Clinical trials: Morphine, completed
Opiate Abuse, Marijuana Abuse
Detecting Drugs of Abuse Via Exhaled Breath Samples Using Differential Mobility Spectrometry
This Phase II STTR program consists of two major goals within the overarching goal of developing and validating a proprietary device (BID2) for marijuana and opioid detection in breath samples.
- Conditions
- Opiate Abuse, Marijuana Abuse, Diagnostic
- Trial name
- NCT05384470
- Testing
- Marihuana, BID2 Instrument - breathalyzer
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Opioid Use, Side Effect of Drug
Pharmacokinetics of Morphine and Oxycodone in Frail Elderly Undergoing Cardiac Surgery
Single centre observational cohort study. 20 older patients undergoing cardiac surgery who receive standard of care pain treatment.
- Conditions
- Opioid Use, Side Effect of Drug, Postoperative Pain
- Trial name
- NCT04696445
- Testing
- Morphine & Oxycodone
- Where
- Netherlands
- Volunteers
- 34 people
- Sponsor
- St. Antonius Hospital
Hysterectomy
Study to Evaluate the Efficacy, Safety and Tolerability of N1539
To determine the analgesic efficacy, duration of effect, and safety of single doses of N1539 in subjects undergoing open abdominal hysterectomy
- Trial name
- NCT01084161
- Testing
- N1539, Morphine
- Where
- 12 sites in Georgia, Poland and 1 more
- Volunteers
- 486 people
- Sponsor
- Alkermes, Inc.
Obesity
Intravenous Ibuprofen for Laparoscopic Bariatric Surgery
Primary objective of this study is to test hypothesis that IV ibuprofen decreases 24 hours morphine requirement using IV PCA in patients after laparoscopic bariatric surgery.
- Trial name
- NCT01707251
- Testing
- Intravenous Ibuprofen, Saline
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Jacobi Medical Center
Anesthesia
Decreased Neuraxial Morphine After Cesarean Delivery
The purpose of this study is to compare 50mcg to 150mcg morphine in epidural for the goal of decreasing side effects of medication with lower dose in patients who receive a QL block
- Trial name
- NCT04279054
- Testing
- Morphine Sulfate 150 mcg, Morphine Sulfate 50mcg
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- University of Alabama at Birmingham
Sedation
Pharmaco-Economic Study Of Ultiva In Intensive Care Unit(ICU)Subjects
The study will evaluate the pharmaco-economic consequences of the use of a remifentanil based regimen compared with a conventional sedative based regimen in terms of duration of mechanical ventilation, length of stay in ICU…
- Trial name
- NCT00158873
- Testing
- midazolam, lorazepam, fentanyl
- Where
- 15 sites in Netherlands
- Volunteers
- 224 people
- Sponsor
- GlaxoSmithKline
Pain, Procedural
Oral Morphine Versus Ketamine in Pain Management
The study will mainly focus on procedural pain management using oral morphine versus rectal ketamine during paediatric burn and wound dressing at Mbarara Regional Referral Hospital.
- Trial name
- NCT05163366
- Testing
- GROUP A, GROUP B
- Where
- 2 sites in Uganda
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Mbarara University of Science and Technology
Cardiac Disease
Opioid Reduced Anesthesia With Parasternal CATheters on Postoperative Delirium After Cardiac Surgery
PostOperative Delirium (POD) is the most common neuropsychiatric complication following cardiac surgery and may be related to morphine consumption.
- Trial name
- ORACAT (NCT05880615)
- Testing
- collection of datas
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Analgesia
Dexmedetomidine vs Dexamethasone as Adjuvant to Bupivacaine in Bilevel Erector Spinae Plane Block in Breast Surgeries
High percent of patients experience chronic pain following breast cancer surgeries thus proper perioperative pain control is crucial to lessen the incidence of such pain.
- Trial name
- NCT05591417
- Testing
- Bilevel Erector spinae plane block, Bilateral Erector spinae plane block with dexamethasone, Bilateral Erector spinae plane block with dexmedetomidine
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- National Cancer Institute, Egypt
Analgesia, Epidural
Neuraxial Ultrasound for Thoracic Epidural Placement
This blinded, randomized study compares standard palpation to ultrasound-assisted landmark identification of the thoracic spine for thoracic epidural catheterization.
- Trial name
- NCT02785055
- Testing
- Thoracic Epidural Placement, Bupivacaine 0.05%, Hydromorphone 0.01mg/mL
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Benaroya Research Institute
Pain, Infant, Newborn
Intravenous and Topical Analgesics for Procedural Pain in Neonates
This study will test which type of pain medication is best for the management of pain in newborn preterm and full-term infants having a deep intravenous cannula inserted.
