Clinical trials: Morphine, completed
Alveolar Childhood Rhabdomyosarcoma, Embryonal Childhood Rhabdomyosarcoma
Retrospective Study in FFPE Samples From Younger Patients With Rhabdomyosarcoma
This retrospective study is looking into mechanisms of drug therapy resistance in FFPE samples in recurrent and refractory Rhabdomyosarcoma (RMS) in pediatric patients who have experienced lung recurrence.
- Conditions
- Alveolar Childhood Rhabdomyosarcoma, Embryonal Childhood Rhabdomyosarcoma, Recurrent Childhood Rhabdomyosarcoma
- Trial name
- NCT06040229
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Shandong First Medical University
Benign Female Reproductive System Neoplasm
Efficacy and Safety of Parecoxib on Morphine Patient-controlled Epidural Analgesia (PCEA) After Gynecologic Surgery
The purpose of this study is to determine the effects of parecoxib in combination with epidural morphine in providing analgesia for patients undergoing gynecological surgery.
- Trial name
- PCEA (NCT01566669)
- Testing
- Parecoxib Sodium, Normal saline
- Where
- China
- Volunteers
- 294 people
- Sponsor
- Liu Weifeng
Sickle Cell Disease, Vaso-Occlusive Crisis
Adjuvant Low-dose Ketamine in Pediatric Sickle Cell Vaso-occlusive Crisis
Acute vaso-occlusive episodes (VOEs) in sickle cell disease (SCD) are primarily managed with opioids. Tolerance and hyperalgesia to opioids develops due to N-methyl-D-aspartate (NMDA)-receptor mediated activation of the…
- Trial name
- AKTSS (NCT03296345)
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Hip Fractures, Acute Pain
PENG Block for Traumatic Hip Fracture in the Emergency Department
The study is a multicenter single-blinded randomized comparative trial. Adult patients older than 20 years of age presenting with acute hip fracture in emergency department between January 1st, 2021 and December 31st, 2021 will…
- Conditions
- Hip Fractures, Acute Pain, Emergency Department
- Trial name
- NCT04997785
- Testing
- Ultrasound-guided Pericapsular Nerve Group (PENG) Block
- Where
- Taiwan
- Volunteers
- 65 people
- Sponsor
- Dalin Tzu Chi General Hospital
Laparotomy
Feasibility and Efficacy of Enhanced Recovery After Surgery (ERAS) on Length of Stay Among Laparotomy Patients at Mbarara Regional Referral Hospital
The main goal of ERAS is to enhance the recovery of patients, and this has secondary effects, such reduced length of hospital stay, minimal postoperative complications and lessen readmission rates.
- Trial name
- ERAS-Lap (NCT03665376)
- Testing
- Carbohydrate drink load, Enhanced Recovery After Surgery (ERAS)
- Where
- Uganda
- Volunteers
- 33 people
- Sponsor
- Mbarara University of Science and Technology
Anterior Cruciate Ligament (ACL) Tear, Arthroscopic Anterior Cruciate Ligament Reconstruction
Intraoperative Periarticular Injection in Arthroscopic Anterior Cruciate Ligament Reconstruction Surgery
In this prospective, assessor-blinded, single-surgeon clinical trial, the goal was to validate the efficacy of PAI in aACLR surgery with a reduced opioid dose, while achieving similar pain relief with few adverse events.
- Trial name
- PAI in ACLR (NCT06630520)
- Testing
- Periarticular injection
- Where
- Taiwan
- Volunteers
- 288 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Inguinal Hernia, Pain, Postoperative
Efficacy of an Anterior Quadratus Lumborum Block vs. a TAP-block for Inguinal Hernia Repair
One of the most common complications after hernia repair is postoperative and chronic pain. TAP (transverse abdominis plain) block is a recommended multimodal method of reducing postoperative pain in laparoscopic and open…
- Trial name
- NCT03023462
- Testing
- Oksykodonhydroklorid, Ondansetron and Droperidol, Ropivacaine
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Ostfold Hospital Trust
Sedation
Safety, Efficacy and Pharmacokinetic Study of Dexmedetomidine in Pediatrics Ages ≥28 Weeks to ≤44 Weeks Gestational Age
The purpose of this study is to investigate the safety, efficacy and pharmacokinetics (PK) of dexmedetomidine (DEX) at 3 different dose levels in infants, ages ≥28 weeks to ≤44 weeks gestational age, administered as a loading…
- Trial name
- NCT01159262
- Testing
- Midazolam, Fentanyl/Morphine, Dexmedetomidine
- Where
- 18 sites in United States, Guatemala
- Volunteers
- 36 people
- Sponsor
- Hospira, now a wholly owned subsidiary of Pfizer
Pain, Postoperative, Nausea and Vomiting, Postoperative
QUALITY OF RECOVERY AFTER INTRAOPERATIVE MORPHINE OR METHADONE
Introduction. Despite the advantages associated with the use of remifentanil during total intravenous anesthesia (TIVA), it has been observed a frequent difficulty in the control of postoperative pain due to the risk of…
- Trial name
- NCT03045133
- Testing
- Methadone, Morphine
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- Pontificia Universidade Catolica de Sao Paulo
Colorectal Cancer, Anesthesia
Effects of Dexmedetomidine/Lidocaine/Intrathecal Morphine on Cancer Metastasis Biomarker After Colorectal Surgery
This is a prospective randomized controlled trial. Investigators aimed to compare the effect of three different anesthetic adjuvants (continuous infusion of lidocaine or dexmedetomidine, intrathecal morphine injection) on the…
- Conditions
- Colorectal Cancer, Anesthesia, Cancer Metastatic, Inflammation
- Trial name
- NCT05742438
- Testing
- Lidocaine IV, Dexmedetomidine IV, intrathecal morphine
- Where
- South Korea
- Volunteers
- 114 people
- Sponsor
- Samsung Medical Center
HIV Infection, Opioid-use Disorder
Effect of Heroin Use on Immune Activation and Cardiovascular Risk in HIV
Despite the advent of safer HIV therapies, high levels of markers of systemic inflammation and increased cardiovascular risk threaten the well-being of individuals living with HIV and present a significant challenge for HIV…
- Conditions
- HIV Infection, Opioid-use Disorder, Cardiovascular Diseases
- Trial name
- NCT03976258
- Testing
- buprenorphine/naloxone, Methadone, Naltrexone Injection
- Where
- 2 sites in United States
- Volunteers
- 190 people
- Sponsor
- MetroHealth Medical Center
Acute Pain
A Study of TRV130 for the Treatment of Pain After Bunionectomy
The primary objective is to evaluate the analgesic efficacy of IV TRV130 compared with placebo in patients with acute postoperative pain after bunionectomy.
