Clinical trials: Morphine, completed
Analgesia
Effect of Intrathecal Morphine on Urinary Bladder Function and Recovery in Patients Having a Cesarean Delivery
The enhanced recovery anesthesia concept has been widely adopted, including cesarean delivery. Modern obstetrical anesthesia aims to offer an experience to a patient undergoing a cesarean delivery similar to normal vaginal…
- Trial name
- NCT05042817
- Testing
- 100 mcg morphine, 0.9% NaCl, 50 mg prilocaine + 2.5 mcg sufentanil
- Where
- Belgium
- Volunteers
- 56 people
- Sponsor
- University of Liege
Renal Colic
Pramipexole and Morphine for Renal Colic
Opioid analgesics are among the most commonly prescribed class of medications in the US. While opioids may effectively control pain and other sensory disorders under acute conditions, the rates of misuse/abuse and accidental…
- Trial name
- NCT04160520
- Testing
- Pramipexole, Morphine
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- East Carolina University
Vertebral Subluxation, Spine Disease
Erector Spinae Block vs Morphine in Vertebral Fixation
The study aims to shed light about the potential role of Erector Spinae Block in the management of postoperative pain following vertebral fixation surgery via posterior approach.
- Conditions
- Vertebral Subluxation, Spine Disease, Spondylolisthesis
- Trial name
- ATLANTE (NCT04729049)
- Testing
- Erector Spinae plane Block, Patient controlled analgesia with intravenous morphine
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- AUSL Romagna Rimini
Pain, Postoperative, Cognition
Outcomes of Thoracoabdominal Nerve Block Through Perichondrial Approach* on Postoperative Cognitive Functions
It was planned to compare the opioid consumption and cognitive functions in the postoperative period of patients who received TAPA block for postoperative analgesia and patients who did not prefer the block and who preferred…
- Trial name
- TAPA (NCT05215691)
- Testing
- Group I: TAPA block, Group II: IV Morphine
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Abdominal Pain, Appendicitis
Ketorolac for Moderate to Severe Abdominal Pain in Children
In children and adolescents (older than 6 years in age) who arrive in the pediatric emergency department because they have been having 5 days or less of abdominal pain (possible appendicitis), will patients who are treated with…
- Conditions
- Abdominal Pain, Appendicitis, Analgesia, Child, Only
- Trial name
- KETO-APP (NCT04528563)
- Testing
- Ketorolac Tromethamine 10 MG/ML, Morphine Sulfate 10Mg/1mL Injection
- Where
- Canada
- Volunteers
- 105 people
- Sponsor
- Hamilton Health Sciences Corporation
Chronic Non-malignant Pain, Chronic Pain
Embrace TDD: Post-Market Study to Evaluate Intrathecal Morphine as an Alternative to Systemic Opioids for Chronic Pain
This is a prospective, multi-center, post market study to evaluate Intrathecal (IT) preservative-free morphine sulfate (PFMS) using the SynchroMed™ II infusion system as an alternative to systemic opioids for the treatment of…
- Conditions
- Chronic Non-malignant Pain, Chronic Pain, Pain, Back, Pain, Leg
- Trial name
- NCT03761277
- Testing
- Medtronic SynchroMed™ II infusion system, Preservative-free morphine sulfate (PFMS)
- Where
- 16 sites in United States
- Volunteers
- 93 people
- Sponsor
- MedtronicNeuro
Breast Cancer
Metabolomic Profiling of Erector Spinae Plane Block* for Breast Cancer Surgery
Worldwide, breast cancer is the most common cancer among women, and its incidence and mortality rates are expected to increase significantly in the next years. It remains a major health problem.
- Trial name
- ESP (NCT04689945)
- Testing
- Morphine, Erector Spinae Block, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 91 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Morphine, Histamine
Evaluation of Peripheral Itch Mechanisms Following Injection of Morphine
The aim of this study is to the effect of opioid (morphine) intradermal application on histaminergic and non-histaminergic itch.
- Conditions
- Morphine, Histamine, Cowhage, Isotonic Saline
- Trial name
- NCT04672382
- Testing
- Morphine
- Where
- Denmark
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Healthy
Analgesics in the Pre-hospital Setting: Implications on Hemorrhage Tolerance - Morphine
We are examining how morphine (a commonly used pain medication) will alter responses to simulated blood loss in humans. To simulate blood loss in our research laboratory, participants will complete a test with their lower body in…
- Trial name
- NCT04138615
- Testing
- Morphine
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Abdominal Aorta Aneurysm, Abdominal Aorta Atheroma
Impact of Intra- and Postoperative Continuous Infusion of Lidocaine on Analgesia in Vascular Anaesthesia
The aim of the study is to test the effectiveness and safety of the use of lidocaine infusion in multimodal analgesic management.
- Conditions
- Abdominal Aorta Aneurysm, Abdominal Aorta Atheroma, Surgery, Pain, Postoperative
- Trial name
- NCT04691726
- Testing
- lidocaine 10mg/ml, Metamizole, Morphine
- Where
- Poland
- Volunteers
- 87 people
- Sponsor
- Łukasz Krzych
Total Hip Arthroplasty, Postoperative Pain
PENG Block vs Intrathecal Morphine in Total Hip Arthroplasty
To compare the impact of pericapsular nerve group (PENG) block to intrathecal morphine on postoperative analgesia, motor function and side effects in patients undergoing primary total hip arthroplasty under spinal anesthesia.
- Trial name
- NCT05308420
- Testing
- Pericapsular nerve group (PENG) block, Spinal anesthesia, Intrathecal morphine
- Where
- Croatia
- Volunteers
- 60 people
- Sponsor
- Kresimir Oremus, MD
Postoperative Pain
Ropivacaine Through Continuous Infusion Versus Epidural Morphine for Postoperative Analgesia After Emergency Cesarean Section
The cesarean section is one of the most commonly performed surgeries in the world and it represents 20% of the births in France. Postoperative pain is moderate-to-severe during the first 48 hours after this procedure.
- Trial name
- ROMANCE (NCT02410317)
- Testing
- Ropivacaine, Morphine
- Where
- France
- Volunteers
- 101 people
- Sponsor
- University Hospital, Grenoble
Nephrectomy
Analgesic Effect of Ketamine Vs Ketamine Magnesium Infusion and Their Effect on Postoperative Morphine Consumption
Ketamine and magnesium-ketamine are two analgesics that are being studied for use as adjuvants. They were shown to have anaesthetic and analgesic properties, and as a consequence of this finding, it has been postulated that they…
- Trial name
- NCT05596669
- Testing
- Ketamine
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Egymedicalpedia
Acute Respiratory Failure
Low Dose Morphine to Relieve Dyspnea in Acute Respiratory Failure (OPIDYS)
This study evaluates a pharmacological intervention to relieve dyspnea in intensive care unit patients. Indeed, opioids can be particularly beneficial since 1) dyspnea and pain share many similarities, 2) the benefit of opioids…
- Trial name
- OPIDYS (NCT04358133)
- Testing
- Chlorhydrate de morphine, NaCl 0,9%,
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pain, Postoperative
Intraoperative Lidocaine Infusion as a Sole Analgesic Versus Morphine in Laparoscopic Gastric Bypass Surgery
Postoperative opioid-centric pain management strategies in obese patients are accompanied by the possible development of; opioid-induced ventilatory impairment (OIVI) and hypoxemia.
- Trial name
- NCT05150756
- Testing
- Lidocaine Hydrochloride 2% Intravenous Solution [XYLOCAINE], morphine sulphate (10mg/ ml ampoule)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Efficacy of Caudal Block on Intra-operative Anal Sphincter Muscle Tone
Efficacy of Caudal Block on Intra-operative Anal Sphincter Muscle Tone and Post-operative Analgesia During Anal Sphincter Sparing Procedures Under General Anaesthesia
upplementing general anaesthesia with caudal analgesia in sphincter sparing procedures might be useful as it will provide a satisfactory combination of sphincter muscle tone preservation, good intraoperative and postoperative…
- Trial name
- NCT04651595
- Testing
- Caudal block, Morphine
- Where
- Egypt
- Volunteers
- 26 people
- Sponsor
- Kasr El Aini Hospital
Postoperative Pain
Intrathecal Morphine for Thoracoscopic Surgery
Thoracic surgery is one of the surgeries where postoperative pain is intense. In this study, the investigators aimed to compare the efficacy of two different intrathecal morphine doses administered for postoperative analgesia…
- Trial name
- NCT05588336
- Testing
- Morphine
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Chest Trauma With Ribs Fractures
PEF-Block & Ribs Fractures
Rib fractures are frequent injuries found approximately in 10% severe trauma patient. Rib fractures were correlated in many studies with a higher morbidity and mortality.
- Trial name
- PEF (NCT03396692)
- Testing
- Intravenous morphine patient-controlled analgesia (PCA), Block of the posterior exo-thoracic fascia with Ropivacaine, Block of paravertebral space with Ropivacaine
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Montpellier
Gynecological; Surgery (Previous), Affecting Fetus or Newborn, Due to Obstructed Labor, Analgesia
Postoperative Analgesic Effect of Esketamine
The aim of this study was to determine whether the addition of esketamine to morphine would improve postoperative analgesia after caesarean section.
- Trial name
- NCT05582135
- Testing
- 2 mg morphine sulfate, 0.25mg/kg esketamine, 0.25mg/kg of esketamine in combination with 2 mg morphine sulfate
- Where
- China
- Volunteers
- 119 people
- Sponsor
- Xuanhan County People's Hospital
Neonatal Abstinence Syndrome, Neonatal Opioid Withdrawal
Optimal Morphine Dosing Schedule for Neonatal Abstinence Syndrome
Randomized pilot trial comparing scheduled morphine dosing with a weaning protocol to intermittent morphine dosing on an as-needed basis for newborns with neonatal abstinence syndrome.
- Conditions
- Neonatal Abstinence Syndrome, Neonatal Opioid Withdrawal, Neonatal Opioid Withdrawal Syndrome
- Trial name
- NCT04298853
- Testing
- Morphine PRN, Morphine scheduled
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Indiana University