Clinical trials: Oxycodone, open to volunteers
Pelvic Organ Prolapse (POP), Stress Urinary Incontinence (SUI)
Suzetrigine for Opioid-Sparing Postoperative Analgesia Following Transvaginal Pelvic Reconstructive Surgery
Suzetrigine is a selective NaV1.8 inhibitor that provides peripheral analgesia without opioid-related CNS effects. This single-center stepped-wedge randomized clinical trial evaluates whether a suzetrigine-based postoperative…
- Conditions
- Pelvic Organ Prolapse (POP), Stress Urinary Incontinence (SUI), Postoperative Pain
- Trial name
- NCT07600697
- Testing
- Suzetrigine, Opioid Analgesics (Tramadol or Oxycodone), Scheduled Acetaminophen and Ibuprofen
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, Los Angeles
Pain, Pain, Postoperative
Opioid-Free Orthopaedics
The goal of this investigation is to compare effectiveness of this multimodal regimen at controlling postoperative pain with and without the use of opioid medications.
- Trial name
- NCT04659317
- Testing
- Oxycodone 5 mg Oral Tablet
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- Emory University
Pain, BPH With Urinary Obstruction
Optimizing Pain Control in Transurethral Resection of the Prostate
The purpose of this study is to develop a multi-modal protocol for pain management after TURP that minimizes opioid use. The investigators hypothesize this approach will provide non-inferior pain control to the current standard…
- Conditions
- Pain, BPH With Urinary Obstruction, BPH With Urinary Obstruction With Other Lower Urinary Tract Symptoms
- Trial name
- NCT04102566
- Testing
- Ibuprofen 600 mg, Education
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Benaroya Research Institute
Postoperative Pain, Acute Pain
Suzetrigine Versus Standard Analgesia After Skin Cancer Surgery
This randomized clinical trial will compare suzetrigine with standard analgesia for postoperative pain management after skin cancer surgery.
- Conditions
- Postoperative Pain, Acute Pain, Skin Cancer, Cutaneous Malignancy
- Trial name
- NCT07843134
- Testing
- Suzetrigine, Acetaminophen Plus Ibuprofen
- Where
- 3 sites in United States
- Volunteers
- 230 people
- Sponsor
- University of Minnesota
Laparoscopic Surgery, Liposomal Bupivacaine
The Efficacy and Safety of Liposomal Bupivacaine for Transversus Abdominis Plane Block in Relieving Postoperative Pain After Laparoscopic Surgery
Laparoscopic surgery has become the preferred approach for abdominal surgical interventions due to its advantages of minimal invasiveness, rapid recovery, and reduced complication rates.
- Conditions
- Laparoscopic Surgery, Liposomal Bupivacaine, Transversus Abdominis Plane Block
- Trial name
- NCT07458282
- Testing
- Bupivacaine hydrochloride, Liposomal bupivacaine plus bupivacaine
- Where
- China
- Volunteers
- 318 people
- Sponsor
- Beijing Tiantan Hospital
Acupuncture Analgesia, Acupuncture
ACU_Knee: Role of Acupuncture in Knee Prosthetic Surgery
Post-operative analgesia after total knee arthroplasty (TKA) has always been a challenge in the anesthesiological setting, having to combine good pain control and the need for early mobilization, both factors that can affect the…
- Conditions
- Acupuncture Analgesia, Acupuncture, Acupuncture Therapy, Total Knee Anthroplasty
- Trial name
- ACU_Knee (NCT07123805)
- Testing
- Acupuncture group
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Pain Management
A Clinical Trial of MK-6916 in Participants With Pain After Bunion Removal Surgery (MK-6916-007)
Researchers are looking for new treatments for pain. While there are many approved treatments for pain, the treatments do not work well for everyone. People can also become addicted to certain pain medicines.
- Trial name
- NCT07862595
- Testing
- MK-6916, Hydrocodone/acetaminophen (HB/APAP), Rescue Medication
- Where
- 9 sites in United States
- Volunteers
- 380 people
- Sponsor
- Merck Sharp & Dohme LLC
Herbal Interaction
Evaluating a Potential Pharmacokinetic Kratom-oxycodone Interaction Concurrent With Clinical Endpoints
The goal of this study is to investigate whether the botanical product kratom affects how the body processes the opioid drug oxycodone. The main research questions to be answered are two-fold: 1.
- Trial name
- NCT05846451
- Testing
- Kratom, Oxycodone
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Washington State University
Benign Prostate Hypertrophy(BPH)
Trial to Assess the Efficacy and Safety During Convective Radiofrequency Water Vapor Thermal Therapy (REZUM) for Benign Prostate Hyperplasia
The primary aim of the study is to show that methoxyflurane-lorazepam-percocet combination administrated 'per os' is non inferior to deep intravenous sedation in achieving analgesia during Rezum convective radiofrequency water…
- Trial name
- NCT07017452
- Testing
- Methoxyflurane - Penthrox, Control, Percocet Pill
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Bone Metastases, Lymphoma
Post-Op Pain Control for Prophylactic Intramedullary Nailing.