- Trial name
- NCT02100748
- Testing
- TRV130, Morphine
- Where
- 4 sites in United States
- Volunteers
- 333 people
- Sponsor
- Trevena Inc.
Pain
Low Dose Ketamine Versus Morphine for Moderate to Severe Pain in the Emergency Department
The primary objectives of the study are to evaluate the efficacy of subdissociative dose intravenous ketamine compared with intravenous morphine in relieving acute pain in the ED.
- Trial name
- NCT01835262
- Testing
- Morphine, Ketamine
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Antonios Likourezos
Morphine Consumption, Postoperative Pain
Ultrasound-Guided Pericapsular Nerve Group Block for Pain Control After Hip Surgery
This study evaluated whether an ultrasound-guided pericapsular nerve group (PENG) block could reduce pain and morphine use during the first 24 hours after hip surgery.
- Trial name
- NCT07906613
- Testing
- Ultrasound-Guided Pericapsular Nerve Group Block with Bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Cumhuriyet University
Hernia Lumbar, Lumbar Canal Stenosis
Erector Spinae Plane Block in Lumbar Release Surgery
The aim of this study is to observe or not a reduction in the consumption of morphine within 72 hours of the realization of an erector spinae plane block when preparing for a non-instrumented spine surgery.
- Conditions
- Hernia Lumbar, Lumbar Canal Stenosis, Spinal Cord Compression
- Trial name
- MERLIBERTION (NCT04925882)
- Testing
- Erector spinae plane block
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Clinique Saint Jean, France
Acute Renal Colic
Nasal Fentanyl And Renal Colic
The purpose of this study is to determine whether nasal fentanyl is effective in the treatment of renal colic in adults in emergency department.
- Trial name
- NCT01339624
- Testing
- FENTANYL, Ketorolac Tromethamine AND morphine
- Where
- Italy
- Volunteers
- 65 people
- Sponsor
- Valduce Hospital
Neuropathic Diabetic Ulcer - Foot
Open Multi-center Safety & Efficacy Study of Low Frequency Magnetic Fields to Treat Unresponsive Diabetic Foot Ulcers.
An open multicenter trial to document the efficacy and safety of two therapeutic Extremely Low Frequency Magnetic Fields stimulation devices to promote wound healing of Diabetic Foot Ulcers.
- Trial name
- NCT02145962
- Testing
- Forearm tissue exposure with ELF-MF, Thorax tissue exposure with ELF-MF
- Where
- 2 sites in Mexico
- Volunteers
- 27 people
- Sponsor
- Autonomous University of Morelos
Tumor, Pain
A Study to Evaluate Tapentadol (CG5503) in the Treatment of Chronic Tumor-Related Pain Compared With Placebo and Morphine
The purpose of this study will be to determine whether tapentadol (CG5503) is effective and safe in the treatment of chronic tumor related pain compared to placebo.
- Trial name
- NCT00472303
- Testing
- Tapentadol Extended Release, Morphine Sulphate Controlled Release
- Where
- 71 sites in Austria, Bulgaria and 14 more
- Volunteers
- 622 people
- Sponsor
- Grünenthal GmbH
Postoperative Pain, Postoperative Nausea and Vomiting
A Comparison of Targinact vs. Oxycodone on Gut Function After Colorectal Surgery
Two key requirements for discharge from hospital after major abdominal surgery are adequate oral analgesia and resumption of oral nutrition.
- Trial name
- TACS (NCT02109640)
- Testing
- Targinact, Oxycodone, Laparoscopic segmental colectomy
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University of Edinburgh
Healthy
Comparison of One Morphine Sulfate Sustained-Release 200mg Capsule With Two 100 mg KADIAN Capsules Under Fasting Conditions
The objective of this single-dose, open-label, randomized, two-period crossover study was to compare the rate of absorption and oral bioavailability of a test formulation of morphine sulfate 200 mg sustained-release capsules…
- Trial name
- NCT00759759
- Testing
- morphine sulfate sustained-release capsules, KADIAN (morphine sulfate sustained-release) capsules
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Actavis Inc.
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.