Clinical trials: Metronidazole
Peri-Implantitis
Metronidazole as an Adjunct of Non- Surgical Treatment of Peri-implantitis
The use of systemic antibiotics as and adjunct to non-surgical peri-implant therapy may be an improvement in comparison to these therapies alone.
- Trial name
- NCT03564301
- Testing
- Metronidazole 250 MG
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Juan Blanco Carrión
Healthy Adult
Optical Imaging of Retinal Vascular Metrics Under Different Dietary Conditions
In a typical clinical setting, patient eating habits are not controlled when performing optical coherence tomography (OCT) imaging for retinal diagnostics.
- Trial name
- NCT07818239
- Testing
- Consumption of a high fat meal, Consumption of a high carbohydrate meal
- Where
- Austria
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Dental Caries
Use of Antibacterial Cement in Infected Dentin
Dental materials with antibacterial properties can prevent the harmful effects caused by oral cariogenic bacteria. This double-blind controlled clinical trial evaluated the performance of antibacterial cement for sealing infected…
- Trial name
- AC (NCT01449136)
- Testing
- Antibacterial cement
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- University of Pernambuco
Helicobacter Pylori Infection
ILTHPI - Comparison of Medicament Containing Tetracycline, Metronidazole, Bismuth Versus Amoxicillin, Metronidazole, Clarithromycin
Helicobacter pylori (H. pylori) is a spiral shaped, microaerophilic, gram negative bacterium. The organism resides in the acid and mucous layer of the human gastric mucosa, adheres to and colonizes the mucosal surface of the…
- Trial name
- NCT04853875
- Testing
- Tetracycline, Metronidazole, Bismuth subcitrate, Amoxicillin, Metronidazole, Clarithromycin
- Where
- Taiwan
- Volunteers
- 104 people
- Sponsor
- Mackay Memorial Hospital
High Blood Pressure
CardioCare Quest: A Co-created Game for Improving Hypertension Treatment Compliance in Arizona
This project aims to address healthcare disparities among Navaho people diagnosed with hypertension or prehypertension through three main objectives.
- Trial name
- NCT06487637
- Testing
- CardioCare Quest
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Northern Arizona University
Recurrent Bacterial Vaginosis
Vaginal Microbiota Transplant
This is a randomized trial of vaginal microbiome transplant vs. saline placebo to restore a Lactobacillus dominant vaginal microbial community in women with recurrent bacterial vaginosis.
- Trial name
- MOTIF (NCT04046900)
- Testing
- Vaginal microbiome transplant, Oral Metronidazole, Sterile saline
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Douglas Kwon
Periodontitis, Periodontal Diseases
The Impact of Obesity on Nonsurgical Periodontal Therapy
The purpose of this study is to investigate the effect that obesity may have on the nonsurgical treatment (with and without the adjunct use of metronidazole) of destructive periodontal diseases (chronic periodontitis).
- Conditions
- Periodontitis, Periodontal Diseases, Obesity
- Trial name
- NCT01405365
- Testing
- Metronidazole, Scaling and root planning
- Where
- Brazil
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Focus: Otologic Surgery Training
Virtual Temporal Bone Surgery: Defining and Translating Metrics
The goal of this project is to improve the efficiency of training and assessment of technical skill in surgical treatment of otologic disease.
- Trial name
- NCT01493765
- Testing
- Simulator training with expert scoring
- Where
- 10 sites in United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Perianal Fistula, Perianal Abscess
Antibiotic Treatment foLlowing Surgical drAinage of Perianal abScess; the ATLAS Trial
Rationale: Perianal fistula is a burdening disease with an annual prevalence of 2/100.000 in the Dutch population. More than 90% of crypto-glandular fistulas originate from anorectal abscess.
