Clinical trials: Misoprostol
Other Abortion
Misoprostol vs. Sublingual Misoprostol and Laminaria For Second Trimester Termination of Pregnancy
1. Comparison between the duration of time from the beginning of cervical preparation until abortion, between sublingual misoprostol and the combination of sublingual misoprostol with laminaria for second trimester medical…
- Trial name
- NCT02013960
- Testing
- Cytotec
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Failed Induction of Labor
A Novel Protocol for Labour Induction
The use of foley catheter was tested many times and proved to be effective for induction of labour.
- Trial name
- NCT01506388
- Testing
- foley catheter, Misoprostol, Vaginal IMN
- Where
- 2 sites in Egypt
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Cairo University
Ulcer Hemorrhage
Evaluate Misoprostol for the Healing of Small Bowel Ulcers in Low-dose Aspirin Users Complicated by Small Bowel Bleeding
ASA is the most commonly drug used worldwide for prevention of cardiovascular diseases. However, ASA is increasingly recognized as a culprit for small bowel bleeding.
- Trial name
- NCT01998776
- Testing
- Misoprostol
- Where
- 2 sites in China, Japan
- Volunteers
- 82 people
- Sponsor
- Chinese University of Hong Kong
Abortion Early
Atorvastatin as a Potential Adjunct to Misoprostol for Termination of Pregnancy
Medication abortion is a way of ending a pregnancy using pills. The current FDA-approved regimen for medication abortion uses mifepristone and misoprostol.
- Trial name
- NCT05342974
- Testing
- Atorvastatin, Misoprostol
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Utah
Early Pregnancy Loss
Optimal Time Interval Between Mifepristone and Misoprostol Administration for Early Pregnancy Loss
A prospective cohort study to explore the optimal time interval between mifepristone and misoprostol administration for medical management of early pregnancy loss.
- Trial name
- TIME (NCT07506512)
- Testing
- 200mg mifepristone and 800mg misoprostol
- Volunteers
- 1,000 people
- Sponsor
- University of Pennsylvania
Postpartum Hemorrhage
Rectal Misoprostol for Reducing Blood Loss in Elective Cesarean Section
This randomized controlled trial aims to evaluate the efficacy of adding preoperative rectal misoprostol to standard oxytocin for reducing intraoperative and postoperative blood loss in women undergoing elective cesarean section.
- Trial name
- NCT07188207
- Testing
- Oxytocin
- Volunteers
- 282 people
- Sponsor
- Assiut University
Cervical Ripening, Induction of Labor
Misoprostol Vaginal Insert (MVI) 100, 150, 200 mcg for Cervical Ripening and Induction of Labor
The purpose of this study is to assess the efficacy and safety of the 100, 150 and 200 mcg Misoprostol Vaginal Insert (MVI 100, MVI 150 and MVI 200) for women requiring cervical ripening and induction of labor.
- Trial name
- NCT00828711
- Testing
- MVI 100, MVI 150, MVI 200
- Where
- 11 sites in United States
- Volunteers
- 374 people
- Sponsor
- Ferring Pharmaceuticals
Hypotonic; Labor
Pharmacokinetics of Misoprostol With Titrated Oral Administration
The AUC240, AUC360, and AUC480 of titrated oral misoprostol are greater than traditional oral misoprostol.
- Trial name
- NCT01271257
- Testing
- Misoprostol
- Where
- Taiwan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Induction of Labour
To Study the Efficacy and Safety of Misoprostol by Sublingual Routes for Induction of Labour
This research is to compare the efficacy and the safety of sublingual misoprostol with vaginal misoprostol administration for the induction of labour for primigravida at 41 or more weeks of pregnancy.
- Trial name
- SL-IOL (NCT04887493)
- Testing
- Misoprostol
- Where
- Bhutan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Bhutan
Primary, Post Partum Hemorrhage
Prevention of Primary Postpartum Haemorrhage
Postpartum hemorrhage, is one of the most deadly complication of pregnancy worldwide and major cause of maternal mortality especially in third world countries .1 PPH affects about 5% of all women giving birth around the world 2…
- Trial name
- NCT04724187
- Testing
- Misoprostol, Oxytocin
- Where
- Pakistan
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Islamabad Medical and Dental College
Labour Induction
Vaginally Administered Versus Per Oral Misoprostol in Induction of Labour
The purpose of this study is to investigate the effectiveness and safety of vaginally administered misoprostol (Misodel) versus per orally administered misoprostol (Cytotec) in induction of labour in nulliparous women.
- Trial name
- NCT02539199
- Testing
- Misoprostol, modified-release pessary, Misoprostol, per-oral tablets
- Where
- 5 sites in Finland
- Volunteers
- 270 people
- Sponsor
- Tampere University Hospital
Hemorrhagic Cystitis, Stem Cell Transplantation
A Double Blind Randomized Study Using Placenta Derived Decidual Stromal Cells for Hemorrhagic Cystitis
A prospective double blind randomized study comparing placenta derived decidual stromal cells with placebo for hemorrhagic cystitis after allogeneic hematopoietic cell transplantation.
- Conditions
- Hemorrhagic Cystitis, Stem Cell Transplantation, Decidual Stromal Cells
- Trial name
- NCT02174536
- Testing
- Decidual stromal cells
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Karolinska Institutet
Induced Vaginal Delivery, Induced; Birth
Outpatient Transcervical Balloon For Induction of Labor
The goal of this randomized control trial is to compare outpatient transcervical foley balloon to inpatient vaginal misoprostol in pregnant women for cervical ripening. The main questions it aims to answer are: 1.
- Trial name
- NCT05798728
- Testing
- Outpatient transcervical foley balloon, Inpatient Vaginal Misoprostol
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Hurley Medical Center
Early Abortion
Advance Provision of Medication Abortion
This mixed-methods study follows a prospective cohort of participants receiving Mifeprex® (mifepristone) by a clinician in advance of a potential unintended pregnancy.
- Trial name
- NCT03829696
- Testing
- Mifeprex® (Mifepristone 200 mg), Misoprostol 800 mcg, ella® (ulipristal acetate emergency contraception 30 mg)
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Abortion, Spontaneous
Optimal Treatment of Miscarriage
The main objective of the study is to determine if there is a difference in the number of women with a complete miscarriage after 10 days between expectant management versus treatment with 800 micrograms of misoprostol…
- Trial name
- NCT01033903
- Testing
- misoprostol
- Where
- Sweden
- Volunteers
- 190 people
- Sponsor
- Region Skane
Cervical Preparation
Mifepristone vs Misoprostol
The Investigator team hypothesizes that in a randomized trial comparing mifepristone-alone or misoprostol-alone for cervical preparation for procedural abortions at 12 to 16 weeks in hospital-based care, the proportion of…
- Trial name
- NCT06502158
- Testing
- Mifepristone, Misoprostol
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Myoma;Uterus, Myomectomy; Surgical Blood Loss
Prevention of HEMOrhagic Risk in Upper MYOmeCTomy by Use of Misoprostol.
In France, uterine fibroids or leiomyomas are the most common benign tumour in women of childbearing age. In 30% of cases, fibroids are symptomatic (menorrhagia, anaemia, pain), in which case surgical management is indicated.
- Trial name
- HEMOMYOC (NCT06882824)
- Testing
- myomectomy with misoprostol
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Clermont-Ferrand
Cervical Ripening
Cervical Ripening With Misoprostol vs Isosorbide Mononitrate ; A Parallel -Arm Randomized Controlled Trial
This randomized controlled trial compared misoprostol and isosorbide mononitrate (IMN) for cervical ripening in prolonged pregnancies.
- Trial name
- NCT07121634
- Testing
- Misoprostol 25 µg Vaginal, Isosorbide Mononitrate
- Where
- Iraq
- Volunteers
- 80 people
- Sponsor
- Raid M. Al-Ani
Abortion, Second Trimester, PPROM
Simultaneous Mifepristone and Misoprostol Versus Misoprostol Alone for Induction of Labor of Nonviable Second Trimester Pregnancy: a Pilot Randomized Controlled Trial
When time allows, administration of mifepristone prior to second trimester induction of labor decreases total labor time. However, in the setting of many pregnancy complications, decreasing time from diagnosis of nonviable…
- Conditions
- Abortion, Second Trimester, PPROM, Rupture, Spontaneous, Fetal Demise
- Trial name
- MIST (NCT05322252)
- Testing
- Mifepristone, Misoprostol
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Washington University School of Medicine
Blood Loss, Dysfunctional Labor
Cooling the Uterus in C-section After Dysfunctional Labor
The objective of the study is to demonstrate whether cooling the uterine smooth muscle during cesarean section (following delivery of the fetus) will promote better uterine contraction and involution resulting in lower blood…
- Conditions
- Blood Loss, Dysfunctional Labor, Uterine Atony
- Trial name
- NCT02910115
- Testing
- Cold laparotomy sponges, Pitocin
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute