Clinical trials: Midazolam
Hemodynamic Instability
Role of Nebulized Dexmedetomidine in Blunting the Effects of Direct Laryngoscopy and Endotracheal Tube on Heart Rate and Blood Pressure.
The goal of this interventional study is to check the effectiveness of nebulized Dexmedetomidine in preventing the rise in blood pressure and heart rate in patients undergoing General Anesthesia.
- Trial name
- NCT06103721
- Testing
- Dexmedetomidine Injection [Precedex], Normal Saline
- Where
- Pakistan
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Muhammad Haroon Anwar
Status Epilepticus
Improving Status Epilepticus Treatment Times
This is a stepped-wedge cluster randomized effectiveness-implementation hybrid study aimed at determining the effect of dissemination of a QI bundle on the time to treatment of SE among hospitalized, non-critically ill children.
- Trial name
- QuITT-SE (NCT06194747)
- Testing
- Quality improvement bundle, Quality improvement bundle and local PDSA cycles with central support, Quality improvement bundle and local PDSA cycles without central support
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- Nationwide Children's Hospital
Vitreous Detachment
Comparison of Propofol Target Controlled Infusion (TCI) and Sevoflurane
This study was an experimental, single-blinded, randomized controlled trial that aimed to compare recovery time between TCI propofol and sevoflurane.
- Trial name
- NCT04865991
- Testing
- TCI Propofol, Sevoflurane
- Where
- Indonesia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Ventricular Tachycardia
Inducibility and Stability of Ventricular Tachycardia Inpatients Undergoing VT Ablation Under General Anesthesia
This research study is being done to see whether general anesthesia (GA) affects our ability to start ventricular tachycardia (VT) during an VT ablation procedure.
- Trial name
- NCT02419547
- Testing
- Versed, Fentanyl, Propofol
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Brigham and Women's Hospital
Analgesia, Children, Only
The Use of Midazolam as Adjuvant to Bupivacaine Intrathecal Anesthesia for Children Undergoing Lower Abdominal Surgeries.
The study will be carried on children undergoing lower abdominal surgeries. Patients will be randomly categorized into two study groups.
- Conditions
- Analgesia, Children, Only, Bupivacaine, Midazolam
- Trial name
- NCT04718259
- Testing
- intrathecal bupivacaine, midazolam
- Where
- Saudi Arabia
- Volunteers
- 120 people
- Sponsor
- Tanta University
Children
Safety and Efficacy of Fentanyl Citrate in Children
Title: Safety and efficacy of fentanyl citrate in combination with midazolam in critically ill children with mechanical ventilation Objective: To evaluate the safety and efficacy of fentanyl citrate in combination with midazolam…
- Trial name
- NCT02172014
- Testing
- midazolam and fentanyl citrate infusion, midazolam and normal saline infusion
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Seoul National University Hospital
Colonoscopy, Sedation and Analgesia
Dose-sparing Balanced Propofol Sedation in Colonoscopy
This randomized controlled trial compared two balanced propofol analgosedation strategies in adults undergoing elective colonoscopy.
- Trial name
- NCT07885059
- Testing
- Standard-dose balanced propofol analgosedation, Dose-sparing balanced propofol analgosedation
- Where
- 2 sites in Croatia
- Volunteers
- 76 people
- Sponsor
- University of Split, School of Medicine
Kidney Transplant; Complications, Drug Interaction Food
Drug Interaction With Envarsus XR and Grapefruit Juice
Transplant patients must take lifelong immunosuppression in order to prevent rejection of their organ. Tacrolimus is the most widely used immnosuppressive agent.
- Trial name
- NCT03916380
- Testing
- Grapefruit Juice
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Shirley M. Tsunoda
Perioperative Blood Glucose and Insulin
Dexmedetomidine Influence on the Level of Perioperative Blood Glucose and Insulin of Elderly Diabetes Patients
Dexmedetomidine is a kind of high selectivity alpha 2 agonists adrenaline, can inhibit the activity of sympathetic nerve, alleviate pain,and improve cardiovascular stability in the operation period.
- Trial name
- NCT02154074
- Testing
- general anesthesia induction, Isoflurane, Dexmedetomidine
- Where
- China
- Volunteers
- 92 people
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Depth of Anesthesia Monitoring, BIS-EEG
The Effects of Midazolam, Dexmedetomidine, and Esketamine on Bispectral Index and Raw Electroencephalogram in Patients Under Propofol-Remifentanil Baseline Anesthesia
This prospective, single-center, randomized interventional study aims to investigate the effects of commonly used adjunct anesthetic drugs on the Bispectral Index (BIS) and electroencephalographic (EEG) activity during total…
- Trial name
- NCT07699523
- Testing
- Midazolam, Dexmedetomidine, Esketamine
- Where
- China
- Volunteers
- 120 people
- Sponsor
- China-Japan Friendship Hospital
Treatment Resistant Depression, Major Depressive Disorder
Sustained Mood Improvement With Laughing Gas Exposure: A Randomized Controlled Pilot Trial
The purpose of the study is to investigate a short-term treatment option for major depressive disorders by administering nitrous oxide gas.
