Clinical trials: Morphine, completed
Chronic Obstructive Pulmonary Disease (COPD)
Palliation of Dyspnea in Advanced Chronic Obstructive Pulmonary Disease (COPD)
Chronic Obstructive Pulmonary Disease (COPD) affects at least 750,000 Canadians and is currently the 4th leading cause of death in Canada.
- Trial name
- ROS-003 (NCT00982891)
- Testing
- Opioid (morphine sulphate) in low dose
- Where
- 3 sites in Canada
- Volunteers
- 45 people
- Sponsor
- Nova Scotia Health Authority
Pain, Unspecified Adult Solid Tumor, Protocol Specific
Inhaled Morphine Compared With Morphine By Mouth in Treating Cancer Patients With Breakthrough Pain
RATIONALE: Morphine that is inhaled may be more rapidly absorbed than morphine that is given by mouth. It is not yet known if inhaled morphine is more effective than morphine given by mouth in relieving breakthrough pain.
- Trial name
- NCT00020618
- Testing
- morphine sulfate, quality-of-life assessment
- Where
- United States
- Sponsor
- Dana-Farber Cancer Institute
Psychotic Disorders, Anxiety
A Study of Dose-response Relationship and the Evidence Based Multisensory Stimulation Intervention
Design: This parallel randomized controlled trial (RCT) was conducted according to the Consolidated Standards of Reporting Trials (CONSORT).
- Conditions
- Psychotic Disorders, Anxiety, Complementary Therapies, Clinical Trial
- Trial name
- NCT05012709
- Testing
- multisensory stimulation therapy
- Where
- Taiwan
- Volunteers
- 95 people
- Sponsor
- Jianan Psychiatric Center, Ministry of Health and Welfare
Pain Management
Efficacy of Hylenex in the Treatment of Pain Among Hospice Patients
The overall aim of this study is to find out whether Hylenex recombinant (for short, Hylenex) in subcutaneous (SC) injection improves the speed and effectiveness of SC opioids in hospice patients.
- Trial name
- NCT00547664
- Testing
- Hylenex recombinant , morphine, saline, Saline
- Where
- 3 sites in United States
- Volunteers
- 88 people
- Sponsor
- HPC Healthcare, Inc.
Pain
A Study To Characterize The Pharmacokinetics Of Oxycodone In Healthy Volunteers
This is an open-label (both the physician and healthy volunteer know which medication will be administered), single-dose, 6- dosing period study to characterize the pharmacokinetics of oxycodone (process by which oxycodone is…
- Trial name
- NCT01552863
- Testing
- Oxycodone
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Pain Therapeutics
Postoperative Pain, Abdominal Surgery by Laparotomy
Rectus Sheath Block as an Adjunct to General Anesthesia for Midline Laparotomy Pain
This study evaluates whether adding an ultrasound-guided rectus sheath block (RSB) to general anesthesia can improve pain control after midline laparotomy.
- Trial name
- RSB-MIDLINE (NCT07393763)
- Testing
- Ultrasound-guided rectus sheath block
- Where
- Indonesia
- Volunteers
- 46 people
- Sponsor
- Udayana University
Adenotonsillectomy, Analgesia
Individualized Analgesia for Pediatric Adenotonsillectomy
The objective of this randomized clinical trial is to assess the safety and effectiveness of post-adenotonsillectomy analgesia with individualized opioid analgesia regime in children.
- Trial name
- NCT04527393
- Testing
- Individualized oral morphine, Conventional oral morphine
- Where
- China
- Volunteers
- 542 people
- Sponsor
- Children's Hospital of Fudan University
Osteoarthritis
Proof-of-concept Study to Assess the Efficacy, Tolerability and Safety of a Single Intraarticular Dose of GZ389988 Versus Placebo in Patients With Painful Osteoarthritis of the Knee
Primary Objective: To assess the efficacy of a single intraarticular dose of GZ389988 compared to placebo for relief of knee pain in patients with osteoarthritis (OA) of the knee.
- Trial name
- NCT02845271
- Testing
- GZ389988, acetaminophen or paracetamol, fixed combination of paracetamol + codeine
- Where
- 2 sites in Germany
- Volunteers
- 104 people
- Sponsor
- Genzyme, a Sanofi Company
Gastric Motility Disorder
Effect of Methylnaltrexone on GI Transit in Healthy Volunteers
This is a single-center, randomized, double blind, placebo-controlled study evaluating the effects of placebo, codeine, methylnaltrexone and codeine with methylnaltrexone on gastrointestinal motility and colonic transit of solids…
- Trial name
- NCT01055704
- Testing
- Methylnaltrexone only, Codeine only, Methylnaltrexone + codeine
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Healthy
Double Blind Randomized, Monocentric, Cross-over, Placebo-controlled Study to Evaluate the Effect of Morphine and Naloxone on Motivation (MBBAnalgesic)
The aim of the current study is to examine the role of the opioïd system on the cognitive parameters of motivation. They are embedded in a conceptual framework of motivation that merges decision-making and reinforcement learning…
- Trial name
- MBBAnalgesic (NCT02267304)
- Testing
- 50 mL of sodium chloride (0,9%), Morphine 0,05mg/kg, Naloxone 10mg
- Where
- France
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Intensive Care, Neonatal, Analgesia
Clonidine for Analgesia to Preterm Infants During Neonatal Intensive Care
A prospective pharmacokinetic (PK), pharmacodynamic (PD) and pharmacogenetic (PG) observation study, including the PK/PD/PG relationship, in clonidine administered for analgesia and sedation to preterm newborn infants receiving…
- Conditions
- Intensive Care, Neonatal, Analgesia, Hypnotics and Sedatives
- Trial name
- NCT04928651
- Testing
- Clonidine
- Where
- 2 sites in Sweden
- Volunteers
- 40 people
- Sponsor
- Region Skane
Healthy
Comparison of Two KADIAN 10 mg Capsules to a KADIAN 20 mg Capsule Under Fasted Conditions
The objective of this single-dose, open-label, randomized, two-treatment, two-period crossover study was to compare the relative bioavailability of a test formulation of KADIAN (2 x 10 mg) capsules manufactured by Alpharma Inc.
