Clinical trials: Paracetamol
Colorectal Disorders
Early Diuresis Following Colorectal Surgery
The purpose of this study is to find out if giving a medicine called furosemide, which is a diuretic or water pill, after colon surgery will safely shorten the patient's length of hospital stay.
- Trial name
- NCT02351934
- Testing
- Furosemide, Celecoxib, Gabapentin
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- Mayo Clinic
Shoulder Pain, Opioid Use
Multimodal Analgesia in Shoulder Arthroplasty
Opioid medications are associated with many side effects and the risk of abuse or overdose. Orthopaedic surgeons are currently investigating ways to control pain after surgery while limiting the amount of opioid medications…
- Trial name
- NCT03586934
- Testing
- Acetaminophen, Celecoxib 200mg, Celecoxib 400 mg
- Where
- United States
- Sponsor
- Rush University Medical Center
PDA
Paracetamol (Acetaminophen) for Closure of PDA in Preterm Infants
There is a report that acetaminophen may have a role in pharmacological closure of PDA (Patent arterial duct) in preterm infants.
- Trial name
- NCT01755728
- Testing
- Paracetamol, Ibuprofen, Closure of PDA
- Where
- Israel
- Volunteers
- 19 people
- Sponsor
- Hillel Yaffe Medical Center
Cleft Palate
Efficacy of Oral Versus Intravenous Acetaminophen for Primary Pediatric Cleft Palate Repair
The purpose of this investigator-initiated study is to determine whether acetaminophen is an effective pain reliever for primary cleft palate repair in children and possesses opioid sparing effects.
- Trial name
- NCT01500109
- Testing
- Oral acetaminophen, Ofirmev®, Opioid only
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Loma Linda University
Acute Postoperative Pain, Chest Wall Surgery
Prospective Feasibility, Analgesic Effectiveness, and Safety Study of a Visual Analog Scale-Guided Multimodal Pain Algorithm After Posterior Rib Remodeling With Osteosynthesis
This prospective single-group study will evaluate a visual analog scale-guided multimodal analgesia algorithm during the first five days after posterior rib remodeling with osteosynthesis.
- Trial name
- NCT07805928
- Testing
- VAS-Guided Multimodal Analgesia Algorithm, Ultrasound-Guided Thoracic Wall Regional Block
- Where
- Colombia
- Volunteers
- 160 people
- Sponsor
- Research Inc
Cerebral Palsy, Postoperative Pain
Combined Popliteal and Adductor Canal Blocks for Postoperative Analgesia in Children With Cerebral Palsy
This prospective, randomized, controlled trial aims to evaluate the postoperative analgesic efficacy of combined ultrasound-guided popliteal sciatic nerve block and adductor canal block in children with cerebral palsy undergoing…
- Trial name
- NCT07801365
- Testing
- Adductor Canal Block + Popliteal Sciatic Nerve Block Group, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Head and Neck Cancer, Radiation-Induced Mucositis
Opioid Therapy vs Multimodal Analgesia in Head and Neck Cancer
The purpose of this study is to compare the daily pain level scores for patients taking opioids alone for pain relief, compared with those treated by multimodal analgesia with three medications: pregabalin, naproxen, and…
- Trial name
- NCT04221165
- Testing
- Opioids, PAiN - multimodal analgesia
- Where
- Canada
- Volunteers
- 49 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Opioid Abuse (Disorder), Opioid Analgesia
Reducing Opioid Use After Upper Extremity Surgery: Testing Lower Prescriptions and Pill Quantity
The goal of this clinical trial is to evaluate strategies for optimizing postoperative multimodal pain regimens and reducing opioid dependency in patients undergoing upper extremity surgery.
- Conditions
- Opioid Abuse (Disorder), Opioid Analgesia, Opioid Analgesic Adverse Reaction, Opioid Consumption
- Trial name
- NCT07750639
- Testing
- Naproxen, Acetaminophen, oxycodone
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- AdventHealth
Inflammation, Inflammatory Response
Effects of Multimodal Analgesia on Serum MCP-1, BDNF, and MiRNA-124 in Hysterectomy Surgery
The inflammatory process is the main mechanism in the occurrence of acute postoperative pain. It is also the main risk for the development of acute pain into persistent pain.
- Conditions
- Inflammation, Inflammatory Response, Acute Pain, Chronic Pain
- Trial name
- NCT05069311
- Testing
- Multimodal analgesia, Conventional intravenous analgesia
- Where
- Indonesia
- Volunteers
- 62 people
- Sponsor
- Udayana University
Chronic Rhinosinusitis (Diagnosis)
Effect of Post-operative Ibuprofen After Surgery for Chronic Rhinosinusitis
Endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS) is a common procedure in the US, with about 250,000 cases performed annually.
- Trial name
- NCT03055507
- Testing
- Ibuprofen 400 mg, Acetaminophen 650 mg, OxyCODONE 5 Mg Oral Tablet
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Washington
Primary Diffuse Large B-cell Lymphoma of the Central Nervous System (CNS), Aggressive B-cell Lymphoma With Secondary Involvement of the CNS
Venetoclax, Ibrutinib, Prednisone, Obinutuzumab, and Revlimid (VIPOR) for Diffuse Large B-cell Lymphoma Involving the Central Nervous System
Background: People with primary diffuse large B-cell lymphoma of the central nervous system (CNS) and aggressive B-cell lymphomas with secondary CNS involvement have a poor prognosis.
- Trial name
- NCT05211336
- Testing
- Obinutuzumab, Prednisone, Lenalidomide
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- National Cancer Institute (NCI)
Fever, Hyperthermia
The Fever and Antipyretic in Critically Illness Evaluation Study
The purpose of this multination multicenter observational study is to determine the impact of fever and antipyretic on outcomes in critically ill patients.
- Trial name
- FACE (NCT00940654)
- Testing
- Antipyretic therapy
- Where
- 2 sites in Japan, South Korea
- Volunteers
- 1,426 people
- Sponsor
- Japanese Society of Intensive Care Medicine
Breast Cancer
The Impact of Intravenous Anaesthesia on Angiogenesis in Patients With Breast Cancer (TIVA/TCI-BC)
Because neoplastic disease is one of the leading causes of death worldwide and breast cancer is one of the most frequent neoplasia among women, the possibility of influencing the evolution of patients starting from the moment of…
- Trial name
- TIVA/TCI-BC (NCT02839668)
- Testing
- Lidocaine, Sevoflurane, TIVA-TCI
- Where
- Romania
- Volunteers
- 120 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Neck Pain
Effect of Exercise Among Turtle Neck Syndrome in Pakistani Patients
Turtle neck also known as Text neck or anterior head syndrome is an overuse syndrome which occurs due to repetitive stress to neck, either by hanging it down or forward using phone or electronic devices.
- Trial name
- NCT05730868
- Testing
- myofascial release, muscle energy technique, MFR & MET
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- University of Karachi
Pain, Nausea
A Multi-Center Actual-Use Study on the Safety of CL 108 for the Treatment of Moderate to Severe Acute Pain Associated With Osteoarthritis of the Knee or Hip
The purpose of CLCT-006, a multi-center open-label study, is to evaluate the safety of CL-108 (hydrocodone 7.5 mg/APAP 325 mg, promethazine 12.5 mg) for the treatment of moderate to severe acute pain ("flare") associated with…
- Conditions
- Pain, Nausea, Vomiting
- Trial name
- NCT02462850
- Testing
- CL-108
- Where
- United States
- Volunteers
- 178 people
- Sponsor
- Charleston Laboratories, Inc
Migraine, Head Pain
A Study Comparing the Effectiveness and Safety of ULTRACET® (Tramadol HCl/Acetaminophen) Versus Placebo for the Treatment of Acute Pain From a Migraine Headache
The purpose of this study is to evaluate the effectiveness and safety of tramadol HCl/acetaminophen as a pain medication compared with placebo in the treatment of acute pain from a migraine headache.
- Conditions
- Migraine, Head Pain, Headache
- Trial name
- NCT00297375
- Testing
- tramadol HCl/acetaminophen
- Volunteers
- 375 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Primary Dysmenorrhea
Effects of Therapeutic Tapping in Primary Dysmenorrhea
Dysmenorrhea is more common among women of reproductive age, as it affects their quality of life and limit their daily activities and normal functioning.
- Trial name
- NCT05909956
- Testing
- KinesioTape, General Physio session
- Where
- Pakistan
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Postoperative Pain
A Phase 1 Study to Evaluate Pregabalin and Acetaminophen in Healthy Volunteers
This is a Phase 1, randomized, double-blind, placebo-controlled, single and multiple ascending dose study to determine a maximum tolerated dose of IV PGB and to evaluate the safety, tolerability, and PK of an admixture of IV PGB…
- Trial name
- NCT04265456
- Testing
- Pregabalin 100mg, Acetaminophen 1300mg
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Nevakar, Inc.
Music and Anesthesia
The Effects of Instrumental Music on Intraoperative Parameters and Postoperative Pain and Side Effects
The clinical study started after receiving ethical approval from the Clinical Research Ethics Committee of Van Yüzüncü Yıl University and obtaining patient consent.
- Trial name
- NCT05886231
- Testing
- music sound therapy
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Analgesia, Postoperative Pain
Multimodal Analgesic Treatment Versus Traditional Morphine Analgesia After Cardiac Surgery
To test if multimodal analgesia with different analgesic medication offer better pain relief, lesser side effects and is safe compared to conventionel opiod analgesia after cardiac surgery.
- Trial name
- NCT01966172
- Testing
- Ibuprofen, Gabapentin, Morphine
- Where
- Denmark
- Volunteers
- 180 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
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