Clinical trials: Paracetamol
Acute Pain
Nefopam/Paracetamol Fixed Dose Combination in Acute Pain After Impacted Third Molar Extraction
This study aims to evaluate the analgesic efficacy of single and multiple doses of a new fixed dose combination of nefopam hydrochloride 30 mg and paracetamol 500mg taken orally in comparison to each single component.
- Trial name
- NCT04622735
- Testing
- nefopam hydrochloride 30mg / paracetamol 500mg X2, Paracetamol 500 Mg Oral Tablet X2, Nefopam HCl 30 MG Oral Tablet X2
- Where
- 19 sites in Belgium, France and 3 more
- Volunteers
- 321 people
- Sponsor
- Unither Pharmaceuticals, France
Prostate Cancer
Evaluation of Safety and Feasibility of OGX-011 in Combination With 2nd-line Chemotherapy in Patients With HRPC
This study is for patients with cancer of the prostate gland that has metastasized or spread outside the prostate to other parts of the body.
- Trial name
- NCT00327340
- Testing
- custirsen (OGX-011)/mitoxantrone, custirsen (OGX-011)/docetaxel
- Where
- 10 sites in Canada
- Volunteers
- 70 people
- Sponsor
- Achieve Life Sciences
Acute Pain, Postoperative Pain
Comparison of the Effectiveness of Preemptive Paracetamol and Ibuprofen in Acute Postoperative Pain
This study will evaluate two different analgesic regimen used for acute postoperative pain.
- Trial name
- NCT03063658
- Testing
- Paracetamol, Ibuprofen 800 mg
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 108 people
- Sponsor
- Ankara University
Patent Ductus Arteriosus in Preterm Infants
Comparison of Infusion Paracetamol Protocols in PDA
The aim of this study was to evaluate the effect of paracetamol on patent ductus arteriosus (PDA) closure and clinical outcomes in preterm infants when used as standard intermittent bolus and continuous intravenous (IV) infusion.
- Trial name
- NCT04469413
- Testing
- Paracetamol Infusion
- Where
- Turkey (Türkiye)
- Volunteers
- 138 people
- Sponsor
- Ankara University
Breast Cancer
The AVIATOR Study: Trastuzumab and Vinorelbine With Avelumab OR Avelumab & Utomilumab in Advanced HER2+ Breast Cancer
This research study is studying a combination of drugs as a possible treatment for breast cancer. The drugs involved in this study are: Group A: Trastuzumab (Herceptin) + Vinorelbine (Navelbine) Group B: Trastuzumab + Vinorelbine…
- Trial name
- NCT03414658
- Testing
- Vinorelbine, Trastuzumab, Avelumab
- Where
- 17 sites in United States
- Volunteers
- 100 people
- Sponsor
- Adrienne G. Waks
Healthy Volunteers
Placebo Effect of Paracetamol in Healthy Volunteers
Paracetamol is one of the most commonly used drugs in the world, indicated for the symptomatic treatment of fever and pain of mild to moderate. More precisely, it is a drug used to relieve pain and reduce fever.
- Trial name
- HOP (NCT01053650)
- Testing
- Paracetamol
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Missed Abortion
Sublingual Versus Vaginal Misoprostol In Medical Treatment of First Trimestric Missed Miscarriage
The aim of this work is to compare the effectiveness of vaginal versus sub-lingual misoprostol for medical treatment of first trimester missed miscarriage.
- Trial name
- NCT02686840
- Testing
- sublingual misoprostol, vaginal misoprostol
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Ain Shams University
Adenocarcinoma
Safety and Efficacy of Avelumab in Small Intestinal Adenocarcinoma
This is a single-agent, open label, one-arm phase 2 pilot study of avelumab in patients with advanced or metastatic adenocarcinoma of the small intestine.
- Trial name
- NCT03000179
- Testing
- Avelumab
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Nurse's Role
Laughter Therapy and Mindfulness Practices
Nurses working by shifts under intense stress and pressure and using complicated technological products- undergo fatigue and attention deficit with the effect of the many negative factors caused by work setting.
- Trial name
- NCT05634343
- Testing
- experimental group 1, experimantal group 2
- Where
- Turkey (Türkiye)
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Nagihan Koroglu Kaba
Labour Duration
Intravenous Paracetamol Versus Intramuscular Tramadol in Shortening the Duration of Labour.
It is a well established fact that the pain of labour can be excrutiating and ways to shorten the duration of labour has been sought after.
- Trial name
- NCT07394491
- Testing
- paracetamol, Tramadol hydrochloride
- Where
- Nigeria
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- Federal Teaching Hospital Abakaliki
Acute Post-operative Pain Following Caesarean Section
Opioid-free Analgesia for the Management of Acute Post-operative Pain Following Caesarean Section
Background: Multimodal analgesia; a combination of opioid and non-opioid analgesics, for management of acute post-operative pain significantly reduces the incidence of adverse effects associated with liberal post-operative opioid…
- Trial name
- OFAAPPCS (NCT04539249)
- Testing
- Magnesium sulphate, Pentazocine
- Where
- Nigeria
- Volunteers
- 324 people
- Sponsor
- Olakunle Ifeoluwa Makinde
Postoperative Pain
Quadratus Lumborum Block Versus Transversus Abdominis Plane Block for Postoperative Analgesia in Children
The aim of the present study is to evaluate and compare the analgesic effect of ultrasound-guided Quadratus Lumborum Block with ultrasound-guided Transversus Abdominis plane block in pediatric Laparoscopic lower abdominal…
- Trial name
- NCT04552548
- Testing
- regional nerve block
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Minia University
Pain, Hernia
Ibuprofen to Decrease Opioid Use and Post-operative Pain Following Unilateral Inguinal Herniorrhaphy
This is a prospective, randomized, double-blinded, and placebo-controlled trial comparing oxycodone/acetaminophen prescribed with or without ibuprofen for pain control following open unilateral inguinal hernia repair, with…
- Trial name
- NCT02929589
- Testing
- Ibuprofen, Opioid Medication, Ibuprofen + Opioid medication
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Mike O'Callaghan Military Hospital
Perioperative Pain
Pain Control Without Opioids
Adequate outpatient pain control after uncomplicated laparoscopic appendectomy or cholecystectomy can be achieved with minimal breakthrough drugs when used in combination with around the clock non-opioid medications.
- Trial name
- NCT04813991
- Testing
- Ibuprofen 600 mg, OxyCODONE 5 Mg Oral Capsule
- Where
- United States
- Sponsor
- Hackensack Meridian Health
Non-Hodgkin's Lymphoma
Ultrafast Truxima Infusion in Non-Hodgkin's Lymphoma: Txagorapid Study
The objective of this pilot study is therefore to assess the safety of Truxima ultrafast infusion within 30 minutes in patients with non-Hodgkin's lymphoma.
- Trial name
- NCT05191225
- Testing
- RiTUXimab Injection [Truxima]
- Where
- Spain
- Volunteers
- 48 people
- Sponsor
- Laida Cuevas Palomares
Vertebral Fracture, Compression Fracture
Spine Bone Cements Outcomes - Post Market Follow-up
A Post-Market Clinical Follow-Up (PMCF) Study to collect clinical data on safety and performance of all TEKNIMED Spine range of products: SPINEFIX, HIGH V+, OPACITY+ and F20 bone cements and mixing and injection systems, and all…
- Conditions
- Vertebral Fracture, Compression Fracture, Osteoporotic Fractures
- Trial name
- NCT06367582
- Testing
- Vertebroplasty (VP), Kyphoplasty (KP), Pedicular Screw Augmentation (PSA)
- Where
- 12 sites in France, Portugal and 2 more
- Volunteers
- 500 people
- Sponsor
- Teknimed
Head and Neck Cancer, Analgesia
Multimodal Pain Study in Free Flap Patients
This study will be a randomized, prospective study comparing Pain Management Arm A and Pain Management Arm B. Arm A will have scheduled Tylenol with opioids available as needed (PRN) in the peri-operative period.
- Trial name
- NCT04246697
- Testing
- Tylenol, Oxycodone, Morphine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Kansas Medical Center
Neck Pain
Randomized Controlled Trial of Chiropractic Manipulation Versus Medical Therapy for Chronic Neck Pain
The purpose of this study is to determine whether chiropractic manipulation or medical therapy is effective in the treatment of chronic neck pain.
- Trial name
- NCT00429624
- Testing
- Chiropractic manipulation, acetaminophen
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Colorado, Denver
Cardiopulmonary Bypass Induced Lipid Peroxidation
Inhibition of Lipid Peroxidation During Cardiac Surgery
Acute kidney injury is a major complication of cardiac surgery requiring cardiopulmonary bypass (CPB). Hemolysis and rhabdomyolysis frequently occur during CPB.
- Trial name
- NCT01366976
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Vanderbilt University
Leukemia, Lymphoma
Irradiated Donor Lymphocytes and Rituximab in Treating Patients With Relapsed or Refractory Lymphoproliferative Disease
RATIONALE: When irradiated lymphocytes from a donor are infused into the patient they may help the patient's immune system kill cancer cells. Monoclonal antibodies, such as rituximab, can block cancer growth in different ways.
- Conditions
- Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00176475
- Testing
- rituximab, therapeutic allogeneic lymphocytes
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
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