Clinical trials: Paracetamol
Osteoarthritis, Back Pain
A Study to Compare Oxycodone/Naloxone Prolonged Release Against Codeine/Paracetamol in the Treatment of Moderate to Severe Chronic Low Back Pain or Pain Due to Osteoarthritis
The purpose of this study is to compare oxycodone/naloxone combination tablet and codeine/paracetamol tablets in the treatment of moderate to severe chronic low back pain or pain due to osteoarthritis.
- Trial name
- NCT00784810
- Testing
- Oxycodone/Naloxone, Codeine/Paracetamol
- Where
- United Kingdom
- Volunteers
- 247 people
- Sponsor
- Napp Pharmaceuticals Limited
Gastric Emptying
Does Adding Milk to Tea Delay Gastric Emptying?
Most pre-operative fasting regimes dictate that if there is any milk added to tea or coffee, the preoperative fasting time should be extended from 2 to 6 hours.
- Trial name
- GETEAM (NCT01809938)
- Testing
- Black tea, Tea with milk
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Pemphigus
Long-Term Extension Study of Ofatumumab in Subjects With Pemphigus Vulgaris
This study is designed as a multi-country, multicenter, open label extension to Phase III trial OPV116910. The primary objective is to provide continued treatment with ofatumumab subcutaneous (SC) for eligible subjects who…
- Trial name
- NCT02613910
- Testing
- Ofatumumab, Acetaminophen/paracetamol, Antihistamine (cetirizine or equivalent)
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- GlaxoSmithKline
Pain
Open-Label CA-008 (Vocacapsaicin) in Bunionectomy
A Phase 2, open-label study of CA-008 to evaluate post-surgical pain control with CA-008.
- Trial name
- NCT03885596
- Testing
- CA-008, Ketorolac, Acetaminophen IV
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Concentric Analgesics
Common Cold
Effects of Two Doses of a Common Cold Treatment on Alertness
This study will investigate any improvement in alertness and performance based on cognitive function and mood assessment in subjects suffering the common cold, when taking a novel paracetamol and caffeine combination verses…
- Trial name
- NCT01686646
- Testing
- paracetamol + caffeine, paracetamol
- Where
- United Kingdom
- Volunteers
- 240 people
- Sponsor
- GlaxoSmithKline
Multiple Myeloma
An Efficacy and Safety Study of Daratumumab in Patients With Multiple Myeloma Who Have Received at Least 3 Prior Lines of Therapy (Including a Proteasome Inhibitor [PI] and Immunomodulatory Drug [IMiD]) or Are Double Refractory to a PI and an IMiD
The purpose of this study is to evaluate the efficacy and safety of 2 daratumumab treatment regimens in participants with multiple myeloma who have received at least 3 prior lines of therapy (including a proteasome inhibitor [PI]…
- Trial name
- NCT01985126
- Testing
- Daratumumab 16 mg/kg (Part 1), Daratumumab 8 mg/kg (Part 1), Methylprednisolone
- Where
- 23 sites in United States, Canada and 1 more
- Volunteers
- 124 people
- Sponsor
- Janssen Research & Development, LLC
Migraine
Acetaminophen and Ibuprofen With and Without Magnesium and Primary Migraine in Childhood
Aim: The purpose of this study was to evaluate both the effects of ibuprofen and/or acetaminophen for the acute treatment of primary migraine in children in or out prophylactic treatment with magnesium.
- Trial name
- NCT01756209
- Testing
- Magnesium 400Mg, Ibuprofen 10 mg/kg, acetaminophen 15 mg/kg
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- University of Catanzaro
Post Operative Pain
Maxigesic IV Phase 3 Bunionectomy Study
The purpose of the study is to determine the clinical efficacy and safety of Maxigesic IV, acetaminophen IV, Ibuprofen IV versus placebo IV for the treatment of acute postoperative pain after bunionectomy
- Trial name
- NCT02689063
- Testing
- Maxigesic IV, IV Acetaminophen, IV Ibuprofen
- Where
- 2 sites in United States
- Volunteers
- 276 people
- Sponsor
- AFT Pharmaceuticals, Ltd.
Carpal Tunnel, Ganglion Cyst
Post-operative Analgesia in Elective, Soft-tissue Hand Surgery
The purpose of this research study is to find out which combination of pain medications following surgery work the best and result in the fewest side effects.
- Conditions
- Carpal Tunnel, Ganglion Cyst, Trigger Finger, De Quervain Disease
- Trial name
- NCT02029235
- Testing
- Acetaminophen/Ibuprofen, Acetaminophen/Hydrocodone
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Alexander Payatakes, M.D.
Pain, Postoperative, Bunion
Safety and Efficacy of COV795 in Moderate to Severe Post-Operative Bunionectomy Pain With an Open-label Extension
The primary objective of this study is to show the effectiveness of repeated doses of COV795 versus placebo, using the summed pain intensity difference over the first 48 hours in subjects with acute moderate to severe pain…
- Trial name
- NCT01484652
- Testing
- COV795
- Where
- 5 sites in United States
- Volunteers
- 329 people
- Sponsor
- Mallinckrodt
Heart Diseases
Multimodal Analgesia in Cardiac Surgery (Pilot Study)
The investigators objective is to assess the effectiveness of an opioid sparing multimodal approach for enhancing the recovery in Cardiac Surgical patients.
- Trial name
- NCT02734940
- Testing
- Lidocaine, Unrestricted Fentanyl, Ketamine
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Virginia Commonwealth University
Patent Ductus Arteriosus, Preterm Infant
Randomized Controlled Trial to Evaluate the Safety and Efficacy of Acetaminophen in Preterm Infants Used in Combination With Ibuprofen for Closure of the Ductus Arteriosus
The purpose of the present study is to determine whether treatment of hemodynamically significant patent ductus arteriosus with a combined therapy of intravenous Ibuprofen and oral acetaminophen has higher success rate in closing…
- Conditions
- Patent Ductus Arteriosus, Preterm Infant, Bronchopulmonary Dysplasia
- Trial name
- NCT03701074
- Testing
- Ibuprofen and acetaminophen
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of South Alabama
Acute Liver Failure, Acute Liver Injury
Safety Study of Ornithine Phenylacetate to Treat Patients With Acute Liver Failure/Severe Acute Liver Injury
This Phase 2a clinical study is designed to provide data on OCR-002 in patients with acute liver failure/acute liver injury (ALF/ALI) in regard to: safety and tolerability; metabolism of the compound to glutamine and…
- Trial name
- STOP-ALF (NCT01548690)
- Testing
- Ornithine Phenylacetate
- Where
- 11 sites in United States
- Volunteers
- 47 people
- Sponsor
- William Lee
Fibromyalgia
Randomized Controlled Trial of CES for Fibromyalgia
Given recent increasing opioid-related deaths and evidence showing against the use of opioids for non-malignant chronic pain, there is growing need for non-narcotic pain management.
- Trial name
- NCT04115033
- Testing
- Alpha-stim
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- VA Office of Research and Development
Postoperative Pain
Maxigesic® IV Phase 3 Exposure Study
The study aims to determine the tolerability of repeated doses of Maxigesic® IV over an extended period of exposure.
- Trial name
- NCT04005755
- Testing
- Maxigesic® IV
- Where
- 4 sites in United States, New Zealand
- Volunteers
- 232 people
- Sponsor
- AFT Pharmaceuticals, Ltd.
Inguinal Hernia
Determine the Clinical Advantage of IV vs PO Acetaminophen
There is limited research on the clinical outcome differences between intravenous (IV) acetaminophen versus oral (PO) acetaminophen.
- Trial name
- NCT03558555
- Testing
- Acetaminophen IV Soln, Oral Acetaminophen, Saline
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Yan Lai
Pain
Perioperative Systemic Acetaminophen to Improve Postoperative Quality of Recovery After Ambulatory Breast Surgery
Recent evidence demonstrates that perioperative pain continues to be poorly managed among ambulatory surgical patients. More importantly, few interventions that minimize postoperative pain have also shown to improve patient…
- Trial name
- NCT01852955
- Testing
- IV acetaminophen
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Northwestern University
Post Operative Pain
RCT (Randomized Controlled Trial) of IV Acetaminophen for Post Operative Vaginal Reconstruction Pain
This randomized controlled trial will evaluate the effects of perioperative intravenous (IV) acetaminophen on postoperative narcotic consumption and pain scores in subjects undergoing vaginal reconstructive surgery.
- Trial name
- NCT02043704
- Testing
- IV Acetaminophen
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- TriHealth Inc.
Pain Measurement
Comparison Between Dexamethasone and Ibuprofen on Pain Prevention and Control Following Surgical Implant Placement
Background and aim: Postoperative pain is an adverse effect of oral surgeries and may therefore be prevented or minimized. This study compares the efficacy of preemptive ibuprofen and dexamethasone protocols in pain prevention…
- Trial name
- CBDIPPCFSIP (NCT02763059)
- Testing
- Ibuprofen 600 mg, Dexamethasone 4 mg, Acetaminophen 1000 mg
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Low Back Pain
Ibuprofen With or Without Acetaminophen for Low Back Pain
This is a randomized clinical trial comparing two interventions for acute low back pain: 1. Ibuprofen + acetaminophen 2. Ibuprofen + placebo Participants will include patients who present to an emergency room for management of…
- Trial name
- NCT03554018
- Testing
- Acetaminophen, Ibuprofen 600 mg, Educational intervention
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Montefiore Medical Center