Clinical trials: Midazolam, completed
Early Gastric Cancer, Gastric Adenoma
Performance of Endoscopic Submucosal Dissection According to the Sedation Method
Although proper sedation is mandatory for endoscopic procedures such as endoscopic submucosal dissection, the effects of sedation on ESD performance and complications have not been fully evaluated.
- Trial name
- NCT01806753
- Testing
- Intermittent midazolam/propofol injection controlled by endoscopist, Continuous propofol infusion with opioid administration
- Where
- South Korea
- Volunteers
- 157 people
- Sponsor
- Yonsei University
Shock,, Sepsis
Effects of Sedatives on Sublingual Microcirculation of Patients With Septic Shock
Previous studies have demonstrated that altered microvascular blood flow is an important marker of severe sepsis. Usually, these patients need invasive ventilatory support, frequent use of sedatives and it is unknown if these…
- Trial name
- NCT01618396
- Testing
- Sedation drug (Propofol and Midazolam)
- Where
- Brazil
- Volunteers
- 16 people
- Sponsor
- Casa de Saúde São José
Osteoarthritis Nos, of Sacroiliac Joint
Optimal Performance of RFA of the Nerves Supplying the Posterior Sacroiliac Joint Complex.
The procedure is supposed to ablate the sacral lateral branches that form the medial cluneal nerves (MCN). The anatomy of the sacral lateral branches is such that, in addition to innervating the SIJ, distal branches of these…
- Trial name
- NCT02808962
- Testing
- Cooled RFA of sacral lateral branches
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Milton S. Hershey Medical Center
Total Knee Replacement, Genicular Nerve Block
Genicular and Anterior Femoral Cutaneous Nerve Blocks for Total Knee Arthroplasty
The goal of this randomized controlled trial is to examine if there is a relationship between the addition of the genicular nerve block and anterior femoral cutaneous nerve block in providing analgesia and the use of oral and…
- Conditions
- Total Knee Replacement, Genicular Nerve Block, Opioid Use
- Trial name
- NCT05980546
- Testing
- Bupivacaine Injection, Dexamethasone injection, Fentanyl
- Where
- United States
- Volunteers
- 244 people
- Sponsor
- Hospital for Special Surgery, New York
Healthy Volunteers
Drug Interaction Study of CT1812 in Healthy Volunteers
This is Phase 1, single-center, open-label, single-sequence drug-drug interaction study to determine the effect of CT1812 (560 mg) once daily on the pharmacokinetics of 4 probe drugs (tolbutamide, midazolam, dextromethorphan and…
- Trial name
- NCT03716427
- Testing
- CT1812, tolbutamide, dextromethorphan
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Cognition Therapeutics
Healthy
Study Evaluating The Co-Administration Of Moxidectin And Midazolam In Healthy Subjects
The purpose of this study is to evaluate the effect of single doses of midazolam on the plasma concentration of a single dose of moxidectin in healthy young adult subjects, and to assess the safety of co-administration of…
- Trial name
- NCT00856362
- Testing
- Moxidectin, Midazolam
- Where
- Germany
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Postoperative Pain
Caudal Block for Inguinal Hernioplasty in Children
This is a prospective, randomized, controlled clinical study designed to determine the effectiveness of caudal block combined with general anesthesia in providing intra- and postoperative analgesia, and its effect on hemodynamic…
- Trial name
- NCT05958589
- Testing
- Caudal block with levobupivacaine, General anesthesia, Inguinal hernioplasty
- Where
- Serbia
- Volunteers
- 70 people
- Sponsor
- University of Novi Sad
Ciprofol
Changes of Ciprofol Dosage and Bispectral Index Required for Loss of Consciousness in Patients of Different Ages
This study aims to explore dose requirements for loss of consciousness and bispectral index changes during general anesthesia induction with ciprofol in patients of different ages, providing a reference for its rational clinical…
- Trial name
- NCT07148596
- Testing
- It is an observational study without any intervention measures.
- Where
- China
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- General Hospital of Ningxia Medical University
Sepsis, Systemic Inflammatory Response Syndrome
Influence of Age, Sepsis and SLCO1A2 Polymorphisms on Rocuronium Pharmacokinetics
This study aims to evaluate the influence of age and sepsis on in vivo activity of OATP1A2 using rocuronium (ROC) as a probe and evaluating the pharmacokinetics and pharmacodynamics in ASA I-III surgical patients.
- Conditions
- Sepsis, Systemic Inflammatory Response Syndrome, Septic Shock
- Trial name
- ROCSEPSIS (NCT02399397)
- Testing
- Serial blood sampling, Train of four monitoring, Blood testing for liver and renal function
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Forearm Fractures
Supraclavicular Block vs Bier's Block for Forearm Trauma Surgery
This study compared two common anesthesia techniques used for forearm trauma surgery-Bier's block and the supraclavicular block-to determine which provides better surgical conditions and patient comfort.
