Clinical trials: Misoprostol
Letrozole
The Value of Pretreatment With Letrozole on Induction Time of Medical Evacuation With Misoprostol in Cases of Missed Abortion
The aim is to evaluate the effect of letrozole pretreatment on the induction time during medical evacuation using misoprostol in women diagnosed with missed abortion, and to compare its efficacy and safety to misoprostol alone.
- Trial name
- NCT07753655
- Testing
- Intervention Group: letrozole followed by misoprostol, Control Group: misoprostol only
- Volunteers
- 74 people
- Sponsor
- Cairo University
Medical; Abortion, Fetus
Effectiveness of Pretreatment Letrozole Versus Misoprostol Alone in Missed Abortion
Background and Rationale Abortion accounts for about 8% of maternal mortality worldwide. Surgical intervention is the definitive treatment for abortion but it is invasive.
- Trial name
- NCT04194658
- Testing
- Letrozole 2.5mg
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pain
Misoprostol Prior to Office Hysteroscopy in Patients With no Risk Factors for Experiencing Unacceptable Pain
The aim of this study is to assess whether vaginal misoprostol reduces pain during office hysteroscopy in parous patients with no risk factors for experiencing severe or unacceptable pain.
- Trial name
- NCT02318225
- Testing
- Misoprostol
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Endometrial Disorder
Misoprostol Administration Before Operative Hysteroscopy
The objective of this study is to compare the efficacy of oral, sublingual, vaginal, and no misoprostol prior to operative hysteroscopy in premenopausal women.
- Trial name
- NCT01805115
- Testing
- Oral misoprostol, Sublingual misoprostol, Vaginal misoprostol
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- CHA University
Postpartum Hemorrhage
Effect of Adjunctive Misoprostol Treatment on Blood Loss at Vaginal Delivery
This document defines the Clinical Investigation Protocol for a study designed to determine whether blood loss after spontaneous vaginal delivery is altered by the addition of misoprostol administration to the standard use of…
- Trial name
- NCT02411916
- Testing
- misoprostol
- Where
- United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- New York City Health and Hospitals Corporation
Labour Induction
Misoprostol for Labour Induction
Objective: To compare the efficacy and safety of the misoprostol vaginal insert (MVI) with an off-label use of oral misoprostol (OM). Design: Pair-matched case-control study. Setting: Tertiary-care academic centre in Germany.
- Trial name
- NCT02904317
- Volunteers
- 138 people
- Sponsor
- Asklepios Kliniken Hamburg GmbH
Hemorrhage, Postpartum
Intrauterine Misoprostol Versus Rectal Misoprostol in Reducing Blood Loss During Cesarean Section
98 pregnant women attending for CS will be randomized into 2 groups. Rectal misopristol group who will receive 400 microgram misoprostol rectally preoperatively with urinary catheter insertion and intrauterine misopristol group…
- Trial name
- NCT03723031
- Testing
- Misoprostol
- Where
- Egypt
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Cairo University
Contraception
Comparative Safety and Efficacy of Vaginal Misoprostol Versus Lidocaine-prilocaine Cream in Levonorgestrel IUD Insertion
the aim of the present study is to compare the safety and Efficacy of vaginal misoprostol versus Lidocaine-prilocaine cream in reducing pain during levonorgestrel IUD Insertion in women delivered only by cesarean deliveries
- Trial name
- NCT04339348
- Testing
- vaginal misoprostol, Lidocaine-Prilocaine Topical cream
- Where
- Egypt
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Cairo University
Medical Abortion, Complete or Unspecified, Without Complication
Randomized Study of Letrozole and Trilostane for Medical Abortion
In menstruation an effective shedding of the endometrial lining occurs. Both progesterone and estrogen levels fall sharply at this time.
