Clinical trials: Morphine, completed
Pain Management
Intravenous Acetaminophen and Morphine Versus Intravenous Morphine Alone for Acute Pain in the Emergency Department
In emergency medicine, acute pain is a common reason for consultation. It is recommended that patients in moderate to severe pain should receive a combination of intravenous acetaminophen and morphine.
- Trial name
- ADAMOPA (NCT04148495)
- Testing
- acetaminophen IV
- Where
- 11 sites in France
- Volunteers
- 415 people
- Sponsor
- Nantes University Hospital
Cancer
Double Bedtime Dosing During Immediate-release Morphine Administration to Cancer Patients
This is a double -blind randomized crossover study to provide evidence for the expert advice based recommendation of the Expert Working Group of the European Association for Palliative Care (EAPC) that patients during treatment…
- Trial name
- NCT00201539
- Testing
- single dose Morphine, double dose Morphine
- Where
- 2 sites in Norway
- Volunteers
- 19 people
- Sponsor
- Norwegian University of Science and Technology
Postoperative Pain, Opioid Use
The Effect of Bilateral Erector Spina Plane Block on Postoperative Pain in Adult Cardiac Surgery.
Failure to adequately prevent pain after heart surgery increases morbidity and results in a high incidence of persistent poststernotomy pain syndrome.
- Trial name
- NCT04906239
- Testing
- Erector Spinae Plane Block
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Postural Balance
Multi-Sensory Training and Wrist Fractures
The aim of the study is to investigate whether individuals with fall-related wrist fractures have impaired posterior control, reduced proprioception in their lower limbs and/or vestibular asymmetry compared with those who have…
- Trial name
- NCT03478228
- Testing
- Multi-Sensory Training
- Where
- Iceland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Landspitali University Hospital
Cancer
PECTORAL PLANE BLOCK COMPAIRED TO ERECTOR SPINAE PLANE BLOCK IN MULTIMODAL ANALGESIA FOR MASTECTOMY PATIENTS IN SOUTH ASIAN POPULATION -A PROSPECTIVE RANDOMISED CONTROL TRIAL
This prospective randomized controlled trial was conducted at the Department of Anesthesia, Shaukat Khanum Memorial Cancer Hospital and Research Centre (SKMCH\&RC), Lahore.
- Trial name
- NCT07197177
- Testing
- regional block
- Where
- Pakistan
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Shaukat Khanum Memorial Cancer Hospital & Research Centre
Withdrawal Symptoms
A Study to Evaluate Withdrawal Effects Following Dosing of Oxycodone/Naltrexone in Methadone-Maintained Subjects
This single-center study is a randomized, double-blind, active-controlled, multiple-dose, parallel group study to evaluate the potential withdrawal effects, safety and tolerability, and pharmacokinetic and pharmacodynamic effects…
- Trial name
- NCT02391571
- Testing
- Oxycodone/Naltrexone Capsules, Oxycodone
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Elite Laboratories, Inc
Anesthesia, Surgery
Association Between Clinical Effect of Morphine With PCA After Surgery and Pharmacogenetics
Identification of the genetic polymorphisms that could be correlated either with a better clinical response or with a major predisposition of patients to develop tolerance and/or side effects to the treatment with morphine.
- Trial name
- PCA-Gene (NCT01233752)
- Testing
- morphine chlorhydrate
- Where
- 2 sites in Italy
- Volunteers
- 224 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Nerve Block, Dexmedetomidine
Dexmedetomidine as Adjuvant for FNB in TKA
The aim of the study was to find out whether addition of dexmedetomidine to lower concentration of ropivacaine preoperatively in femoral nerve block (FNB) would intensify analgesia and preserve quadriceps muscle strength after…
- Trial name
- NCT03658421
- Testing
- Dexmedetomidine, ultrasound-guided femoral nerve block, intravenous patient-controlled analgesia pump with morphine
- Where
- 2 sites in China
- Volunteers
- 90 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Bronchiectasis Post-Tuberculosis Lung Disease
Respiratory Muscle Stretching Exercise for Improving Quality of Life of Patients With Bronchiectasis
Bronchiectasis is a chronic condition often arising after the successful treatment of lung tuberculosis, leading to diminished functional exercise capacity, increased fatigue, and reduced quality of life.
- Trial name
- NCT06722547
- Testing
- Standard PR, Standard PR plus Respiratory Muscle Stretching
- Where
- Indonesia
- Volunteers
- 50 people
- Sponsor
- Universitas Padjadjaran
Healthy Volunteers
A Study of the Abuse Liability Potential of Samidorphan in Healthy, Non-Dependent, Recreational Opioid Users
The purpose of this study is to evaluate the abuse potential and safety of samidorphan in healthy, non-dependent, adult, recreational opioid users.
