Clinical trials: Moxifloxacin
Intra-abdominal Infection
A Comparative Study of Ampicillin/Sulbactam Versus Moxifloxacin in the Treatment of Complicated Intra-abdominal Infections
On the basis of monotherapy for intra-abdominal infection, the investigators are conducting this study to identify the difference of drug efficacy between ampicillin/sulbactam and moxifloxacin.
- Trial name
- NCT00952796
- Testing
- moxifloxacin, ampicillin/sulbactam
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Intraocular Pressure
Ocular-hypertensive Response to Topical Steroids in Children After Bilateral Strabismus Surgery
This study aims to compare the effects of topical (Rimexolone versus Dexamethasone) on the IOP in children under 13 years of age who underwent bilateral strabismus surgery, and to compare the effects of topical (Rimexolone versus…
- Trial name
- NCT02816905
- Testing
- 0.1 % Dexamethasone, 0.1% Fluorometholone, 1% Rimexolone
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Multidrug Resistant Tuberculosis
Patient-reported Experiences and Quality of Life Outcomes in the TB-PRACTECAL Clinical Trial
PRACTECAL-PRO is a sub-study of a TB-PRACTECAL clinical trial for multidrug resistant Tuberculosis. It evaluates the effectiveness of TB-PRACTECAL interventions from the patient perspective in terms of their quality of life…
- Trial name
- PRACTECAL-PRO (NCT03942354)
- Testing
- Bedaquiline, Pretomanid, Moxifloxacin
- Where
- 6 sites in Belarus, South Africa and 1 more
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Medecins Sans Frontieres, Netherlands
Healthy
CAEB071 Thorough QTc Study in Healthy Volunteers
This study has been designed in compliance with the ICH-E14 guideline 2005 to evaluate the QT/QTc interval prolongation and proarrhythmic potential for non-antiarrhythmic drugs.
- Trial name
- NCT01594255
- Testing
- sotrastaurin, Avelox
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Tuberculosis, Multidrug-Resistant, Extensively Drug-Resistant Tuberculosis
Pragmatic Clinical Trial for a More Effective Concise and Less Toxic MDR-TB Treatment Regimen(s)
TB PRACTECAL is a multi-centre, open label, multi-arm, randomised, controlled, phase II-III trial; evaluating short treatment regimens containing bedaquiline and pretomanid in combination with existing and re-purposed anti-TB…
- Conditions
- Tuberculosis, Multidrug-Resistant, Extensively Drug-Resistant Tuberculosis, Tuberculosis, Pulmonary
- Trial name
- TB-PRACTECAL (NCT02589782)
- Testing
- Bedaquiline, Pretomanid, Moxifloxacin
- Where
- 7 sites in Belarus, South Africa and 1 more
- Volunteers
- 552 people
- Sponsor
- Medecins Sans Frontieres, Netherlands
Osteomyelitis
Patients Response to Early Switch To Oral:Osteomyelitis Study
Based on the current literature, investigators hypothesize that patients with osteomyelitis who are treated with the standard approach of intravenous antibiotics for the full duration of therapy will have the same clinical…
- Trial name
- PRESTO:Osteo (NCT02099240)
- Testing
- oral antibiotics, intravenous antibiotics
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Julio Ramirez
Cardiac Repolarization in Healthy Subjects
A TQT Study to Evaluate the Electrocardiographic Effects of Carbidopa in Healthy Subjects
The purpose of this trial is to assess the effects of a single supratherapeutic dose of carbidopa on cardiac repolarization relative to placebo in healthy adult subjects.
- Trial name
- NCT06161220
- Testing
- Carbidopa capsule, Moxifloxacin Tablets, USP
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Impax Laboratories, LLC
Skin Diseases, Infectious
Study the Safety and Efficacy of PTK 0796 in Patients With Complicated Skin and Skin Structure Infection (CSSSI)
A Phase III trial to demonstrate the safety and efficacy of PTK 0796 in the treatment of complicated skin and skin structure infections (cSSSI).
- Trial name
- CSSI (NCT00865280)
- Testing
- PTK 0796, linezolid, moxifloxacin
- Where
- 7 sites in United States
- Volunteers
- 143 people
- Sponsor
- Paratek Pharmaceuticals Inc
Healthy Volunteers, Safety After Oral Intake
Effects of Energy Drinks on Cardiovascular Endpoints
This is a clinical trial looking at the impact of energy drinks on heart related parameters. The study will enroll 3 participants who will be exposed to 8 different interventions.
- Trial name
- NCT07212803
- Testing
- Energy Drink B
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of the Pacific
Liver Abscess
Moxifloxacin Versus Ceftriaxone in the Treatment of Primary Pyogenic Liver Abscess
This clinical trial compares the use of moxifloxacin versus ceftriaxone in the treatment of primary pyogenic liver abscess. The trial will include nonpregnant adults presenting with primary liver abscess based on clinical…
- Trial name
- NCT00895089
- Testing
- Moxifloxacin (Avelox), ceftriaxone
- Where
- Taiwan
- Volunteers
- 24 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Healthy
A Study to Evaluate the Effects of Esketamine on Cardiac Repolarization in Healthy Participants
The purpose of the study is to assess the effects of esketamine on QT/QTc intervals and electrocardiogram (ECG) morphology at therapeutic exposures of esketamine and noresketamine (intranasal administration) and supratherapeutic…
- Trial name
- NCT02737605
- Testing
- Intranasal Esketamine, Intravenous Esketamine, Moxifloxacin
- Where
- Germany
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Healthy Volunteers
The Effect of Buprenorphine Delivered by Buprenorphine Transdermal System (BTDS) on QT Intervals in Healthy Volunteers
The purpose of this study is to examine the effect of buprenorphine on QT interval corrected for heart rate (QTc) in healthy subjects.
- Trial name
- NCT01148537
- Testing
- Buprenorphine transdermal patch, Avelox (moxifloxacin hydrochloride) tablet
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Purdue Pharma LP
Embryo Transfer
A Study to Evaluate Pharmacokinetics, Pharmacodynamics and Tissue Concentrations of Epelsiban
This multi-cohort phase I study is designed to assess the pharmacokinetics (PK) and pharmacodynamics (PD) of oxytocin and to evaluate epelsiban (GSK557296) potential to reduce subendometrial contractractility induced by oxytocin…
- Trial name
- NCT02213029
- Testing
- Epelsiban, Oxytocin, Ortho-Cylcen (21)® tablet
- Where
- 2 sites in United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy Volunteer
A Study to Investigate the Effects of Brensocatib on QT Interval in Healthy Participants
The study has 2 Parts: The primary purpose of Part 1 is to determine the supratherapeutic dose of brensocatib to be used in Part 2 of the study.
- Trial name
- NCT05355935
- Testing
- Brensocatib, Moxifloxacin
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Insmed Incorporated
Alzheimer's Disease
QTc Study of Rosi XR in Healthy Volunteers
This study is a randomised double blind, parallel group, and will evaluate the effects of repeat oral doses of RSG- XR for 21 days on the QTc interval compared to placebo in a population of healthy adult males and females.
- Trial name
- Rosi XR (NCT00884533)
- Testing
- Rosi XR, Moxifloxacin
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Bacterial Conjunctivitis
A Study to Evaluate the Safety and Efficacy of Gatifloxacin for the Treatment of Bacterial Conjunctivitis
This is a 7 day study to evaluate the safety and efficacy of topical gatifloxacin ophthalmic solution for the treatment of bacterial conjunctivitis in subjects from birth to 31 days of age
- Trial name
- NCT00464438
- Testing
- gatifloxacin, moxifloxacin 0.5% eye drops
- Where
- 2 sites in United States, Canada
- Volunteers
- 171 people
- Sponsor
- Allergan
Bacterial Pneumonia, Community-Acquired Infections
Omadacycline vs Moxifloxacin for the Treatment of CABP (EudraCT #2013-004071-13)
The purpose of this study is to evaluate the safety and efficacy of omadacycline as compared to moxifloxacin in the treatment of adults with community-acquired bacterial pneumonia.
- Trial name
- NCT02531438
- Testing
- Omadacycline, Moxifloxacin
- Where
- 140 sites in United States, Belgium and 23 more
- Volunteers
- 774 people
- Sponsor
- Paratek Pharmaceuticals Inc
Healthy Participants
A Study to Evaluate the Effects of Loperamide (JNJ-289679) on Electrocardiogram Intervals in Healthy Adult Participants
The purpose of this study is to assess the effects of loperamide on QT/ QT interval corrected for heart rate (QTc) intervals and electrocardiogram (ECG) morphology at therapeutic and supratherapeutic exposures in healthy…
- Trial name
- NCT04225078
- Testing
- Loperamide, Moxifloxacin
- Where
- Belgium
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Healthy
Ocular Availability in Human Tears After Topical Administration of 1.5% Levofloxacin Compared to Active Comparators
The primary objective of this study is to compare the concentration in human tears of levofloxacin and the active comparators at 15 minutes, 2,6, 12, and 24 hours after instillation of a single drop of medication.
- Trial name
- NCT00703313
- Testing
- 1.5% levofloxacin ophthalmic solution, 0.5% moxifloxacin hydrochloride ophthalmic solution, 0.3% gatifloxacin ophthalmic solution
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Santen Inc.
Healthy Subjects
A Study in Healthy Subjects to Investigate Whether Administration of Clazosentan Can Affect Normal Heart Function
The study will investigate whether administration of clazosentan can affect normal heart function in healthy subjects
- Trial name
- NCT03657446
- Testing
- Clazosentan, Moxifloxacin
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Idorsia Pharmaceuticals Ltd.