- Trial name
- NCT00759902
- Testing
- morphine sulfate extended-release capsules, KADIAN (morphine sulfate extended-release) capsules
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Actavis Inc.
Elderly, Malignant Tumor
Epidural Anesthesia-analgesia and Long-term Outcome
Surgical resection is one of the most important treatments for resectable cancer; on the other hand, cancer recurrence and/or metastasis are the major reasons of treatment failure.
- Conditions
- Elderly, Malignant Tumor, Surgical Resection, Epidural Anesthesia
- Trial name
- NCT03012945
- Testing
- Combined epidural-general anesthesia, General anesthesia
- Where
- 5 sites in China
- Volunteers
- 1,802 people
- Sponsor
- Peking University First Hospital
To Evaluate Clinical Results, Insulin Resistance and Inflammatory Response to Trauma in Morbidly Obese Patients
Clinical Evaluation, Organic Response in Obesity Patients Subjected to Vertical Videolaparoscopy Gastroplasty With or Without Perioperative Cares Recommended by the Acerto Project. Randomized Study.
Background To evaluate clinical results, insulin resistance and inflammatory response to trauma in morbidly obese patients undergoing laparoscopic Sleeve gastrectomy who received either traditional preoperative care or treatment…
- Trial name
- NCT02113995
- Testing
- ACERTO protocol vs Traditional care
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Cuiaba University
Cesarean Section
Comparison of 0.1 and 0.05mg Intrathecal Morphine for Post-cesarean Analgesia.
The purpose of this study is to determine the ideal dose of spinal morphine for use in Cesarean section. Spinal anesthesia (single injection in the lower back to numb patients from the waist down) is commonly used in Cesarean…
- Trial name
- NCT03427463
- Testing
- receiving 0.1 mg IT morphine, recieving 0.05 mg IT morphine
- Where
- United States
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Toxicology, Bariatric Surgery Analgesia
Preoperative Toxicological Screening on Perioperative Anesthetic Management
Background: Preoperative substance use is a growing concern in patients undergoing metabolic bariatric surgery (MBS), but its impact on short-term outcomes remains debated.
- Conditions
- Toxicology, Bariatric Surgery Analgesia, Bariatric Surgery, Substance Use
- Trial name
- NCT07100314
- Testing
- Multi-Drug One Step Screen Test Panel (Urine)
- Where
- Egypt
- Volunteers
- 1,260 people
- Sponsor
- General Committee of Teaching Hospitals and Institutes, Egypt
Pain, Postoperative
Comparison of Post-operative Pain in Short Versus Long Stitch for Laparotomy Closure
Laparotomy is a surgical procedure where an incision is made through the abdominal wall in order to gain access to the peritoneal cavity. Midline laparotomy incisions were the main type of abdominal access.
- Trial name
- Shortstitch (NCT03828409)
- Testing
- Short stitch, Long stitch
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Healthy
Non-intrusive Detection of Temporary Neurologic Impairment By Opioids
Research is being conducted to better understand the physiologic effects (relating to the action of a drug when taken by a healthy person) of opioid use on oculomotor (relating to the motion of the eye) dynamics and to identify…
- Trial name
- NCT04223609
- Testing
- Oxycodone, EyeLink 1000 Plus, Oculo-Cognitive Addition test (OCAT)
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Chronic Post Cesarean Pain
Comparative Study on the Effect of Quadratus Lumborum Block Versus Intrathecal Morphine on the Incidence of Chronic Pain Post Caesarean Section
The aim of this study is to compare the incidence of CPSCP in patients receiving QLB quadratus lumborum block and ITM versus control as a primary outcome and associated risk factors that might predispose patients to develop CPSCP.
- Trial name
- NCT05602038
- Testing
- Quadratus laborum block, Intrathecal morphine, intrathecal bupivacaine
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Adenotonsillitis, Tonsillitis
Analgesic Effect of IV Acetaminophen in Tonsillectomies
Acetaminophen (paracetamol) is a first-line antipyretic and analgesic for mild and moderate pain for pediatric patients. Its common use (particularly in oral form) is underscored by its wide therapeutic window, safety profile…
- Trial name
- NCT01691690
- Testing
- Acetaminophen (paracetamol), Normal Saline Flush, Midazolam
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Nationwide Children's Hospital
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