Clinical trials: Metronidazole
Recurrent Bacterial Vaginosis
Vaginal Microbiota Transplant
This is a randomized trial of vaginal microbiome transplant vs. saline placebo to restore a Lactobacillus dominant vaginal microbial community in women with recurrent bacterial vaginosis.
- Trial name
- MOTIF (NCT04046900)
- Testing
- Vaginal microbiome transplant, Oral Metronidazole, Sterile saline
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Douglas Kwon
Freezing of Gait Symptoms in Parkinson's Disease, Deep Brain Stimulation
Imaging Biomarkers of FOG Response to DBS
For this study, the investigators are recruiting 54 individuals with Parkinson's Disease and Freezing of Gait (FOG) who are planning to undergo Deep Brain Stimulation (DBS).
- Trial name
- NCT06951906
- Testing
- fMRI
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Medical University of South Carolina
Helicobacter Pylori Infection
Quadruple vs Tailored Therapy in the Treatment of Helicobacter Pylori Infection
Non-bismuth quadruple therapies have been proposed as potential strategies in improving the efficacy of first-line treatments. The non-bismuth quadruple therapy in its concomitant variant consists of proton pump inhibitor…
- Trial name
- NCT04621487
- Testing
- Amoxicillin, Metronidazole, Clarithromycin
- Where
- Croatia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Split, School of Medicine
Perianal Abscess, Perianal Fistula
Perianal Abscess Recurrence and Fistula Formation: Antibiotics Following Incision and Drainage Trial
Most perianal abscesses (PA) result from an infection originating in anal crypts that extend into anal glands in the intersphincteric plane.
- Trial name
- PARFAIT (NCT04549311)
- Testing
- Antibiotic 1 arm (amoxicillin + clavulanic acid), Antibiotic 2 arm (ciprofloxacin + metronidazole)
- Where
- 3 sites in Canada
- Volunteers
- 15 people
- Sponsor
- Sunnybrook Health Sciences Centre
Clostridium Enterocolitis, Pseudomembranous Colitis
A Study of GT267-004 Versus Vancomycin and GT267-004 Versus Metronidazole in Patients With C.Difficile - Associated Diarrhea
Approximately 520 patients will be entered into this study taking place throughout the US and Canada. This study aims to determine if an investigational drug is safe and effective for treating symptoms of C.
- Trial name
- NCT00106509
- Testing
- tolevamer potassium-sodium (GT267-004)
- Where
- 140 sites in United States, Canada and 1 more
- Volunteers
- 520 people
- Sponsor
- Genzyme, a Sanofi Company
Acute Uncomplicated Diverticulitis
Non-antibiotic Management in Acute Uncomplicated Diverticulitis
Diverticulitis is a common condition that causes swelling and pain in part of the colon (the large intestine). Doctors classify it as "mild" when there are no serious complications.
- Trial name
- NAMAD (NCT07625267)
- Testing
- Symptomatic treatment (ibuprofen and acetaminophen), Amoxicillin-clavulanate, Ciprofloxacin plus metronidazole
- Sponsor
- Montefiore Medical Center
Opioid Sensitivity, Individual Difference
A118G SNP and OPRM1 Gene Opioid-Mediated Effects in Humans
Within-subject, double-blind, placebo-controlled examination of opioid abuse potential in healthy individuals as a function of A118G SNP on the OPRM1 gene.
- Conditions
- Opioid Sensitivity, Individual Difference, Abuse Opioids
- Trial name
- NCT02360371
- Testing
- Within-subject test of blinded study medication
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Sexually Transmitted Infections, Schistosoma Haematobium
Urogenital Schistosomiasis and Sexually Transmitted Infections in Madagascar
A cross-sectional study of urogenital schistosomiasis and sexually transmitted infections (STI) prevalence and associated morbidity in a rural community in Madagascar.
- Trial name
- FGS/MGS/STI (NCT00713999)
- Testing
- Treatment with anti-STI and anti-schistosoma regimens
- Where
- Madagascar
- Volunteers
- 680 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Neuropathy, Painful Diabetic
Neurofeedback for the Management of Neuropathic Pain in People With Diabetes
We will conduct a high-quality, blinded, randomized controlled trial (RCT) to rigorously test the effectiveness of EEG-based NF in patients with diabetes-related neuropathic pain.
- Trial name
- NCT06603792
- Testing
- EEG-neurofeedback
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- University of Southern Denmark
Preterm Premature Rupture of Membrane, Pregnancy, High Risk
Improvement of PPROM Management With Prophylactic Antimicrobial Therapy (iPROMPT)
To conduct an unblinded pragmatic randomized controlled trial (pRCT) "Improvement of PPROM Management with Prophylactic Antimicrobial Therapy (iPROMPT)" of a seven-day course of ceftriaxone, clarithromycin, and metronidazole…
- Conditions
- Preterm Premature Rupture of Membrane, Pregnancy, High Risk, Preterm Birth
- Trial name
- NCT06396078
- Testing
- Ceftriaxone 1000 MG, Clarithromycin 500mg, Metronidazole 500 mg
- Where
- 2 sites in United States
- Volunteers
- 56 people
- Sponsor
- Ohio State University
Apical Periodontitis, Post Endodontic Pain
Silver Nanoparticle-Reinforced Double Antibiotic Paste in Symptomatic Apical Periodontitis: A Randomized Controlled Trial
Background Apical periodontitis (AP) is an inflammatory condition of the periapical tissues. The Symptomatic Apical periodontitis (SAP) represents the active phase of the disease, presenting with pain and tenderness.
- Conditions
- Apical Periodontitis, Post Endodontic Pain, Periapical Healing, Inflammatory Biomarkers
- Trial name
- NCT07762599
- Testing
- silver nanoparticles reinforced double antibiotic paste, Double Antibiotic Paste
- Where
- India
- Volunteers
- 50 people
- Sponsor
- All India Institute of Medical Sciences
Wounds and Injuries, Surgery--Complications
Preoperative Oral Antibiotics With vs Without Mechanical Bowel Preparation to Reduce Surgical Site Infections Following Colonic Resection: an International Randomized Controlled Trial.
The ORALEV Study found that preoperative oral antibiotics can reduce the incidence of surgical site infections after colonic resection, compared with no preparation.
- Trial name
- ORALEV2 (NCT04161599)
- Testing
- Cefuroxime (750mg) I.V, Colonic Surgery, Cefuroxime 750mg oral
- Where
- 10 sites in China, Greece and 4 more
- Volunteers
- 968 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Helicobacter Pylori Infection, Dyspepsia
Pylori Duo for Adjunctive Treatment and Prevention of Recurrence of Helicobacter Pylori Infection
This randomized, double-blind, placebo-controlled, single-center clinical trial will evaluate the efficacy and safety of Pylori Duo as an adjunctive treatment in adult patients with confirmed Helicobacter pylori infection.
- Conditions
- Helicobacter Pylori Infection, Dyspepsia, Gastrointestinal Adverse Effects
- Trial name
- NCT07729293
- Testing
- Omeprazole, Pylera (Bismuth subcitrate potassium, metronidazole, tetracycline) given in combination with omeprazole, Pylori Duo
- Where
- Spain
- Volunteers
- 140 people
- Sponsor
- Gala Servicios Clinicos S.L.
Appendicitis
Acute Appendicitis: Active Observation With and Without Antibiotics
This study evaluates if early provision of antibiotics is a superior treatment compared to "traditional wait and see" with regard to symptom relief for suspected acute uncomplicated appendicitis.
- Trial name
- NCT03985514
- Testing
- Antibiotic treatment (Piperacillin/Tazobactam, 4 gram x 3), followed by 8-10 days of out-hospital oral antibiotic treatment (Ciprofloxacin 500 mgx2,Flagyl 400 mgx3)., Active observation
- Where
- Sweden
- Volunteers
- 126 people
- Sponsor
- Göteborg University
Diabetes
Transforming Primary Care Payment in Hawaii
To design an innovative payment system that improves upon fee-for-service (FFS), incorporates behavioral economic principles, and improves work satisfaction among primary care physicians (PCPs) while improving quality and…
- Trial name
- NCT02731716
- Testing
- New Payment Model, Social Comparisons, A1c Member/Provider Incentive
- Volunteers
- 117 people
- Sponsor
- University of Pennsylvania
Hemorrhoid Pain, Hemorrhoids
Topical Analgesia Post-Haemorrhoidectomy
Symptomatic haemorrhoids, or piles, have significant effects on quality of life. The treatment for advanced disease is surgical excision (haemorrhoidectomy) which is extremely effective.
- Trial name
- NCT04276298
- Testing
- Metronidazole cream, Metronidazole and Diltiazem cream, Metronidazole and Lidocaine cream
- Where
- New Zealand
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- University of Auckland, New Zealand
Helicobacter Pylori Infection
Comparison of 12-day Reverse Hybrid Therapy and 12-day Standard Triple Therapy for Helicobacter Pylori Infection
Reverse hybrid therapy is a one-step two-phase treatment for Helicobacter pylori infection with less cost than standard triple therapy.
- Trial name
- REHYTRI (NCT02359435)
- Testing
- Reverse hybrid therapy, Standard triple therapy
- Where
- Taiwan
- Volunteers
- 440 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Diverticular Disease of Colon, Colostomy Complication
Comparing Hartmann's Procedure and Primary Resection With Anastomosis in Hinchey III-IV Diverticulitis: Focus on Ostomy Closure and Long-Term Outcomes
Brief Summary This multicenter study compares the effectiveness of primary anastomosis with diverting loop ileostomy to Hartmann's procedure for managing perforated sigmoid diverticulitis in stable patients.
- Conditions
- Diverticular Disease of Colon, Colostomy Complication, Colostomy - Stoma
- Trial name
- ARES (NCT06794905)
- Volunteers
- 578 people
- Sponsor
- Azienda Sanitaria Locale Napoli 2 Nord
Diarrhea, Clostridium Difficile
Pharmacokinetics and Safety of Tigecycline in the Treatment of Clostridium Difficile Associated Diarrhea (CDAD)
This is a prospective, non-comparative, interventional, observational pilot study of the safety and pharmacokinetics of intravenous (IV) tigecycline in conjunction with standard oral therapy in patients with known mild to severe…
- Trial name
- NCT01401023
- Testing
- Tigecycline
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Gary E. Stein, Pharm.D.
Gastric Cancer
Digital Rehabilitation for Gastric Cancer Surgery After Neoadjuvant Therapy
The goal of this clinical trial is to investigate the effects of a perioperative multimodal rehabilitation program on the incidence of postoperative complications and perioperative clinical indexes including functional capacity…
- Trial name
- NCT07441850
- Testing
- perioperative multimodal rehabilitation program with telephone supervision, Usual Care, perioperative multimodal rehabilitation program with digital supervision
- Where
- China
- Volunteers
- 186 people
- Sponsor
- Beijing Friendship Hospital
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