Clinical trials: Oxycodone, completed
Cancer
Immediate-Release Oxycodone Capsules Study in Cancer Pain
The efficacy of dose titration of OxyNorm™(Oxycodone) immediate-release capsules versus morphine immediate-release tablets in the treatment of cancer pain.
- Trial name
- NCT01675622
- Testing
- Oxycodone, Morphine
- Volunteers
- 242 people
- Sponsor
- Mundipharma (China) Pharmaceutical Co. Ltd
Postoperative Pain
Comparison of the Efficacy and Safety of Q8003 Versus Its Individual Components in Bunionectomy Patients
This is a randomized, double-blind, multicenter, fixed dose factorial study of Q8003 12 mg/8 mg and Q8003 6 mg/4 mg versus its individual morphine sulfate and oxycodone hydrochloride components for the management of acute…
- Trial name
- NCT00831051
- Testing
- Q8003, Morphine sulfate, Oxycodone HCl
- Where
- 6 sites in United States
- Volunteers
- 197 people
- Sponsor
- QRxPharma Inc.
Opioid Use, Side Effect of Drug
Pharmacokinetics of Morphine and Oxycodone in Frail Elderly Undergoing Cardiac Surgery
Single centre observational cohort study. 20 older patients undergoing cardiac surgery who receive standard of care pain treatment.
- Conditions
- Opioid Use, Side Effect of Drug, Postoperative Pain
- Trial name
- NCT04696445
- Testing
- Morphine & Oxycodone
- Where
- Netherlands
- Volunteers
- 34 people
- Sponsor
- St. Antonius Hospital
Pain, Nausea
Phase III Study of the Safety and Efficacy of Cl-108 in the Treatment of Moderate to Severe Pain
This is a double-blind, randomized, multiple-dose, placebo- and positive-controlled study of CL-108 (hydrocodone 7.5 mg/APAP 325 mg, promethazine 12.5 mg) in patients with moderate to severe pain following surgical removal of…
- Conditions
- Pain, Nausea, Vomiting
- Trial name
- NCT01780428
- Testing
- CL-108 (hydrodocone 7.5 mg, acetaminophen 325 mg, promethazine 12.5 mg)
- Where
- United States
- Volunteers
- 460 people
- Sponsor
- Charleston Laboratories, Inc
Back Pain
The Safety and Efficacy of the Buprenorphine Transdermal System (BTDS) in Subjects With Chronic Back Pain.
The objective of this study is to assess the safety of the buprenorphine transdermal system (5, 10, and 20) in comparison to placebo transdermal system and immediate release oxycodone/ acetaminophen in subjects with chronic back…
- Trial name
- BP96-0604 (NCT00315445)
- Testing
- Buprenorphine transdermal patch, OXY/APAP
- Where
- 12 sites in United States
- Volunteers
- 134 people
- Sponsor
- Purdue Pharma LP
Ankle Fracture (Bimalleolar Equivalent, Bimalleolar, or Trimalleolar), Ankle Fracture - Lateral Malleolus
Rebound Pain Following Regional Anaesthesia for Ankle Fracture Surgery
Regional anaesthesia is a commonly used and effective analgesic modality in orthopaedic surgery. The benefits of peripheral nerve blocks (PNB) include better pain relief, limited opioid consumption and high patient…
- Conditions
- Ankle Fracture (Bimalleolar Equivalent, Bimalleolar, or Trimalleolar), Ankle Fracture - Lateral Malleolus, Ankle Fracture - Medial Malleolus, Rebound Pain
- Trial name
- NCT06864312
- Testing
- continuous infusion of levobupivacaine, oxycodone
- Where
- Ireland
- Volunteers
- 120 people
- Sponsor
- University College Cork
Sleep Apnea
Impact of Tramadol and Oxycodone on Sleep Apnea
Postoperative pain is usually treated with opioids. Among them, oxycodone is popular in the daily practice as it is administered orally and is easily titrated.
- Trial name
- TROXAT (NCT03454217)
- Testing
- Oxycodone, Tramadol
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Kidney Stones
Visceral Pain From the Upper Urinary Tract - a Trial on the Effect of Morphine and Oxycodone in Patients Undergoing PCNL
The purpose of this study is to investigate the effect of oxynorm versus morphine after operation for kidney stone (PCNL). In addition the relationship between pain symptoms and referred sensory and trophic changes will be…
- Trial name
- NCT00784472
- Testing
- oxycodone, morphine
- Where
- Denmark
- Volunteers
- 55 people
- Sponsor
- Katja venborg Pedersen
Parkinson's Disease With Severe Pain
A Randomised Placebo Controlled Study of OXN PR for Severe Parkinson's Disease Associated Pain
To demonstrate superiority of OXN PR compared to placebo with respect to analgesic efficacy in subjects with chronic severe pain associated with Parkinson's disease (PD), as assessed by averaged 24 hour pain scores collected for…
- Trial name
- NCT01439100
- Testing
- Oxycodone/Naloxone Prolonged Release tablets
- Where
- 31 sites in Czechia, Germany and 5 more
- Volunteers
- 172 people
- Sponsor
- Mundipharma Research GmbH & Co KG
Pain, Postoperative
Study of MK-0663/Etoricoxib in Postorthopedic Knee Replacement Surgery Pain (MK-0663-098)
The purpose of this study was to evaluate the efficacy and safety of Etoricoxib compared to placebo and ibuprofen in the treatment of postoperative pain associated with unilateral total knee replacement surgery.
