Clinical trials: Oxycodone
Analgesia After ED Discharge for Extremity Injuries
Comparing the Efficacy of Oral Opioids for Outpatient Acute Pain Management After ED Discharge Discharge
There will be 3 randomized, double-blinded clinical trials to help determine which of commonly prescribed oral opioid combination is most effective in managing acute extremity pain after discharge from the adult emergency…
- Trial name
- NCT01402375
- Testing
- Hydrocodone (first trial), Codeine (first trial), Oxycodone (for second trial)
- Where
- United States
- Volunteers
- 720 people
- Sponsor
- Montefiore Medical Center
Healthy
Study to Determine the Effects of Co-Administration of Alcohol on the Absorption of Oxycodone From a Proprietary Controlled-Release Formulation
The study is designed to test whether or not the rate and extent of absorption of oxycodone from a proprietary controlled-release formulation is significantly affected by co-administration of alcohol compared with controlled…
- Trial name
- NCT01677039
- Testing
- Test formulation administered with water, Test formulation administered with 20% ethanol, Test formulation administered with 40% ethanol
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Pfizer
Pain, Post-operative, Third Molar
Controlled Trial to Determine Most Effective Post-Operative Analgesia After Third Molar Extraction
This is a prospective randomized clinical trial that will investigate which post-operative medications in conjunction with a multimodal analgesia approach can most effectively control post-operative pain and reduce opioid…
- Conditions
- Pain, Post-operative, Third Molar, Oral Surgery, Pain, Acute
- Trial name
- NCT06484439
- Testing
- Ketorolac, Oxycodone, Acetaminophen
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Disc Herniation, Lumbosacral Radiculopathy
CT Guided Injection for Low Back Radiculopathy: A Randomized Clinical Trial
Herniated disc sometimes cause back pain radiating down to a leg. This pain can be so severe that it is functionally disabling. The purpose of this randomized clinical trial is to determine if corticosteroid medication, delivered…
- Trial name
- NCT01267825
- Testing
- CT-guided corticosteroid+ bupivicaine, Standard medical care
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Montefiore Medical Center
Pain, Postoperative
Post Operative Pain Management for ACL Reconstruction
Health care providers are seeking methods to limit post-operative pain and opioid prescriptions to reduce the burden of the national opioid use epidemic.
- Trial name
- NCT05316168
- Testing
- Bupivacaine HCl 0.5% Injectable Solution, Dexamethasone, Infiltration between Popliteal Artery and Capsule of the knee (iPACK)
- Where
- United States
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Upper Abdominal Malignancies, Upper Gastrointestinal Cancer
Comparison of CT-Guided Celiac Plexus Neurolysis and Pharmacotherapy
After enrolment, patients were randomly assigned to two groups by means of a lottery procedure, whereby each patient blindly chose one of two labelled slips, resulting in group assignment to receive.
- Trial name
- NCT07761650
- Testing
- CT-guided celiac plexus neurolysis, Standard pharmacotherapy
- Where
- Pakistan
- Volunteers
- 110 people
- Sponsor
- Mayo Hospital Lahore
Analgesia
Medico-economic Evaluation of Sublingual PCA (Zalviso) Versus Oxycodone-PCA in the Management of Postoperative Pain.
More than 230 million surgical operations are been realized all over the world every year. A surgical intervention can cause postoperative acute pain.
- Trial name
- MEZO (NCT03882320)
- Testing
- Patient Controlled Analgesia (PCA)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Flank Pain, Urinary Bladder, Overactive
Therapeutic Merit of Solifenacin in the Mitigation of Ureteral Stent-induced Pain and Lower Urinary Tract Symptoms
Most ureteral stent insertions follow ureteroscopy procedures for stone management. Stents are essentially designed to prevent the blockage of the ureter.
- Trial name
- NCT01381120
- Testing
- Solifenacin succinate treatment, Oxycodone and acetaminophen combination treatment
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- Barrie Urology Associates
Postoperative Nausea and Vomiting, Colorectal Neoplasms
Acupuncture for Postoperative Nausea and Vomiting in Patients Undergoing Colorectal Surgery
Background: PONV is one of the prevalent discomforts in the early phase of recovery after surgery. Evidence suggests that the stimulation of the P6 acupuncture point can reduce the occurrence of PONV.
- Trial name
- AcuPONV (NCT02509143)
- Testing
- High-dose acupuncture with intravenous infusion of ramosetron, P6 stimulation with intravenous infusion of ramosetron, Intravenous infusion of ramosetron
- Where
- 2 sites in South Korea
- Volunteers
- 60 people
- Sponsor
- Pusan National University Yangsan Hospital
Pain, Pain, Postoperative
Opioid-Free Orthopaedics
The goal of this investigation is to compare effectiveness of this multimodal regimen at controlling postoperative pain with and without the use of opioid medications.
- Trial name
- NCT04659317
- Testing
- Oxycodone 5 mg Oral Tablet
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- Emory University
Anterior Cruciate Ligament Rupture
Are Opioids Needed After ACL Reconstruction
As the public health sector continues to confront the opioid epidemic, orthopaedic surgeons must revisit pain management protocols to reduce unnecessary opioid prescriptions.
- Trial name
- NCT04285853
- Testing
- Oxycodone
- Where
- 3 sites in United States
- Volunteers
- 98 people
- Sponsor
- Emory University
Opioid Prescribing
Postoperative Nudges to Reduce Opioid Prescribing
This study tests the effectiveness of two email-based behavioral nudges, one based on peer behavior and one based on best practice guidelines, in reducing excessive opioid prescriptions after surgery.
- Trial name
- POST-OP (NCT05070338)
- Testing
- Guideline-Based (Injunctive Norm) Nudges, Peer-Based (Social Norm) Nudges
- Where
- United States
- Volunteers
- 640 people
- Sponsor
- RAND
Healthy Volunteers
Single-Dose PK Study of an Oxycodone/Acetaminophen Solution in Healthy Subjects
A single-dose study evaluating the oral PK of an oxycodone/apap solution in healthy subjects under fasted conditions
- Trial name
- NCT02966860
- Testing
- Oral solution OC/APAP
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Mallinckrodt
Postoperative Pain, Opioid Dependence
PG and PK of Oxycodone to Personalize Post-op Pain Management Following Surgery in Children
Each year, in the U.S. alone, >6 million children undergo painful surgery; up to 50% of them experience significant and serious side effects with opioids and inadequate pain relief.
- Trial name
- NCT03495388
- Testing
- Oxycodone
- Where
- 2 sites in United States
- Volunteers
- 129 people
- Sponsor
- Senthil Sadhasivam
Shoulder Pain, Hiatal Hernia
Pain Relief After Hiatal Hernia Repair Surgery
Referred shoulder pain (pain felt when the problem is actually in a different location) is very common after laparoscopic (small, narrow cut) hernia surgery.
- Trial name
- NCT04936711
- Testing
- Resteck Shiatsu Neck and Back Massager, Marcaine
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Norton Thoracic Institute
Pain Management
Pain Management in Head and Neck Surgery Patients
Our study aims to see if the addition of a scheduled non-opioid pain regimen will decrease the use and risk of opioid pain medications as well as improve pain control in head and neck surgery patients.
- Trial name
- NCT03121963
- Testing
- Oxycodone, Acetaminophen, Gabapentin
- Sponsor
- University of Alabama at Birmingham
Pain, Postoperative
Comparison of Adverse Drug Reactions Associated for Oxycodone and Morphine in Postoperative Pain After Abdominal Hysterectomy
The objective of this study is compare adverse reactions associated with oxycodone and morphine for the treatment of postoperative pain after abdominal hysterectomy
- Trial name
- NCT02936934
- Testing
- Morphine, Oxycodone
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Hospital Civil de Guadalajara
Head and Neck Cancer, Pain, Postoperative
Pre-Operative Pregabalin for Post-Operative Pain in Head and Neck Cancer Surgery
The purpose of this study is to evaluate and reduce pain and improve quality of life in patients being treated for head and neck cancer with primary tumor resection and bilateral neck dissections.
- Trial name
- NCT03714867
- Testing
- Pregabalin 150mg
- Where
- United States
- Sponsor
- Augusta University
Pain
A Trial Assessing the Outcome of Celecoxib Administration Versus Placebo Following Anterior Cruciate Ligament (ACL) Reconstruction
The aim of this study is to directly compare the clinical outcomes of both the celecoxib and placebo groups following anterior cruciate ligament (ACL) reconstruction. The study will have short and long term goals.
- Trial name
- NCT01186887
- Testing
- Celecoxib
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Ottawa Hospital Research Institute
Nasopharyngeal Carcinoma
Comparison of Oxycodone to Control Moderate or Severe Oral Mucositis Pain Induced by Chemoradiotherapy
Background:Although concurrent chemoradiotherapy is effective for improving disease-free survival and overall survival in patients with locally advanced nasopharyngeal carcinoma.
- Trial name
- NCT03045484
- Testing
- Controlled-release oxycodone, Chemoradiotherapy
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Sun Yat-sen University