Clinical trials: Ondansetron
Postoperative Nausea and Vomiting
Aprepitant With Dexamethasone Versus Ondansetron With Dexamethasone for PONV Prophylaxis in Patients Having Craniotomy
We hypothesize that the combination of aprepitant with dexamethasone will provide significantly improved prophylaxis against Postoperative nausea and vomiting compared with the combination of ondansetron and dexamethasone, in…
- Trial name
- NCT00734929
- Testing
- Aprepitant + Dexamethasone, Ondansetron + Dexamethasone
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- Duke University
Ondansetron, Lozenge
Ondansetron Lozenge Versus Intravenous for Prevention of Shivering in Cesarean Section
This study aims to compare the effect of ondansetron lozenge and intravenous for prevention of shivering in cesarean section (CS).
- Conditions
- Ondansetron, Lozenge, Intravenous, Prevention
- Trial name
- NCT07511491
- Testing
- Ondansetron lozenge, Ondansetron intravenous
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
Hypotension After Spinal Anesthesia
Lingual Ondansetron in Reduction of Spinal Hypotension in Cesarean Section
The goal of this clinical trial is to learn if drug ondansetron, used in lingual form, lowers the incidence of spinal anesthesia-induced hypotension in cesarean sections. It will also learn about the safety of drug ondansetron.
- Trial name
- NCT07037654
- Testing
- ondansetron lingual film
- Where
- Egypt
- Volunteers
- 112 people
- Sponsor
- Suez Canal University
Spinal Induced Hypotension
Ephedrine Versus Ondansetron During Cesarean Delivery
More than 30% of the patients receiving spinal anesthesia develop hypotension. Hypotension developed during cesarean section (C/S) under spinal anesthesia may jeopardize uteroplacental circulation leading to fetal compromise and…
- Trial name
- NCT05127876
- Testing
- Ondansetron 4 MG, Ondansetron 8mg, EPHEDrine 10 Mg/mL-NaCl 0.9% Intravenous Solution
- Where
- Egypt
- Volunteers
- 168 people
- Sponsor
- Ain Shams University
Electro-acupuncture, Chemotherapy-induced Nausea and Vomiting
The Comparative Study on the Efficacy and Safety of Single Acupoint and Matching Acupoints
The purpose of this study is to clarify whether the matching acupoints are more effective than a single point by electro-acupuncture in the management of chemotherapy-induced nausea and vomiting.
- Trial name
- NCT03061396
- Testing
- Matching points PC6+CV12, Single points PC6
- Where
- China
- Volunteers
- 208 people
- Sponsor
- Tianjin University of Traditional Chinese Medicine
Ondansetron, Cesarean Section
Effects of Ondansetron on Hemodynamics in Cesarean Section Under Spinal Anesthesia
BACKGROUND: Spinal anesthesia (SA) induced maternal hypotension is the most frequent and troublesome complication in cesarean section (CS), compromising both maternal and neonatal well-being.
- Conditions
- Ondansetron, Cesarean Section, Spinal Anesthesia, Hemodynamics
- Trial name
- EffOnd (NCT03629522)
- Testing
- Ondansetron 8Mg/4mL Injection
- Where
- 2 sites in Tunisia
- Volunteers
- 100 people
- Sponsor
- University Hospital, Mahdia
Breast Cancer
Olanzapine for the Prevention of Chemotherapy-Induced Nausea and Vomiting in Chinese Breast Cancer Patients
The Olanzapine Regimen will be superior to the Standard Regimen, as measured by the proportion of patients with Complete Response in the 120 hours following AC chemotherapy.
- Trial name
- NCT03079219
- Testing
- Experimental drug: Aprepitant, Experimental drug: Ondansetron, Experimental drug: Dexamethasone
- Where
- Hong Kong
- Volunteers
- 120 people
- Sponsor
- CCTU
Prolonged QTc Interval
Granisetron Versus Ondansetron: Comparative Effects on ECG, QTc
Postoperative nausea and vomiting [PONV] are common and distressing symptoms after surgery performed under general anaesthesia. 5HT3 antagonists are routinely used for prevention as well as treatment of PONV.
- Trial name
- NCT01352130
- Testing
- Ondansetron, Granisetron
- Where
- India
- Volunteers
- 70 people
- Sponsor
- Tata Memorial Hospital
Atrial Fibrillation
Ondansetron for the Management of Atrial Fibrillation
"Afib" is a common irregular heartbeat. Afib can cause stroke, blood clots, dementia and death. Medicines used to treat Afib often do not work well and can cause serious side effects.
- Trial name
- NCT05844501
- Testing
- Ondansetron 8mg
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- Indiana University
Cesarean Section
Role of Prophylactic Antiemetics in Women Receiving Intrathecal Morphine and Lipophilic Opioids Added to Bupivacaine for Cesarean Section
Because the majority of Caesarean deliveries are performed under neuraxial anaesthesia, Intrathecal morphine has become the gold standard for post-Caesarean delivery analgesia.
- Trial name
- NCT06704139
- Testing
- Morphine - .25 mg, fentanyl + morphine, Ondansetron + Dexamethasone
- Volunteers
- 100 people
- Sponsor
- Assiut University
Laparoscopic Marsupialization of Renal Cyst
Prophylactic Effects of Ondansetron, Ramosetron, and Palonosetron on Patient-Controlled Analgesia Related Nausea and Vomiting After Urologic Laparoscopic Surgery
The aim of this prospective randomized controlled study was to compare the prophylactic effects of intravenous single dose of ondansetron, ramosetron, and palonosetron on PCA-related nausea and vomiting after urologic…
- Trial name
- NCT01169805
- Testing
- Ondansetron, Ramosetron, Palonosetron
- Where
- South Korea
- Volunteers
- 105 people
- Sponsor
- Yonsei University
Narcotic Use, Pain
Decreasing Narcotics in Advanced Pelvic Surgery
In recent years, there has been an emphasis on the creation of "enhanced-recovery", "fast-track" or "multi-modal" pathways to improve perioperative care (1-4).
- Conditions
- Narcotic Use, Pain, Constipation, Nausea
- Trial name
- Pain (NCT02110719)
- Testing
- Celebrex, Gabapentin, IV acetaminophen
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital
Postoperative Nausea and Vomiting, Nausea and Vomiting, Postoperative
Study Of An NK-1 Anti-Emetic Medication For The Prevention Of Post-Operative Nausea And Vomiting In Female Patients
The purpose of this study is to determine the effectiveness of this medication in preventing nausea and vomiting in female patients at risk for post-operative nausea and vomiting (PONV).
- Trial name
- NCT00600990
- Testing
- GW597599
- Where
- 55 sites in United States, Australia and 10 more
- Volunteers
- 624 people
- Sponsor
- GlaxoSmithKline
Pancreatic Cancer
New Treatment Option for Pancreatic Cancer
In the United States, approximately 30,000 new cases of pancreatic cancer are diagnosed each year and an almost equal number of deaths are related to this cancer.
- Trial name
- NCT01364805
- Testing
- Intravenous Vitamin C, Gemcitabine
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Jeanne Drisko, MD, CNS, FACN
Morbid Obesity
Enhanced Recovery After Laparoscopic Sleeve Gastrectomy - a Randomised Controlled Trial
The investigators wish to standardise and optimise perioperative care for consecutive patients undergoing laparoscopic sleeve gastrectomy for weight loss.
- Trial name
- NCT01303809
- Testing
- Enhanced Recovery After Surgey for Sleeve Gastrectomy
- Where
- New Zealand
- Volunteers
- 106 people
- Sponsor
- University of Auckland, New Zealand
Gastroenteritis, Vomiting
Symptomatic Treatment of Acute Gastroenteritis
Vomiting in children with acute gastroenteritis is a major factor of failure of oral rehydration therapy. Effective symptomatic treatment of vomiting would lead to an important reduction in the use of Intravenous Fluid Therapy.
- Conditions
- Gastroenteritis, Vomiting, Acute Gastroenteritis
- Trial name
- NCT01257672
- Testing
- Ondansetron, Domperidone
- Where
- 15 sites in Italy
- Volunteers
- 356 people
- Sponsor
- IRCCS Burlo Garofolo
Esketamine, Thoracoscopic Surgery
An Exploratory Study of Esketamine in Patients After Thoracoscopic Surgery
Thoracic surgery can produce severe postoperative acute pain, which can easily lead to cough weakness, atelectasis, respiratory restriction, pneumonia, hypoxemia, secretion retention, respiratory failure and other adverse events.
- Trial name
- NCT05458453
- Testing
- Esketamine
- Where
- 2 sites in China
- Volunteers
- 80 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Gastric Cancer
Observational Study of Perioperative Chemotherapy in Gastric Cancer
This study will assess the efficacy and toxicity of perioperative chemotherapy with Epirubicin + Cisplatin + Capecitabine (ECX) in routine clinical practice in a network of public hospitals in Santiago, Chile.
- Trial name
- PRECISO (NCT01633203)
- Testing
- epirubicin + cisplatin + capecitabine polychemotherapy
- Where
- Chile
- Volunteers
- 61 people
- Sponsor
- Grupo Oncologico Cooperativo Chileno de Investigation
Cataract
Conscious Sedation Efficacy of the MKO Melt (Midazolam, Ketamine, Ondansetron)
The investigators hypothesized that the combination of Valium, Tramadol and Zofran is superior to the substantially more expensive MKO melt in patient satisfaction after cataract surgery.
- Trial name
- NCT03653520
- Testing
- Diazepam, Tramadol, Ondansetron
- Where
- United States
- Volunteers
- 651 people, healthy volunteers welcome
- Sponsor
- Avanti Anesthesia
Hypotension
The Effect of Ondansetron on Spinal Anesthesia in Caesarean Section
The purpose of this study is to compare the administration of two different doses of ondansetron to placebo to prevent hypotension and bradycardia following spinal anaesthesia.
- Trial name
- NCT03931863
- Testing
- Ondansetron 4mg, Ondansetron 8mg, 100ml normal saline 0.9 percent
- Where
- Greece
- Volunteers
- 180 people
- Sponsor
- Aretaieion University Hospital