Clinical trials: Paracetamol
Osteoarthritis, Hip
Minimal Opioid Use After Total Hip Replacement (THR)
Total hip arthroplasty can be associated with significant postoperative pain. Side effects of pain management may impair participation in physical therapy and slow readiness for discharge from the hospital.
- Trial name
- NCT03090152
- Testing
- Periarticular injection (Deep injection), Periarticular injection (Superficial injection), Bupivacaine
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Hospital for Special Surgery, New York
Gastric Emptying
Does Adding Milk to Tea Delay Gastric Emptying?
Most pre-operative fasting regimes dictate that if there is any milk added to tea or coffee, the preoperative fasting time should be extended from 2 to 6 hours.
- Trial name
- GETEAM (NCT01809938)
- Testing
- Black tea, Tea with milk
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Postoperative Pain
Continuous Subpleural Infusion of Bupivacaine
Rationale: For the past 3 years the investigators have routinely used an axial subpleural tunneling technique that del Study Design: All patients over the age of 18 having an isolated thoracoscopic procedure performed at Inova…
- Trial name
- NCT01566838
- Testing
- Subpleural pain catheter with infusion of 0.125% bupivacaine, Standard acute pain management
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Inova Health Care Services
Patent Ductus Arteriosus, Preterm Infant
Randomized Controlled Trial to Evaluate the Safety and Efficacy of Acetaminophen in Preterm Infants Used in Combination With Ibuprofen for Closure of the Ductus Arteriosus
The purpose of the present study is to determine whether treatment of hemodynamically significant patent ductus arteriosus with a combined therapy of intravenous Ibuprofen and oral acetaminophen has higher success rate in closing…
- Conditions
- Patent Ductus Arteriosus, Preterm Infant, Bronchopulmonary Dysplasia
- Trial name
- NCT03701074
- Testing
- Ibuprofen and acetaminophen
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of South Alabama
Adenotonsillectomy, Analgesia
Post-operative Course of Dexamethasone to Reduce Tonsillectomy Morbidity
The goal of this study is determine if an oral systemic course of steroids is a safe and effective option in lowering pain and complications following adenotonsillectomy in various pediatric age groups.
- Conditions
- Adenotonsillectomy, Analgesia, Surgery
- Trial name
- NCT04879823
- Testing
- Dexamethasone, Ibuprofen, Acetaminophen
- Where
- 2 sites in United States
- Volunteers
- 222 people
- Sponsor
- David Chi, MD
Pain
A Dental Pain Study to Test the Effectiveness of a New Pain Reliever Medicine
To assess the safety and effectiveness one dose of a new pain reliever medicine (JNJ-10450232 at either the 250 or 1000 mg strength) compared with placebo (sugar pill) or acetaminophen 1000 mg after surgical removal of third…
- Trial name
- NCT02209181
- Testing
- JNJ-10450232 / Not yet marketed, acetaminophen / Tylenol
- Where
- United States
- Volunteers
- 269 people
- Sponsor
- McNeil Consumer Healthcare Division of McNEIL-PPC, Inc.
Pain, Postoperative
Intravenous Acetaminophen for Non-Narcotic Postoperative Pain Management Following Knee Arthroscopy
The purpose of this randomized, placebo controlled, single blind study is to determine if postoperative pain levels, as measured by a verbal numeric pain rating scale (VNRS), are reduced with the administration of IV…
- Trial name
- IVTYLENOL (NCT02025634)
- Testing
- Intravenous Acetaminophen
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- AdventHealth
Post Operative Analgesia, Bariatric Surgery
Oral Acetaminophen for Post-Op Pain Management in Bariatric Surgery Patients
Adult patients with morbid obesity who have had Roux-en-Y gastric bypass (RYGB) or laparoscopic sleeve gastrectomy (LSG) surgery have impaired drug metabolism.
- Conditions
- Post Operative Analgesia, Bariatric Surgery, Bariatric Surgery (Gastric Bypass), Bariatric Surgery Patients
- Trial name
- NCT06658574
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Rutgers, The State University of New Jersey
Chronic Low Back Pain
Study to Evaluate the Safety and Efficacy of ABT-712 in Subjects With Moderate to Severe Chronic Low Back Pain (CLBP)
The primary purpose of the study is to test the efficacy of 2 tablets (twice daily) of ABT-712, compared to placebo, administered over a 4-week period in participants with moderate to severe mechanical chronic low back pain…
- Trial name
- NCT00763321
- Testing
- ABT-712
- Where
- 31 sites in United States
- Volunteers
- 287 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Fever
Acetaminophen Before Vaccines for Infants Study (AVIS)
The purpose of this study is to see whether giving acetaminophen (the medicine in Tylenol) for routine infant vaccinations is helpful in preventing fever or other symptoms.
- Trial name
- NCT00325819
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 374 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Post-operative Pain
IV Acetaminophen for Acute Post Operative Pain in C-Section Patients
Post-operative pain management after C-section is an important topic as the number of elective c-sections increases each year. Pain is managed either by giving opioids or by using non-opioids.
- Trial name
- NCT02069184
- Testing
- IV Acetaminophen
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Montefiore Medical Center
Osteoarthritis
A Comparative Study of Tramadol Hydrochloride Plus Acetaminophen Tablets Maintenance Versus Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Maintenance in Participants With Knee Osteoarthritis
The purpose of this study is to compare the effectiveness of tramadol hydrochloride 37.5 milligram (mg) plus acetaminophen 325 mg maintenance with that of non-steroidal anti-inflammatory drugs (NSAIDs) maintenance in participants…
- Trial name
- NCT00635349
- Testing
- Meloxicam, Aceclofenac, Tramadol Hydrochloride Plus Acetaminophen
- Volunteers
- 143 people
- Sponsor
- Janssen Korea, Ltd., Korea
Pelvic Organ Prolapse
IV Acetaminophen for Postoperative Pain After Pelvic Organ Prolapse Repair
The purpose of this study is to determine whether preoperative IV Acetaminophen reduces postoperative pain and narcotic consumption in women undergoing surgical repair of pelvic organ prolapse.
- Trial name
- NCT02155738
- Testing
- IV Acetaminophen, IV normal saline
- Where
- United States
- Volunteers
- 204 people
- Sponsor
- Halina M Zyczynski, MD
Metastatic Cancer
S1916 Digital Medicine Program for Pain Control in Cancer Patients
This is a feasibility study to assess the use of a Digital Medicine Program (consisting of an FDA-approved ingestible sensor co-encapsulated with oxycodone/acetaminophen (5 mg/325 mg), a small wearable patch, and a mobile…
- Trial name
- NCT04194528
- Testing
- Oxycodone/acetaminophen 5/325 mg, Proteus digital medicine program
- Where
- 5 sites in United States
- Volunteers
- 2 people
- Sponsor
- SWOG Cancer Research Network
Subarachnoid Hemorrhage, Subdural Hematoma
Efficacy of Bromocriptine For Fever Reduction in Acute Neurologic Injury
The purpose of this study is to evaluate the antipyretic effect of bromocriptine in critically-ill patients with acute neurologic injury and fever from infectious and non-infectious etiologies.
- Conditions
- Subarachnoid Hemorrhage, Subdural Hematoma, Traumatic Brain Injury, Ischemic Stroke
- Trial name
- BFF (NCT03496545)
- Testing
- Bromocriptine 5 MG, Acetaminophen 650 MG
- Where
- 2 sites in United States
- Volunteers
- 47 people
- Sponsor
- University of California, San Francisco
Pain, Fracture, Sprain
Fentanyl Administered Intraorally for Rapid Treatment of Orthopedic Pain
Assess whether transbuccal fentanyl provides more rapid relief of orthopedic pain, than does the comparator Percocet
- Trial name
- FAIRTOP (NCT00685295)
- Testing
- Fentanyl, Lansoprazole, Oxycodone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Pain, Postoperative, Opioid Use
IV vs. Oral Acetaminophen as a Component of Multimodal Analgesia After Total Hip Arthroplasty
The purpose of this study is to determine how well two different methods of administrating Tylenol reduce pain and improve patient satisfaction after total hip replacement (THR) surgery.
- Trial name
- IV Tylenol (NCT03020966)
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Hospital for Special Surgery, New York
Leukemia, Mast-Cell, Mantle-cell Lymphoma
Phase 2 Trial of Prophylactic Rituximab Therapy for Prevention of CGVHD
To determine if rituximab administered after allogeneic transplantation decreases the incidence of chronic graft-vs-host disease (cGvHD)
- Trial name
- NCT00186628
- Testing
- Total lymphoid irradiation, Rituximab, Anti-thymoglobulin, rabbit (ATG, rabbit ATG)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Stanford University
COVID-19
Four Different Experimental Drug Regimens to Standard of Care for the Treatment of Symptomatic Outpatients With COVID-19
This exploratory study is a randomized, single center, open label study of four different experimental treatment arms versus standard of care for the treatment of SARS-CoV-2 infection in symptomatic outpatients with mild disease…
- Trial name
- NCT04532931
- Testing
- Paracetamol, Artesunate-amodiaquine, Pyronaridine-artesunate
- Where
- South Africa
- Volunteers
- 192 people
- Sponsor
- Shin Poong Pharmaceutical Co. Ltd.
Pain, Hernia
Ibuprofen to Decrease Opioid Use and Post-operative Pain Following Unilateral Inguinal Herniorrhaphy
This is a prospective, randomized, double-blinded, and placebo-controlled trial comparing oxycodone/acetaminophen prescribed with or without ibuprofen for pain control following open unilateral inguinal hernia repair, with…
- Trial name
- NCT02929589
- Testing
- Ibuprofen, Opioid Medication, Ibuprofen + Opioid medication
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Mike O'Callaghan Military Hospital