- Trial name
- NCT01615211
- Testing
- Letrozole, Trilostane
- Where
- Sweden
- Volunteers
- 36 people
- Sponsor
- Kristina Gemzell Danielsson
Medical Abortion
The Extended Gestational Age Medical Abortion Study
This open-label, comparative study will compare the efficacy, safety, and acceptability of 200 mg mifepristone followed in 24-48 hours by 800mcg buccal misoprostol or 400mcg sublingual misoprostol for termination of pregnancy in…
- Trial name
- NCT00997347
- Testing
- Mifepristone and misoprostol
- Where
- 12 sites in United States, Georgia and 3 more
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Cervical Priming
Efficacy and Safety Study of the Misoprostol Vaginal Priming Insert (MVPI) Prior to Hysteroscopy
A Phase II, multicenter, double-blind, randomized, placebo-controlled, dose-ranging, study to assess the efficacy and safety of the 100, 200, 400, 800, 1200 and 1600 mcg Misoprostol Vaginal Priming Insert (MVPI) for Women…
- Trial name
- NCT00925938
- Testing
- misoprostol
- Where
- 2 sites in United States
- Volunteers
- 51 people
- Sponsor
- Ferring Pharmaceuticals
Labour Induction
Vaginally Administered Versus Per Oral Misoprostol in Induction of Labour
The purpose of this study is to investigate the effectiveness and safety of vaginally administered misoprostol (Misodel) versus per orally administered misoprostol (Cytotec) in induction of labour in nulliparous women.
- Trial name
- NCT02539199
- Testing
- Misoprostol, modified-release pessary, Misoprostol, per-oral tablets
- Where
- 5 sites in Finland
- Volunteers
- 270 people
- Sponsor
- Tampere University Hospital
Intrauterine Device
Misoprostol for Cervical Ripening Before Copper Intrauterine Device Removal
Intrauterine devices are the most common used method of contraception in the world, mostly in developing countries, because they offer long-term, reversible and relatively safe contraception.
- Trial name
- NCT03600064
- Testing
- Misoprostol
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Postpartum Hemorrhage
In Vitro Myometrial Contractions in Laboring and Non-laboring Women
The purpose of this study is to compare the ability of an isolated sample of uterine muscle tissue (in a tissue bath) to contract in the presence of various drugs.
- Trial name
- NCT01689311
- Testing
- Oxytocin, Ergonovine, Prostaglandin F2alpha
- Where
- Canada
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Blood Loss in Myomectomy
Sublingual Misoprostol in Decreasing Blood Loss Prior to Myomectomy
The aim of the study is to compare the effectiveness of sublingual administered prostaglandin E1 synthetic analogue (misoprostol) 400 microgram versus placebo before myomectomy to decrease blood loss during and after the…
- Trial name
- SL-MISO (NCT02709564)
- Testing
- Misoprostol 400 sublingual
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
Cervical Ripening
Cervical Ripening With Misoprostol vs Isosorbide Mononitrate ; A Parallel -Arm Randomized Controlled Trial
This randomized controlled trial compared misoprostol and isosorbide mononitrate (IMN) for cervical ripening in prolonged pregnancies.
- Trial name
- NCT07121634
- Testing
- Misoprostol 25 µg Vaginal, Isosorbide Mononitrate
- Where
- Iraq
- Volunteers
- 80 people
- Sponsor
- Raid M. Al-Ani
Post Partum Hemorrhage
Oral Tranexamic Acid Plus Sublingual Misoprostol in Atonic Postpartum Hemorrhage
The aim of the study is to evaluate the effect of oral tranexamic acid plus, sublingual misoprostol in the management of atonic postpartum hemorrhage (PPH) after vaginal delivery
- Trial name
- NCT03870256
- Testing
- misoprostol, Carbetocin, TA
- Where
- Egypt
- Volunteers
- 135 people
- Sponsor
- Aswan University Hospital
Preeclampsia Severe
Uterotonics for Severe Preeclampsia
The study compares the effect of Intravenous carbetocin versus combined use of intravenous oxytocin and rectal misoprostol for prevention of postpartum hemorrhage during delivery of women with severe preeclampsia
- Trial name
- NCT04756661
- Testing
- Carbetocin, Oxytocin, Misoprostol
- Where
- Egypt
- Volunteers
- 124 people
- Sponsor
- Assiut University
Abortion, Therapeutic
Acceptability and Feasibility of a Simplified Medical Abortion Service Delivery in Western Ukraine
The study will examine how a simplified outpatient medical abortion procedure using mifepristone and misoprostol, with the option to take mifepristone at a place of woman's choosing, works in Ukraine.
- Trial name
- NCT02981030
- Testing
- Mifepristone, Misoprostol
- Where
- 2 sites in Ukraine
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Abortion, Spontaneous
Optimal Treatment of Miscarriage
The main objective of the study is to determine if there is a difference in the number of women with a complete miscarriage after 10 days between expectant management versus treatment with 800 micrograms of misoprostol…
- Trial name
- NCT01033903
- Testing
- misoprostol
- Where
- Sweden
- Volunteers
- 190 people
- Sponsor
- Region Skane