Clinical trials: Misoprostol
Pregnancy
Labour Induction With Misoprostol, Dinoprostone and Bard Catheter
This is a randomised study aimed at comparing the currently most frequently used prostaglandin dinoprostone to two other methods, the cheaper and perhaps more effective prostaglandin misoprostol and a transcervical catheter.
- Trial name
- LI (NCT00602095)
- Testing
- misoprostol, dinoprostone, Bard Catheter (balloon catheter)
- Volunteers
- 592 people
- Sponsor
- Karolinska University Hospital
Pregnancy Trimester, Second, Induced Abortion
Randomized Trial Comparing Misoprostol and Foley Bulb for Pregnancy Termination in the Second Trimester
The purpose of this study is to compare two methods of pregnancy termination on the time to delivery in the second trimester.
- Trial name
- NCT00324519
- Testing
- Foley bulb, misoprostol
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Florida
Postpartum Hemorrhage
Oral Misoprostol Versus Intravenous Oxytocin in Preventing Blood Loss After Non-scheduled Cesarean Section
Postpartum hemorrhage (PPH) ranks among the leading causes of maternal morbidity and mortality, both in developed and developing countries.
- Trial name
- NCT00107874
- Testing
- misoprostol
- Where
- Switzerland
- Volunteers
- 56 people
- Sponsor
- University Hospital, Basel, Switzerland
Myoma;Uterus
Preoperative Vaginal Dinoprostone Versus Misoprostone in Abdominal Myomectomy
Aim and objectives; To compare the efficacy of preoperative administration of dinoprostone 20 mg versus 400 ug misoprostol vaginally in decreasing the amount of bleeding during abdominal myomectomy
- Trial name
- NCT05761418
- Testing
- Dinoprostone, Misoprostol
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Blood Loss, Surgical, Uterine Myoma
Effect of Rectal Misoprostol in Reducing Intra-operative Blood Loss During Myomectomy
A total of 200 women for elective abdominal myomectomy were randomly allocated into two groups. 100 women in experimental group were administered 400ug Misoprostol (2 tablets of Prosotec®) through the rectal route prior to…
- Trial name
- NCT05108597
- Testing
- Misoprostol
- Where
- Pakistan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Pak Emirates Military Hospital
Cervical Ripening, Induction of Labor
Pharmacokinetic (PK) Study of the 200 Microgram (mcg) Misoprostol Vaginal Insert (MVI 200) in Women at Term Gestation (The MVI-PK Study)
The purpose of this study is to determine the pharmacokinetics (PK) of misoprostol acid for the MVI 200 in women requiring cervical ripening and induction of labor.
- Trial name
- NCT01283022
- Testing
- MVI 200
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Ferring Pharmaceuticals
Retained Placenta
Intraumbilical Misoprostol in Retained Placenta
Administration of intraumbilical misoprostol to women with retained placenta despite active management of third stage of labour reduces the need for manual removal of placenta and the amount of blood loss vaginally.
- Trial name
- NCT01840813
- Testing
- Misoprostol, Normal saline
- Where
- Iraq
- Volunteers
- 46 people
- Sponsor
- Hawler Medical University
Abortion, Second Trimester, Abortion, Medical
Foley Balloon for Cervical Preparation Before Dilation and Evacuation
To evaluate the Foley Balloon technique for cervical preparation before second trimester surgical abortion between 16 and 21 weeks estimated gestational age in combination with misoprostol to prepare the cervix before dilation…
- Trial name
- NCT06850974
- Testing
- Foley Balloon Catheter, Misoprostol, Laminaria
- Where
- Mozambique
- Volunteers
- 102 people
- Sponsor
- Stony Brook University
Pregnancy
Evaluation of Telemedicine Medical Abortion Service in Ecuador
This research seeks to demonstrate that a telemedicine model for the provision of legal abortion services in Ecuador is safe, feasible and acceptable to users requesting a medication abortion and who are less than 12 weeks…
- Trial name
- NCT06270056
- Testing
- Misoprostol
- Where
- 3 sites in Ecuador
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Labor Induction
BMI-Associated Labor Induction: A Prospective Trial
The primary objective of this study is to determine if planned induction of labor at 39 weeks for nulliparous with pre-pregnancy BMI ≥ 35 kg/m2 reduces the incidence of cesarean section compared to expectant management
- Trial name
- BALI (NCT04035382)
- Testing
- Labor induction
- Where
- 2 sites in United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Baystate Medical Center
Induced Vaginal Delivery
MISOBEST - Orally Misoprostol Solution (Cytotec®) Versus Orally Misoprostol as a Tablet (Angusta®) for Induction of Labor
The aim of the study is to evaluate efficacy of the cervical ripening of misoprostol administration in oral tablet, Angusta® compared with the off-label solution of misoprostol (Cytotec®) for induction of labor (IOL).
- Trial name
- NCT05424445
- Testing
- Misoprostol
- Where
- Sweden
- Volunteers
- 884 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Labor Induction
A Randomized Trial of Two Regimens of Misoprostol for Second Trimester Termination for Intrauterine Fetal Death
Misoprostol (Cytotec®) is a synthetic prostaglandin E1 analog that has been marketed in the United States since 1988 as a gastric cytoprotective agent.
- Trial name
- NCT00141895
- Testing
- Misoprostol
- Where
- Lebanon
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Cervical Ripening
Misoprostol Versus Effox as Cervical Ripening Agent Prior Surgical Evacuation
Ninety healthy pregnant women candidate for surgical evacuation after confirming 1st trimester pregnancy loss were enrolled in the study.
- Trial name
- NCT02738177
- Testing
- Misoprostol, Isosorbide-5-mononitrate, misoprostol and Isosorbide-5-mononitrate
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Cairo University
Induction of Labor Affected Fetus / Newborn
Cervical Ripening in Obese Women: Efficacy of 25 mcg Versus 50 mcg of Misoprostol
This is a prospective clinical trial to determine if 50 mcg versus 25 mcg po every four hours of misoprostol has improved efficacy and similar safety in obese women undergoing cesarean section.
- Trial name
- NCT03748147
- Testing
- Misoprostol
- Volunteers
- 300 people
- Sponsor
- University of Cincinnati
Hemorrhage, Surgical, Myoma;Uterus
Comparison Effectiveness of Rectal Misoprostol & Intravenous Tranexamic Acid Reducing Hemorrhage in Myomectomy
Fibroids are the most commonly encountered tumors in the female reproductive system. In patients, fibroids most often lead to abnormal uterine bleeding and the resulting anemia.
- Conditions
- Hemorrhage, Surgical, Myoma;Uterus, Effect of Drug, Postoperative Hemorrhage
- Trial name
- NCT06114758
- Testing
- Cytotec 200Mcg Tablet, Transamine
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Ankara Etlik City Hospital
Elective Cesarean Section
Oxytocin Bolus Versus Infusion in Elective Cesarean Section"
Bolus administration of oxytocin is superior to infusion in time to achieving adequate uterine tone.
- Trial name
- INBOX (NCT05236985)
- Testing
- Oxytocin bolus or oxytocin infusion
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Stony Brook University
Endometrial Disorder
Misoprostol Administration Before Operative Hysteroscopy
The objective of this study is to compare the efficacy of oral, sublingual, vaginal, and no misoprostol prior to operative hysteroscopy in premenopausal women.
- Trial name
- NCT01805115
- Testing
- Oral misoprostol, Sublingual misoprostol, Vaginal misoprostol
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- CHA University
Transient Tachypnea of the Newborn, Neonatal Respiratory Distress
Efficacy of Misoprostol in Prevention of Neonatal Respiratory Morbidity in Parturient at Early Term Elective Caesarian Section
Neonatal respiratory morbidities represent a common group of post natal complications including respiratory distress syndrome, transient tachypnea of newborn, and persistent pulmonary hypertension of newborn.
- Trial name
- NCT04780412
- Testing
- Misoprostol
- Where
- Egypt
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Postpartum Hemorrhage
Comparison Between Rectal & Sublingual Misoprostol Before Caesarian Section To Reduce Intra & Post-Operative Blood Loss
The aim of the work is to evaluate \& compare the effectiveness of rectally administered PGE1 synthetic analogue (misoprostol) 400 microgram versus sublingually administered misoprostol before caesarean section to decrease blood…
- Trial name
- NCT02083107
- Testing
- Misoprostol
- Where
- Egypt
- Volunteers
- 636 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Anembryonic Pregnancy, Gestation Abnormality
Mifepristone and Misoprostol for Fetal Demise
This is a pilot clinical trial to evaluate whether the medical management of early pregnancy failure with mifepristone and misoprostol is an effective and acceptable treatment.
- Conditions
- Anembryonic Pregnancy, Gestation Abnormality, Intrauterine Fetal Demise Term
- Trial name
- MIMID (NCT00177372)
- Testing
- mifepristone/misoprostol
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh