Clinical trials: Paracetamol, completed
Postoperative Pain, Postpartum Anxiety
Acupressure for Pain and Anxiety After Cesarean Section
The goal of this clinical trial is to evaluate whether acupressure combined with standard post-operative modern medical care can reduce pain and anxiety in postpartum women after cesarean delivery under spinal anesthesia.
- Conditions
- Postoperative Pain, Postpartum Anxiety, Acupressure
- Trial name
- NCT07805720
- Testing
- Acupressure, Standard care
- Where
- Vietnam
- Volunteers
- 60 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Postoperative Pain, Hysterectomy
Efficacy and Safety of Intravenous Acetaminophen Over 48 Hrs for the Treatment of Post-op Pain After Gynecologic Surgery
This study will be investigating the efficacy and safety administration of multiple doses of intravenous (IV) acetaminophen (IVAPAP) in the 48 hour period following Gynecologic Surgery.
- Trial name
- NCT00399568
- Testing
- IV Acetaminophen
- Where
- 27 sites in United States
- Volunteers
- 331 people
- Sponsor
- Mallinckrodt
Lung Cancer
Comparison of Efficacy of Paravertebral and Epidural Analgesia After Videothoracoscopic Lung Lobectomy
Thoracic surgery correlates with significant pain in postoperative period. In order to alleviate the pain various combinations of pharmaceuticals and administration methods are employed.
- Trial name
- NCT02040662
- Testing
- Continuous Thoracic Epidural Block, Continuous Thoracic Paravertebral Block, Patient-Controlled Analgesia with Morphine
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- Pulmonary Hospital Zakopane
Surgery, Stoma Ileostomy
Trans Abdominal Plane Block (TAP Block) in Surgery of Stoma Reversal and Its Effect on Post Operative Recovery: a Prospective, Randomized, Muticenter Study
The primary purpose of TAPAS study is to demonstrate the superiority of analgesic effect of trans abdominal plane block (TAP block) performed at the beginning of stoma reversal, compared to standard of care.
- Trial name
- Tapas (NCT03971513)
- Testing
- Trans abdominal plane
- Where
- 2 sites in France
- Volunteers
- 149 people
- Sponsor
- University Hospital, Clermont-Ferrand
Cancer
A Study of Safety and Effectiveness of Ultracet in Patients With Chronic Cancer Pain
The purpose of this study is to evaluate the analgesic (painkiller) effectiveness and safety of combination of tramadol HCI (37.5 mg)/acetaminophen (325 mg) in the treatment of chronic cancer pain.
- Trial name
- NCT01968018
- Testing
- Tramadol HCI/acetaminophen
- Where
- Thailand
- Volunteers
- 35 people
- Sponsor
- Janssen-Cilag Ltd.,Thailand
Chronic Fatigue Syndrome
Cytokine Inhibition in Chronic Fatigue Syndrome Patients
Rationale: Chronic fatigue syndrome (CFS) is a medically unexplained syndrome for which no somatic or pharmacological treatment has been proven effective.
- Trial name
- CiCFS (NCT02108210)
- Testing
- Anakinra
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Pain
Clinical Confirmation of a Pharmacodynamic Interaction Between Tropisetron and Paracetamol
A previous study has shown that tropisetron inhibits the analgesic effect of paracetamol in healthy volunteers. This study aims at confirming this pharmacodynamic interaction in patients with post-surgery pain.
- Trial name
- Tropisétron (NCT00487110)
- Testing
- Tropisetron, paracetamol
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Clermont-Ferrand
Lower Extremity Problem, Surgery
Ibuprofen IV vs Acetaminophen IV for the Treatment of Pain Following Orthopaedic Low Extremity Surgery
This study aims to evaluate the efficacy of IV Ibuprofen versus IV Acetaminophen in the reduction of pain following orthopedic low extremity procedures
- Conditions
- Lower Extremity Problem, Surgery, Postoperative Pain
- Trial name
- NCT03771755
- Testing
- Ibuprofen, Acetaminophen
- Where
- Indonesia
- Volunteers
- 62 people
- Sponsor
- Universitas Indonesia
Pain
To Evaluate the Safety and Efficacy of Acetaminophen 650 mg and 1000mg in Dental Pain After Surgery
The objective of this study is to evaluate the safety and efficacy of acetaminophen 650 mg and acetaminophen 1000 mg in dental surgery.
- Trial name
- NCT01115673
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 540 people
- Sponsor
- McNeil Consumer Healthcare Division of McNEIL-PPC, Inc.
Pain Management, Posterior Spinal Fusion
Multi-Modal Anesthesia Protocol in Pain Management of Patients Undergoing Posterior Lumbar Spinal Fusion Surgery
This study consisted of a randomized controlled trial designed to evaluate a Multimodal Analgesia (MMA) Protocol on patients undergoing Posterior Spinal Fusion.
- Trial name
- NCT05413902
- Testing
- Toradol, Morphine, Orphenadrine
- Where
- Puerto Rico
- Volunteers
- 100 people
- Sponsor
- University of Puerto Rico
Unilateral U/S PVB
Evaluation of Unilateral Ultrasound Guided Paravertebral Block as Perioperative Analgesia For Lower Limb-Sparing Surgery In Adult Cancer Patients
Ultrasound imaging has revolutionized the practice of regional anesthesia in that the operator can visualize and identify the paravertebral space, needle during its passage through the tissues, as well as deposition and spread of…
- Trial name
- NCT04396561
- Testing
- Paravertebral group (group P):
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Anesthesia, Local
Effectiveness of Buccal Infiltration During Vital Pulpotomy After Administering Two Analgesic Premedications
This Randomized study was designed to assess and compare the effect of two analgesic premedications (Ibuprofen BP 100 mg/5 ml and Paracetamol 200 mg/5ml.) on the anesthetic efficacy of buccal infiltration in vital pulpotomy of…
- Trial name
- NCT03423329
- Testing
- Brufen, Cital
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Labor Pain
Analgesic Effects of Intravenous Paracetamol on Labor Pain
The purpose of this study is to determine whether intravenous paracetamol is effective in treating labor pain.
- Trial name
- NCT01394731
- Testing
- Acetaminophen, Meperidine
- Where
- Saudi Arabia
- Sponsor
- King Abdulaziz University
Pain, Hispanics
Efficacy of NSAID and Acetaminophen in the Control of Post-Operative Pain in Patients Undergoing Total Knee Replacement
An alternate perioperative pain control protocol composed of intravenous ketorolac and oral acetaminophen for patients who underwent total knee replacement was designed with the aim to determine its efficacy when compared to pain…
- Conditions
- Pain, Hispanics, Opioid Use, Multimodal Analgesia
- Trial name
- NCT05393414
- Testing
- Opioid based protocol, Opioid sparing protocol
- Where
- Puerto Rico
- Volunteers
- 81 people
- Sponsor
- University of Puerto Rico
Metastatic Castration-resistant Prostate Cancer, Prostate Cancer
Phase I/II Study of Immunotherapy Combination BN-Brachyury Vaccine, M7824, N-803 and Epacadostat (QuEST1)
Background: Immunotherapy drugs help the body to fight cancer. Scientists think that combining some of these drugs will make them work better than when used alone.
- Conditions
- Metastatic Castration-resistant Prostate Cancer, Prostate Cancer, Prostate Neoplasm, Advanced Solid Tumor
- Trial name
- NCT03493945
- Testing
- M7824, N-803, MVA-BN-Brachyury
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- National Cancer Institute (NCI)
Nail Diseases, Nail Abnormality
Hydrocodone Compared to Acetaminophen and Ibuprofen for Post-nail Procedure Analgesia
The purpose of this study is to assess the safety and efficacy of ropivacaine and hydrocodone for nail-procedure associated pain management.
- Trial name
- NCT05544734
- Testing
- Hydrocodone 5Mg/Acetaminophen 325Mg Tab, Acetaminophen 1000mg, Ibuprofen 400 mg
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Weill Medical College of Cornell University
Lymphoma, Large B-Cell, Diffuse
A Study on Pharmacokinetics (PK), Efficacy and Safety of Subcutaneous (SC) Versus Intravenous (IV) Rituximab, in Combination With CHOP (Cyclophosphamide, Doxorubicin, Vincristine, Prednisone) in Previously Untreated Participants With CD20 Positive Diffuse Large B-Cell Lymphoma (DLBCL)
This is a multicenter China-only study to investigate the PK, efficacy and safety of SC rituximab versus IV rituximab, both in combination with CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) in previously untreated…
- Trial name
- NCT04660799
- Testing
- Rituximab IV, Rituximab SC, Cyclophosphamide
- Where
- 8 sites in China
- Volunteers
- 50 people
- Sponsor
- Hoffmann-La Roche
Dental Pain
Study of Long-Acting Acetaminophen in Postoperative Dental Pain
The purpose of the study is to evaluate the efficacy and safety of acetaminophen ER 1500 mg (two 750 mg tablets) over 10 to 12 hours in the dental pain model following third molar extraction(s) and to evaluate the…
- Trial name
- NCT01960114
- Testing
- Acetaminophen ER
- Where
- United States
- Volunteers
- 403 people
- Sponsor
- McNeil Consumer Healthcare Division of McNEIL-PPC, Inc.
Migraine Disorders
Valproate Versus Topiramate in Migraine
Investigators aim to compare the effect of valproate versus topiramate in migraine by assessing the reduction in MMD in each group, the percentage of patients who achieved ≥ 50% reduction in the monthly headache days frequency…
- Trial name
- NCT06248931
- Testing
- Valproic acid, Topiramate 50 MG
- Where
- Egypt
- Volunteers
- 600 people
- Sponsor
- Kafrelsheikh University
Progressive Multiple Sclerosis
A Study to Characterize Subcutaneous or Intravenous Alemtuzumab in Patients With Progressive Multiple Sclerosis
Primary Objective: To characterize the pharmacodynamic profile of 2 treatment courses of alemtuzumab administered by subcutaneous injection and 2 treatment courses of alemtuzumab administered by intravenous infusion in patients…
- Trial name
- SCALA (NCT02583594)
- Testing
- Acyclovir, Methylprednisolone, alemtuzumab GZ402673
- Where
- Spain
- Volunteers
- 24 people
- Sponsor
- Genzyme, a Sanofi Company
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