Clinical trials: Moxifloxacin
Chronic Bronchitis
SYMPROVE III: Health Services Research Study for Treatment of the Moderate and Severe Acute Exacerbations of Chronic Bronchitis (AECB)
In this study data of patients with moderate or severe acute exacerbations of chronic bronchitis (AECB) were collected. There were two different cohorts which were compared (Moxifloxacin and other antibiotics) concerning…
- Trial name
- SYMPROVE III (NCT00879008)
- Testing
- Moxifloxacin (Avelox, BAY12-8039)
- Where
- Germany
- Volunteers
- 345 people
- Sponsor
- Bayer
Healthy Volunteer
A Study of the Effect of RO4917838 on the QTcF Interval in Healthy Volunteers
This multiple-center, multiple-dose, randomized, double-blind, double-dummy, placebo-controlled, positive-controlled, parallel group study will investigate the effect of RO4917838 on the QTc interval in healthy volunteers.
- Trial name
- NCT01613040
- Testing
- Moxifloxacin, RO4917838
- Where
- 2 sites in United States, France
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Nicotine Dependence, Contraception
Smoking, Sex Hormones, and Pregnancy
The investigators aim to (1) examine the association between levels of progesterone (Prog), allopregnanolone (Allo), and the estradiol/progesterone (E2/P) ratios with smoking-related symptomatology during ad libitum smoking and…
- Trial name
- NCT01811225
- Testing
- Low-dose Progesterone, High-dose Progesterone
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Healthy
A Thorough QT/QTc Study to Assess the Effects of Androxal in Healthy Male Subjects
This is a Phase I, single-site, randomized, double-blinded, double-dummy, placebo- and positive-controlled, 4-period crossover study to evaluate the effect of two dose levels of Androxal on cardiac repolarization.
- Trial name
- NCT02117830
- Testing
- Androxal 25 mg capsules, Androxal 250 Capsules, Moxifloxacin 400 mg
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Repros Therapeutics Inc.
Healthy Subjects
To Study the Effect of Cenerimod on the Electrical Activity of the Heart, in Men and Women. To Study the Effect of Cenerimod on the Use of Oral Contraceptives in Women. To Study the Effect That Charcoal Has on the Elimination of Cenerimod From the Body, in Women and Men.
This is a single-center, randomized, double-blind for cenerimod, open-label for moxifloxacin, placebo- and moxifloxacin-controlled, parallel-group study to investigate the effect of cenerimod on the duration of the QT interval in…
- Trial name
- NCT04255277
- Testing
- Combined oral contraceptives (COC), Moxifloxacin 400mg, Cenerimod 0.5 mg
- Where
- France
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Viatris Innovation GmbH
Bacterial Infections
A Study To Assess The Effect Of Linezolid On QTc Interval
The FDA has asked Pfizer to assess the risk of linezolid on QT interval (obtained from ECG readings) which could predispose patients to ventricular arrhythmias. This study is conducted to satisfy this requirement.
- Trial name
- NCT00795145
- Testing
- Linezolid 900 mg, Linezolid 1200 mg, Linezolid 600 mg
- Where
- Singapore
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Pfizer
Bacterial Infections, Eye Infections
Study of AzaSite Versus Vigamox in the Tears of Healthy Volunteers
The purpose of this study is to evaluate the drug concentrations of AzaSite compared to Vigamox in tears of healthy volunteers
- Trial name
- NCT00575367
- Testing
- AzaSite (azithromycin ophthalmic solution), Vigamox (moxifloxacin hydrochloride ophthalmic solution)
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Corneal Infiltrates
A Phase II Study of Moxidex Ophthalmic Solution for Treatment of Marginal Corneal Infiltrates
The purpose of the study is to determine whether Moxidex ophthalmic solution is safe and effective in treating marginal corneal infiltrates.
- Trial name
- NCT00579020
- Testing
- Moxifloxacin/dexamethasone phosphate ophthalmic solution, Moxifloxacin ophthalmic solution 0.5%, Dexamethasone phosphate solution, 0.1%
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Alcon Research
Blood Glucose, Low, Hypoglycemia
EFFECTS OF MOXIFLOXACIN AND GEMIFLOXACIN ON BLOOD GLUCOSE AND ECG MORPHOLOGY OF EUGLYCEMICS:A CLINICAL STUDY
EFFECTS OF MOXIFLOXACIN AND GEMIFLOXACIN ON BLOOD GLUCOSE LEVEL OF EUGLYCEMICS:A PRE-CLINICAL AND CLINICAL STUDY. Our aim and objectives are to: 1.
- Trial name
- CT (NCT04692623)
- Testing
- Moxifloxacin 400mg, Gemifloxacin 320 MG
- Where
- Pakistan
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Shaheed Benazir Bhutto University Sheringal Dir Upper
Drug Interactions, Healthy
A Drug Interaction Study of Folic Acid and Oral Contraceptive Tablets Containing Norgestimate (NGM) /Ethinyl Estradiol (EE) in Healthy Women.
The purpose of the study is to assess the effect of folic acid administration on the blood level and the breakdown products of OC study drug (250 mcg norgestimate[NGM]/35 mcg Ethinyl Estradiol [EE]) tablets.
- Conditions
- Drug Interactions, Healthy, Pharmacokinetics
- Trial name
- NCT00709982
- Testing
- Norgestimate; Ethinyl Estradiol; Folic acid
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Healthy Volunteer
An Investigational Study to Evaluate the Cardiac Safety Assessment (TQTc Study) of ESK-001
This a phase 1, partially blinded, randomized, crossover study to determine the pharmacokinetics (PK) and QT/QTc interval of study drug (ESK-001) in healthy volunteer participants,
- Trial name
- NCT07378579
- Testing
- ESK-001, Moxifloxacin (400 mg)
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Alumis Inc
Human Experimentation (Human Volunteers)
Evaluation of Possible Effects on the QT/ QTc Interval of Rupatadine in Healthy Volunteers
This phase I trial will evaluate the effects of rupatadine, at a dose of 10 mg OD (authorised and marketed dose) and the 100mg/day (supratherapeutic dose) on the ECG parameters with a special focus on its effect on cardiac…
- Trial name
- NCT00199225
- Testing
- Rupatadine, moxifloxacin, Continous electrocardiographic register
- Where
- Spain
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- J. Uriach and Company
Corneal Health, Cataract Surgery
2-Site Safety Study of Besivance Versus Vigamox Prophylactically in Routine Cataract Surgery
The purpose of this study is to demonstrate that Besivance is equal to Vigamox in safety and tolerance when used prophylactically in subjects undergoing routine cataract surgery.
- Trial name
- STB-01 (NCT01455233)
- Testing
- besivance, vigamox
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Ophthalmology Consultants, Ltd.
Acute Otitis Media
Phase III Study of an Otic Formulation in Acute Otitis Media With Tympanostomy Tubes
The purpose of this study is to determine if a topical otic formulation is safe and effective in treating middle ear infections in patients with ear tubes.
- Trial name
- NCT00579189
- Testing
- Moxidex otic solution, Moxifloxacin otic solution, Tympanostomy tubes
- Volunteers
- 776 people
- Sponsor
- Alcon Research
Pneumonia
Study to Evaluate the Efficacy and Safety of Intravenous Infusion With Nemonoxacin Malate Sodium Chloride
The purpose of this study is to Evaluate the Efficacy, safety and pharmacokinetics of Intravenous Nemonoxacin Compared with Intravenous Moxifloxacin in Adult Patients with community-acquired pneumonia (CAP).
- Trial name
- NCT01944774
- Testing
- Nemonoxacin 500 mg, Nemonoxacin 650 mg, Moxifloxacin 400 mg
- Where
- 2 sites in China, Taiwan
- Volunteers
- 207 people
- Sponsor
- TaiGen Biotechnology Co., Ltd.
Insulin Sensitivity, Cardiovascular Risk
Oral Contraceptives, Insulin Resistance and Cardiovascular Risk Profile in Pre-Menopausal Women
Birth control pills are the most commonly used method of birth control. The purpose of this research study is to examine whether birth control pills change heart disease risk and how the body handles blood sugar when given to…
- Conditions
- Insulin Sensitivity, Cardiovascular Risk, Perimenopausal Disorder
- Trial name
- NCT01475513
- Testing
- Ortho Cyclen®
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Healthy Volunteers - Male and Female
A Study to Evaluate the Effects of KP-001 on the QT/QTc Intervals in Healthy Adults
This is a Phase 1, single-center, randomized, single-blind (participants are blinded), placebo controlled, four-way cross over TQT study (4×4 Williams square design) to investigate the effect of KP-001 on the QTc interval using…
- Trial name
- NCT06649942
- Testing
- KP-001, Moxifloxacin 400 mg
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kaken Pharmaceutical
Cataract
Study of Efficacy and Safety of Vigadexa in Treating Inflammation and Infection Post-cataract Surgery
To demonstrate that the combination formulation of Moxifloxacin/Dexamethasone Eye Drop is effective and safe for the prevention of postoperative inflammation as a consequence of cataract extraction surgery.
- Trial name
- NCT00870103
- Testing
- Vigadexa (moxifloxacin 0.5% and dexamethasone 0.1%) eye drops
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Alcon Research
Carcinoma, Renal Cell
VEG111485: A QTc Study of Pazopanib
This is a Phase I, randomized, double-blind, placebo-controlled, study to estimate the effects of daily oral dosing of 800 mg pazopanib on electrocardiographic parameters (QTc interval duration) as compared with placebo in…
- Trial name
- NCT00861029
- Testing
- Pazopanib, Moxifloxacin
- Where
- 8 sites in United States
- Volunteers
- 2 people
- Sponsor
- GlaxoSmithKline
Mild Spinal Tuberculosis
Short-Course Anti-tuberculosis Regimens for Mild Spinal Tuberculosis
To evaluate the non-inferiority in efficacy between the rifapentine- and moxifloxacin-containing short-course regimens (with rifampicin replaced by rifapentine and ethambutol replaced by moxifloxacin, while isoniazid and…
- Trial name
- NCT06917495
- Testing
- Rifampin, Isoniazid, Rifapentine (RPT)
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shandong University