- Conditions
- Perianal Fistula, Perianal Abscess, Drain Abscess
- Trial name
- ATLAS (NCT05385887)
- Testing
- Ciprofloxacin 500 mg, Metronidazole 500 mg
- Where
- 11 sites in Netherlands
- Volunteers
- 298 people
- Sponsor
- dr. IJM Han-Geurts
Dientamoeba Fragilis Infection
Paromomycin or Metronidazole for Symptomatic Dientamoeba Fragilis in Adults
Dientameba Fragilis (D.fragilis) is a protozoan found in the digestive tract - in the human colon. there are disagreements regarding the preferred treatment for these cases, with several regimens tested in mostly small…
- Trial name
- COMFORTER (NCT06907498)
- Testing
- Paromomycin
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Sheba Medical Center
Dietary Habits
Analysis of MicroBial Metabolites After Eating Refined Food
The purpose of this study is to learn more about what happens in the human body after consuming a meal that contains ultra-processed foods like hamburgers, and if this is different to what happens after consuming a meal that…
- Trial name
- AMBER (NCT04308473)
- Testing
- Ultra-processed Food Meal, Whole Food Meal
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Healthy, Sepsis
The Role of the Microbiota in the Systemic Immune Response
The objective of this study is to investigate the role of the gut microbiota in the systemic priming of immune effector cells. Twelve healthy male volunteers, 18-35 years of age, will be treated with broad spectrum antibiotics…
- Trial name
- MISSION-1 (NCT02340182)
- Testing
- Vancomycin, Ciprofloxacin, Metronidazole
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- W.J. Wiersinga, MD, PhD
Shoulder Instability, Joint Instability
Neurocognitive Loading Following Anterior Shoulder Stabilization: A Randomized Controlled Trial
The goal of this randomized controlled clinical trial is to learn if adding neurocognitive loading to standard shoulder rehabilitation improves physical and psychological recovery in adults who have undergone arthroscopic…
- Conditions
- Shoulder Instability, Joint Instability, Postoperative Care
- Trial name
- NCT07631819
- Testing
- Standard Rehabilitation, Neurocognitive Loading
- Volunteers
- 32 people
- Sponsor
- Hacettepe University
H Pylori Infection Eradication, Antibiotics Therapeutic Strategies
Therapeutic Trial Comparing Triple Therapy Guided by the PCR Detection of Clarithromycin Resistance vs Empiric Concomitant Quadruple Therapy for Helicobacter Pylori Infection
The H pylori infection remains a public health problem. The eradication rate with the first line triple therapy (PPI-amoxicillin-clarithromycin) is insufficient (estimated at 70%) due to the frequency of resistance to…
- Conditions
- H Pylori Infection Eradication, Antibiotics Therapeutic Strategies, H Pylori Eradication
- Trial name
- Hepysé (NCT02576236)
- Testing
- Quadruple concomitant therapy treatment, Triple therapy guided by the result of the molecular resistance test
- Where
- France
- Volunteers
- 2,500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Spinal Cord Injuries
Musculoskeletal Plasticity After Spinal Cord Injury
Patients with spinal cord injury (SCI) experience metabolic syndrome, diabetes, obesity, pressure ulcers, and cardiovascular disease at far greater rates than the general population.
- Trial name
- NCT02622295
- Testing
- Single-session electrically induced exercise, Electrically-induced exercise training
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Richard K Shields
Complicated Intra-abdominal Infection
Study to Assess Efficacy and Safety of PF-06947386 in Japanese Adult Patients With Complicated Intra-abdominal Infection
Study C3591036 is a Phase 3 study to assess the efficacy and safety of PF-06947386 in Japanese adult patients with complicated intra-abdominal infection requiring hospitalization.
- Trial name
- NCT04927312
- Testing
- PF-06947386, Metronidazole
- Where
- 29 sites in Japan
- Volunteers
- 60 people
- Sponsor
- Pfizer
Surgical Site Infection, Postoperative Complications
Prophylatic Effect Preoperative Antibiotics With Mechanical Bowel Preparation in SSIs
Surgical site infection (SSI) is a major postoperative complication after abdominal surgery especially in colorectal field, which significantly increases length of stay (LOS), readmission incidence and expense.
- Conditions
- Surgical Site Infection, Postoperative Complications, Bowel Preparation, Oral Antibiotics
- Trial name
- NCT03856671
- Testing
- Neomycin,metronidazole
- Where
- China
- Volunteers
- 309 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Apical Periodontitis, Post Endodontic Pain
Silver Nanoparticle-Reinforced Double Antibiotic Paste in Symptomatic Apical Periodontitis: A Randomized Controlled Trial
Background Apical periodontitis (AP) is an inflammatory condition of the periapical tissues. The Symptomatic Apical periodontitis (SAP) represents the active phase of the disease, presenting with pain and tenderness.
- Conditions
- Apical Periodontitis, Post Endodontic Pain, Periapical Healing, Inflammatory Biomarkers
- Trial name
- NCT07762599
- Testing
- silver nanoparticles reinforced double antibiotic paste, Double Antibiotic Paste
- Where
- India
- Volunteers
- 50 people
- Sponsor
- All India Institute of Medical Sciences
Vaginitis, Infectious Vaginosis
A Study to Compare Efficacy and Safety of an Ovule Containing Terconazole, Clindamycin and Fluocinolone Versus an Ovule Containing Metronidazole, Nystatin and Fluocinolone in the Treatment of Secondary Vulvar/ or Vaginal Symptoms of Infectious Vaginitis/ and Infectious Vaginosis
The purpose of this comparative study is to evaluate the efficacy of an ovule with triple active agents (terconazole, clindamycin and fluocinolone) versus another ovule with triple active agents (nystatin, metronidazole and…
- Trial name
- NCT01867164
- Testing
- Gynoclin V, Vagitrol V
- Where
- 2 sites in Mexico
- Volunteers
- 160 people
- Sponsor
- Janssen-Cilag, S.A.
Differential Diagnosis, Diagnostic Accuracy
Evaluation of One-Shot Vision Differential Diagnosis (OSVDE) and Multi-Step Conversational Non-Inferiority (MSCNE) in AI Medical Interviewing
This study evaluates the diagnostic performance of a multimodal artificial intelligence (AI) system (AIMD.1) using de-identified medical images and semi-synthetic patient simulations.
- Trial name
- OSVDE-MSCNE (NCT07470463)
- Testing
- AI Diagnostic System (AIMD.1)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Magic Health Inc. (d.b.a. Nolla Health)
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