Clinical trials: Oxycodone
Opioid Use
Does Altering Narcotic Prescription Methods Affect Opioid Distribution Following Select Upper Extremity Surgeries?
It has been well established that prescription opioid misuse and prescription opioid abuse is on the rise. In the late 1990's and early 2000's, there was a large push to make "pain" the fifth vital sign.
- Trial name
- NCT03570320
- Testing
- Modification of opioid prescription method
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- John Yanik
Epidural, Oxycodone
Epidural Oxycodone for Pain Management for Lower Limb Amputation
The aim of this study is to evaluate the effect of epidural oxycodone for pain management after lower limb amputation.
- Conditions
- Epidural, Oxycodone, Pain, Lower Limb Amputation
- Trial name
- NCT06276179
- Testing
- Oxycodone, Bupivacaine
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Kafrelsheikh University
Osteoarthritis, Osteoarthritis, Knee
A Safety and Tolerability Study of JNJ-42160443 in Patients With Moderate to Severe, Chronic Knee Pain From Osteoarthritis
The purpose of this study is to evaluate pain relief, safety, and tolerability of a new treatment (JNJ-42160443) for moderate to severe pain of osteoarthritis of the knee in comparison to a standard pain treatment and placebo.
- Conditions
- Osteoarthritis, Osteoarthritis, Knee, Pain, Arthralgia
- Trial name
- NCT01094262
- Testing
- Oxycodone CR (standard pain medication), JNJ-42160443
- Where
- 44 sites in United States, Canada
- Volunteers
- 196 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Pain
Randomized Trial of Two Analgesics in Elderly ED Patients
The purpose of this study is to perform a randomized, double blind 2-arm clinical trial of the comparative efficacy of 2 oral analgesics in the the management of acute pain in elderly patients who present and then are discharged…
- Trial name
- NCT02703610
- Testing
- Oxycodone/acetaminophen, Ibuprofen/acetaminophen
- Where
- United States
- Sponsor
- Albany Medical College
Opioid Use
Opioid Use Post-Discharge After Ambulatory Distal Arm Surgery
The aim of this study is to determine if a standardized evidence-based opioid prescription following elective hand and forearm surgery at Toronto Western Hospital (TWH) will decrease the number of unused opioid pills consumed by…
- Trial name
- NCT04044820
- Testing
- Standardized Prescription
- Where
- Canada
- Volunteers
- 292 people
- Sponsor
- University Health Network, Toronto
Motivation, Drug Effect
How Stress Alters Opioid Drug Effects
The main objective of the study is to test the hypothesis that opioid drug effects vary as a function of pre-drug affective state.
- Conditions
- Motivation, Drug Effect, Stress Reaction, Misuse, Opioid
- Trial name
- OPIOIDREWARD (NCT06485817)
- Testing
- Oxycodone, Stress State Induction, Control State Induction
- Where
- Norway
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Pain, Postoperative
PIB Versus CI Through a Popliteal Sciatic Nerve Catheter for Analgesia Following Major Ankle Surgery
This is a clinical study to investigate and compare a new programmed intermittent bolus (PIB) delivery method for continuous popliteal sciatic nerve block for pain relief in patients undergoing major ankle surgery compared with…
- Trial name
- NCT02707874
- Testing
- CI 0.2% ropivacaine, PIB 0.2% ropivacaine
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University Health Network, Toronto
Opioid Use, Opioid Prescribing, Dispensing, and Patient Use
Opioid Package Prototype (OPP)
The overall objective of this clinical trial is to identify the impact of selected package features, known as the Opioid Package Prototype (OPP), on the safe and effective use of opioids.
- Trial name
- NCT04598074
- Testing
- Opioid Package Prototype (OPP), Usual Care (standard amber vial)
- Where
- United States
- Volunteers
- 352 people
- Sponsor
- UConn Health
Distal Radius Fracture, Pain Management
Narcotic Versus Non-narcotic Medication for Pain Management After Wrist/Hand Fractures
The purpose of this study is to evaluate two drug options for pain control in patients following wrist injury. Participants will be randomized to one of the 2 pain relief treatments to determine what treatment provides the most…
- Conditions
- Distal Radius Fracture, Pain Management, Metacarpal Fracture
- Trial name
- NCT03375593
- Testing
- Hydrocodone 5Mg/Acetaminophen 500Mg Tab, Acetaminophen 500Mg Tab, Ibuprofen 600 mg tab
- Where
- Canada
- Volunteers
- 250 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Chronic Pain
Use of Driving Tests to Evaluate Patient Performance on Oral Opioids
Many patients seen at Pain Centers are advised not to drive if they are on long-term opioid medications. Although such advice is routinely given considering patients' safety, unnecessary restrictions to driving can cause…
- Trial name
- OpDrive (NCT00659035)
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Asokumar Buvanendran
Postoperative Pain, Mitral Valve Disease
ESP vs ESP With PECS
Patients scheduled for minimally invasive mitral valve repair. Each patient will be treated with intravenous (i.v.) oxycodone - patient-controlled analgesia (PCA).
