Clinical trials: Morphine, completed
Prescription Drug Abuse (Not Dependent)
Influence of Medication on Functional Connectivity
This study will assess the effects of acute low-dose opioid administration on functional neuroimaging measures in healthy individuals
- Trial name
- NCT03612713
- Testing
- Oxycodone Medication First
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Yale University
Multiple Sclerosis
A Study of Suboptimally Controlled Participants Previously Taking Injectable DMDs for RMS (CLICK-MS)
To evaluate the effectiveness, patient-reported outcomes (PROs) and safety of cladribine tablets in participants with relapsing forms of multiple sclerosis (RMS) including relapsing-remitting multiple sclerosis (RRMS) and active…
- Trial name
- NCT03933215
- Testing
- Cladribine
- Where
- 18 sites in United States
- Volunteers
- 100 people
- Sponsor
- EMD Serono Research & Development Institute, Inc.
Depression
Magnetic Seizure Therapy (MST) for Severe Mood Disorder
This study will compare the clinical efficacy and side effects of Magnetic Seizure Therapy (MST) and Electroconvulsive Therapy (ECT) in patients currently experiencing a major depressive episode in the context of either unipolar…
- Trial name
- NCT00488748
- Testing
- Thymatron, Magstim Theta
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- Sarah Lisanby
Healthy Volunteers
A Study of the Abuse Liability Potential of Samidorphan in Healthy, Non-Dependent, Recreational Opioid Users
The purpose of this study is to evaluate the abuse potential and safety of samidorphan in healthy, non-dependent, adult, recreational opioid users.
- Trial name
- NCT02218021
- Testing
- Samidorphan, Oxycodone
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Alkermes, Inc.
Sprains and Strains, Pain
A Study of the Efficacy and Safety of Tramadol HCl/Acetaminophen, Hydrocodone Bitartrate/Acetaminophen and Placebo in Patients With Pain From an Ankle Sprain With a Partial Torn Ligament
The purpose of this study is to explore the pain-relieving effects and safety of two analgesic treatment regimens as compared to placebo in patients experiencing acute musculoskeletal pain.
- Trial name
- NCT00236535
- Volunteers
- 603 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Cancer Pain
IV PCA With or Without Continuous Dose vs Oral Opioid to Maintain Analgesia for Severe Cancer Pain After Successful Titration
Based on the previous HMORCT09-2, the results show that IV PCA for analgesia maintenance improvements control of severe cancer pain after successful titration.
- Trial name
- NCT04785768
- Testing
- Hydromorphone Hydrochloride Injection, Morphine Sulfate Sustained-release Tablets
- Where
- China
- Volunteers
- 1,372 people
- Sponsor
- Fujian Cancer Hospital
Premature Birth
Balanced Anesthesia for Intubation of Premature Infants
The study aim is to compare a balanced anesthesia of the medicines used in all other age groups with the routine premedication in use for premature's with regards to the success in the intubation procedure, the need for analgesia…
- Trial name
- NCT00216944
- Testing
- Tracheal intubation for respiratory care in preterm infants
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Lund University Hospital
Renal Colic, Urinary Calculi
Efficacy Study of Different Analgesic Options in Kidney Stone Pain Management
Abdominal pain is one of the most common presentations to an emergency department (ED). Among patients presenting with abdominal pain, a common diagnosis in the Middle East is renal colic (urolithiasis or Kidney stones).
- Trial name
- NCT02187614
- Testing
- Diclofenac, Morphine, Paracetamol
- Where
- Qatar
- Volunteers
- 1,645 people
- Sponsor
- Hamad Medical Corporation
Emergencies
International Prospective Study on Morphine-induced Adverse Drug Reactions in Emergency Departments.
Morphine is the gold standard for treatment of severe acute pain but it has a number of adverse effects. No study has so far managed to identify the morphine-induced adverse drug reactions.
- Trial name
- EI-Morphinique (NCT01654055)
- Where
- France
- Volunteers
- 1,128 people
- Sponsor
- University Hospital, Toulouse
Chronic Pain
OTR Tablet 40 mg Fasted-state Bioequivalence Study
This is an open-label, single dose, randomised, cross-over study to confirm the bioequivalence (BE) of OTR tablet 40 mg and OXYCONTIN tablet 40 mg in a fasted state in Chinese subjects with chronic pain
- Trial name
- NCT03398278
- Testing
- Oxycodone Tamper Resistant, OXYCONTIN®
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Mundipharma (China) Pharmaceutical Co. Ltd
Mammoplasty, Postoperative Pain
Study of EXPAREL in Patients Undergoing Breast Augmentation
This is a Phase 4, prospective, open-label, non-randomized, sequential study with two treatment groups differing only in the technique used for EXPAREL administration (instillation or infiltration).
- Trial name
- NCT01582490
- Testing
- Instillation - EXPAREL, Infiltration - EXPAREL
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Relapsing Forms of Multiple Sclerosis
A Cross-sectional Study to Assess the Effectiveness and Safety of Ofatumumab (Kesimpta®) in Patients With Relapsing Multiple Sclerosis in the Spanish Clinical Practice
This was a non-interventional, cross-sectional, multicentric, and nationwide study, based on primary and secondary data collection.
- Trial name
- CRONOS-MS (NCT06251986)
- Testing
- ofatumumab
- Where
- 31 sites in Spain
- Volunteers
- 310 people
- Sponsor
- Novartis Pharmaceuticals
Respiratory Insufficiency, Clinical Deterioration
Wearable Wireless Respiratory Monitoring System That Detects and Predicts Opioid Induced Respiratory Depression
An observational study will be conducted in approximately 14 participants to evaluate the ability of a wearable, wireless acoustic Respiratory Monitoring System (RMS) to accurately measure a participant's respiratory rate, tidal…
- Trial name
- NCT06442488
- Testing
- Respiratory Monitoring System
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Jeffrey Joseph
Neonatal Abstinence Syndrome
Treatment of Neonatal Abstinence Syndrome
This study compares treatment of Neonatal Abstinence Syndrome (NAS) with two different drugs for the difference in the length of treatment.
- Trial name
- HOMENOW (NCT01723722)
- Testing
- Methadone, Diluted Deodorized Tincture of Opium
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Eastern Maine Medical Center
Pain, Procedural
Oral Morphine Versus Ketamine in Pain Management
The study will mainly focus on procedural pain management using oral morphine versus rectal ketamine during paediatric burn and wound dressing at Mbarara Regional Referral Hospital.
- Trial name
- NCT05163366
- Testing
- GROUP A, GROUP B
- Where
- 2 sites in Uganda
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Mbarara University of Science and Technology
Myocardial Revascularization, Spinal Anesthesia
Spinal Anesthesia Associated With General Anesthesia in Coronary Artery Bypass
CONTEXT: In patients eligible for coronary artery bypass surgery, anesthesia should provide a number of conditions that exceed the limits of cardiovascular stability, myocardial protection and other organs.
- Conditions
- Myocardial Revascularization, Spinal Anesthesia, Postoperative Care, Fentanyl
- Trial name
- NCT02840006
- Testing
- General anesthesia only, General anesthesia and Spinal anesthesia
- Where
- 2 sites in Brazil
- Volunteers
- 60 people
- Sponsor
- Daniel Gioielli de Castilho
Relapsing Multiple Sclerosis
A Multi-Center, Open-Label Long-Term Extension Study of CNM-Au8 In Patients With Stable Relapsing Multiple Sclerosis
Open-label, long-term extension study available to participants who have completed CNMAu8.201.
- Trial name
- VISIONMS-LTE (NCT04626921)
- Testing
- CNM-Au8
- Where
- 5 sites in Australia
- Volunteers
- 55 people
- Sponsor
- Clene Nanomedicine
Pain, Huntington Disease
Evaluating the Relationship of Morphine Consumption and Pain-related Molecules in Hepatic Surgical Patients
According to above basic findings, it is important to confirm those results in clinic. In this branch, the investigators will use patient control analgesic (PCA) device to investigate the consumption of morphine for patients…
- Conditions
- Pain, Huntington Disease, Hepatic Surgery
- Trial name
- NCT01919034
- Where
- Taiwan
- Volunteers
- 15 people
- Sponsor
- National Cheng-Kung University Hospital
Chronic Pain
A Comparison of Morphine and Morphine Plus Dexmedetomidine in Chronic Cancer Pain
The purpose of this study is to determine whether dexmedetomidine added to morphine is effective in the treatment of chronic cancer pain.
- Trial name
- NCT02289261
- Testing
- Morphine, Morphine plus dexmedetomidine
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Cukurova University
Pain
Perioperative Pain Management In Spine Surgery Patients: Part I
The purpose of this study is a comparison of pain management in opioid-tolerant spine surgery patients using a perioperative dosing goal of 150% of patient's baseline oral morphine equivalent (OME), as compared to standard…
- Trial name
- NCT01447888
- Testing
- 150% Oral Morphine Equivalent (OME), Clinical Judgment
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Allina Health System
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