Clinical trials: Morphine, completed
Postoperative Pain, Total Knee Arthroplasty
Peri-Articular-Multimodal Drug and Oral Celecoxib in Management of Postoperative Pain of Total Knee Arthroplasty
This study is a randomized-clinical-trial on 146 patients candidate for total knee arthroplasty (TKA) who were randomly allocated to three treatment groups, including 1) a cocktail consisting of bupivacaine, morphine…
- Trial name
- NCT05324995
- Testing
- Multimodal Drug, epinephrine, celecoxib
- Where
- Iran
- Volunteers
- 146 people
- Sponsor
- Isfahan University of Medical Sciences
Rotator Cuff Tear
Arthroscopic Rotator Cuff Repair With Multimodal Analgesia(MMA)
The purpose of this study is to compare the efficacy of periarticular injections consisting of ropivacaine, morphine, epinephrine, cefotetan, and hyaluronic acid with the efficacy of periarticular injections consisting of the…
- Trial name
- NCT01204606
- Testing
- Arthroscopic rotator cuff repair with intraoperative periarticular injection, Arthroscopic rotator cuff repair with non-injection of MMA drugs
- Where
- South Korea
- Volunteers
- 54 people
- Sponsor
- Seoul National University Hospital
Idiopathic Pulmonary Fibrosis
Morphine Sulfate/Placebo for the Treatment of PulmonAry Fibrosis Cough
Idiopathic pulmonary fibrosis (IPF) is a disease of unknown cause that results in scarring of the lungs. Cough is reported by 85% of patients with IPF and can be a distressing symptom with significant physical, social and…
- Trial name
- PAciFy Cough (NCT04429516)
- Testing
- Morphine Sulfate
- Where
- United Kingdom
- Volunteers
- 44 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Hallux Valgus
Efficacy and Safety of Intranasal Morphine for Pain After Bunion Surgery
Study designed to evaluate the efficacy and safety of Intranasal (IN) Morphine Nasal Spray (MNS075) 3.75 mg, 7.5 mg, 15 mg, and 30 mg, intravenous (IV) morphine 7.5 mg, or IN placebo in patients with moderate to severe…
- Trial name
- NCT00388011
- Testing
- Intranasal Morphine (MNS075) 3.75 mg, Intravenous Morphine 7.5 mg, Intranasal morphine (MNS075) 7.5 mg
- Volunteers
- 187 people
- Sponsor
- Javelin Pharmaceuticals
Cancer Pain
An Observation Study to Assess the Efficacy and Safety of Proportional Doses of Painkyl® in Patients With Breakthrough Cancer Pain
An open-label, single arm, observation study, to assess the efficacy and safety of proportional doses of Painkyl® in patients with breakthrough cancer pain.
- Trial name
- NCT05209906
- Testing
- Fentanyl Buccal Soluble Film
- Where
- Taiwan
- Volunteers
- 37 people
- Sponsor
- Mackay Memorial Hospital
Postoperative Pain Management
Escalating Ketamine Doses and Pre-emption
Ketamine affects postoperative pain when administered intravenously immediately before, during or at the end of surgical procedures.
- Trial name
- NCT01070108
- Testing
- Ketamine
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Medication Abuse, Harm Reduction
Clinical Decision Support to Improve System Naloxone Co-prescribing
The objective of this study is to evaluate the impact of a clinical decision support (CDS) alert to facilitate the co-prescribing of naloxone, an opioid overdose reversal agent, with high-risk opioid prescriptions.
- Conditions
- Medication Abuse, Harm Reduction, Opioid Overdose, Opioid Prescribing
- Trial name
- NCT06271668
- Testing
- Naloxone Co-prescribing Clinical Decision Support (CDS)
- Where
- United States
- Volunteers
- 114,272 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Delirium, Lumbar Radiculopathy
Shaping Anesthetic Techniques to Reduce Post-operative Delirium
The purpose of this study is to determine if light sedation with spinal anesthesia reduces the incidence of delirium compared to receiving general anesthesia during spinal surgery in older adults.
- Conditions
- Delirium, Lumbar Radiculopathy, Lumbar Osteoarthritis, Lumbar Spine Disc Degeneration
- Trial name
- SHARP (NCT03133845)
- Testing
- Light sedation with propofol, Induction with propofol, Maintenance anesthetic using a volatile anesthetic
- Where
- United States
- Volunteers
- 218 people
- Sponsor
- Johns Hopkins University
Living Donor Hepatectomy
Perioperative Epidural Anesthesia and Analgesia on Gut Microbiota
As the only curative treatment for end-stage liver diseases, liver transplantation has been widely carried out around the world.