- Trial name
- NCT07418086
- Testing
- Bier's Block (IVRA), Supraclavicular Block
- Where
- Pakistan
- Volunteers
- 66 people
- Sponsor
- Sargodha Medical College
Propofol, Target Controlled Infusion
Propofol TCI Administered by Gastroenterologists During Endoscopy: a Randomized Double Blind Controlled Study
Many studies address safety and effectiveness of non-anesthesiologist propofol sedation (NAPS) for GI endoscopy. Target Controlled Infusion (TCI) is a sophisticated tool for providing optimal sedation regimen and avoiding under…
- Conditions
- Propofol, Target Controlled Infusion, Moderate Sedation, Gastrointestinal Endoscopy
- Trial name
- PropTCI/2012 (NCT01941888)
- Testing
- Propofol, Midazolam, Target Controlled Infusion
- Where
- 2 sites in Italy
- Volunteers
- 140 people
- Sponsor
- Ospedale San Raffaele
Critical Illness and Mechanical Ventilation
Early Goal-Directed Sedation Compared With Standard Care in Mechanically Ventilated Critically Ill Patients
The Use of sedative drugs in intensive care is widespread. A cohort study conducted in Australia and New Zealand in 2010 revealed a high prevalence of deep sedation within the first 48 hours of mechanical ventilation which was…
- Trial name
- SPICE III RCT (NCT01728558)
- Testing
- Early goal Directed Sedation, Standard care sedation
- Where
- 74 sites in Australia, Ireland and 6 more
- Volunteers
- 4,000 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Failure of Respiratory Function
Evaluation of Pupillary Distension Reflexes, as a Tool for the Monitoring of Analgesia for Patients in Intensive Care.
Sedation-analgesia is an important therapy for patients in resuscitation. It requires a surveillance, in order to avoid excessive or insufficient dosages of sedative or nonmorphinics, sources of side effects.
- Trial name
- PUPILLO REA (NCT02843893)
- Testing
- Measure the minimum intensity of a painful stimulation
- Where
- France
- Volunteers
- 51 people
- Sponsor
- University Hospital, Grenoble
Healthy
Effects of BI 44370 TA Orally Applied as Tablets on the Pharmacokinetics of Orally Administered Midazolam Solution in Healthy Volunteers
Evaluation of the long-term (48 h) and short-term (1 h) effects of BI 44370 BS on the pharmacokinetics of midazolam as marker of a possible inhibition of CYP 3A4; safety and tolerability.
- Trial name
- NCT02217514
- Testing
- Midazolam, BI 44370 low dose, BI 44370 medium dose
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Major Depressive Disorder, Healthy Controls
Elucidating the Neurocircuitry of Irritability With High-Field Neuroimaging to Identify Novel Therapeutic Targets
The study is investigating dysfunctions in neurocircuitry in regards to irritability with healthy controls (HC) and individuals with Major Depressive Disorder (MDD) by performing MRIs.
- Trial name
- UNIKET (NCT05046184)
- Testing
- Ketamine Hydrochloride, Midazolam injection
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Dental Anxiety, Impacted Third Molar Tooth
Three Anxiolytic Drugs Used in Third Molar Surgery
This study was to compare the effectiveness of three drugs (Passiflora incarnata, Erythrina mulungum, Midazolam) in controlling anxiety in patients undergoing bilateral extraction of asymptomatic, impacted mandibular third molars.
- Trial name
- NCT02065843
- Testing
- Mulungu, Passiflora incarnata, midazolam
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Sergipe
Pharmacokinetic Assessments in Healthy Volunteers
A Drug Interaction Study of the Effects of PPI-668 on the Pharmacokinetics of Midazolam and Omeprazole
The primary objectives of the study are to: Evaluate the potential effects of PPI-668 at steady state on the pharmacokinetic (PK) profile of midazolam following a single oral dose in human subjects.
- Trial name
- NCT01786382
- Testing
- PPI-668, Midazolam, Omeprazole
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Presidio Pharmaceuticals, Inc.
Procedural Sedation
Propofol vs. Midazolam-based Balanced Propofol for Nonanesthesiologist Moderate Sedation in Colonoscopy
Nonanesthesiologist administration of propofol for sedation is actually a field of growing interest for endoscopists, as demonstrated by recent American and European guidelines on this issue.
- Trial name
- MIDAPROP (NCT01428882)
- Testing
- Midazolam, Propofol
- Where
- Spain
- Volunteers
- 135 people
- Sponsor
- Infante, Javier Molina, M.D.
Neoplasm Malignant
Safety and Pharmacokinetic Study of Cabazitaxel in Patients With Advanced Solid Tumors and Liver Impairment
Primary Objectives: To determine the maximum tolerated dose (MTD) and safety of Cabazitaxel when administered to advanced solid tumor patients with varying degrees of hepatic impairment To determine the pharmacokinetics (PKs) of…
- Trial name
- NCT01140607
- Testing
- Cabazitaxel (XRP6258)
- Where
- 14 sites in United States
- Volunteers
- 56 people
- Sponsor
- Sanofi
Anxiety Disease
Comparative Evaluation of Three Anxiety Control Protocols in Third Molar Extraction
The surgery for the extraction of the third molars is a procedure in Dentistry that generates a large picture of anxiety in the patient. One of the ways to try to soften this picture, are the professionals to use sedation.
- Trial name
- NCT03165500
- Testing
- Diazepam, Midazolam, Nitrous Oxide + Oxygen Gas
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho