Clinical trials: Oxycodone
Pain, Postoperative
Multimodal Pain Management After Robotic-Assisted Total Laparoscopic Hysterectomy
Hysterectomy is the most common major gynecologic surgery performed in the US and is performed for a variety of indications including malignancy, pelvic mass, endometriosis, leiomyoma, and pelvic organ prolapse.
- Trial name
- RA-TLH (NCT04429022)
- Testing
- Gabapentin, Acetaminophen, Celecoxib
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Metastatic Cancer
S1916 Digital Medicine Program for Pain Control in Cancer Patients
This is a feasibility study to assess the use of a Digital Medicine Program (consisting of an FDA-approved ingestible sensor co-encapsulated with oxycodone/acetaminophen (5 mg/325 mg), a small wearable patch, and a mobile…
- Trial name
- NCT04194528
- Testing
- Oxycodone/acetaminophen 5/325 mg, Proteus digital medicine program
- Where
- 5 sites in United States
- Volunteers
- 2 people
- Sponsor
- SWOG Cancer Research Network
Opioid Misuse and Addiction, Pain
Toward Zero Prescribed Opioids for Outpatient General Surgery
Investigators have created an opioid reduction "package" which includes patient education, non-narcotic pain control instructions, and limited (or no) opioid pain prescriptions provided at discharge in an attempt to reduce the…
- Trial name
- NCT05327777
- Testing
- Oxycodone, Zero Opioid Protocol
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Healthy
Non-intrusive Detection of Temporary Neurologic Impairment By Opioids
Research is being conducted to better understand the physiologic effects (relating to the action of a drug when taken by a healthy person) of opioid use on oculomotor (relating to the motion of the eye) dynamics and to identify…
- Trial name
- NCT04223609
- Testing
- Oxycodone, EyeLink 1000 Plus, Oculo-Cognitive Addition test (OCAT)
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Chronic Rhinosinusitis (Diagnosis)
Effect of Post-operative Ibuprofen After Surgery for Chronic Rhinosinusitis
Endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS) is a common procedure in the US, with about 250,000 cases performed annually.
- Trial name
- NCT03055507
- Testing
- Ibuprofen 400 mg, Acetaminophen 650 mg, OxyCODONE 5 Mg Oral Tablet
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Washington
Pain, Nausea
A Controlled Study to Determine the Efficacy and Safety of CL-108 5 mg for Acute Pain and the Prevention of OINV
To determine the analgesic efficacy of CL-108 5 mg by comparison with placebo and the anti-emetic efficacy of CL-108 5 mg by comparison with hydrocodone 5 mg/acetaminophen 325 mg.
- Conditions
- Pain, Nausea, Vomiting
- Trial name
- NCT03657810
- Testing
- CL-108 5 mg, Norco
- Where
- 5 sites in United States
- Volunteers
- 349 people
- Sponsor
- Charleston Laboratories, Inc
Pain
Evaluate The Pharmacokinetics and Safety Of Oxycodone Oral Solution In Pediatric and Adolescent Subjects
The objective of this study is to characterize the pharmacokinetics and to evaluate the safety of single and multiple doses of Oxycodone Oral Solution in pediatric and adolescent subjects for postoperative pain.
- Trial name
- NCT01959204
- Testing
- Oxycodone
- Where
- 9 sites in United States
- Volunteers
- 97 people
- Sponsor
- VistaPharm, Inc.
Pain
Study to Collect Information on How Well the Study Drug Naproxen Sodium Tablets Works Compared to Hydrocodone/Acetaminophen Tablets in Order to Relieve Pain in Participants Experiencing Moderate to Severe Pain After Having Their Wisdom Teeth Removed
With this study researchers want to collect information on how long the pain relief lasts after a fixed dose of naproxen sodium or hydrocodone/acetaminophen or placebo (contains no medication) over 12 hours in subjects…
- Trial name
- NCT04307940
- Testing
- Naproxen Sodium (Aleve, BAY117031), Hydrocodone/Acetaminophen
- Where
- United States
- Volunteers
- 221 people
- Sponsor
- Bayer
Pain, Postoperative, Spine Injuries and Disorders
An Analysis of the Efficacy of a Pre-Emptive Multimodal Pain Regimen in Reducing Acute Post-Operative Pain and Narcotic Pain Medication Requirements in Spine Surgery
The aim of this study is to investigate the hypothesis that multimodal pain regimen (consisting of acetaminophen, celecoxib, gabapentin, and oxycodone) administered pre-operatively before elective spine surgery significantly…
- Conditions
- Pain, Postoperative, Spine Injuries and Disorders, Narcotic Use
- Trial name
- NCT04522206
- Testing
- Pre-op Multimodal analgesia (MMA) regimen + standard post-op oxycodone
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- NYU Langone Health
Pain
Utility of Pharmacogenomic Testing and Postoperative Dental Pain Outcomes
Opioid analgesics are the most common postoperative pain medications used among dentists in the United States.Although these medications are highly effective in the postoperative dental pain management, not all patients optimally…
- Trial name
- NCT02932579
- Testing
- Pharmacogenomic Testing, Ibuprofen, hydroxycontin/acetominophen
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Outpatient Surgery, Pain, Postoperative
Patient Narcotic Requirements After Outpatient Otolaryngology Procedures
Patient's pain level and narcotic requirements will be evaluated after routine outpatient Otolaryngology procedures. This will be done by having study participants record their pain level and medication usage from home.
- Trial name
- NCT03404518
- Testing
- Norco, Ibuprofen
- Where
- 2 sites in United States
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Pain Management
Analgesic Efficacy of (MSIR)/Acetaminophen vs. Oxycodone/Acetaminophen (Percocet)
Oxycodone and Hydrocodone are the most commonly used oral opioid analgesics in the emergency department and in outpatient settings.
- Trial name
- NCT03088826
- Testing
- Morphine Sulfate, Oxycodone, Acetaminophen
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Antonios Likourezos
Meniscus Tear, Tibial, Pain, Postoperative
Ketorolac as an Adjuvant Agent for Postoperative Pain Control Following Arthroscopic Meniscus Surgery
The utilization of arthroscopic surgery to treat meniscus injuries has continued to increase in recent years, partly due to a younger, more active population, and improved technology and technique.
- Conditions
- Meniscus Tear, Tibial, Pain, Postoperative, Postoperative Complications, Ketorolac Adverse Reaction
- Trial name
- NCT04246541
- Testing
- Ketorolac, Oxycodone-Acetaminophen
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Pain, Postoperative
Study of MK-0663/Etoricoxib in Postorthopedic Knee Replacement Surgery Pain (MK-0663-098)
The purpose of this study was to evaluate the efficacy and safety of Etoricoxib compared to placebo and ibuprofen in the treatment of postoperative pain associated with unilateral total knee replacement surgery.
- Trial name
- NCT00820027
- Testing
- Etoricoxib 90 mg, Etoricoxib 120 mg, Ibuprofen 600 mg
- Volunteers
- 776 people
- Sponsor
- Organon and Co
Musculoskeletal Pain
Comparing Five Oral Analgesics for Treatment of Acute Pain in the Emergency Department (ED)
This study compares the efficacy of five oral analgesics: 5 mg oxycodone + 325 mg acetaminophen, 5 mg hydrocodone + 300 mg acetaminophen, 30 mg codeine + 300 mg acetaminophen, 400 mg ibuprofen + 1000 mg acetaminophen, and 800 mg…
- Trial name
- NCT03173456
- Testing
- oxycodone/APAP, hydrocodone/APAP, codeine/APAP
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Albert Einstein College of Medicine
ACL Injury, Postoperative Pain
Ketorolac as an Adjuvant Agent for Postoperative Pain Control Following Arthroscopic ACL Surgery
1. The investigators aim to examine the use of IV and oral ketorolac as an adjunctive agent to the standard of care pain protocol for postoperative pain control following ACL reconstruction surgery. 2.
- Trial name
- NCT04246554
- Testing
- Ketorolac, Oxycodone-Acetaminophen
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Rhinoplasty, Non-steroidal Ant Inflammatory Drugs
Narcotics vs NSAIDs for Post-operative Analgesia in Outpatient Rhinoplasty
The purpose of this study is to compare the efficacy and safety of oral opiate pain medication vs non-steroidal ant inflammatory drugs (NSAIDs) in the treatment of postoperative rhinoplasty pain.
- Conditions
- Rhinoplasty, Non-steroidal Ant Inflammatory Drugs, Opioid Use
- Trial name
- NCT03457116
- Testing
- Norco, NSAID
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- NYU Langone Health
Adenotonsillectomy, Post-operative Analgesia
Non-opioids for Analgesia After Adenotonsillectomy in Children
The goal of this study is to determine if non-opioid pain control is a safe way to manage pain after adenotonsillectomy surgery in children.
- Conditions
- Adenotonsillectomy, Post-operative Analgesia, Opioid Use
- Trial name
- NCT03618823
- Testing
- Oxycodone, Ibuprofen, Acetaminophen
- Where
- United States
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- David Chi, MD
Hip Surgery, Post Operative Pain Control
Post Operative Pain Control After Pediatric Hip Surgery
Hip surgery in children is painful and the optimal modality for managing post-operative pain has not been established. This prospective randomized controlled trail compares lumbar plexus catheter (LPC), lumbar epidural catheter…
- Trial name
- NCT03435692
- Testing
- Lumbar Plexus Catheter, Lumbar Epidural Catheter, Patient Controlled Analgesia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Malignant Neoplasms of Female Genital Organs, Gynecologic Cancer
Wound Infiltration With Liposomal Bupivacaine vs. Standard Wound Infiltration With Bupivacaine in Patient's Undergoing Open Gynecologic Surgery on an Enhanced Recovery Pathway
Bupivacaine is a drug that is traditionally given as an injection to numb surgical sites. Liposomes are molecules that are similar to fats.
- Trial name
- NCT02740114
- Testing
- Bupivacaine, Liposomal Bupivacaine, Oxycodone
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- M.D. Anderson Cancer Center