- Trial name
- NCT04079673
- Testing
- Patient controlled epidural analgesia, Intravenous patient controlled analgesia
- Where
- Taiwan
- Volunteers
- 42 people
- Sponsor
- National Taiwan University Hospital
Femoracetabular Impingement, Pain, Postoperative
Intra-articular Morphine and Clonidine Injections for Pain Management in Hip Arthroscopy
The purpose of this study is to determine whether intraoperative (during surgery) morphine and clonidine hip injections are effective in postoperative pain management for patients undergoing hip arthroscopy.
- Trial name
- NCT02530151
- Testing
- Morphine with clonidine, Normal saline
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Northwestern University
Pain
Bioequivalency Study of Morphine Sulfate Injection, Solution and Tablet Under Fasted Conditions
Determine the pharmacokinetics and optimize study design for subsequent studies with morphine sulfate tablets and solution.
- Trial name
- NCT00994942
- Testing
- morphine sulfate
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Roxane Laboratories
Osteoarthritis, Post-traumatic; Arthrosis
Do Corticosteroid Injections During Total Knee Replacement Improve Early Clinical Results?
Prior to surgery, a pharmacist will randomly assign participating patients to one of two groups. One group will get an injection in the knee during surgery that contains medications to limit pain and an antibiotic.
- Trial name
- NCT00492973
- Testing
- methylprednisolone acetate, active comparator
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- New Lexington Clinic
Pain
Safety and Efficacy of Intravenous Hydromorphone in Elderly Emergency Department Patients With Acute Severe Pain
The hydromorphone protocol is more effective than usual care in Emergency Department (ED) patients age 65 years and older in terms of proportion who choose to forgo additional pain medication within 60 minutes post-baseline in…
- Trial name
- NCT01429285
- Testing
- Hydromorphone, Usual care
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Cesarean Section Complications, Opioid Use
Precision Opioid Care After Cesarean Delivery (PRECISE-CD)
The purpose of this research is to study serious clinical problems from surgical pain and the use of oxycodone or other opioids in women having a Cesarean Delivery to improve the safety and efficacy of surgical pain relief.
- Trial name
- PRECISE-CD (NCT05280743)
- Testing
- Oxycodone
- Where
- United States
- Volunteers
- 341 people
- Sponsor
- Grace Lim, MD, MS
Cardiovascular
Comparison of Effects of Oxycodone and Sufentanil on Cardiovascular Stress Induced by Tracheal Intubation in the Patients With Coronary Heart Disease Undergoing Major Noncardiac Surgery
To evaluate the effect of oxycodone and sufentanil in preventing cardiovascular responses to tracheal intubation in the patients with coronary heart disease (CHD).
- Trial name
- NCT04121416
- Testing
- Oxycodone 10mg, Sufentanil
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shengjing Hospital
Intradermal Test
The Standard Concentration of Morphine as a Positive Control for Intradermal Skin Test
This study aims to compare skin reactivity results between morphine and histamine as a positive control agents in intradermal skin test.
- Trial name
- NCT00853476
- Where
- Thailand
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Organic Cation Transporter 1, Morphine
Genetic Variation in Organic Cation Transport 1 (OCT1) and Its Significance for Morphine Pharmacokinetics
The main objective of the trial is to investigate the effect of known genetic variants in organic cation transporter 1 (OCT1) on the effect of morphine after major surgery
- Trial name
- NCT03425084
- Testing
- Morphine
- Where
- 2 sites in Denmark
- Volunteers
- 86 people
- Sponsor
- University of Southern Denmark
Anesthesia, Caudal
Use of Caudal Anesthesia Supplemented With Morphine in Children Undergoing Renal Surgery
The aim of this study is to test an efficacy and safety of supplemented by Morphine caudal anesthesia in children who undergo renal surgery in our department.
- Trial name
- NCT01869036
- Testing
- caudal anesthesia, caudal anesthesia supplemented with morphine
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Shaare Zedek Medical Center
Acute Pain
Efficacy of Intravenous (IV) Paracetamol for Treatment of Acute Pain
The purpose of this study is to determine whether Iv paracetamol is as effective as Iv Morphine sulfate on control of the acute pain in Patient with limb trauma.
- Trial name
- NCT01465984
- Testing
- Paracetamol
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Tehran University of Medical Sciences
Arthralgia, Bunion
A Study to Evaluate the Effectiveness and Safety of Tapentadol (CG5503) in the Treatment of Acute Pain From Bunionectomy.
The purpose of this study is to evaluate the effectiveness (level of pain control) and safety of the administration of 2 different dose levels of tapentadol (CG5503) compared with oxycodone and with placebo in subjects who have…
- Conditions
- Arthralgia, Bunion, Hallux Valgus, Pain
- Trial name
- NCT00613938
- Testing
- Tapentadol (CG5503), oxycodone
- Where
- 7 sites in United States
- Volunteers
- 901 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
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