Clinical trials: Morphine, completed
Pain
Drug Interactions Between Morphine and Orally or IV Administered Acetaminophen
Morphine is the opioid used to treat pain after surgery. Acetaminophen (called APAP) can reduce the amount of opioids needed for this. The problem is that morphine slows down digestion. That can delay pain relief from APAP pills.
- Trial name
- NCT02848729
- Testing
- Oral Acetaminophen, IV Acetaminophen, IV Morphine
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mallinckrodt
Sickle Cell Disease
Methadone in Pediatric and Adult Sickle Cell Patients
To determine the pharmacokinetics of methadone in children and adults with SCD who are experiencing a painful episode.
- Trial name
- MSCD (NCT00761085)
- Testing
- Morphine, Methadone
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Washington University School of Medicine
Postoperative Complications
Does Local Morphine Add to Local Anesthetics in Serratus Anterior Plane Block Has a System Analgesic Effect?
the investigators aim is to investigate and explore the effect 10 mg morphine added to local anesthetics in serratus anterior plane block for post mastectomy pain management after modified radical mastectomy in patients with…
- Trial name
- NCT02962024
- Testing
- Morphine Sulfate, Bupivacaine Hydrochloride
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Fatma Adel El sherif,MD
Anesthesia; Functional
Effects of Analgesics in Cesarean Section Elective
Two approved treatments for spinal anesthesia will be compared in women undergoing cesarean section. It is usual to perform cesarean sections using spinal anesthesia with a local anesthetic (bupivacaine) plus some opioid, such as…
- Trial name
- CES (NCT03386630)
- Testing
- Hyperbaric bupivacaine+Sufentanil, Hyperbaric bupivacaine+Morphine
- Where
- Spain
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Fundación Pública Andaluza Progreso y Salud
Pain, Postoperative
Transversus Abdominis Plane Block and Quadratus Lumborum Block in Pediatric Patients
In the pediatric age group, postoperative pain is very important for the children to have a comfortable and problem-free postoperative period.
- Trial name
- NCT04209478
- Testing
- Tramadol hydrochloride
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Neonatal Abstinence Syndrome
How to Treat Opiate Withdrawal in Neonates
Three different drugs are used in a randomised, double blind, clinical multi-centre trial with three arms. Major objective is to investigate the duration of drug treatment based on the Finnegan score.
- Trial name
- NCT02810782
- Testing
- Phenobarbital, Chlorpromazine, Morphine
- Volunteers
- 120 people
- Sponsor
- University of Zurich
Pain Management, Paravertebral Block
CTPVB for Hepatectomy
Moderate to severe postoperative pain often influence patients quality of recovery after hepatectomy. Systemic opioids given with patient-controlled analgesia has been used after hepatectomy in many medical center, but the…
- Conditions
- Pain Management, Paravertebral Block, Hepatectomy
- Trial name
- NCT03990922
- Testing
- Continuous Paravertebral block with ropivacaine, Continuous Paravertebral "block" with saline, Patient-controlled analgesia with morphine
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Cui Xulei
Pain
Safety and Efficacy of Patient Controlled Analgesia in the Emergency Department
The aims of this study are to assess efficacy and safety of patient-controlled analgesia (PCA) when applied to the Emergency Department setting and to compare the efficacy and safety of two PCA dosing regimens.
- Trial name
- NCT00910208
- Testing
- Patient-controlled analgesia, morphine
- Where
- United States
- Volunteers
- 211 people
- Sponsor
- Albert Einstein College of Medicine
Abdominal Cancer, Abdominal Pain
Safety and Efficacy of Intrathecally Administered Magnesium Sulfate
Magnesium sulfate safety profile has been documented by histopathological analysis in experimental studies. magnesium sulfate added to local anesthetics decrease postoperative opioid requirements.
- Trial name
- NCT03459417
- Testing
- intrathecal morphine+LA, intrathecal morphine+LA+ Mg sulp. 50, intrathecal morphine+LA+ Mg sulp. 100
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- South Egypt Cancer Institute
Scoliosis Idiopathic, Scoliosis; Adolescence
Erector Spinae Plane Block in Scoliotic Adolescents
For scoliotic surgeries, Erector Spinae Plane Block (ESPB) can add to the multimodal approach for perioperative pain management with decreasing the opioids requirement, improving recovery and decreasing ICU stay.
- Conditions
- Scoliosis Idiopathic, Scoliosis; Adolescence, Erector Spinae Plane Block
- Trial name
- NCT03968146
- Testing
- Erector Spinae Plane Block, Fentanyl, additional Fentanyl
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Kasr El Aini Hospital
Postoperative Pain, Cholecystitis; Gallstone
Bilateral vs. Unilateral Erector Spinae Plane Block
The importance of multimodal analgesia for postoperative pain management is well known and regional anesthesia techniques are commonly prefferred to provide better analgesia.
- Trial name
- NCT03781687
- Testing
- Bilateral ESP Block, Unilateral ESP Block, Intravenous Morphine patient controlled analgesia device
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Kocaeli University
Laparoscopic Renal Surgery, Pain Management
TQLB for Postoperative Pain After Laparoscopic Partial Nephrectomy
This prospective, randomized study,control study aims to compare the analgesic effect,opioids consumption,quality of recovery,length of hospital stay，et al.
- Conditions
- Laparoscopic Renal Surgery, Pain Management, Nerve Block
- Trial name
- NCT03982784
- Testing
- single-injection TQLB(transmuscular quadratus lumborum block), Morphine given as IPCA(intravenous patient controlled analgesia)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Cui Xulei
Tumor, Pain
A Study to Evaluate Tapentadol (CG5503) in the Treatment of Chronic Tumor-Related Pain Compared With Placebo and Morphine
The purpose of this study will be to determine whether tapentadol (CG5503) is effective and safe in the treatment of chronic tumor related pain compared to placebo.
- Trial name
- NCT00472303
- Testing
- Tapentadol Extended Release, Morphine Sulphate Controlled Release
- Where
- 71 sites in Austria, Bulgaria and 14 more
- Volunteers
- 622 people
- Sponsor
- Grünenthal GmbH
Sleep Apnea Syndromes
Impact of Intrathecal Morphine on Sleep Apnea Syndrome
Intrathecal morphine is commonly used as an analgesic adjunct for hip arthroplasty performed under spinal anaesthesia. Sleep apnea syndrome is a condition that affects up to 10% of the patients.
- Trial name
- NCT02566226
- Testing
- Bupivacaine with normal saline, Bupivacaine with intrathecal morphine
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Hysterectomy, Postoperative
A Study to Evaluate the Efficacy and Safety of Tapentadol (CG5503) in the Treatment of Acute Pain After Abdominal Hysterectomy
The main objective of this study is to demonstrate the efficacy and safety of multiple-dose application of three different oral doses of CG5503 IR (tapentadol immediate release) compared to placebo in women undergoing abdominal…
- Trial name
- NCT00478023
- Testing
- Morphine, CG5503 IR
- Where
- 52 sites in Hungary, Latvia and 7 more
- Volunteers
- 854 people
- Sponsor
- Grünenthal GmbH
Acute Pain
First Evaluation of Morphine Hydrochloride by Nebulisation in Healthy Volunteers
Acute pain relief in emergency setting is still a public health priority. Pain is the primary reason for emergency room use, but the situation of "oligo-analgesia" persists in all countries.
- Trial name
- AEROMORPH1 (NCT01975753)
- Testing
- Morphine, Fentanyl
- Where
- France
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Neonatal Abstinence Syndrome, Neonatal Opioid Withdrawal
Improving Outcomes in Neonatal Abstinence Syndrome
1: SPECIFIC Aim I: To compare treatment options for neonatal abstinence syndrome (NAS) due to in-utero narcotic exposure. One hundred eighty four full-term infants with a diagnosis of NAS requiring medications will be studied.
- Trial name
- NCT01958476
- Testing
- Neonatal Morphine Solution, Methadone, Phenobarbital
- Where
- 8 sites in United States
- Volunteers
- 117 people
- Sponsor
- Tufts Medical Center
Caesarean Section, Spinal Anesthesia
Effect of Bilateral Quadratus Lumborum Block for Pain Relief in Patients With Cesarean Section
Cesarean section commonly induces moderate to severe pain for 48 hours. These patients have additional compelling reasons to provide adequate pain relief as early mobilization is a key factor to prevent the risk of thromboembolic…
- Conditions
- Caesarean Section, Spinal Anesthesia, Quadratus Lumborum Block, Analgesia
- Trial name
- NCT03199170
- Testing
- Intrathecal morphine, Bilateral Quadratus Lumborum Block, Intrathecal morphine with bilateral Quadratus Lumborum Block
- Where
- Thailand
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Pain, Postoperative
Study of Oral Morphine Sulfate Administration in Pediatric Subjects
This is a multicenter, open-label study to evaluate the safety and PK of oral morphine sulfate in pediatric subjects with post-operative pain.
- Trial name
- NCT03429400
- Testing
- Morphine Sulfate
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- West-Ward Pharmaceutical
Femoracetabular Impingement, Pain, Postoperative
Intra-articular Morphine and Clonidine Injections for Pain Management in Hip Arthroscopy
The purpose of this study is to determine whether intraoperative (during surgery) morphine and clonidine hip injections are effective in postoperative pain management for patients undergoing hip arthroscopy.
- Trial name
- NCT02530151
- Testing
- Morphine with clonidine, Normal saline
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Northwestern University