Clinical trials: Omeprazole
Solid Tumors
Evaluate the Effects of Patupilone on the Pharmacokinetics of Midazolam and Omeprazole in Patients With Advanced Malignancies (Extension)
The purpose of this extension study is to evaluate the potential inhibitory effects of patupilone on metabolism using midazolam and omeprazole as the respective probe drugs.
- Trial name
- NCT00442741
- Testing
- Patupilone, Patupilone + Omeprazole
- Sponsor
- Novartis Pharmaceuticals
Gastroesophageal Reflux Disease
Ilaprazole for the Treatment of Gastroesophageal Reflux Disease (GERD) in Chinese Patients
This study is designed to evaluate the efficacy and tolerability of ilaprazole relative to that of esomeprazole in healing erosive esophagitis and resolving accompanying symptoms of GERD.
- Trial name
- NCT02860624
- Testing
- 10 mg ilaprazole, 40mg esomeprazole
- Volunteers
- 550 people
- Sponsor
- Livzon Pharmaceutical Group Inc.
GERD
A Randomized Trial of Medical and Surgical Treatments for Patients With GERD Symptoms That Are Refractory to Proton Pump Inhibitors
Background: Gastroesophageal reflux disease (GERD), which affects at least 20% of adult Americans, may be especially common and severe in Veteran patients.
- Trial name
- NCT01265550
- Testing
- Nissen fundoplication, baclofen, Desipramine
- Where
- 15 sites in United States
- Volunteers
- 366 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Helicobacter Pylori Infection, Eradication
Furazolidone Quadruple Regimen Eradicate H. Pylori Infection
Research protocol: Experimental group: First line solution (furazolidone regimen): esomeprazole magnesium 20 mg +colloidal bismuth pectin 200mg+ amoxicillin 1000 mg + furazolidone 100 mg, twice daily, for 14 days.
- Trial name
- NCT06823791
- Testing
- Furazolidone, Clarithromycin
- Where
- China
- Volunteers
- 493 people, healthy volunteers welcome
- Sponsor
- Liaocheng People's Hospital
Symptomatic Gastroesophageal Reflux Disease (sGERD)
A Multicenter, Randomized, Double-Blind Parallel-Group, Placebo-Controlled Efficacy Study Comparing 4 Weeks of Treatment With Esomeprazole 20 mg Once Daily to Placebo qd for the Resolution of Upper Abdominal Pain in Patients With Symptomatic Gastroesophageal Reflux Disease (sGERD)
This study compares 4 weeks of treatment with Esomeprazole 20 mg once daily to Placebo in the treatment of Upper Abdominal Pain in patients with Symptomatic Gastroesophageal Reflux Disease (sGERD)
- Trial name
- NCT00626535
- Testing
- Esomeprazole
- Volunteers
- 500 people
- Sponsor
- AstraZeneca
Helicobacter Pylori Infection
5 Day Concomitant Versus 10 Day Sequential Therapy for Eradication of H. Pylori Infection
A five day quadruple concomitant therapy is as effective and safe as a 10 day sequential therapy for eradication of H. pylori infection.
- Trial name
- NCT01544517
- Testing
- Eradication therapy (amoxicillin; esomeprazole; tinidazole; levofloxacin)
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- University of Campania Luigi Vanvitelli
Drug Interactions
Open-Label, Multiple-Dose, Non-Randomized Study to Assess Drug-Drug Interactions of Proellex® in Female Subjects
This study will assess possible drug-drug interactions with specific isoenzymes over a total study duration of 6-8 weeks. Blood samples collected pre and post-dose, and urine samples collected post dose will be analyzed.
- Trial name
- NCT00741468
- Testing
- Proellex, CYP1A2 probe, CYP2C9 probe
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Repros Therapeutics Inc.
Erosive Esophagitis
Study to Evaluate the Safety and Efficacy of CJ-12420 in Patients With Erosive Esophagitis
The purpose of this study is to demonstrate the efficacy of CJ-12420, once daily (QD), compared to esomeprazole in patients with erosive esophagitis classified as Los Angeles (LA) classification grades A to D at Week 8
- Trial name
- NCT02456935
- Testing
- CJ-12420 100 mg QD, Esomeprazole 40 mg QD
- Where
- South Korea
- Volunteers
- 280 people
- Sponsor
- HK inno.N Corporation
Antibiotic Resistant Strain, Microbial Colonization
Fecal Microbiota Transplantation for Eradication of Carbapenem-resistant Enterobacteriaceae Colonization
Antibiotic resistance has emerged world wide and is of major concern. Multidrug resistant (MDR) bacteria is widely spread and is now a major factor in morbidity and mortality in health-care settings.
- Trial name
- NCT03391674
- Testing
- Fecal Microbiota Transplantation
- Where
- Israel
- Sponsor
- Rambam Health Care Campus
Healthy
A Study to Evaluate the Effect of Omeprazole on the Pharmacokinetics of BMS-986205 in Healthy Participants
The purpose of this study is to assess the effect of multiple dose administrations of Omeprazole on the pharmacokinetics of BMS-986205.
