Clinical trials: Oxytocin
AOD Use, Abuse, and Dependence
Intranasal Oxytocin and Social Cognition, Implicit Preferences and Craving in Alcohol Drinkers
This is a randomized, placebo controlled, double blind crossover study of the effects of intranasal oxytocin on social cognition, implicit preferences and craving in moderate to heavy social alcohol drinkers.
- Trial name
- NCT01829516
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Vaginal Atrophy
Dose-relationship of Vaginally Administrated Oxytocin in Postmenopausal Women
Up to 50% of all postmenopausal women, experience vaginal drynes, i.e. vaginal atrophy is a consequence due to the lack of estrogen.
- Trial name
- OXYPEP002 (NCT01987804)
- Testing
- Oxytocin 100 i.u., Oxytocin 400 i.u.
- Where
- Sweden
- Volunteers
- 64 people
- Sponsor
- PepTonic Medical AB
Delivery, Obstetric, Cesarean Section
Comparison Between Two Medical Devices for Labor Induction After Previous C-section
The objective of the study ist to compare the Dilapan-S and the Cook Ballon device for the mechanical induction of labour in women with a previous C-section.
- Conditions
- Delivery, Obstetric, Cesarean Section, Obstetric Delivery
- Trial name
- DiBal (NCT06506721)
- Testing
- Double ballon device, Cook, Hygroscopic cervix dilators, Dilapan-S
- Where
- Switzerland
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Alcoholism
Oxytocin in Alcohol Use Disorder
Background: Oxytocin is a naturally occurring substance in the body. Studies show that oxytocin may affect how the body responds to alcohol. Researchers believe oxytocin may be a possible treatment for alcoholism.
- Trial name
- NCT02711189
- Testing
- Oxytocin
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Hypopituitarism, Central Diabetes Insipidus
Identification and Clinical Relevance of an Oxytocin Deficient State (CRH Study)
Oxytocin (OT) is a hypothalamic peptide that enters the peripheral circulation via the posterior pituitary gland. OT plays a key role in regulating appetite, psychopathology, prosocial behavior and sexual function.
- Conditions
- Hypopituitarism, Central Diabetes Insipidus, Panhypopituitarism, Psychological Disorder
- Trial name
- NCT04902235
- Testing
- Experimental: CRH administration
- Where
- Spain
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Induction of Labor
Cervical Ripening for Induction of Labor: Misoprostol Versus Oxytocin in Conjunction With Foley Balloon
The purpose of this study is to specifically investigate the efficacy of an alternative pharmacologic cervical ripening agent, misoprostol, versus the standard oxytocin, as an adjunct to Foley balloon for induction of the…
- Trial name
- NCT01139801
- Testing
- Oxytocin, Misoprostol
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Aultman Health Foundation
Post Partum Hemorrhage
Combating Maternal Mortality in Uganda: An Assessment of the Role of Misoprostol in Prevention of Post-Partum Hemorrhage
Null hypothesis: 10 IU Oxytocin is better than sublingual misoprostol 600µg in management of third stage of labor Alternative hypothesis: Sublingual misoprostol 600µg is non- inferior to 10 IU oxytocin and will not be more than…
- Trial name
- NCT01866241
- Testing
- Misoprostol
- Where
- Uganda
- Volunteers
- 1,140 people
- Sponsor
- Mbarara University of Science and Technology
Schizophrenia
Antipsychotic Effects of Oxytocin
The objective of the study is to compare the efficacy of intranasal oxytocin versus intranasal placebo to improve symptoms in schizophrenia patients who have residual symptoms despite being on adequate treatment with…
- Trial name
- NCT01621737
- Testing
- Oxytocin
- Where
- 2 sites in United States
- Volunteers
- 42 people
- Sponsor
- University of California, San Diego
Glucose Metabolism Disorders (Including Diabetes Mellitus)
The Role of Oxytocin in Regulating Blood Glucose
Investigating the effect of oxytocin on pancreatic endocrine functions by determining insulin and glucagon secretion within physiological ranges of plasma glucose.
- Trial name
- GLOXY-1 (NCT06334172)
- Testing
- Oxytocin
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Induction of Childbirth
3-hour Versus 12-hour Double-balloon Catheter for Labor Induction
This study aims to demonstrate that a 3-hour ultra-short cervical ripening protocol using a double-balloon catheter significantly reduces the induction-to-birth interval by at least 6 hours compared to the standard 12-hour…
- Trial name
- BAL3H (NCT07492186)
- Testing
- Cook® double-balloon catheter
- Where
- France
- Volunteers
- 280 people
- Sponsor
- Centre Hospitalier de PAU
Postpartum Hemorrhage
Effect of Ephedrine, Phenylepinephrine, and Norepinephrine on Myometrial Contractility in Pregnant People With Type II and Gestational Diabetes During Cesarean Section: An In-vitro Study
The goal of this study is to learn about how medication that is used to help treat low blood pressure during a Cesarean delivery (CD) can cause changes to the uterine muscle tissue and its ability to contract, in patients with…
- Trial name
- NCT06285396
- Testing
- Ephedrine, Phenylephrine, Norepinephrine
- Where
- Canada
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Medical Induction of Labor Affecting Newborn
Premature Rupture of Membranes With a Bishop Score<6: Comparison of Medical Induction/Expectant Management
The study is intended to compare expectant management and on presentation labor induction in women with premature rupture of membranes. The means of labor induction and cervical ripening are either oxytocin or dinoprostone.
- Trial name
- NCT02825641
- Testing
- Oxytocin, Dinoprostone
- Where
- Israel
- Volunteers
- 458 people
- Sponsor
- Rambam Health Care Campus
Borderline Personality Disorder, BPD
Examining Dose-Related Effects of Oxytocin on Social Cognition Across Populations
Social cognition impairment is critical to the pathology and morbidity of a number of psychiatric disorders, including the schizophrenia spectrum, the autism spectrum and the personality disorders, thus representing a dimension…
- Conditions
- Borderline Personality Disorder, BPD, Schizotypal Personality Disorder, SPD
- Trial name
- NCT02149823
- Testing
- Syntocinon 24 Intranasal Units (IU), Syntocinon 40 Intranasal Units (IU)
- Where
- 2 sites in United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Maria de las Mercedes Perez Rodriguez
Post Anaesthetic Shivering
Nefopam vs Tramadol in the Prevention of Post Anaesthetic Shivering
Post Anaesthetic Shivering is a common complication of Subarachnoid block. It is graded based on it's severity and has been known to cause various problems like patient's discomfort, hypoxia, change in hemodynamic variables of…
- Trial name
- NCT02441673
- Testing
- Nefopam, Tramadol, Metoclopramide
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Lagos State Health Service Commission
Complications; Cesarean Section
Control of Blood Loss During Caesarean Section
trial of 3 protocols to determine the best one to control blood loss during caesarean section
- Trial name
- NCT01412073
- Testing
- oxytocin, Misoprostol
- Where
- Egypt
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Cairo University
Postprocedural Delayed Gastric Emptying
The Effect of Oxytocin on the Gastric Emptying
The investigators are going to examine whether oxytocin has a prokinetic effect on gastric emptying in patients suffering from gastro paresis. Oxytocin infusion will be compared with sodium chloride infusion.
- Trial name
- NCT00776360
- Testing
- oxytocin
- Volunteers
- 12 people
- Sponsor
- Skane University Hospital
Alcohol Use Disorder, Alcoholism
Oxytocin and Naltrexone: Investigation of Combined Effects on Stress- and Alcohol Cue-induced Craving in Alcohol Use Disorder
Alcohol use disorder (AUD) is a chronic relapsing disorder. Alcohol craving, a hallmark symptom of AUD that drives relapse in patients, is only insufficiently treated by existing medication.
- Conditions
- Alcohol Use Disorder, Alcoholism, Alcohol Addiction
- Trial name
- ON-ICE (NCT05093296)
- Testing
- Oxytocin nasal spray, Naltrexone Pill
- Where
- Germany
- Volunteers
- 62 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Preterm Pregnancy, Labor Induction
Preterm Induction of Labor Timing of Amniotomy: A Randomized Controlled Trial
Artificial rupture of membranes (amniotomy) is a commonly used technique to safely induce and augment labor. It has been shown to reduce the duration of spontaneous and induced labor in term patients (≥37 weeks' gestation).
- Trial name
- PITA (NCT03504670)
- Testing
- Early Amniotomy, Late Amniotomy
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- University of Alabama at Birmingham
Autism
An fMRI Study of the Effect of Intravenous Oxytocin vs. Placebo on Response Inhibition and Face Processing in Autism
To study the effect of oxytocin on face processing and response inhibition in autistic adults by fMRI.
- Trial name
- NCT00263796
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Anagnostou, Evdokia, M.D.
Missed Abortion
Oxytocin Effectiveness in First Trimester Dilatation and Curettage
The aim of this study is to investigate the impact of oxytocin on perioperative blood loss during the D\&C procedure, as well as to assess early and late complications associated with it's use.
- Trial name
- NCT06469203
- Testing
- Oxytocin, Sodium Chloride 0.9% Inj
- Volunteers
- 160 people
- Sponsor
- Assuta Ashdod Hospital