- Trial name
- NCT00213200
- Testing
- morphine, amethocaine
- Where
- 2 sites in Canada
- Volunteers
- 108 people
- Sponsor
- The Hospital for Sick Children
Postoperative Pain, Renal Insufficiency
Pain Management After Cardiac Surgery - Opioids or NSAID
The aim of this randomized controlled study is to shed light on the analgesic properties and side-effect profile of an opiod-based regimen as opposed to an Ibuprofene based regimen.
- Conditions
- Postoperative Pain, Renal Insufficiency, Myocardial Infarction
- Trial name
- NCT02479165
- Testing
- Ibuprofene, Oxycodone
- Volunteers
- 182 people
- Sponsor
- Aalborg University Hospital
Pain, Postoperative
Intravenous Methadone for Sternotomy Pain Control in Cardiac Surgery
Background Postoperative pain is significant in cardiac surgical patients. Perioperative analgesia with intermittent administration of opioids can result in significant fluctuations in serum opioid concentrations.
- Trial name
- MethadoneRCT (NCT06728371)
- Testing
- Methadone, Morphine
- Where
- Hong Kong
- Volunteers
- 86 people
- Sponsor
- Chinese University of Hong Kong
Pain, Postoperative Period
Ketamine Combination With Spinal Morphine for Post Thoracic Surgery Pain : A Randomized Control Study
Thoracotomy is one of the most painful operation. Continuous thoracic epidural or paravertebral analgesia are gold standard for postoperative pain. But both techniques require skills.
- Trial name
- NCT02570230
- Testing
- NSS, Ketamine
- Where
- Thailand
- Volunteers
- 32 people
- Sponsor
- Mahidol University
Chronic Pain, Cardiac Surgery
Bilateral Erector Spinae Plane Block for Postoperative Chronic Pain After Open Heart Surgery
The aim of this study is to investigate the effect of bilateral erector spinae plane (ESP) block application on postoperative chronic pain in patients undergoing on-pump open-heart surgery.
- Conditions
- Chronic Pain, Cardiac Surgery, Post Operative Pain
- Trial name
- NCT06315959
- Testing
- Bilateral ultrasound guided erector spinae plane block, morphine PCA, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 71 people
- Sponsor
- Ondokuz Mayıs University
Pain
A Study to Look at Tapentadol Tablets in Children and Adolescents in Pain
Tapentadol has already been studied in adults. This study is needed to find out if tapentadol works and is safe to use in children and adolescents with long-term pain.
- Trial name
- NCT02151682
- Testing
- Tapentadol prolonged release, Morphine prolonged release
- Where
- 23 sites in Belgium, Bulgaria and 8 more
- Volunteers
- 73 people
- Sponsor
- Grünenthal GmbH
Morbid Obesity, Postoperative Pain
Opioid-Free vs Opioid-Based Anesthesia in Bariatric Surgery
This prospective randomized controlled trial aims to compare the clinical effectiveness and safety of opioid-free anesthesia (OFA) versus traditional opioid-based anesthesia (OBA) in adult patients undergoing laparoscopic…
- Conditions
- Morbid Obesity, Postoperative Pain, Opioid Free Anesthesia, Bariatric Surgery
- Trial name
- NCT07337135
- Testing
- Opioid-Based Anesthesia (Remifentanil-Based Protocol), Opioid-Free Anesthesia (Dexmedetomidine-Ketamine-Lidocaine Protocol)
- Where
- Portugal
- Volunteers
- 60 people
- Sponsor
- Hospital dos Lusíadas
Postoperative Pain, Cesarean Section
Intrathecal Morphine 75 mcg Versus 100 mcg for Post-Cesarean Analgesia: A Randomized Double-blind Trial
This study evaluates the efficacy and safety of two different doses of intrathecal morphine (75 mcg versus 100 mcg) for postoperative analgesia in patients undergoing elective cesarean delivery under spinal anesthesia.
- Conditions
- Postoperative Pain, Cesarean Section, Obstetric Anesthesia
- Trial name
- ITM-CESAREAN (NCT07516717)
- Testing
- Intrathecal Morphine
- Where
- Venezuela
- Volunteers
- 240 people
- Sponsor
- Hospital Universitario de Caracas
Nausea and Vomiting, Postoperative
10% Carbohydrate Drink for Preventing Post-operative Nausea and Vomiting (PONV) After Spinal Morphine
PONV after intrathecal morphine, occurs up to 30-40 percent. The patients having TKR normally are female, obese and non-smoker which are risk factors for PONV.
- Trial name
- NCT01301404
- Testing
- 10% carbohydrate drink
- Where
- Thailand
- Volunteers
- 120 people
- Sponsor
- Mahidol University
Pain, Nausea
Optimal Dose of Prophylactic Naloxone in Reducing Opioid-Induced Side Effects in Children/Adolescents
This is an investigator initiated dose finding study designed to determine the optimal dose of naloxone to prevent or minimize the most common side effects induced by opioids, namely itching, nausea, and vomiting.
- Conditions
- Pain, Nausea, Pruritus
- Trial name
- NCT00330343
- Testing
- naloxone
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Johns Hopkins University
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