- Trial name
- NCT03936374
- Testing
- BMS-986205, omeprazole
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Bariatric Surgery Candidate
Study to Compare the Bioavailability of Omeprazole 20 mg Before and After Undergoing Surgery for Morbid Obesity
The principal aim was to evaluate whether gastric bypass surgery modifies the bioavailability of omeprazole 20 mg at one month and six months after surgery.
- Trial name
- OBS-2011/001 (NCT03378960)
- Testing
- Omeprazole 20mg
- Where
- Spain
- Volunteers
- 43 people
- Sponsor
- Emilio Vargas Castrillón
Hiatal Hernia, Hiatal Hernia With Gastroesophageal Reflux Disease
Complications of Laparoscopic Hiatal Hernia Repair Complicated by Gastroesophageal Reflux Disease Using the ERAS Protocol
Nissen fundoplication with cruroraphy performed according to ERAS protocols in patients with HH complicated by GERD.
- Trial name
- hiatal hernia (NCT07138235)
- Testing
- laparoscopic hiatal hernia repair
- Volunteers
- 106 people
- Sponsor
- Osh State University
Colitis, Ulcerative, Crohn Disease
Phase 4, Vedolizumab-4002 Post-marketing, Disease-Drug-Drug Interaction Study
The purpose of this study is to evaluate in a step-wise approach the disease drug-drug interaction (DDI) potential for vedolizumab to indirectly affect the exposure of cytochrome P-450 (CYP) substrate drugs by modulating…
- Trial name
- NCT02760615
- Testing
- Caffeine, Losartan, Omeprazole
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Takeda
Gastroesophageal Reflux Disease (GERD)
Study to Assess Management Strategies for the Use of Esomeprazole (Nexium) in Helicobacter Pylori Infected Patients
The primary objective of this study is to investigate whether eradication treatment of Helicobacter pylori followed by therapy with esomeprazole for a total of 8 weeks extends the time to relapse in patients with gastroesophageal…
- Trial name
- NCT00574925
- Testing
- Esomeprazole
- Where
- Switzerland
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Zurich
Erosive Esophagitis
Study to Confirm the Safety and Efficacy of CJ-12420 in Patients With Erosive Esophagitis
The purpose of this study is to confirm the efficacy of CJ-12420, Once daily (QD), compared to esomeprazole in patients with erosive esophagitis classified as Los Angeles (LA) classification grades A to D at Week 8.
- Trial name
- NCT03006874
- Testing
- CJ-12420 100mg QD, Esomeprazole 40mg, CJ-12420 50mg QD
- Where
- South Korea
- Volunteers
- 302 people
- Sponsor
- HK inno.N Corporation
Healthy Volunteers
A Study of Interaction of Zasocitinib (TAK-279) With Other Medicines in Healthy Adults
The main aim of this study is to find out how zasocitinib (TAK-279) interacts with other medicines taken by mouth (orally). This will be examined by how the body processes medicines, which is called pharmacokinetics or PK.
- Trial name
- NCT06793943
- Testing
- Zasocitinib, COC, Metformin
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Takeda
Intragastric Acidity
Pharmacodynamic Study Comparing the Effects of Two Different Forms of Omeprazole (P07812) (COMPLETED)
This randomized, crossover study is to evaluate the early effectiveness, defined as effect on intragastric pH during the first 4 hours after dosing, of Zegerid, Prilosec over-the-counter (OTC) Tablets, and placebo on the 4th day…
- Trial name
- NCT01077076
- Testing
- Zegerid, Prilosec OTC™ Tablets
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bayer
Helicobacter Pylori Infection
Metronidazole- Versus Tinidazole-Based Bismuth Quadruple Therapy for Helicobacter Pylori Eradication
This randomized, open-label clinical trial will compare two bismuth-containing quadruple therapies for the first-line treatment of Helicobacter pylori infection. Adults aged 18 years or older with confirmed H.
- Trial name
- NCT07746934
- Testing
- Metronidazole, Tinidazole 500mg, tetracyline
- Where
- Vietnam
- Volunteers
- 600 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Healthy
Clinical Trials on Evaluate the Red Ginseng and Fermented-Red Ginseng Affect to Drug Metabolizing Enzyme and Transporter in Healthy Volunteers
The purpose of this study is to evaluate the possibility of drug interactions before and after taking red ginseng or fermented-red ginseng by estimating metabolic rate of indicator drugs for cytochrome P450 and P-glycoprotein.
- Trial name
- NCT02056743
- Testing
- CYP cocktail, Fexofenadine 30mg, Red ginseng
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chonbuk National University Hospital
Cough
Bronchial Hyper-responsiveness in Reflux Cough
The study aim is to determine the effect of 8 weeks of anti-reflux treatment (full acid suppression) on bronchial hyper-responsiveness and whether there is a symptomatic improvement.
- Trial name
- NCT00668317
- Testing
- Omeprazole, Ranitidine
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust