Clinical trials: Moxifloxacin
Endophthalmitis, Trauma, Corneal
Use Of Intracameral Moxifloxacin For Prophylaxis Of Open Globe Endophthalmitis
Endophthalmitis is a severe inflammatory eye condition with profound impairment of vision, which can lead to irreversible visual loss and requires immediate treatment.
- Trial name
- NCT05079854
- Testing
- Intraocular Instillation Solution, Moxifloxacin Ophthalmic
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Federal University of São Paulo
Side-effect of Antibiotic
Penetration of Moxifloxacin Into Liver Tissue of Patients Undergoing Liver Resection.
The aim of the study is to provide data on the pharmacokinetics (PK) of moxifloxacin (MXF) in serum and liver tissue of patients undergoing liver resection due to primary or secondary tumor of the liver.
- Trial name
- MOXI (NCT01302951)
- Testing
- Moxifloxacin 400 mg
- Where
- Germany
- Volunteers
- 34 people
- Sponsor
- University Hospital, Saarland
Healthy Individuals, Bioequivalence Study
Bioequivalence Study of Mofest® 400mg (Moxifloxacin) Tablet With Avelox® 400mg (Moxifloxacin) Tablet in Healthy Pakistani Subjects
Single oral dose, of test and reference Tablet will be administered to healthy volunteers, after at least 10 hours fast together with 240 mL of ambient temperature water at their scheduled dosing time-points.
- Trial name
- BE (NCT04873570)
- Testing
- Moxifloxacin 400mg
- Where
- Pakistan
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Karachi
Healthy
Electrophysiological Effects of Tipranavir Co-administered With Ritonavir on the QT Interval in Healthy Female and Male Subjects
To demonstrate that tipranavir (TPV) co-administered with ritonavir (RTV) does not affect the QT interval more than placebo co-administered with ritonavir
- Trial name
- NCT02248883
- Testing
- TPV low, Moxifloxacin, TPV high
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Qt Interval, Variation in
Effect of Imeglimin on QT/QTc Intervals in Healthy Subjects
The purpose of this study is to assess the effect of a single therapeutic dose and a single supra-therapeutic dose of imeglimin on the QT/QTc interval
- Trial name
- NCT02924337
- Testing
- Imeglimin, Moxifloxacin
- Where
- United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Poxel SA
TB
Comparison of the Effect Between Levofloxacin and Moxifloxacin Among MDR-TB Patients
Fluoroquinolone is a one of the most important drugs for treatment of multidrug-resistant TB (MDR-TB). Among them, levofloxacin and moxifloxacin has been used most widely.
- Trial name
- NCT01055145
- Testing
- levofloxacin, moxifloxacin
- Where
- 29 sites in South Korea
- Volunteers
- 182 people
- Sponsor
- Seoul National University Hospital
Healthy Volunteer
TMC207TBC1003 - A Study in Healthy Volunteers Investigating the Effect of Single-dose TMC207 on the QT/QTc Interval Under Fed Conditions
The purpose of this study is to evaluate the effect of an 800-mg single dose of TMC207 on the QT/QTc interval in healthy volunteers.
- Trial name
- NCT01291563
- Testing
- Moxifloxacin, TMC207
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Tibotec BVBA
Patient Preference
A Trial Evaluating Patient Preference of Dropless vs Drops Post Cataract Surgery
To evaluate the safety and ocular efficacy of Dextenza in combination with an intracameral antibiotic and NSAID in controlling post-operative ocular pain and inflammation compared to standard of care topical therapy in patients…
- Trial name
- CIMPLIFY (NCT04205916)
- Testing
- Dexamethasone, Standard of care surgery
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ophthalmic Consultants of Long Island
Hyperuricemia, Gout
Thorough QT (TQT) Study to Evaluate the Effect of LC350189 on Cardiac Repolarization in Healthy Male and Female Subjects
This is a Phase 1, single-center, randomized, partially double-blind, placebo- and positive controlled, 4-way crossover study to evaluate the effect of a therapeutic and a supratherapeutic dose of LC350189 on the QTcF in healthy…
- Conditions
- Hyperuricemia, Gout, Qt Interval, Variation in
- Trial name
- NCT04966325
- Testing
- LC350189 200mg, Moxifloxacin 400mg, LC350189 600mg
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- LG Chem
Nicotine Dependence, Contraception
Smoking, Sex Hormones, and Pregnancy
The investigators aim to (1) examine the association between levels of progesterone (Prog), allopregnanolone (Allo), and the estradiol/progesterone (E2/P) ratios with smoking-related symptomatology during ad libitum smoking and…
- Trial name
- NCT01811225
- Testing
- Low-dose Progesterone, High-dose Progesterone
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Healthy
A Study to Evaluate the Cardiac Safety of a Single Dose of AL-335 Administered on a Background of Simeprevir and Odalasvir and of Repeated Doses of Odalasvir Administered Alone in Healthy Participants
The main purpose of this study is to assess the effect of a single supratherapeutic dose of AL-335 administered on top of multiple doses of odalasvir (ODV) and simeprevir (SMV) versus placebo on QT/QT interval corrected for heart…
- Trial name
- NCT03155893
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Healthy Participants
A Study to Evaluate the Effects of Loperamide (JNJ-289679) on Electrocardiogram Intervals in Healthy Adult Participants
The purpose of this study is to assess the effects of loperamide on QT/ QT interval corrected for heart rate (QTc) intervals and electrocardiogram (ECG) morphology at therapeutic and supratherapeutic exposures in healthy…
- Trial name
- NCT04225078
- Testing
- Loperamide, Moxifloxacin
- Where
- Belgium
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Community-acquired Pneumonia
Community-Acquired Pneumonia - Study on the Initial Treatment With Antibiotics of Lower Respiratory Tract Infections
The purpose of this study is to compare the cost(effectiveness) of three existing antibiotic strategies for patients with community-acquired pneumonia admitted to the hospital, but not the ICU.
- Trial name
- CAP-START (NCT01660204)
- Testing
- Preferred empirical treatment
- Where
- 7 sites in Netherlands
- Volunteers
- 2,283 people
- Sponsor
- UMC Utrecht
Pulmonary Disease, Chronic Obstructive
QTc Study GSK573719+GW642444
This is a randomized, placebo controlled, four period incomplete block,crossover thorough QT study to estimate the effect of repeat dose GSK573719/GW642444M (Vilanterol) combination and GSK573719 monotherapy on the QTc interval…
- Trial name
- NCT01521377
- Testing
- Moxifloxacin, GSK573719/Vilanterol 125/25mcg, GSK573719
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Keratitis Bacterial
Steroids and Cross-linking for Ulcer Treatment
Steroids and Cross-linking for Ulcer Treatment (SCUT II) is an international, randomized, double-masked, clinical trial. The purpose of this study is to determine differences in 6-month visual acuity between medical antimicrobial…
- Trial name
- SCUT II (NCT04097730)
- Testing
- Moxifloxacin Ophthalmic, Difluprednate Ophthalmic, Riboflavin Ophthalmic
- Where
- 3 sites in United States, India
- Volunteers
- 280 people
- Sponsor
- Thomas M. Lietman
Chronic Generalized Periodontitis
Moxifloxacin in Situ Gel to Treat Periodontal Pocket.
In this Randomized clinical trial locally delivered moxifloxacin in situ gel was evaluated as an adjunct to scaling and root planing for efficacy in the treatment of chronic periodontitis and for short-term effects on the…
- Trial name
- NCT02016157
- Testing
- Moxifloxacin
- Where
- India
- Volunteers
- 5 people
- Sponsor
- Sri Hasanamba Dental College and Hospital
Healthy
Study to Define the Electrocardiogram Effects of a Single Dose of LX4211 in Healthy Subjects
This Phase 1 study is to investigate the effects of higher doses of LX4211 (800 mg and 2000 mg) do not differ from placebo in the mean change in QTcI from Baseline in healthy subjects.
- Trial name
- NCT01913002
- Testing
- LX4211 800 mg, LX4211 2000 mg, moxifloxacin 400 mg
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Lexicon Pharmaceuticals
Mycobacterium Tuberculosis
Pharmacokinetic Issues of Moxifloxacin Plus Rifapentine
The purpose of this study is to determine the pharmacokinetics (how a drug is absorbed, distributed, and eliminated by the body) of moxifloxacin alone versus moxifloxacin given with rifapentine.
- Trial name
- NCT00460759
- Testing
- Moxifloxacin, Rifapentine
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Keratoconus, Ectasia
Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas
To evaluate the efficacy of ultraviolet-A (UVA)-induced cross-linking of corneal collagen (CXL) as a method to increase the biomechanical and biochemical stability of the cornea by inducing additional cross-links within or…
- Conditions
- Keratoconus, Ectasia, Degeneration
- Trial name
- NCT01024322
- Testing
- Ciprofloxicine or Vigamox or other., Nonsteroidal (Acular, Voltaren Xibrom, etc), Steroid (FML, Pred Forte, Flarex, etc.)
- Where
- 3 sites in United States
- Volunteers
- 1,189 people
- Sponsor
- Cxlusa
HIV Infections
Atazanavir and Ritonavir (ATV/RTV) and an Oral Contraceptive in Healthy Females
The purpose of this study is to administer a combined oral contraceptive (ethinyl estradiol and norgestimate) with the HIV treatment of atazanavir and ritonavir to healthy females in order to assess if the concentrations of the…
- Trial name
- NCT00357604
- Testing
- Ortho Tri-Cyclen (ethinyl estradiol + norgestimate), Ortho Tri-Cyclen LO (ethinyl estradiol + norgestimate) + Atazanavir/Ritonavir for 14 days then Ortho Tri-Cyclen for 7 days
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb