Clinical trials: Oxycodone, open to volunteers
Anterior Cruciate Ligament Injuries
Reduce Opiate Exposure With ACL Surgery
This is a randomized control trial to investigate the effectiveness of a multimodal opiate sparing analgesic regimen in controlling post-operative pain and potentially reduce post-operative opioid consumption in patients…
- Trial name
- NCT06561035
- Testing
- Opiate Sparing, Opiate Based
- Where
- 3 sites in United States
- Volunteers
- 56 people
- Sponsor
- Campbell Clinic
Laparoscopic Surgery
Short Title: Standard vs. Lower Pressure Pneumoperitoneum
This study aims to investigate the effect of varying insufflation pressures on post-operative pain and adequacy of surgical field visualization among patients undergoing laparoscopic surgery with a minimally invasive gynecologic…
- Trial name
- NCT06338865
- Testing
- Carbon dioxide, Bupivacaine, Oxycodone
- Where
- United States
- Volunteers
- 294 people
- Sponsor
- Cedars-Sinai Medical Center
Pain Control
RCT: Suzetrigine vs Norco for Post-op Pain
Journavx (suzetrigine) is a novel non-opioid analgesic that is FDA approved for acute pain management and may offer a promising alternative for managing postoperative pain.
- Trial name
- NCT07195669
- Testing
- Suzetrigine (SUZ), Norco
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Jacob Lensing
Parotidectomy
Celecoxib for ENT Pain Management
The goal of this clinical trial is to find out whether pain can be managed after an operation with celecoxib instead of oxycodone.
- Trial name
- NCT06505187
- Testing
- Celecoxib, Tylenol, Oxycodone
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- University of Wisconsin, Madison
Alzheimer Disease
Clinical Analgesic Management in Dementia
This study is designed to assess the efficacy and safety of oxycodone in managing moderate to severe pain in patients with Alzheimer's disease.
- Trial name
- CALM-D (NCT07323914)
- Testing
- Tylex
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Xuanwu Hospital, Beijing
Postoperative Pain
Evaluate the Safety and Efficacy of HL-1186 Tablet for Postoperative Analgesia in Abdominal Surgery
This clinical trial is a multiple-center, randomized, double-blind, placebo- and active-controlled parallel-group Phase II/III clinical trial, to evaluate the efficacy and safety of HL-1186 Tablets for Postoperative Analgesia in…
- Trial name
- NCT07709598
- Testing
- HL-1186, Oxycodone-Acetaminophen
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Shanghai Huilun Pharmaceutical Co., Ltd.
Laparoscopic Surgery, Liposomal Bupivacaine
The Efficacy and Safety of Liposomal Bupivacaine in Relieving Postoperative Pain After Laparoscopic Surgery
Compared with traditional laparotomy, laparoscopic surgery offers advantages including minimal invasiveness, accelerated patient recovery, and reduced hospital stay.
- Conditions
- Laparoscopic Surgery, Liposomal Bupivacaine, Local Infiltration
- Trial name
- NCT07458256
- Testing
- Bupivacaine hydrochloride, Liposomal bupivacaine plus bupivacaine
- Where
- China
- Volunteers
- 190 people
- Sponsor
- Beijing Tiantan Hospital
Video-assisted Thoracoscopic Surgery (VATS), Pain Management
The Efficacy and Safety of Liposomal Bupivacaine in Relieving Postoperative Pain After Video-assisted Thoracoscopic Surgery
Video-assisted thoracoscopic surgery (VATS) is less invasive compared to traditional thoracotomy. It is reported that the incidence of acute pain following VATS exceeds 80%.
- Conditions
- Video-assisted Thoracoscopic Surgery (VATS), Pain Management, Liposomal Bupivacaine, Local Injection
- Trial name
- NCT07432711
- Testing
- Bupivacaine hydrochloride, Liposomal bupivacaine plus bupivacaine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Beijing Tiantan Hospital
Narcotic Use
Nonopioid Analgesia After Labral Surgery
This is a randomized, single blinded, standard of care controlled clinical trial. This project aims to compare postoperative pain control in patients in two treatment arms of rotator cuff repair: a treatment group given a…
- Trial name
- NCT03825809
- Testing
- Celecoxib, Hydrocodone-Acetaminophen, Ketorolac
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Knee Injuries, Pain, Postoperative
Opioids Versus Non-Opioids Postoperative After Knee Arthroscopic Surgery
The purpose of this study is to look at pain management with opioids versus non-opioids after knee arthroscopy. This study will determine 1) whether the most commonly used non-narcotic medications provide pain relief comparable…
- Conditions
- Knee Injuries, Pain, Postoperative, Opioid Use
- Trial name
- NCT03858231
- Testing
- Norco 5Mg-325Mg Tablet, Ibuprofen 600 mg, Acetaminophen 325Mg Tab
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Sanford Health
Drug Interactions, Drug Kinetics
Opioid Drug Interaction Study
This study will examine the effects of doses of opioid/placebo and doses of alprazolam/placebo, alone and in combination. The primary outcomes are pharmacodynamic measures (subjective ratings of drug liking and other…
- Trial name
- NCT06757140
- Testing
- Alprazolam, Oxycodone
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Shanna Babalonis, PhD
Knee Arthroplasty, Total, Post Operative Pain, Acute
Suzetrigine vs. Standard Care Pain Relief Following Outpatient Knee Replacement Surgery
The purpose of this research is to see if a person having an outpatient total knee replacement will have a difference in their pain and the amount of pain medication (opioids) used after discharge if they are given suzetrigine (a…
- Conditions
- Knee Arthroplasty, Total, Post Operative Pain, Acute, Opioid Consumption, Postoperative
- Trial name
- NCT07796152
- Testing
- Suzetrigine, Opioid standard care pain medicine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Endeavor Health
Opioid Abuse (Disorder), Opioid Analgesia
Reducing Opioid Use After Upper Extremity Surgery: Testing Lower Prescriptions and Pill Quantity
The goal of this clinical trial is to evaluate strategies for optimizing postoperative multimodal pain regimens and reducing opioid dependency in patients undergoing upper extremity surgery.
- Conditions
- Opioid Abuse (Disorder), Opioid Analgesia, Opioid Analgesic Adverse Reaction, Opioid Consumption
- Trial name
- NCT07750639
- Testing
- Naproxen, Acetaminophen, oxycodone
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- AdventHealth
Tonsillectomy, Pharyngoplasty
Suzetrigine in Tonsillectomy for Opioid-sparing Pain Management
The goal of this clinical trial is to learn if a non-opioid pain medicine called suzetrigine can lower how much opioid pain medicine adults need after tonsil surgery (tonsillectomy) or a similar throat surgery.
- Conditions
- Tonsillectomy, Pharyngoplasty, Suzetrigine, Opioid
- Trial name
- STOP (NCT07821931)
- Testing
- Suzetrigine, Acetaminophen, oxycodone
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Stanford University
Postoperative Pain Management
Suzetrigine Versus Usual-care Opioids for Postop Pain in Sports
The goal of this clinical trial is to learn if a Suzetrigine-based multimodal pain regimen can reduce the volume of opioid consumption while maintaining non-inferior pain control compared to an opioid-based multimodal pain…
- Trial name
- NCT07355166
- Testing
- Suzetrigine, Multimodal Pain Regimen
- Volunteers
- 140 people
- Sponsor
- University of California, Los Angeles
Healthy
Abuse Potential of Gabapentin Taken Orally Concomitantly With Oxycodone Hydrochloride in Healthy, Non-Drug-Dependent, Recreational Opioid Users
The purpose of the present study is to assess prospectively the abuse potential of gabapentin when taken with and without oxycodone compared to placebo in healthy non-drug-dependent recreational opioid drug users under fasted…
- Trial name
- NCT07813026
- Testing
- Oxycodone 20mg, gabapentin 600 mg, Gabapentin 1200mg
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Viatris Inc.
Laparoscopic Hysterectomy
Oxycodone Versus Sufentanil in Patient-controlled Intravenous Analgesia After Laparoscopic Hysterectomy
This study is designed to evaluate the efficacy and safety of hydrocodone in patient-controlled intravenous analgesia (PCIA) during gynecological laparoscopy, thus to explore suitable PCIA scheme to optimize postoperative pain…
- Trial name
- Oxycodone (NCT06690307)
- Testing
- patient controlled intravenous analgesia(PCIA)
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Affiliated Hospital of Nantong University