Clinical trials: Metronidazole
Helicobacter-associated Gastritis
Study of Nitazoxanide (NTZ) Based New Therapeutic Regimens for Helicobacter Pylori
Current Helicobacter Pylori infection preferred treatment involves; proton pump inhibitor (PPI)-based triple or qudrable regimens.
- Trial name
- NCT02422706
- Testing
- Nitazoxanide, Metronidazole(MTZ), Omeprazole
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Sherief Abd-Elsalam
Helicobacter Pylori Infection
Sequential Versus Quadruple Therapy in the Second-line Treatment
Objectives: A recent randomized trial showed that 14-day sequential therapy containing high dose proton pump inhibitor was higher than 95% in the first line treatment.
- Trial name
- NCT03208426
- Testing
- Esomeprazole (S14), Esomeprazole (BQ10), Amoxicillin (ST14)
- Where
- Taiwan
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Microbial Colonization, Periodontal Diseases
Impact of Non-surgical Periodontal Therapy on Oral and Gut Microbiome
Periodontitis is an inflammatory disease characterized by a dysbiotic microbiome which can lead to bone destruction and tooth loss.
- Conditions
- Microbial Colonization, Periodontal Diseases, Periodontal Inflammation
- Trial name
- NCT04580355
- Testing
- One-Stage Full Mouth Debridement, Amoxicillin 500mg, Metronidazole 400mg
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Campinas, Brazil
Surgical Site Infection, Thrombosis
Tumescent Anesthesia Antibiotic Delivery (TAAD)
This is a multicenter randomized clinical trial (RCT) comparing two modes of antibiotic delivery: Control: Intravenous Antibiotic Delivery (IVAD) Treatment: IVAD + TAAD The Food \& Drug Administration (FDA) has approved our…
- Conditions
- Surgical Site Infection, Thrombosis, Sepsis
- Trial name
- TAAD (NCT03226626)
- Testing
- Tumescent Anesthesia and antibiotic delivery (TAAD) plus IVAD, SubQKath
- Volunteers
- 330 people
- Sponsor
- HK Surgical, Inc.
Helicobacter Pylori Infection, Comorbidities and Coexisting Conditions
Real-world Treatment of H. Pylori Eradication in Patients with Comorbidity
Most of the studies of H. pylori eradication were conducted in academic institutes and designed to enrolled patients who did not have comorbidities.
- Conditions
- Helicobacter Pylori Infection, Comorbidities and Coexisting Conditions, Real-world Outcome, Medication Adherence
- Trial name
- Real-world_Hp (NCT05475431)
- Testing
- The sequential therapy, The triple therapy, The hybrid therapy
- Where
- 2 sites in Taiwan
- Volunteers
- 1,053 people
- Sponsor
- National Cheng-Kung University Hospital
Anal Fistula, Anal Abscess
Oral Antibiotics for Anal Abscess
BACKGROUND Anal abscess and perianal fistula is a high prevalence disorder in general population that affect adult patients on young ages, affecting them significantly their social and quality of life.
- Trial name
- OFF (NCT03643198)
- Testing
- ANTIBIOTIC (METRONIDAZOLE AND CIPROFLOXACIN), CONTROL
- Where
- Spain
- Volunteers
- 210 people
- Sponsor
- Germans Trias i Pujol Hospital
Bacterial Infections
VNRX-5133 Drug-Drug Interaction in Healthy Adult Volunteers
This is a 2-part, drug-drug interaction study to evaluate potential PK interactions after single doses in Part 1 and multiple doses in Part 2.
- Trial name
- NCT03332732
- Testing
- VNRX-5133, VNRX-5022, Metronidazole
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Venatorx Pharmaceuticals, Inc.
Intracerebral Hemorrhage, Intracerebral Haemorrhage
International Care Bundle Evaluation in Cerebral Hemorrhage Research
Spontaneous intracerebral haemorrhage (ICH) accounts for approximately 10-15% of all strokes but stands for 50% of stroke-related morbidity and mortality.
- Conditions
- Intracerebral Hemorrhage, Intracerebral Haemorrhage, Intraventricular Hemorrhage, Stroke
- Trial name
- I-CATCHER (NCT06429332)
- Testing
- Reversal of Oral anticoagulation within 30 minutes, Early intensive blood pressure lowering, Treatment of pyrexia
- Where
- 54 sites in United States, Australia and 6 more
- Volunteers
- 3,500 people
- Sponsor
- Region Skane
Ulcerative Colitis
Parasitic Infections and Ulcerative Colitis: Combining Anti-parasitic and Immunomodulatory Treatments May Achieve Remission
The study aimed to explore the link between parasitic infections and the severity of ulcerative colitis (UC). 120 UC patients were divided into three groups: those without infection, those with Giardia lamblia infection treated…
- Trial name
- NCT06583863
- Testing
- Echinacea Extract, MetroNIDAZOLE 500 MG Oral Tablet [Flagyl]
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Benha University
Chronic Periodontitis, Smoking
MTZ Plus AMX in the Treatment of Smokers and Non-smokers
Randomized controlled clinical trials have demonstrated that the use of amoxicillin (AMX) and metronidazole (MTZ) as adjuncts to mechanical therapy improves the clinical and microbiological outcomes of scaling and root planing…
- Trial name
- NCT01837199
- Testing
- Metronidazole plus Amoxicillin
- Where
- Brazil
- Volunteers
- 64 people
- Sponsor
- University of Guarulhos
Appendicitis
Are Post-operative Antibiotics Indicated in Simple Appendicitis?
