Clinical trials: Midazolam, open to volunteers
Anesthesia, Sedation and Analgesia
Prospective IR-led Sedation Feasibility
This study wants to see if some interventional radiology (IR) procedures can be done without using general anesthesia. General anesthesia needs a lot of staff and equipment. It can also cause side effects.
- Conditions
- Anesthesia, Sedation and Analgesia, Interventional Radiology
- Trial name
- NCT07443254
- Testing
- ketamine, Fentanyl (IV), Midazolam
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- CAMC Health System
Neoplasm of Breast
Therapeutic Education and Nursing Support Program for Supportive Care, in Patients Treated With Hormone Therapy for Non-metastatic Breast Cancer
To compare the efficacy of the addition of a therapeutic education program combined with nursing phone follow-up, compared to conventional management alone, on the management of adverse events (AEs) related to adjuvant hormone…
- Trial name
- ETAPH (NCT04794075)
- Testing
- Therapeutic Education and Nursing Support Program for Supportive Care
- Where
- 9 sites in France
- Volunteers
- 300 people
- Sponsor
- Centre Hospitalier Emile Roux
Healthy
A Study of LY4355756 in Healthy Participants
The purpose of the study is to assess how LY4355756 is absorbed by the body and how safe it is to healthy participants. There will be four inpatient stays at the clinical research unit (CRU).
- Trial name
- NCT07765498
- Testing
- LY4355756, Midazolam
- Where
- United States
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Delirium in the Intensive Care Unit
Impact on Delirium of the Use of DEXmedetomidine as First-line Sedation in PEDIAtric Intensive Care
The goal of this clinical trial is to learn if dexmedetomidine can reduce delirium in critically ill children, needing mechanical ventilation for more than 12 hours.
- Trial name
- PEDIADEX (NCT07542990)
- Testing
- Dexmedetomidine, Midazolam
- Where
- 7 sites in France
- Volunteers
- 266 people
- Sponsor
- University Hospital, Tours
Liver Malignant Tumors
Clinical Effectiveness of Microwave Ablation Using Starwave Microwave Generator for Hepatic Malignancies
The purpose of this study is to determine the technical success rate of creating a safety margin of 5 mm or more including the tumor by performing image-guided percutaneous microwave thermal therapy using a microwave generator…
- Trial name
- NCT06426992
- Testing
- Starwave Microwave Ablation System, Microwave Ablation, Ultrasound-CT fusion guidance system
- Where
- South Korea
- Volunteers
- 128 people
- Sponsor
- Seoul National University Hospital
Percutaneous Endoscopic Gastrostomy, Enteral Nutrition Feeding
Comparison of Sedated and Unsedated PEG in Elderly ASA IV Patients
This prospective observational cohort study aims to compare the safety and clinical outcomes of sedated and unsedated percutaneous endoscopic gastrostomy procedures in elderly patients classified as ASA IV.
- Conditions
- Percutaneous Endoscopic Gastrostomy, Enteral Nutrition Feeding, Dysphagia, Elderly Patients (>65 Years)
- Trial name
- NCT07758153
- Volunteers
- 70 people
- Sponsor
- Mersin University
Anesthesia
Effect of Sedative and Anxiolytic Premedication on Children Experience After General Anesthesia
Children undergoing general anesthesia for surgery commonly need sedative and anxiolytic premedication but little clinical evidence supports is benefit for children older than 7 years old.
- Trial name
- pediaPREM (NCT05681572)
- Testing
- Midazolam, Dexmedetomidine
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Montpellier
EEG Data Analysis, Orthopedic Surgery
Characteristic Electroencephalogram of General Anesthesia
Patients were enrolled according to predefined inclusion and exclusion criteria. Following surgical admission, standard monitoring was initiated, including continuous assessment of heart rate, blood pressure, electrocardiogram…
- Trial name
- NCT07468162
- Testing
- After the use of sedative drugs, the changes in the electroencephalogram (EEG) spectrum were observed with an EEG monitor
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Lower Limb Orthopedic Surgery
Intravenous Dexmedetomidine Versus Midazolam in Preventing Shivering in Trauma Patients Undergoing Lower Limb Orthopedic Surgery Under Spinal Anesthesia
Shivering is a common and significant complication following spinal anesthesia, with a reported incidence of 40-60% especially in trauma patients due to pain, stress response, blood loss, and disrupted thermoregulation.
- Trial name
- NCT07300826
- Testing
- Dexmedetomidine, Midazolam
- Volunteers
- 100 people
- Sponsor
- Assiut University
Postoperative Pain
Sacral Canal Block for Hip Replacement the Efficacy and Safety of Controlled Intraoperative Hypotension
To observe the efficacy and safety of sacral canal block in controlled blood pressure reduction during hip replacement in the elderly, and to provide a better option for controlled blood pressure reduction during clinical hip…
- Trial name
- NCT07064434
- Testing
- Sacral canal block combined with general anesthesia, Simple general anesthesia
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- General Hospital of Ningxia Medical University
Sedation Complication, Mechanical Ventilation in Neonates
Pharmacokinetics-pharmacodynamics of Morphine With or Without Midazolam Administered by Continuous Infusion in Neonatal Intensive Care
This study aims to describe a dose-effect relationship of morphine alone and morphine and midazolam administered as continuous infusion in neonates hospitalized in Neonatal intensive care unit and undergoing mechanical…
- Trial name
- NCT05371886
- Testing
- Dose-effect relationship of morphine +/- midazolam administration
- Where
- 5 sites in France
- Volunteers
- 180 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Healthy Adult Participants
An Open-Label Drug Interaction Clinical Study to Evaluate Itraconazole, Rifampin, Midazolam and SIM0270 in Chinese Healthy Adult Participants
This study is an open-label, fixed-sequence, two-period Phase 1 clinical trial in healthy adult Chinese participants with a total of 3 cohorts, 16-20 healthy adult Chinese participants are planned to be enrolled in each cohort.
- Trial name
- SIM0270-104 (NCT07357610)
- Testing
- SIM0270, itraconazole, Rifampin
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jiangsu Simcere Pharmaceutical Co., Ltd.
Drug Effect
Pharmacokinetics of Sedatives and Analgesics During Extracorporeal Membrane Oxygenation (ECMO) Support
This study will measure plasma concentrations of dexmedetomidine, fentanyl, morphine and midazolam in pediatric patients supported with extracorporeal membrane oxygenation (ECMO) aiming to understand the pharmacokinetics of these…
- Trial name
- NCT03593408
- Testing
- Dexmedetomidine, Fentanyl, Midazolam
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Boston Children's Hospital
Awake Fiberoptic Intubation, Difficult Airway
Comparison of Two Sedation Regimens for Awake Fiberoptic Intubation
The purpose of this study is to examine the effects of different sedation drugs used for the awake fiberoptic intubation procedure.
- Trial name
- NCT05736198
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- University of Illinois Chicago
Laparoscopic Cholecystectomy Surgery
Attenuate the Stress Response in Laparoscopic Cholecystectomy
Aims of this study are to compare the effectiveness of dexmedetomidine versus fentanyl-midazolam in attenuating hemodynamic stress response during laparoscopic cholecystectomy (mainly HR).
- Trial name
- NCT07425444
- Testing
- Dexmedetomidine, Fentanyl- midazolam
- Volunteers
- 50 people
- Sponsor
- Assiut University
Cataract Surgery, Cognitive Impairment
Remimazolam for Cataract Surgery
The goal of this study is to assess any post operative cognitive changes following benzodiazepine administration during cataract surgery. The investigators will compare effects of Midazolam vs.
- Trial name
- NCT05980117
- Testing
- Remimazolam, Midazolam
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, Los Angeles
Lung Cancers, Peripheral Pulmonary Nodules
General Anesthesia vs Conscious Sedation for Radial Endobronchial Ultrasound
The endoscopic investigation of lung lesions is experiencing significant growth with the increasing number of lung cancer screening programs.
- Trial name
- RESSOURCE (NCT06950515)
- Testing
- Peripheral EBUS under Concious sedation, Peripheral EBUS under General Anesthesia
- Where
- Canada
- Volunteers
- 306 people
- Sponsor
- Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
Knee Osteoarthritis, Replacement, Knee
Exploration of Appropriate BIS Range and Propofol Effect-site Concentration During Total Intravenous Anesthesia With Concomitant Adjuvants.
The goal of this clinical trial is to determine the appropriate Bispectral Index (BIS) range and propofol effect-site concentration required to maintain adequate anesthesia depth during total intravenous anesthesia (TIVA)…
- Conditions
- Knee Osteoarthritis, Replacement, Knee, Elective Surgical Patients, ASA Class I/II Patients
- Trial name
- NCT07736352
- Testing
- Propofol + Remifentanil +Midazolam, Propofol + Remifentanil + Dexmedetomidine, Propofol + Remifentanil + Esketamine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- China-Japan Friendship Hospital
Healthy Adult Participants
A Multiple-dose Study Investigating the Drug-drug Interaction Potential and QTc Effects of Fosmanogepix in Healthy Adult Subjects
This is a Phase 1, fixed-sequence, multiple-dose study in approximately 42 healthy adult participants. The study will be conducted in two parts.
- Trial name
- NCT07881224
- Testing
- Fosmanogepix, The medicine cocktail (caffeine, bupropion, flurbiprofen, omeprazole, dextromethorphan and midazolam), Probe substrates (repaglinide, rosuvastatin, and digoxin)
- Where
- Netherlands
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Basilea Pharmaceutica
Sedation During GI Endoscopy
Tolerability of Remimazolam Versus Midazolam in EUS
This study will observe and compare patient experience during outpatient diagnostic endoscopic ultrasound (EUS) when moderate sedation is provided with either remimazolam plus fentanyl or midazolam plus fentanyl, according to…
- Trial name
- REM-EUS (NCT07600073)
- Where
- Italy
- Volunteers
- 126 people
- Sponsor
- Azienda Socio Sanitaria Territoriale di Lecco