Clinical trials: Oxytocin
Placenta, Retained, Postpartum Hemorrhage
Optimisation of the Management of Placental Delivery in Second Trimester Pregnancy Interruption
Interruption of a pregnancy after 14 weeks gestation may be required when the fetus is dead, severely malformed or in cases of maternal illness.
- Trial name
- NCT00120042
- Testing
- Misoprostol, Oxytocin
- Where
- Australia
- Volunteers
- 251 people
- Sponsor
- The University of Western Australia
Nicotine Dependence
The Gender-Sex Hormone Interface With Craving & Stress-Related Changes in Smoking
The purpose of the overall parent study is to determine the impact of gender and hormones (estradiol, progesterone, testosterone and cortisol) on responses to stress and smoking cues presented in daily, "real-world" cue…
- Trial name
- SCOR-III (NCT01576874)
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Kevin Gray, MD
Post-Partum Haemorrhage
A Clinical Trial to Study the Effectiveness of a Care Bundle to Prevent Bleeding After a Woman Has Given Birth
Every six minutes a mother dies from postpartum haemorrhage (PPH) in low-resource countries, in the prime of her life and often leaving behind a young family.
- Trial name
- E-MOTIVE (NCT04341662)
- Testing
- E-MOTIVE intervention, Usual care
- Where
- 6 sites in Kenya, Nigeria and 3 more
- Volunteers
- 99,659 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Pre-eclampsia, Fetus or Newborn; Effects of Induction of Labor
Induction With Foley OR Misoprostol (INFORM) Study
Between 40,000 and 80,000 pregnant women die annually from pre-eclampsia and eclampsia. Magnesium sulphate and anti-hypertensive therapies can reduce the morbidity associated with pre-eclampsia.
- Trial name
- INFORM (NCT01801410)
- Testing
- Foley Catheter, Misoprostol
- Where
- 2 sites in India
- Volunteers
- 602 people
- Sponsor
- University of Liverpool
Oxytocin and Abdominal Myomectomy
Oxytocin Infusion and Abdominal Myomectomy
Objective:To compare oxytocin infusion with control, in patients undergoing abdominal myomectomy in terms of mean blood loss. Design: Single blinded randomized control trial Setting: Obstetrics and Gynecology Department, Military…
- Trial name
- NCT03702946
- Testing
- oxytocin in abdominal myomectomy
- Where
- 2 sites in Pakistan
- Volunteers
- 60 people
- Sponsor
- Armed Forces Hospital, Pakistan
Chronic Daily Headache
Effect of Intranasal Oxytocin on Headache in Chronic Daily Headache
The objective of this prospective, randomized, double-blind, parallel-group, placebo-controlled study is to determine the effectiveness of intranasal oxytocin in subjects suffering from chronic daily headache.
- Trial name
- NCT00963040
- Testing
- Syntocinon, Sterile water
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- MedVadis Research Corporation
Abortion, Missed
Misopristol Versus Pitocin for Second Trimester Abortion
Second trimester abortion can be done surgically or medically. Medical abortion with mifepristone and misopristol is one of the common protocol, but misopristol have high rate side effect.
- Trial name
- NCT00784797
- Testing
- mifepristone and misopristol, mifepristone and oxytocin
- Where
- Israel
- Volunteers
- 145 people
- Sponsor
- Hadassah Medical Organization
Pregnancy, Induced Labor
Adjuvant Oxytocin for Preinduction Ripening With a Foley catheter--a Clinical Trial
The transcervical Foley catheter (TFC) is a proven and effective mode of cervical ripening. It is common practice to use TFC with simultaneous low-dose oxytocin under the assumption that the combination results in a more…
- Conditions
- Pregnancy, Induced Labor, Cervical Ripening
- Trial name
- NCT00468520
- Testing
- low dose oxytocin
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Columbia University
Healthy
Hair Biomarkers Study
Young children aged 0-4 years may be exposed to adverse childhood experiences (ACEs) and/or early life adversity (ELA), which are linked with worse physical and mental health across their lifespan.
- Trial name
- HBS-II (NCT07011082)
- Testing
- Stress preventative measures
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Stanford University
Autism Spectrum Disorder
Interest of Oxytocin as an Adjuvant Treatment of Psycho-educational Measures in Challenging Behaviors in Children With Autism Spectrum Disorders and Moderate to Severe Intellectual Disability: Feasibility and Safety Study.
The investigation team propose in this study to specifically evaluate the feasibility of using oxytocin in the form of an intranasal spray in a specific population of children with autism spectrum disorder and intellectual…
- Trial name
- OT-DEFI (NCT05864508)
- Testing
- Oxytocin nasal spray
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Toulouse
Animal Assisted Therapy
Title: Urinary Oxytocin Levels in Children Receiving Animal-Assisted Therapy
There has been growing interest in animal-assisted therapy (AAT) in recent decades due to increasing reports indicating its health benefits for adult patients.
- Trial name
- NCT06414876
- Testing
- Hospital dog
- Volunteers
- 50 people
- Sponsor
- Uppsala University
Post-Abortion, Hemorrhage, Obstetric
Oxytocin Receptor Expression in Pregnancy
This study aims to determine when during gestation oxytocin receptor (OXTR) expression increases in the myometrium, which will contribute new insight to the management of obstetric hemorrhage and our understanding of normal and…
- Trial name
- NCT03907735
- Testing
- Myometrial tissue sample collection
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Hemorrhage
Changes in Hemorrhage With Prophylactic Oxytocin for Dilation and Evacuation
The purpose of this study is to assess the effectiveness of prophylactic oxytocin on hemorrhage rates for second trimester dilation and evacuation (D\&E) in the clinic setting.
- Trial name
- NCT06141447
- Testing
- Oxytocin + normal saline, Normal saline
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Healthy Volunteer Study
Dose Ranging Study of Intravenous Oxytocin for Analgesia to Heat Pain
This is a study of participants that will receive intravenous (IV) infusions of oxytocin (naturally occurring hormone that is made by the brain). In this study healthy participants will be recruited for the study.
- Trial name
- NCT05179421
- Testing
- Low dose oxytocin, High dose oxytocin
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Obstetrics
Carbetocin Versus Oxytocin in the Management of Atonic Post Partum Haemorrhage (PPH) in Women Delivered Vaginally: A Randomised Controlled Trial
200 women will be randomly divided into 2 equal groups using computer generated random numbers. Group 1 will receive Carbetocin 100 µgm (Pabal® Ferring, UK) and group 2 will receive oxytocin 5IU (Syntocinon®, Novartis…
- Trial name
- NCT02304055
- Testing
- Carbetocin, Oxytocin
- Where
- 2 sites in Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Pain
Oxytocin and Pain Sensitivity and Threshold
Oxytocin is neurohypophysial peptide that acts mainly as a neuromodulator in the brain. In addition,oxytocin have an important roles in sexual reproduction , in particular during and after childbirth.
- Trial name
- NCT01988649
- Testing
- Intranasal Oxytocin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwestern University
Autism Spectrum Disorder
Translating Neuroprediction Into Precision Medicine Via Brain Priming
The present study examines the impact of oxytocin (OXT) and Pivotal Response Treatment (PRT) on the development of language, social, and play skills in young children with Autism Spectrum Disorder (ASD).
- Trial name
- NCT03370510
- Testing
- Oxytocin, Pivotal Response Treatment
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Yale University
Schizophrenia
Oxytocin as Adjunctive Therapy for Schizophrenia
Background: A large body of research has shown that Oxytocin (OXT) is an important prosocial peptide and there is also initial evidence that the central OXT system is altered in several mental disorders that are characterized by…
- Trial name
- NCT01699997
- Testing
- Oxytocin
- Where
- 7 sites in Italy
- Volunteers
- 32 people
- Sponsor
- IRCCS Centro San Giovanni di Dio Fatebenefratelli
Arginine Vasopressin Deficiency, Diabetes Insipidus
Effect of Intranasal Oxytocin on Emotion Recognition and Acute Psycho-Social Stress-induced Cortisol Increase in Patients With Central Diabetes Insipidus and Healthy Controls
This study aims to investigate the potential beneficial effects of intranasal oxytocin compared to placebo on emotion recognition and acute psychosocial stress in patients with arginine vasopressin deficiency compared to matched…
- Trial name
- OxyMOTION (NCT06676774)
- Testing
- Oxytocin nasal spray
- Where
- Switzerland
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Depression, Anxiety
A Mindfulness-Based Stress Reduction Training Program Model
Mindfulness-based practices are used to regulate mood, alleviate or completely eliminate symptoms that cause stress and depression, and positively influence well-being.
- Conditions
- Depression, Anxiety, Stress, Well-Being, Psychological
- Trial name
- NCT07544355
- Testing
- The mindfulness group-"Mindfulness-Based Stress Reduction Program", The life skills workshop group-"Lifestyle Management and Well-being Workshop"
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University