Hypothesis: A single dose of prophylactic antibiotics is as effective as a three dose regime in preventing post-operative complications in paediatric patients with simple appendicitis.
- Trial name
- NCT01420367
- Testing
- metronidazole and cephalzolin
- Where
- Australia
- Volunteers
- 300 people
- Sponsor
- Monash University
Traumatic Brain Injury
Comparative Effectiveness of Intervention in Multi-level Hospitals for Acute Traumatic Brain Injury(Metric-TBI)
A prospective, multicenter, observational cohort study is designed to compare the effectiveness of intervention in multi-grade hospitals for acute traumatic brain injury and to optimize clinical outcomes.
- Trial name
- NCT06429774
- Testing
- Neurological function, Mental State, cognitive function, and life quality assessment, Peripheral blood test
- Where
- 64 sites in China
- Volunteers
- 2,000 people
- Sponsor
- Beijing Tiantan Hospital
Mobility Impairment, Clinical Workflow Optimization
Deployment and Evaluation of Humanoid Robotics in Coalition-Aligned Clinical Care Settings
This clinical trial evaluates the deployment of humanoid robotics in coalition-aligned healthcare settings. The study measures biometric performance, ESG compliance, and operational impact across patient care, sanitation, and…
- Conditions
- Mobility Impairment, Clinical Workflow Optimization, Sanitation Protocol Compliance, ESG-linked Healthcare Robotics Deployment
- Trial name
- HEALTH (NCT07214896)
- Testing
- Skin Cell Dip, Stem Cell Dip, Wage Token Distribution
- Where
- 4 sites in United States, Germany and 1 more
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
Percutaneous Coronary Intervention, Intravenous Ultrasound
IVUS-FFR Accuracy for Coronary Stenosis
IVUS-FFR Online Accuracy for Coronary Stenosis What is this study testing? This study is testing a new technology called IVUS-FFR , which uses ultrasound imaging inside heart arteries (IVUS) to quickly measure whether a narrowed…
- Conditions
- Percutaneous Coronary Intervention, Intravenous Ultrasound, Coronary Physiology
- Trial name
- IVUS-FFR (NCT07446023)
- Testing
- Ultrasound-Derived Fractional Flow Reserve Computational System
- Where
- China
- Volunteers
- 292 people
- Sponsor
- China National Center for Cardiovascular Diseases
Helicobacter Infection
The Efficacy of the 7 Days Tailored Therapy as the 1st Eradication of H. Pylori Infection
To compare the eradication success rate between 10-days sequential therapy and 7-days tailored therapy based on H. pylori culture and antimicrobial susceptibility testing.
- Trial name
- NCT02373280
- Testing
- 10 day sequential therapy (Esomeprazole, amoxicillin, clarithromycin, metronidazole), 7 day tailored PPI triple therapy (clarithromycin-containing triple therapy), 7 day moxifloxacin based triple therapy [Esomeprazole, Moxifloxacin, Amoxicillin]
- Where
- South Korea
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Type 2 Diabetes Mellitus
Type 2 Diabetes Exemplar: A Remote Care Service for North West London
The aim of T2DEx is to assess the feasibility, usability, acceptability, cost-effectiveness and safety of a digital support service for people in North West London at high risk of developing complications from Type 2 Diabetes…
- Trial name
- T2DEx (NCT04731142)
- Testing
- Huma, Video group consultations, KNOW Diabetes
- Where
- 7 sites in United Kingdom
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Clostridium Difficile Infection
Fecal Microbiota Therapy for Recurrent Clostridium Difficile Infection
Interventional, single arm, single-centre trial to evaluate the effectiveness and safety of fecal microbiota therapy (FMT) in the investigators population.
- Trial name
- NCT02686645
- Testing
- Fecal Microbiota, vancomycin, Loperamide
- Volunteers
- 50 people
- Sponsor
- Queen Elizabeth II Health Sciences Centre
Aging, Mortality
Longevity Metrics AI/ML Development Study
This study builds AI models that score diagnostic screening tests, and that predict screening results, clinical judgment, and life expectancy.
- Conditions
- Aging, Mortality, Cardiovascular Disease Prevention, Metabolic Syndrome
- Trial name
- NCT07808619
- Testing
- AIML scored health screening battery
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Longevity Metrics, Inc.
Acute Uncomplicated Diverticulitis
APLAUD Trial (Antibiotics vs PLacebo for Acute Uncomplicated Diverticulitis)
The goal of this clinical trial is to determine whether antibiotics improve recovery from acute uncomplicated diverticulitis (AUD) in racially and ethnically diverse United States clinical practice.
- Trial name
- NCT07492134
- Testing
- Amoxicillin-Clavulanate 875 Mg-125 Mg Oral Tablet, Metronidazole, Cefuroxime
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Vanderbilt University Medical Center
Surgical Site Infection
Comparative Study of Postoperative Surgical Site Infections in Diabetic and Non-Diabetic Patients
This prospective observational study aims to compare the incidence and characteristics of postoperative surgical site infections (SSIs) between diabetic and non-diabetic patients undergoing elective general surgical procedures.
- Trial name
- NCT07049614
- Testing
- Diabetic Patients, Non-Diabetic Patients
- Where
- Pakistan
- Volunteers
- 132 people
- Sponsor
- Superior University
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