragm Ultrasound-Guided External Diaphragm Pacing
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Daishan Jiang
Pancreatic Cancer
Gut Microbiome Modulation to Enable Efficacy of Checkpoint-based Immunotherapy in Pancreatic Adenocarcinoma
A multi-institutional, single arm pilot study of antibiotics and pembrolizumab for the treatment of surgically resectable pancreatic cancer.
- Trial name
- NCT03891979
- Testing
- Pembrolizumab, Ciprofloxacin 500mg PO BID days 1-29, Metronidazole 500mg PO TID days 1-29
- Where
- United States
- Sponsor
- NYU Langone Health
Gingivitis
Comparisons Of Different Antiplaque Agents On Gingivitis In Orthodontic Patients
Fixed orthodontic treatment affects the periodontium by allowing plaque accumulation on teeth if the oral ecosystem is unfavorable which initially causes gingivitis to progress into periodontitis, and later enamel…
- Trial name
- NCT06305546
- Testing
- Chlorhexidine Gluconate, Metronidazole, combination gel (chlorhexidine and metronidazole)
- Where
- Pakistan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Anam Sattar
Helicobacter Pylori Infection
Tetracycline Versus Doxycycline for HP Rescue Therapy
This randomized controlled clinical trial will evaluate the efficacy and safety of proton pump inhibitor, bismuth, metronidazole, and either tetracycline or doxycycline for Helicobacter pylori rescue treatment.
- Trial name
- NCT05018923
- Testing
- Rabeprazole, Bismuth potassium citrate, Metronidazole
- Where
- China
- Volunteers
- 242 people
- Sponsor
- Shanghai Zhongshan Hospital
Bacterial Vaginitis
Honghe Fujie Lotion for the Treatment of Bacterial Vaginosis
This is a Randomized, Positive -Controlled, Multi-center Trial enrolling 240 subjects with Bacterial Vaginosis who will be randomized at a ratio of 1:1 to receive active Honghe Fujie lotion or Metronidazole Suppositories.
- Trial name
- NCT03446443
- Testing
- Honghe Fujie lotion, Metronidazole Suppositories
- Where
- 8 sites in China
- Volunteers
- 240 people
- Sponsor
- Dongfang Hospital Beijing University of Chinese Medicine
Anal Incontinence
Does the Negativation of the Glucose Hydrogen Breath Test Come Along With a Reduction of the Symptoms of Gaz Incontinence ?
The objectives of this work are: 1/to estimate the frequency of a positive glucose breath test in favour of a small intestinal bacterial overgrowth in a population of patients consulting for gaz incontinence by comparison to a…
- Trial name
- NCT01275560
- Testing
- Metronidazole, CArbosylane
- Where
- France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Gait, Balance
Sensor Ankle Brace for Special Operations Rehabilitation
The primary purpose of this study overall is to validate a modified version of a commercially available ankle brace. Inertial measurement unit sensors will be incorporated into an existing ankle brace ("sXAB") by TayCo Brace…
- Conditions
- Gait, Balance, Biomechanical Data, Postural Control
- Trial name
- NCT07776223
- Testing
- Sensor-enabled Athletic X Ankle Brace (sXAB)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Indiana University
Stroke
High vs Low-frequency of High-intensity Training in Chronic Stroke
The purpose of this pilot study is to investigate the potential role of training frequency on locomotor outcomes following high-intensity gait training and provision of a home walking program.
- Trial name
- F-ITT (NCT06612723)
- Testing
- high-intensity gait training, Physical activity coaching
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Indiana University
Hepatic Disease, Biliary Disease
Development and Prospective Validation of an AI-Based Diagnostic Model for Hepato-Pancreato-Biliary Diseases
The rapid advancement of artificial intelligence (AI) has expanded its applications in healthcare, particularly in diagnostic assistance, intelligent triage, and patient interaction.
- Conditions
- Hepatic Disease, Biliary Disease, Pancreas Disease, Artificial Intelligence (AI) in Diagnosis
- Trial name
- NCT07716670
- Testing
- AI Integration type 1, AI Integration type 2
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Secondary Malignant Neoplasm of Brain and Cerebral Meninges
18F-Fluciclovine PET to Distinguish Tumor Progression From Radiation Necrosis
The purpose of this study is to evaluate whether 18F-fluciclovine PET/CT of the brain, is able to distinguish radiation necrosis from tumor progression in cases where MRI is inconclusive.
- Trial name
- NCT03930173
- Testing
- 18F-fluciclovine, PET/CT of the brain
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Case Comprehensive Cancer Center
Trauma, Nervous System
Northwest Therapies Trauma Psilocybin Study Compassionate Use Study
The on-boarding of unregulatable trauma in the United States has reached 20%, which is 1/5 of the population. A population of this magnitude, by definition has now reached an epidemic classification.
- Trial name
- NWTTPS (NCT05042466)
- Testing
- Trauma
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- NWTraumatherapies
Chronic Pancreatitis, Pancreatic Neoplasm
Prediction Model of Pancreatic Neoplasms in CP Patients With Focal Pancreatic Lesions
This study aims to develop XGBoost machine learning model to predict pancreatic neoplasms in CP patients with focal pancreatic lesions.
- Conditions
- Chronic Pancreatitis, Pancreatic Neoplasm, Machine Learning
- Trial name
- NCT07045181
- Testing
- XGBoost machine learning
- Where
- China
- Volunteers
- 113 people
- Sponsor
- Changhai Hospital
Helicobacter Pylori Infection
Feasibility Study of the Proposed Test-and-treat Screening Program in Younger Participants With H. Pylori Infection
This prospective non-interventional study is being conducted as part of the EU4Health project Eurohelican. The main goal of this pilot study is to evaluate the feasibility and acceptability of implementing the proposed…
- Trial name
- NCT06216639
- Testing
- Bismuth Subcitrate, Esomeprazole, Metronidazole
- Where
- Slovenia
- Volunteers
- 2,000 people
- Sponsor
- National Institute of Public Health, Slovenia
Pelvic Inflammatory Disease
Uncomplicated Pelvic Inflammatory Disease. Treatment With Moxifloxacin.
Comparison of various antibiotics in treatment of uncomplicated pelvic inflammatory disease
- Trial name
- MAIDEN (NCT00683865)
- Testing
- Ofloxacin, Avelox (Moxifloxacin, BAY12-8039)
- Where
- 77 sites in Denmark, Finland and 11 more
- Volunteers
- 749 people
- Sponsor
- Bayer
Coronary Artery Disease
Impact of Coronary CT Angiography, Physiologic Assessment and Pharmacotherapy on the Clinical Outcomes
The investigators aim to investigate the prognostic implication of stenosis and plaque features on coronary CT angiography (CCTA), physiologic assessment, and pharmacotherapy after invasive coronary angiography.
- Trial name
- PRIME-CT (NCT04547231)
- Testing
- Fractional flow reserve, Coronary CT angiography
- Where
- South Korea
- Volunteers
- 992 people
- Sponsor
- Seoul National University Hospital
Infected Immature Permanent Teeth
Regenerative Endodontic Therapy (RET) for the Management of Immature Non-vital Permanent Teeth in Children
This study evaluates the efficacy of Antibiotic pastes or Calcium hydroxide disinfection on healing of periapical pathology and continued root development of infected non-vital immature permanent teeth in children.
- Trial name
- NCT03327844
- Testing
- RET using antibiotics (Ciprofloxacin and Metronidazole), RET using non-setting Calcium Hydroxide
- Where
- 2 sites in Singapore
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National University Health System, Singapore
Hemorrhoids, Postoperative Pain
Topical Versus Oral Metronidazole Following Excisional Haemorrhoidectomy
This study aims to determine if topical metronidazole reduces pain more than oral metronidazole following excisional haemorrhoidectomy.
- Trial name
- NCT03343509
- Testing
- Metronidazole Oral, Metronidazole Ointment
- Where
- 2 sites in New Zealand
- Volunteers
- 120 people
- Sponsor
- University of Auckland, New Zealand
Prostate Cancer
PROSTVAC in Combination With Nivolumab in Men With Prostate Cancer
Background: The immune system is the cells and organs in the body that recognize and fight infection and cancer. The prostate specific antigen (PSA)/TRICOM (PROSTVAC) vaccine might teach the immune system to find and kill certain…
- Trial name
- NCT02933255
- Testing
- PROSTVAC-V/F, Nivolumab, Prostatectomy
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Cancer Institute (NCI)
Vaginal Infection
Multi-Center Study of New Medications to Treat Vaginal Infections
The purpose of this study is to evaluate the safety and efficacy of metronidazole gel in the treatment of vaginal infections.
- Trial name
- SMART GIVES (NCT02308033)
- Testing
- Metronidazole, Gel vehicle
- Where
- 35 sites in United States
- Volunteers
- 204 people
- Sponsor
- Curatek Pharmaceuticals, LLC
Spondylarthritis, Spondylarthropathies; Spondylitis, Ankylosing
Effects of a Digital Exercise Intervention on Sleep and Physical Activity in Patients With Spondyloarthritis
The goal of this clinical trial is to assess whether a tailored digital Adapted Physical Activity (APA) program can improve physical activity levels and sleep quality in adults diagnosed with spondyloarthritis (SpA).
- Trial name
- ASPIRE (NCT07034404)
- Testing
- Digital Adapted Physical Activity, Control (Standard treatment)
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Grenoble
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