- Trial name
- NCT02218021
- Testing
- Samidorphan, Oxycodone
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Alkermes, Inc.
Relapsing Multiple Sclerosis
Relapsing Forms of Multiple Sclerosis (RMS) Study of Bruton's Tyrosine Kinase (BTK) Inhibitor Tolebrutinib (SAR442168) (GEMINI 1)
Primary Objective: To assess efficacy of daily SAR442168 compared to a daily dose of 14 mg teriflunomide (Aubagio) measured by annualized adjudicated relapse rate (ARR) in participants with relapsing forms of MS Secondary…
- Trial name
- GEMINI 1 (NCT04410978)
- Testing
- Tolebrutinib, Teriflunomide
- Where
- 179 sites in United States, Austria and 22 more
- Volunteers
- 974 people
- Sponsor
- Sanofi
Osteo Arthritis Knee
The Effect of Prolonged Multimodal Analgesic Regimen on Post Hospital Discharge Opioid Use and Pain Control After Primary Total Knee Arthroplasty
It is well recognized that a multimodal analgesia program targeting multiple pain pathways, is more effective for controlling pain during the hospital stay and in the acute postoperative period than monotherapy-based regimens…
- Trial name
- NCT04003350
- Testing
- Oxycodone, Tramadol, Tylenol
- Where
- United States
- Volunteers
- 216 people
- Sponsor
- Rothman Institute Orthopaedics
Basketball Performance
Lower Body Plyometric Training Effects on Upper Body in Basketball Players
The present study investigates effect of lower body plyometric training on upper body performance, muscle size, hormonal factors, and neuromuscular activity in male basketball players, with a focus on vertical strength transfer…
- Trial name
- LBPT-VST (NCT07339436)
- Testing
- Plyometric Training
- Where
- Iran
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Birjand University of Medical Sciences
Pregnancy
Maternal Microcirculation & SDF Imaging
This is a study of pregnant women undergoing a cesarean delivery. It will compare their microcirculation before and after the anesthetic. Microcirculation means blood flow to the extremely small blood vessels in the body.
- Trial name
- NCT02376192
- Testing
- Initial MicroScan® (Microvision Medical) SDF Measurement, Spinal Anesthesia- Bupivacaine, Comparative MicroScan® (Microvision Medical) SDF Measurement
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- IWK Health Centre
Surgery
Ambulatory Gynecologic Surgery: Finding the Optimal Opioid Prescription
Currently there is a nationwide epidemic in opioid abuse and overdose deaths. While the opioid epidemic is multi-factorial one major source of excess opioids may be over-prescribing in the post-operative period.
- Trial name
- NCT03588910
- Testing
- Acetaminophen, Ibuprofen 600 mg, Oxycodone
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Pain
Ultrasound Guided Bilateral Erector Spinae Plane Block in Caesarean Delivery
Erector Spinae plane block (ESPB) is a regional anesthesia technique described three years ago. Its use for many indications has been identified by case reports in the literature.
- Trial name
- NCT04118413
- Testing
- erector spinae plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Cigli Regional Training Hospital
Nausea
Nausea in Patients Receiving Hydromorphone vs Oxycodone After Total Hip Replacement Surgery
The study aims to compare the incidence of side effects caused by Oxycodone and Hydromorphone.
- Trial name
- NCT02295124
- Testing
- Oxycodone, Hydromorphone
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University Health Network, Toronto
Intractable Pain
Prometra's Utilization in Mitigating Pain (PUMP)
Clinical evaluation of the safety and efficacy of the Prometra Programmable Infusion Pump to accurately supply drug to the intrathecal space for the treatment of chronic pain.
- Trial name
- PUMP (NCT00817596)
- Testing
- Infusion Pump (Prometra)
- Where
- 3 sites in United States
- Volunteers
- 110 people
- Sponsor
- Flowonix Medical
Dexmedtomidine in Erector Spinae Block for Laparscopic Cholecystectomy
Dexmetomidine With Erector Spinae Plane Block in Cholecystectomy
Sixty patients scheduled for elective laparoscopic cholecystectomy will be randomly assigned using sealed envelope into two equal groups (30 patients each).
- Trial name
- NCT05369468
- Testing
- dexmedetomidine as adjuvant with bupivacaine, Bupivacain only
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tanta University
Acute Pain
Acupuncture Versus Intravenous Morphine in the Management of Acute Pain in the Emergency Department
Inadequate pain management is a common problem encountered in ED settings. Pain relief medications use is often limited by their side effects.
- Trial name
- AcuMAP (NCT02460913)
- Testing
- Acupuncture, Morphine titration
- Volunteers
- 300 people
- Sponsor
- University of Monastir
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