Nationally, the opioid crisis has become a major epidemic with increasing mortality rates each year. Orthopedic surgeons routinely prescribe narcotics instead of NSAIDs for post-op pain control because of risk of delayed healing…
- Conditions
- Bone Metastases, Lymphoma, Multiple Myeloma, Opioid Use
- Trial name
- NCT03823534
- Testing
- Ketorolac, Normal saline, Acetaminophen
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- St. Louis University
Carpal Tunnel Syndrome
Exparel and Education to Avoid Opioids After Carpal Tunnel Release
This trial seeks to use the long acting local anesthetic Exparel, in conjunction with opioid education, to attempt to avoid any post-operative opioid use following carpal tunnel surgery.
- Trial name
- NCT03867539
- Testing
- Differing pain management strategy
- Where
- 2 sites in United States
- Volunteers
- 64 people
- Sponsor
- Kettering Health Network
Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose…
- Conditions
- Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension, Urinary Tract Infections in Children, Hypertension
- Trial name
- POPS or POP02 (NCT04278404)
- Testing
- The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Postoperative Pain, Postoperative Ileus
Effect of Liposomal Bupivacaine TAPB Combined With Oxycodone PCIA on Postoperative Gastrointestinal Recovery in Patients Undergoing Major Abdominal Surgery
Rationale and Objective: The purpose of this study is to evaluate the clinical efficacy and safety of a novel multimodal analgesia regimen, combining transversus abdominis plane block (TAPB) with patient-controlled intravenous…
- Trial name
- NCT07651722
- Testing
- ropivacaine hydrochloride, Liposomal bupivacaine (LB), Sufentanil citrate
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Tianjin First Central Hospital
Lumbar Spine Stenosis, Lumbar Spine Degeneration
OpalGenix- Personalized Postoperative Pain Management Following Lumbar Spinal Fusion and Decompression Surgery in Adults
The proposed research is an important extension of an ongoing perioperative personalized analgesia and intravenous opioid pharmacogenetic research.
- Trial name
- NCT05452694
- Where
- 3 sites in United States
- Volunteers
- 235 people
- Sponsor
- OpalGenix, Inc
Colorectal Cancer, Opioid-free Anesthesia
Effect of OFA, OSA Versus Opioid-based Anesthesia on NETs and Cancer Cell Malignancy After Colorectal Cancer Surgery
Adult patients aged 18-80 years old, American Society of Anesthesiologists physical status I-III, who were scheduled for elective colorectal cancer surgery under general anesthesia were recruited for this study.
- Conditions
- Colorectal Cancer, Opioid-free Anesthesia, NETs
- Trial name
- NCT07264556
- Testing
- OA strategy, OSA stategy, OFA strategy
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Fudan University
Hip or Knee Replacement
CBP-0276 to Reduce Opioid Use in Adults Undergoing Major Orthopedic Surgery
Randomized, double-blind, clinical study to evaluate the safety and efficacy of CBP-0276 at doses of 600 mg/day in reducing opioid use in pain management in adult patients undergoing major orthopedic surgery.
- Trial name
- CBP0276-Opd (NCT07687966)
- Testing
- CBP-0276
- Where
- Mexico
- Volunteers
- 80 people
- Sponsor
- Clarent Biopharma, Inc.
Pharmacokinetics, Healthy Volunteer
Single Dose Study, Pharmacokinetics of Oxycodone and PF614 Co-Administered With Nafamostat (PF614-MPAR-102)
A single dose dose study to assess the pharmacokinetics (PK) of oxycodone, when PF614 is administered alone and with nafamostat as an immediate-release (IR) solution and/or extended-release(ER) capsule prototypes.
- Trial name
- NCT06500793
- Testing
- PF614 capsule, Nafamostat Mesylate
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Ensysce Biosciences
Pain, Chronic
Prescription Opioids, Brain Structure, and Cognition in Older Adults With Chronic Pain
The purpose of this study is to determine whether exposure to prescription opioids is associated with brain structural changes on magnetic resonance imaging (MRI), with the primary outcome of white matter integrity as measured by…
- Trial name
- I-COAP (NCT06837857)
- Testing
- Opioid
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Mayo Clinic
Acute Postoperative Pain, Non-steroidal Anti-inflammatory Drugs
Non-steroidal Anti-inflammatory in Cardiac Surgery
Non-steroidal anti-inflammatory drugs (NSAID) are part the multimodal strategy in pain management after surgery. However, major concerns are raised in cardiac surgery given the potential side effects of NSAID with more bleeding…
- Conditions
- Acute Postoperative Pain, Non-steroidal Anti-inflammatory Drugs, Cardiac Surgery, Pain Intensity
- Trial name
- KETOPAIN (NCT06381063)
- Testing
- pain management, ketoprofen
- Where
- France
- Volunteers
- 238 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Opioid Use, Substance Use Disorders
Evaluation of the Safety and Effects of Psychoactive Substances in People With Past Opioid Use
The purpose of this study is to understand how kratom affects people. In this study, kratom will be compared with another substance and a placebo (an inactive substance).
- Conditions
- Opioid Use, Substance Use Disorders, Opioid Analgesia
- Trial name
- NCT07218549
- Testing
- Oxycodone HCl, Kratom 8g, Kratom 12g
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Christopher D. Verrico