Clinical trials: Morphine, completed
Postoperative Pain
Combined Intrathecal Morphine and Dexmedetomidine Analgesia
The current study investigated the effect of adding dexmedetomidine to intrathecal morphine for postoperative analgesia in cancer patients undergoing major abdominal surgery.
- Trial name
- ITMandDEX (NCT02435537)
- Testing
- Dexmedetomidine (Precedex), Bupivacaine, Morphine
- Volunteers
- 90 people
- Sponsor
- Assiut University
Postoperative Pain, Opioid Induced Constipation
A Comparison of Oxycodone/Naloxone and Oxycodone After Laparoscopic Hysterectomy
Objectives: Primary objective: To demonstrate that the treatment with OXN PR tablets up to 72 hrs after surgery is superior to the treatment with OxyPR with regards to constipation in subjects with postoperative pain after…
- Trial name
- NCT01109511
- Testing
- naloxone, oxycodone
- Where
- Norway
- Volunteers
- 85 people
- Sponsor
- Ullevaal University Hospital
Mechanically Ventilated Neonates, Painful Procedures in Newborns
Codeine in Mechanically Ventilated Neonates
The purpose of this study is to determine the absorption and bioavailability of codeine in relation to postnatal (PNA) and postconceptional (PCA) age; determine the parent drug (codeine), its active metabolites, their formation…
- Trial name
- NCT01322204
- Testing
- Codeine
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Pain
Evaluate The Pharmacokinetics and Safety Of Oxycodone Oral Solution In Pediatric and Adolescent Subjects
The objective of this study is to characterize the pharmacokinetics and to evaluate the safety of single and multiple doses of Oxycodone Oral Solution in pediatric and adolescent subjects for postoperative pain.
- Trial name
- NCT01959204
- Testing
- Oxycodone
- Where
- 9 sites in United States
- Volunteers
- 97 people
- Sponsor
- VistaPharm, Inc.
Opioid Dependence
The German Project of Heroin Assisted Treatment of Opiate Dependent Patients
The study will test the hypotheses that heroin assisted treatment, compared to methadone maintenance treatment, is more effective with regard to the improvement of health, reduction of illicit drug consumption, decrease of…
- Trial name
- NCT00268814
- Testing
- Diacetylmorphine, Psycho-education and Counselling, Methadone
- Where
- 7 sites in Germany
- Volunteers
- 1,015 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Spine Fusion, Locoregional Anaesthesia
PeriOPerative Spine Surgery COntrol Pain (POPSSCOP) Study: Intrathecal Morphine vs Erector Spinae Plane Block for Postoperative Pain Management in Spinal Fusion
This is a prospective observational study conducted at the trauma center of Città della Salute e della Scienza of Turin. The aim of the study is to compare two local regional anesthesia techniques in multimodal analgesia for…
- Conditions
- Spine Fusion, Locoregional Anaesthesia, Intrathecal Anesthesia, Erector Spina Plan Block
- Trial name
- POPSSCOP (NCT07245524)
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Cancer
A Study to Evaluate Efficacy and Safety of Oxycodone/Naloxone Compared to OxyContin in Korean Cancer Patients
Objectives: To prove non-inferiority of Targin compared to Oxycontin in terms of change of pain intensity 1. Primary objective: Change of pain intensity (NRS 0-10) score (average pain over 24 hours obtained each evening) within 4…
- Trial name
- TOP (NCT01313780)
- Testing
- Oxycodone/Naloxone, Oxycodone(single compound)
- Where
- South Korea
- Volunteers
- 128 people
- Sponsor
- Mundipharma Korea Ltd
Pain, Postoperative, Lung Neoplasm
PATHOS Study Pain Assessment in Thoracic Oncologic Surgery
A randomized prospective trial to assess whether the use of loco regional anesthesia as adjuvant analgesic therapy is more effective of intravenous analgesia only.
- Trial name
- PATHOS (NCT03134729)
- Testing
- Ropivacaine for Serratus Plane Block (SPB)
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- IRCCS Sacro Cuore Don Calabria di Negrar
Delirium
Dexmedetomidine Versus Morphine and Midazolam in Prevention and Treatment of Delirium After Adult Cardiac Surgery
This randomized double-blind parallel clinical study was conducted on 60 patients undergoing elective cardiac surgery under general anesthesia, at least 60 yr old, ASA I and II, 70-100 kg body weight and height 160-180 cm.