- Trial name
- NCT00820027
- Testing
- Etoricoxib 90 mg, Etoricoxib 120 mg, Ibuprofen 600 mg
- Volunteers
- 776 people
- Sponsor
- Organon and Co
Pain, Postoperative
Dose-response of Ketamine in Patient Controlled Analgesia in Orthopaedic Surgery Patients
To study the multimodal protocol combining adjunct ketamine with oxycodone in intravenous patient-controlled analgesia bolus dosing and effects in patients scheduled for posterolateral lumbar spine fusion with bilateral…
- Trial name
- DoseRespKeta (NCT02994173)
- Testing
- Oxycodone, S-Ketamine 0.25, S-Ketamine 0.5
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Turku University Hospital
Prostate Cancer
Does Postoperative Gabapentin Reduce Pain, Opioid Consumption and Anxiety and Have a Positive Effect on Health Related Quality of Life After Radical Prostatectomy?
The Acute Pain Service (APS) at Sunnybrook has been using Gabapentin 200 mg three times a day (TID) resulting in anecdotal benefits in terms of analgesia and opioid sparing effects.
- Trial name
- NCT00982800
- Testing
- Gabapentin
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Sunnybrook Health Sciences Centre
Unilateral Knee Arthroplasty
Intra-Venous Acetaminophen and Muscle Relaxants After Total Knee
This is a prospective, three-arm, randomized, open-label trial to determine if a new pain control protocol which includes regular dosing of intravenous acetaminophen and orphenadrine for 48 hours after total knee surgery reduces…
- Trial name
- IVAM (NCT02449369)
- Testing
- Preop acetaminophen IV, Preop orphenadrine IV, Postop oral oxycodone & acetaminophen
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- AdventHealth
Ambulatory Surgery, Laparoscopy
Implementation of 23 Hour Surgery Model in a Tertiary Hospital
Extended day surgery or 23 h surgery (23-hour surgery) is a surgical model where patients arrive to the hospital from home at the day of surgery, are operated and recover in a 23 h surgery unit.
- Conditions
- Ambulatory Surgery, Laparoscopy, Shoulder Impingement Syndrome, Ovarian Cysts
- Trial name
- Herko (NCT04142203)
- Testing
- 23 h surgery
- Where
- Finland
- Volunteers
- 993 people
- Sponsor
- Kuopio University Hospital
Pain
Safety of Twice Daily Oxycodone Hydrochloride Controlled-release Tablets in Children With Moderate to Severe Malignant and/ or Nonmalignant Pain Requiring Opioids
The purpose of this study is to characterize the safety of oxycodone hydrochloride (HCl) controlled-release (CR) tablets in opioid tolerant pediatric patients aged 6 to 16 years, inclusive, with moderate to severe malignant…
- Trial name
- NCT01192295
- Testing
- Oxycodone HCl controlled-release tablets
- Where
- 47 sites in United States, Greece and 6 more
- Volunteers
- 155 people
- Sponsor
- Purdue Pharma LP
Hip Pain Chronic
Efficacy of Multimodal Analgesia Following Hip Arthroscopy
The purpose of the full study is to determine whether multimodal analgesia for hip arthroscopy will reduce post-operative pain scores, narcotic consumption and hospital length-of-stay.
- Trial name
- NCT03351439
- Testing
- Zopiclone, Gabapentin, Celebrex
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Western University, Canada
Knee Osteoarthritis, Arthroplasty Complications
Pre vs Post Block in Total Knee Arthroplasty (TKA)
The purpose of this project is to determine if a change in patient reported pain, nausea and vomiting after total knee arthroplasty can be observed with the substitution of a post operative adductor canal block for a preoperative…
- Conditions
- Knee Osteoarthritis, Arthroplasty Complications, Postoperative Pain
- Trial name
- NCT05974501
- Testing
- Dexamethasone, Acetaminophen, Lyrica
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- University of Miami
Subjects With Moderate to Severe, Chronic Nonmalignant Pain
A Randomised, Double Blind, Placebo and Active Controlled, Double Dummy,Parallel Group Study to Determine the Safety and Efficacy of Oxycodone/Naloxone Prolonged Release Tablets in Subjects With Moderate to Severe, Chronic Nonmalignant Pain
The primary objective was to demonstrate the superiority of OXN over placebo over time from the initial dose of study medication to multiple pain events (inadequate analgesia) during the double blind phase.
- Trial name
- NCT01971632
- Testing
- Oxycodone & naloxone combination, prolonged release
- Volunteers
- 463 people
- Sponsor
- Mundipharma Research GmbH & Co KG
Pain Management, Cesarean Section
To Compare the Efficacy and Patient's Satisfaction From Pain Management of Women After Cesarean Section by Pain Relievers' Administration in Fix Protocol Compared to Protocol Following Demand
Cesarean deliveries are prevalent. Unlike other operations, quick recovery is required for the mother to nurture the newborn child and establishing an appropriate mother-child bonding.
- Trial name
- NCT01764048
- Testing
- Fix protocol, medications following demand protocol
- Where
- Israel
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Low Back Pain
Sensory Effects of Oral Opioid Treatment in Patients With Chronic Low Back Pain
Chronic low back pain (CLBP) afflicts up to 50 million U.S. adults and is a primary cause of disability and reduced quality of life.
- Trial name
- NCT02824276
- Testing
- Oxycodone or morphine sulfate immediate release (MSIR)
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Brigham and Women's Hospital