Clinical trials: Paracetamol, completed
Analgesia
A Study Investigating the Pharmacokinetic Profiles of Four Extended Release Paracetamol Formulations
A study investigating the pharmacokinetic profiles of four extended release paracetamol formulations
- Trial name
- NCT01568749
- Testing
- Paracetamol, Paracetamol formulation 1, Paracetamol Formulation 2
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Arthritis, Rheumatoid
ULTRACET (Tramadol Hydrochloride and Acetaminophen) for the Treatment of Rheumatoid Arthritis Pain.
The purpose of this study is to assess the effectiveness of ULTRACET® (a combination analgesic) as add-on therapy in rheumatoid arthritis patients taking an NSAID (e.g.
- Trial name
- NCT00246168
- Testing
- tramadol hydrochloride + acetaminophen
- Volunteers
- 277 people
- Sponsor
- Janssen Korea, Ltd., Korea
Morbid Obesity
Enhanced Recovery After Laparoscopic Sleeve Gastrectomy - a Randomised Controlled Trial
The investigators wish to standardise and optimise perioperative care for consecutive patients undergoing laparoscopic sleeve gastrectomy for weight loss.
- Trial name
- NCT01303809
- Testing
- Enhanced Recovery After Surgey for Sleeve Gastrectomy
- Where
- New Zealand
- Volunteers
- 106 people
- Sponsor
- University of Auckland, New Zealand
Anesthesia, Local
Effectiveness of Buccal Infiltration During Vital Pulpotomy After Administering Two Analgesic Premedications
This Randomized study was designed to assess and compare the effect of two analgesic premedications (Ibuprofen BP 100 mg/5 ml and Paracetamol 200 mg/5ml.) on the anesthetic efficacy of buccal infiltration in vital pulpotomy of…
- Trial name
- NCT03423329
- Testing
- Brufen, Cital
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Acute Pain
A Study to Evaluate Efficacy and Safety of VX-150 in Subjects With Acute Pain Following Bunionectomy
This is a Phase 2 randomized, double-blind, placebo-controlled, 3-arm, parallel design study to evaluate the efficacy and safety of VX-150 in treating acute pain following bunionectomy.
- Trial name
- NCT03206749
- Testing
- VX-150, HB/APAP
- Where
- 4 sites in United States
- Volunteers
- 243 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Bunion, Post-operative Pain
CPL-01 in the Management of Postoperative Pain After Bunionectomy
Subjects receive study drug during bunionectomy and are followed for pain and opioid use, with the hypothesis that those who receive CPL-01 will have less pain and less opioid use than either control arm.
- Trial name
- NCT05831449
- Testing
- Local anesthetic injection of CPL-01, Naropin, 0.5% Injectable Solution, Morphine rescue medication
- Where
- United States
- Volunteers
- 616 people
- Sponsor
- Cali Pharmaceuticals LLC
Testicle Undescended, Pain, Postoperative
Evaluating Pain Outcomes of Caudal vs Ilioinguinal Nerve Block in Children Undergoing Orchiopexy Repair
Surgical intervention to treat undescended testis is a very common pediatric surgical procedure, often performed using an inguinal incision or subscrotal incision approach.
- Trial name
- NCT03041935
- Testing
- Ilioinguinal/iliohypogastric nerve block, Caudal-epidural nerve block, Acetaminophen
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Alberta Children's Hospital
Gastrointestinal Motility Disorder
Absorption of Paracetamol, Talinolol and Amoxicillin After Oral Administration Using Non-caloric and Caloric Water
To visualize the localization and to measure the volume of water in the small intestine by T2-weighted MRI imaging after oral administration of 240 ml water (non-caloric water) and after administration of 240 ml water containing…
- Trial name
- NCT01635608
- Testing
- Acetaminophen, Talinolol, Amoxicillin
- Where
- Germany
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Pain
Study to Collect Information on How Well the Study Drug Naproxen Sodium Tablets Works Compared to Hydrocodone/Acetaminophen Tablets in Order to Relieve Pain in Participants Experiencing Moderate to Severe Pain After Having Their Wisdom Teeth Removed
With this study researchers want to collect information on how long the pain relief lasts after a fixed dose of naproxen sodium or hydrocodone/acetaminophen or placebo (contains no medication) over 12 hours in subjects…
- Trial name
- NCT04307940
- Testing
- Naproxen Sodium (Aleve, BAY117031), Hydrocodone/Acetaminophen
- Where
- United States
- Volunteers
- 221 people
- Sponsor
- Bayer
Hip Disease
Evaluation of Anterior Quadratus Lumborum Block for Postoperative Analgesia in Hip Arthroscopy
Hip arthroscopy is performed frequently and the postoperative course often involves moderate to severe pain. There remains no definitive perioperative pain regimen that has been proven to be effective and safe for this ambulatory…
- Trial name
- NCT03432650
- Testing
- Bupivacaine + dexamethasone, Ultrasound
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Hospital for Special Surgery, New York
Healthy
A Comparative Bioavailability/Food Effect Study of Immediate-Release and Extended-Release Tramadol HCl/Acetaminophen Combination Products Following Single-Dose and Multiple-Dose Administration in Healthy Adult Volunteers
The objectives of this two-part study were to compare the single-dose and multiple-dose pharmacokinetics of extended release and immediate-release fixed combination formulations containing tramadol-HCl/acetaminophen and to…
- Trial name
- NCT00973232
- Testing
- DDS-06C (650 mg acetaminophen and 75 mg tramadol HCl), DDS-06C (650 mg acetaminophen and 75 mg tramadol), Zaldiar®
- Where
- United Kingdom
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Labopharm Inc.
Antiphospholipid Antibody Syndrome
CI(R)CA : Coumadin Interaction With Rofecoxib, Celecoxib and Acetaminophen
Coumadin drug-drug interactions (DDI) are frequent. Patients in permanent use of coumadin are advised to avoid traditional nonsteroidal antiinflammatory drugs to avoid risk of bleeding.
- Trial name
- CI(R)CA (NCT01762891)
- Testing
- Celecoxib, Acetaminophen, Rofecoxib
- Volunteers
- 22 people
- Sponsor
- Hospital Universitario Pedro Ernesto
Osteoarthritis
A Study of the Safety and Effectiveness of Orally Administered CR845 in Patients With Osteoarthritis of the Hip or Knee
To assess the safety and tolerability of orally-administered CR845 in patients with osteoarthritis (OA) of the hip or knee. The study drug is being tested to reduce OA pain, and will be taken twice a day for two weeks, with four…
- Trial name
- NCT02524197
- Testing
- CR845 0.25 mg, CR845 0.50 mg, CR845 1 mg
- Where
- 5 sites in United States
- Volunteers
- 81 people
- Sponsor
- Cara Therapeutics, Inc.
Healthy
A Study of the Newly Formulated Tylenol Tablet (Acetaminophen) to the Tylenol 8 Hour (H) Extended Release (ER) Tablet (Acetaminophen) in Healthy Participants
The purpose of this study is to evaluate the bioequivalence of the newly formulated Tylenol tablet (acetaminophen 650 mg) with respect to the Tylenol 8 Hour (H) Extended Release (ER) tablet (acetaminophen 650 mg) in healthy…
- Trial name
- NCT04230252
- Testing
- Acetaminophen
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Janssen Korea, Ltd., Korea
Scoliosis; Adolescence
Use of Intravenous Acetaminophen in Pediatrics Undergoing Spinal Fusion Surgery
The purpose of this study is to investigate whether perioperative intravenous acetaminophen administration reduces postoperative pain and opioid consumption in adolescents and pediatric patients undergoing spinal fusion surgery.
- Trial name
- NCT04959591
- Testing
- intravenous acetaminophen
- Where
- South Korea
- Volunteers
- 99 people
- Sponsor
- Asan Medical Center
Diffuse Large B-Cell Lymphoma, High Grade B-Cell Lymphoma
Study of Venetoclax Plus DA-EPOCH-R for the Treatment of Aggressive B-Cell Lymphomas
This is a phase I, open label, single-arm, multi-center, dose-finding study of venetoclax in combination with DA-EPOCH-R in patients with aggressive B-Cell Lymphomas.
- Trial name
- V+DA-EPOCH-R (NCT03036904)
- Testing
- Venetoclax, Rituximab, Etoposide
- Where
- 6 sites in United States
- Volunteers
- 31 people
- Sponsor
- Weill Medical College of Cornell University
Anesthesia
Opioid Free Anesthesia: What About Patient Comfort?
66 female patients undergoing breast cancer surgery were randomized in the Jules Bordet Institute, the Belgian oncology institute. One group received an opioid anesthesia, the other group an opioid free one.
- Trial name
- NCT02882035
- Testing
- OFA
- Where
- Belgium
- Volunteers
- 66 people
- Sponsor
- Université Libre de Bruxelles
Pain Management, Cesarean Section
To Compare the Efficacy and Patient's Satisfaction From Pain Management of Women After Cesarean Section by Pain Relievers' Administration in Fix Protocol Compared to Protocol Following Demand
Cesarean deliveries are prevalent. Unlike other operations, quick recovery is required for the mother to nurture the newborn child and establishing an appropriate mother-child bonding.
- Trial name
- NCT01764048
- Testing
- Fix protocol, medications following demand protocol
- Where
- Israel
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Supratentorial Neoplasms
Opioid Free VS Opioid Anesthesia for Craniotomies
Hemodynamic control during craniotomies can be a bit hectic specially during periods of intense noxious stimulation. For long anesthesiologists used high doses of opioids such as fentanyl and remifentanyl to provide analgesia…
- Trial name
- NCT04941040
- Testing
- Opioid free anesthetics, Opioid Anesthetics
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Kasr El Aini Hospital
Sinusitis, Opioid Use
Pain Control Following Sinus Surgery
Given the ongoing national opioid epidemic, an increased interest has developed in optimizing opioid prescribing practices of physicians, including otolaryngologists.
- Conditions
- Sinusitis, Opioid Use, Opioid Abuse, Narcotic Use
- Trial name
- NCT03783702
- Testing
- OxyCODONE 5 Mg (milligram) Oral Tablet, Ibuprofen 600 Mg (milligram) Oral Tablet, Acetaminophen 650 MG (milligram) Oral Tablet
- Where
- 6 sites in United States, Canada
- Volunteers
- 118 people
- Sponsor
- Stanford University
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