- Trial name
- NCT03078946
- Testing
- Dexmedetomidine Hydrochloride, Morphine and Midazolam
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Postoperative Pain
Efficacity, Safety and Cost of Intravenous Morphine Titration Alone or Combined to Ketamine
This is a randomised, controlled, double blinded study comparing in the postoperative setting the analgesic efficacy, the safety and the cost in two groups of patients receiving in the postanesthesia care unit either intravenous…
- Trial name
- KEMO (NCT01146145)
- Testing
- Ketamine
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Multiple Sclerosis
A Multicentre Study of the Efficacy and Safety of Supplementary Treatment With Cholecalciferol in Patients With Relapsing Multiple Sclerosis Treated With Subcutaneous Interferon Beta-1a 44 µg 3 Times Weekly
The aim of this multicentre, randomised, double-blind, placebo-controlled study is to evaluate the efficacy and safety of supplementary treatment with cholecalciferol (vitamin D3) in subjects with relapsing multiple sclerosis (R…
- Trial name
- CHOLINE (NCT01198132)
- Testing
- Cholecalciferol (Vitamin D3), Rebif
- Where
- France
- Volunteers
- 129 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Pain, Postoperative, Ankle Fractures
Efficacy of Multimodal Periarticular Injections in Operatively Treated Ankle Fractures
The purpose of this study is to determine the efficacy and safety of a peri-articular multimodal injection for post-operative pain control following operative management of closed, rotational ankle fractures.
- Trial name
- NCT02967172
- Testing
- Ropivacaine, Epinephrine, Morphine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Iowa
Osteotomy and Spinal Column Surgery
Study of the Effects of Hypnosis Before Undergoing Surgery, on Anxiety in Children Aged 10 to 18 Years
This study aims to find how hypnosis performed just before a painful surgery can change anxiety level, in children aged 10 to 18 years.
- Trial name
- HYPOPANX (NCT01320956)
- Testing
- Pre operative nurse consultation and Hypnosis, Pre operative nurse consultation
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pain
Measuring the Amount of Methadone or Morphine in the Blood of Neonates, Infants & Children After Cardiac Surgery.
Study Population: Neonates, infants and children from birth to 5 years of age undergoing cardiac surgery with CPB. The use of methadone to provide analgesia may be increasing due to advantages compared to other commonly used…
- Trial name
- NCT01094522
- Testing
- Methadone, Morphine
- Where
- 3 sites in United States
- Volunteers
- 47 people
- Sponsor
- Stanford University
Pain
Comparative Bioavailability Study of Morphine Sulfate Immediate Release and Controlled Release
Characterize the steady-state pharmacokinetics of morphine after oral administration of Roxane Laboratories' morphine sulfate immediate release tablets and oral solution and to compare their pharmacokinetics to that of AVINZA.
- Trial name
- NCT00994383
- Testing
- morphine sulfate
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Roxane Laboratories
Pain Management, Postoperative Pain
Effects of S-ketamine on Perioperative Opioid Consumption
This study is a triple-blind randomized controlled trial conducted at a tertiary care hospital in Brussels. It investigates whether a single dose of S-ketamine can reduce opioid (morphine) consumption in the first 24 hours after…
- Conditions
- Pain Management, Postoperative Pain, Opioid Consumption, Postoperative, Opioid Analgesia
- Trial name
- NCT07528651
- Testing
- Esketamine at low dose, Saline (0.9% NaCl)
- Where
- Belgium
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Erasme University Hospital
Shoulder Osteoarthritis, Cuff Tear Arthropathy
Local Infiltration Analgesia Vs. Interscalene Block in Total Shoulder Arthorplasty
Pain management following total shoulder arthroplasty is an important factor in determining patient outcomes and satisfaction. Interscalene brachial plexus blockade has been used successfully to minimize pain in the acute…
- Conditions
- Shoulder Osteoarthritis, Cuff Tear Arthropathy, Massive Rotator Cuff Tear
- Trial name
- NCT04415931
- Testing
- Local infiltration analgesia, Interscalene block
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- University of Missouri-Columbia
Anesthesia, Local, Nerve Pain
SEQ Block for Perioperative Analgesia in Acetabular Surgery
The study will evaluate ultrasound guided SEQ block: single puncture combined lumbar erector spinae plane block and paraspinous sagittal shift (PSSS) quadratus lumborum block when compared with conventional intravenous morphine…
- Conditions
- Anesthesia, Local, Nerve Pain, Pain, Postoperative, Acetabular Fracture
- Trial name
- NCT04688814
- Testing
- Single puncture combined lumbar erector spinae plane block and quadrates lumborum block, Morphine Sulfate
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Alexandria University
Chest Trauma With Ribs Fractures
PEF-Block & Ribs Fractures
Rib fractures are frequent injuries found approximately in 10% severe trauma patient. Rib fractures were correlated in many studies with a higher morbidity and mortality.
- Trial name
- PEF (NCT03396692)
- Testing
- Intravenous morphine patient-controlled analgesia (PCA), Block of the posterior exo-thoracic fascia with Ropivacaine, Block of paravertebral space with Ropivacaine
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Montpellier
Pain
Herb-Opioid Interactions
This is a series of studies in healthy volunteers to assess the potential for adverse interactions between St. John's wort (SJW) extract and two narcotic (opioid) pain medications: oxycodone and fentanyl.
- Trial name
- NCT00027014
- Testing
- St. John's Wort, oxycodone, fentanyl
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
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