- Trial name
- NCT03592485
- Testing
- Erector Spinae Plane blockade, Pectoral Fascia block, Oxycodone
- Where
- Poland
- Volunteers
- 33 people
- Sponsor
- Medical University of Lublin
Anterior Cruciate Ligament Injuries
Reduce Opiate Exposure With ACL Surgery
This is a randomized control trial to investigate the effectiveness of a multimodal opiate sparing analgesic regimen in controlling post-operative pain and potentially reduce post-operative opioid consumption in patients…
- Trial name
- NCT06561035
- Testing
- Opiate Sparing, Opiate Based
- Where
- 3 sites in United States
- Volunteers
- 56 people
- Sponsor
- Campbell Clinic
Healthy, No Evidence of Disease
Effects of Garlic Supplements on Opioids in Healthy Volunteers
RATIONALE: Garlic supplements may alter the pharmacokinetics of oxycodone, thereby affecting its effectiveness as an opioid analgesic for the relief of moderate or severe pain.
- Trial name
- NCT00499460
- Testing
- garlic powder tablets, oxycodone
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Healthy
Pharmacokinetics and Bioequivalence of Vycavert (10 mg Hydrocodone Bitartrate/325 mg Acetaminophen) Compared to the Reference Drug Norco
This study aims to determine whether the hydrocodone and acetaminophen exposures following oral dosing of Vycavert are comparable to those following oral dosing of Norco.
- Trial name
- NCT01456520
- Testing
- Vycavert, Norco
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Pfizer
Caffeine, Pain, Joint
Pain Management After Shoulder Arthroplasty
Pain control is a critical after many surgical procedures. It is well known that orthopaedic surgeries are among the most painful procedures, with total joint arthroplasty being a clear example of this situation.
- Trial name
- NCT04872270
- Testing
- Total Shoulder Arthroplasty, Caffeine Pill, Percocet 10Mg-325Mg Tablet
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Constipation
Opioid Induced Bowel Dysfunction in Patients Undergoing Spinal Surgery
In the present study, the primary aim was to evaluate if oxycodone-naloxone combination compared to oxycodone reduced opioid induced constipation in patients with or without chronic opioid treatment undergoing spine surgery.
- Trial name
- oksineukir (NCT02573922)
- Testing
- oxycodone-naloxone, Oxycodone
- Where
- Finland
- Volunteers
- 180 people
- Sponsor
- Kuopio University Hospital
Patient-Controlled Analgesia
Nausea and Vomiting in Postoperative Paediatric Patients With Patient-Controlled Analgesia (PCA): Morphine vs Oxycodone
POPCORN trial will compare the side effects and effectiveness of Morphine versus Oxycodone medication when prescribed for use as patient controlled analgesia (PCA) for pain relief for paediatric patients after-surgery.
- Trial name
- POPCORN (NCT06186141)
- Testing
- Morphine, Oxycodone
- Where
- Australia
- Volunteers
- 690 people
- Sponsor
- Murdoch Childrens Research Institute
Opioid-induced Respiratory Depression
Combined Effect of Pregabalin and Oxycodone, and Lacosamide and Oxycodone, on Breathing
Opioids are commonly prescribed for moderate to severe pain. While initially intended for moderate to severe acute and cancer pain, opioids are currently frequently considered and prescribed in chronic noncancer pain.
- Trial name
- POLO (NCT05598905)
- Testing
- Pregabalin 150mg, Oxycodone 10mg, Lacosamide 150 mg
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Healthy
A Study to Investigate the Pharmacodynamic Effect of Single Doses of MT-8554 in Healthy Subjects
The purpose of this study is to investigate the pharmacodynamic effect of single doses of MT-8554 in healthy subjects.
- Trial name
- NCT02536209
- Testing
- MT-8554 low dose, MT-8554 high dose, Oxycodone hydrochloride
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tanabe Pharma Corporation
Pain
Oxycodone/Naloxone (OXN) Combination in Moderate to Severe Non-malignant Pain
The main objective of the study is to evaluate the patient preference for pain treatment with respect to quality of life in patients with moderate to severe non malignant pain.
- Trial name
- NCT01167699
- Testing
- Oxycodone and naloxone
- Where
- Belgium
- Volunteers
- 174 people
- Sponsor
- Mundipharma Pharmaceuticals B.V.