Clinical trials: Moxifloxacin
Long QT Syndrome
Effect of Grapefruit on QT Interval in Healthy Volunteers and Patients With Congenital Long QT Syndrome
The list of medications that prolong the QT interval and can provoke torsade de pointes keeps expanding. This list includes not only antiarrhythmic drugs, but also medications with no cardiac indications.
- Trial name
- NCT02680080
- Testing
- Moxifloxacin, Grapefruit group
- Where
- Israel
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Cataract
Bioequivalence of Eye Drops and Spray Administration of Vigamox
The study compares the amounts of Vigamox absorbed when administered as eye drops or in a spray form. Both administrations will be prior to patients undergoing elective cataract surgery and the aqueous samples will be analyzed by…
- Trial name
- NCT00666042
- Testing
- Vigamox - administration in spray form, Vigamox eye drops
- Where
- Israel
- Volunteers
- 16 people
- Sponsor
- Advanced Ophthalmic Pharma
Healthy Subjects
To Study the Effect of Aprocitentan on the Electrical Activity of the Heart in Healthy Men and Women
To demonstrate that multiple-dose administration of oral therapeutic and supratherapeutic doses of aprocitentan do not have a clinically relevant effect on the QT interval.
- Trial name
- NCT04281342
- Testing
- Aprocitentan 25 mg, Aprocitentan 100 mg, Moxifloxacin control to establish assay sensitivity
- Where
- Germany
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Idorsia Pharmaceuticals Ltd.
TQT Study
A Phase 1, Single Ascending Dose, Randomized, Double-Blind, Placebo and Positive Controlled Study to Evaluate the Cardiovascular Effect of Tetrodotoxin in Healthy Adult Subjects
To determine if a single subcutaneous (SC) administration of TTX at various dose levels has an effect on the QT/QTc intervals when assessing concentration QT (C-QT) relationship (i.e., QT/QTc intervals prolongation in relation to…
- Trial name
- NCT04083833
- Testing
- Tetrodotoxin
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Wex Pharmaceuticals Inc.
Diabetes, Healthy
A Thorough QTc Evaluation of the Effect of Semaglutide on Cardiac Repolarisation in Healthy Subjects
This trial is conducted in Europe. The aim of the trial is to evaluate the effect of semaglutide on cardiac repolarisation in healthy subjects.
- Trial name
- NCT02064348
- Testing
- semaglutide, moxifloxacin
- Where
- Germany
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Healthy Volunteers
A Pharmacokinetic And QT Study Of CP-751,871 In Healthy Subjects
This study is primarily to evaluate the single dose pharmacokinetics of CP-751,871 and its effect on QT interval prolongation.
- Trial name
- NCT00926263
- Testing
- CP-751,871, CP-751,871, moxifloxacin, saline
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Pfizer
Corneal Abrasions
IN PATIENTS WITH CORNEAL ABRASIONS TREATED WITH COLLAGEN CORNEAL SHIELDS IN THE EMERGENCY DEPARTMENT SETTING
This is a single-center, double-arm, patient masked, randomized controlled trial. Subjects will be enrolled in the Emergency Department at the Penn State Milton S. Hershey Medical Center.
- Trial name
- NCT07225699
- Testing
- Oasis 72-Hour collagen shield
- Volunteers
- 60 people
- Sponsor
- Milton S. Hershey Medical Center
Pneumonia
Pharmacokinetic Evaluation of Moxifloxacin IV to Enteral Switch Therapy in Intensive Care Patients
In the Intensive Care (IC)-unit moxifloxacin treatment is often started with intravenous administrations. As moxifloxacin is known to have a high oral bioavailability in healthy volunteers, patients are switched to oral or…
- Trial name
- NCT00458900
- Testing
- IV and enteral administration of moxifloxacin
- Where
- Belgium
- Volunteers
- 4 people
- Sponsor
- University Hospital, Ghent
Duchenne and Becker Muscular Dystrophy, Polycytemia Vera
Placebo-Corrected Effects of Therapeutic Dose (100 mg) and Supratherapeutic Dose (300 mg) of ITF2357 (Givinostat) and Moxifloxacin on QT/QTC Interval
The study will evaluate the effect of a therapeutic dose and a supratherapeutic dose of ITF2357 on the QT/QTc interval.
- Trial name
- NCT04821063
- Testing
- ITF2357 10 mg/mL, Moxifloxacin Hydrochloride
- Where
- Canada
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Italfarmaco
Healthy
Clinical Trial to Investigate the Effect on Corrected QT Interval Prolongation by Psychotropic Drugs
To evaluate the corrected QT interval change(automatic-reading) after single oral administration of escitalopram, quetiapine and moxifloxacin versus placebo in healthy Korean Adults.
- Trial name
- NCT01871701
- Testing
- Escitalopram, Quetiapine, Moxifloxacin
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Healthy
Study to Define the Electrocardiogram Effects of a Single Dose of LX4211 in Healthy Subjects
This Phase 1 study is to investigate the effects of higher doses of LX4211 (800 mg and 2000 mg) do not differ from placebo in the mean change in QTcI from Baseline in healthy subjects.
- Trial name
- NCT01913002
- Testing
- LX4211 800 mg, LX4211 2000 mg, moxifloxacin 400 mg
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Lexicon Pharmaceuticals
Cardiac Repolarization, Healthy Volunteers
A Study to Evaluate the Effect of Single Oral Dose of Balinatunfib on Cardiac Repolarization in Healthy Adult Participants.