- Trial name
- SMILE (NCT04957368)
- Testing
- Nitrous Oxide 99 %, Oxygen + Midazolam
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Unity Health Toronto
Peripheral Vascular Diseases, Arterial Occlusive Diseases
Intra-arterial Stem Cell Therapy for Patients With Chronic Limb Ischemia (CLI)
The purposes of this study are to determine whether intra-arterial injection of autologous stem cells is effective in the treatment of chronic limb ischemia (CLI), to characterize stem cell dysfunction in patients with CLI, and…
- Conditions
- Peripheral Vascular Diseases, Arterial Occlusive Diseases, Leg Ulcer, Gangrene
- Trial name
- JUVENTAS (NCT00371371)
- Testing
- Bone marrow punction, BM-MNC infusion
- Where
- Netherlands
- Volunteers
- 160 people
- Sponsor
- UMC Utrecht
Akathisia
Prophylaxis Against Metoclopramide-Induced Akathisia
ABSTRACT Study Objective: To compare the effects of midazolam and diphenhydramine for the prevention of metoclopramide induced akathisia.
- Trial name
- NCT01051271
- Testing
- midazolam
- Volunteers
- 225 people
- Sponsor
- Pamukkale University
Opiod Use Disorder
The Influence of ANS-6637 on Midazolam Pharmacokinetics in Healthy Volunteers
Background: Opioids are medicines that control pain. But they are often misused, which can lead to illness and death. Opioids increase dopamine to the brain, which makes people feel good and often causes them to crave drugs…
- Trial name
- NCT03831971
- Testing
- ANS-6637
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Critical Illness
Lorazepam Sedation for Critically Ill Children
This clinical trial is being performed under the Best Pharmaceuticals for Children Act, signed into law in 2002 in order to improve pediatric labeling for off-patent drugs.
- Trial name
- NCT00109395
- Testing
- Lorazepam, Midazolam, Lorazepam CI
- Where
- United States
- Volunteers
- 179 people
- Sponsor
- The Emmes Company, LLC
Anesthesia Awareness
Heart Rate Variability to Quantify General Anesthesia Depth
The shortage of anesthetic agents can lead to intraoperative awareness while overdosing can trigger severe intra and postoperative problems.
- Trial name
- NCT04788732
- Testing
- ECG and EEG monitoring
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- University of Sao Paulo
Acute Myocardial Infarction, Pain
To Relieve Pain and Anxiety - an Intervention Study in Ambulance Services
This is an intervention study focusing on both medical and nursing questions. The study is a joint project between the Ambulance services at four cities in West Sweden and Knowledge and research centre, PreHospen at University of…
- Trial name
- NCT00792181
- Testing
- Midazolam, Course intervention - a professional development course for caregivers.
- Volunteers
- 2,800 people
- Sponsor
- Sahlgrenska University Hospital
Tumors
Phase 1 Study to Determine the Effect of Lenvatinib (E7080) on the Pharmacokinetics of Midazolam in Subjects With Advanced Solid Tumors
This is a multicenter, open-label, non-randomized Phase 1 study in participants with advanced solid tumors, excluding hepatocellular carcinoma (HCC), that have progressed after treatment with approved therapies, or for which…
- Trial name
- NCT02686164
- Testing
- Lenvatinib, Midazolam
- Where
- 4 sites in United States
- Volunteers
- 51 people
- Sponsor
- Eisai Inc.
Healthy
Identification and Evaluation of Endogenous Markers for the Assessment of CYP3A Activity Using Metabolomics
Identification and evaluation of endogenous markers for the assessment of CYP3A activity using metabolomics.
- Trial name
- NCT01215214
- Testing
- midazolam
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Bronchoscopy, Remimazolam
Efficacy and Safety of Remimazolam Compared With Midazolam During Bronchoscopy:Randomised Controlled Trial
Objectives: Although remimazolam is an ultra-short-acting benzodiazepine with a shorter elimination half-life and faster recovery time than midazolam, studies evaluating its safety and efficacy during bronchoscopy are limited.
- Trial name
- NCT05994547
- Testing
- Byfavo, Midazolam
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Chungbuk National University Hospital