This is a Phase 1, multicenter, randomized, double-blind, double-dummy, single dose, placebo- and positive-controlled, 4-sequence, 4-treatment, 4-period crossover study.
- Trial name
- NCT07272629
- Testing
- Balinatunfib, Moxifloxacin
- Where
- 2 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Sanofi
Pulmonary Tuberculosis
Evaluation of 8 Weeks of Treatment With the Combination of Moxifloxacin, PA-824 and Pyrazinamide in Patients With Drug Sensitive and Multi Drug-Resistant Pulmonary Tuberculosis (TB) (NC-002)
The purpose of this study is to assess the mycobactericidal activity of the moxifloxacin plus PA-824 plus pyrazinamide regimen after 8 weeks of treatment.
- Trial name
- NCT01498419
- Testing
- Moxifloxacin (M), Pretomid (Pa), Pyrazinamide (Z)
- Where
- 8 sites in South Africa, Tanzania
- Volunteers
- 207 people
- Sponsor
- Global Alliance for TB Drug Development
Acanthamoeba Keratitis, Fungal Keratitis
Rose Bengal Electromagnetic Activation With Green Light for Infection Reduction
Rose Bengal Electromagnetic Activation with Green light for Infection Reduction (REAGIR ) is an international, randomized, doubled masked, clinical trial.
- Trial name
- REAGIR (NCT05110001)
- Testing
- Moxifloxacin Ophthalmic, Chlorhexidine Gluconate, Natamycin
- Where
- 2 sites in Brazil, India
- Volunteers
- 330 people
- Sponsor
- University of California, San Francisco
Helicobacter Infection
The Efficacy of the 7 Days Tailored Therapy as 2nd Rescue Therapy for Eradication of H. Pylori Infection
As increasing the antibiotics resistance, the effectiveness of traditional Helicobacter pylori (H. pylori) therapies has been declined coincidentally. In this study, the investigators evaluated the efficacy of H.
- Trial name
- NCT02359331
- Testing
- H. pylori culture and antimicrobial susceptibility testing, 14 days empirical bismuth quadruple therapy (Proton pump inhibitor), Metronidazole
- Where
- South Korea
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Cataract Extraction
Assessment of the Concentrations of Besifloxacin, Moxifloxacin, or Gatifloxacin in the Aqueous Humor of Subjects
This study is being conducted to assess the concentration of besifloxacin, moxifloxacin, or gatifloxacin in aqueous humor samples collected following topical instillation of the associated formulation in subjects undergoing…
- Trial name
- NCT00824070
- Testing
- Besifloxacin hydrochloride, moxifloxacin hydrochloride, gatifloxacin
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Bausch & Lomb Incorporated
Pneumonia
A Study to Assess the Efficacy and Safety of IV/PO Moxifloxacin in Subjects With Community-acquired Pneumonia
The purpose of this study is to assess if a therapy with oral and intravenous moxifloxacin is as effective as a therapy with intravenous ceftriaxone + intravenous azithromycin followed by oral amoxicilline/clavulanate and oral…
- Trial name
- NCT00717561
- Testing
- Avelox (Moxifloxacin, BAY12-8039), Ceftriaxone; Azithromycin; Amoxicilline/clavulanate; Clarithromycin
- Where
- 23 sites in Italy
- Volunteers
- 60 people
- Sponsor
- Bayer
HELICOBACTER PYLORI INFECTIONS
Efficacy and Safety of Second-Line Helicobacter Pylori Eradication
Subjects with persistent H. pylori infection after first-line treatment failure receives either a 14-day PPI-based moxifloxacin triple regimen (esomeprazole, amoxicillin, and moxifloxacin) or a 14-day P-CAB-bismuth-containing…
- Trial name
- NCT07855497
- Testing
- P-CAB-BM quadruple regimen, Moxifloxacin triple regimen
- Where
- South Korea
- Volunteers
- 141 people
- Sponsor
- Seoul National University Bundang Hospital
Breast Cancer, Chronic Myeloproliferative Disorders
Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem Cell Transplant
RATIONALE: A donor stem cell transplant can lower the body's immune system, making it difficult to fight off infection. Giving antibiotics, such as moxifloxacin, may help prevent bacterial infections in patients who have recently…
- Conditions
- Breast Cancer, Chronic Myeloproliferative Disorders, Gestational Trophoblastic Tumor, Infection
- Trial name
- NCT00324324
- Testing
- moxifloxacin hydrochloride
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- OHSU Knight Cancer Institute
Bacterial Conjunctivitis
An Evaluation of the Safety and Efficacy of Moxifloxacin Ophthalmic Solution 0.5% ((VIGAMOX®) Versus Ofloxacin Ophthalmic Solution 0.3% in the Treatment of Bacterial Conjunctivitis in Chinese Patients
The purpose of this study is to evaluate Moxifloxacin 0.5% relative to Ofloxacin 0.3% in the treatment of bacterial conjunctivitis in Chinese patients.
- Trial name
- NCT01573910
- Testing
- Moxifloxacin ophthalmic solution, 0.5%, Ofloxacin ophthalmic solution, 0.3%
- Where
- China
- Volunteers
- 985 people
- Sponsor
- Alcon Research