Clinical trials: Paracetamol
Malignant Neoplasm
KEYMAKER-U01 Substudy 01J: A Study of Pembrolizumab Plus MK-1084 in Participants With Non-Small Cell Lung Cancer (NSCLC) With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) G12C Mutations (MK-3475-01J/KEYMAKER-U01J)
Researchers want to learn if using a study medicine called MK-1084 can help treat Non-Small Cell Lung Cancer (NSCLC). MK-1084 is a type of treatment called targeted therapy for the Kirsten rat sarcoma viral oncogene homolog…
- Trial name
- NCT07252739
- Testing
- MK-1084, Pembrolizumab, Cetuximab
- Where
- 39 sites in United States, Chile and 11 more
- Volunteers
- 140 people
- Sponsor
- Merck Sharp & Dohme LLC
Pain, Postoperative, Cesarean Section Complications
Satisfaction Following Cesarean Section
Presently, the standard of care at the investigators' practice is that the discharging physician decides the type and amount of opioid medication to prescribe a patient following a cesarean section.
- Conditions
- Pain, Postoperative, Cesarean Section Complications, Postpartum Disorder, Opioid Use
- Trial name
- NCT03355248
- Testing
- Oxycodone Acetaminophen
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- ProMedica Health System
Low Back Pain, Acute
Interfascial Infiltration for Acute Unspecific Low Back Pain in the Emergency Department
Pain relief and functional impairment have been shown to remain poor to moderate over weeks after emergency department discharge, in patients who seek ED management for acute nontraumatic, nonradicular low back pain.
- Trial name
- PreSosLumbago (NCT03968185)
- Testing
- Interfascial infiltration, Standard medical treatment
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Montpellier
Benign Prostate Hypertrophy(BPH)
Trial to Assess the Efficacy and Safety During Convective Radiofrequency Water Vapor Thermal Therapy (REZUM) for Benign Prostate Hyperplasia
The primary aim of the study is to show that methoxyflurane-lorazepam-percocet combination administrated 'per os' is non inferior to deep intravenous sedation in achieving analgesia during Rezum convective radiofrequency water…
- Trial name
- NCT07017452
- Testing
- Methoxyflurane - Penthrox, Control, Percocet Pill
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Pain
Antagonistic Interaction CB1-paracetamol
Evaluation of an possible inhibiting effect of Rimonabant on the analgesic effect of Paracetamol in healthy volunteers
- Trial name
- NCT00750347
- Where
- 2 sites in France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Covid19, Covid19 Drug Treatment
Early Treatment of Vulnerable Individuals With Non-Severe SARS-CoV-2 Infection
Coverage Africa is a nested study in the large Anticov platform trial that aims to generate data on new early treatment strategies for mild/moderate COVID-19 patients in resource-limited-settings to reduce the number progressing…
- Conditions
- Covid19, Covid19 Drug Treatment, Severe Acute Respiratory Syndrome Coronavirus 2, SARS-CoV2 Infection
- Trial name
- COVERAGE-A (NCT04920838)
- Testing
- Nitazoxanide and Ciclésonide, Telmisartan 20Mg Oral Tablet, Paracetamol
- Where
- 2 sites in Burkina Faso, Guinea
- Volunteers
- 600 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Breast Surgery, Macromastia
Comparison of ESP and SPSIP Blocks in Breast Surgery
This study aims to compare the efficacy of the ESP and SPSIP blocks in managing postoperative pain following breast surgery. Breast surgery, particularly after oncological and reconstructive procedures, often leads to significant…
- Conditions
- Breast Surgery, Macromastia, Mammaplasty, Modified Radical Mastectomy
- Trial name
- NCT06611644
- Testing
- Erector Spinae Plane Block, SPSIPB blcok, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Çanakkale Onsekiz Mart University
Postoperative Pain, Patient Satisfaction
Post Operative Analgesia and Patient Satisfaction
To understand how patients perceive the quality of care they receive when given different post-operative analgesic medications. Specifically the investigators want to assess whether patients who receive non-opioid analgesia…
- Conditions
- Postoperative Pain, Patient Satisfaction, Analgesia
- Trial name
- NCT04976387
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Analgesia, Postoperative
Ultrasound Guided Paravertebral Block Versus Erector Spinae Block for Postoperative Analgesia After Inguinal Hernia Repair in Pediatric Patients
The aim of the study is to compare postoperative analgesia in pediatric patients undergoing inguinal hernia repair by comparing the efficacy of ultrasound guided paravertebral block versus ultrasound guided erector spinae plane…
- Trial name
- NCT06752252
- Testing
- ultrasound guided paravertebral block, Ultrasound guided erector spinae plane block, control group C
- Where
- 2 sites in Egypt
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Pneumococcal Vaccines
Study Assessing the Effect of Medications to Prevent Fever on Prevenar 13®
The purposes of this study are assess the immunological response (measure the amount of antibodies, i.e. proteins that fight off germs) produced by children after they have been given the 13-valent pneumococcal vaccine (13vPnC)…
- Trial name
- NCT01392378
- Testing
- 13-valent pneumococcal conjugate vaccine, INFANRIX hexa, Paracetamol
- Where
- 14 sites in Poland
- Volunteers
- 908 people, healthy volunteers welcome
- Sponsor
- Pfizer
Acute Pain
Paracetamol UNIFLASH for Buccal Use Phase III Trial in Acute Pain Due to a Tooth Extraction
This study aims to evaluate the analgesic efficacy of single dose of a new paracetamol formulation (paracetamol UNIFLASH) for buccal use in comparison to two different doses of an oral paracetamol form controlled versus placebo.
- Trial name
- NCT04640376
- Testing
- Paracetamol Uniflash 125mg, Panadol 500 MG Oral Tablet X1, Panadol 500 MG Oral Tablet X2
- Where
- 20 sites in France, Italy and 2 more
- Volunteers
- 407 people
- Sponsor
- Unither Pharmaceuticals, France
Pain, Postoperative
Outcomes Of Perioperative Pregabalin On Total Knee Arthroplasty
This study aims to provide high quality evidence from a double-blinded, randomized controlled trial on the efficacy of perioperative pregabalin in reducing morphine requirements, improving pain scores and reducing chronic…
- Trial name
- NCT02954484
- Testing
- pregabalin, Etoricoxib, paracetamol
- Volunteers
- 116 people
- Sponsor
- National University Hospital, Singapore
Multiple Myeloma
Elotuzumab in Autologous Stem Cell Transplantation (ASCT) and Lenalidomide Maintenance for Multiple Myeloma
The purpose of this study is to explore the combination of Elotuzumab in combination with autologous stem cell transplantation and lenalidomide maintenance to see what side effects it may have and how well it works for the…
- Trial name
- NCT02655458
- Testing
- Elotuzumab, Lenalidomide, autologous PBMC reconstitution
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Hearn Jay Cho
Hip Fractures, Neuromuscular Blockade
Continuous Fascia Iliaca Block for Acute Hip Fractures
Hip fractures are a major cause of morbidity and mortality in the elderly with over 30,000 hip fractures occuring in Canada annually and over 1300 in Saskatchewan.
- Conditions
- Hip Fractures, Neuromuscular Blockade, Respiratory Morbidity, Delirium
- Trial name
- NCT03588689
- Testing
- Continuous fascia iliaca block, Ropivacaine
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Saskatchewan
Relapsed Refractory Multiple Myeloma (RRMM)
Mezigdomide and Elranatamab for Relapsed and/or Refractory Multiple Myeloma
The goal of this clinical trial is to find out how well a combination of two medicines (mezigdomide and elranatamab) works in treating patients with refractory/relapsed multiple myeloma.
- Trial name
- MELT-MM (NCT06645678)
- Testing
- Elranatamab, Mezigdomide, Dexamethasone
- Where
- 7 sites in Singapore, South Korea
- Volunteers
- 75 people
- Sponsor
- YOUNGIL KOH
Anesthesia
Multimodal Opioid-free Anesthesia Versus Opioid-based Anesthesia for Patients Undergoing Cardiac Valve Surgeries: RCT
Several studies demonstrated the effectiveness of OFA in patients undergoing non-cardiac surgery. Preoperative use of Cox inhibitors, GABA analogues and acetaminophen have been shown to decrease use of opioids postoperatively .
- Trial name
- NCT04648540
- Testing
- Dexmedetomidine 0.5 mic/kg/h, Fentanyl 1 mic/kg/hr
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pain
The Effect of Dexamethasone in Combination With Paracetamol and Ibuprofen on Postoperative Pain After Spine Surgery
The analgesic effect of dexamethasone is not well described, but studies have shown that dexamethasone can be a safe part of a multimodal analgesic strategy after surgery.
- Trial name
- NCT01953978
- Testing
- Dexamethasone, Morphine, Zofran
- Where
- Denmark
- Volunteers
- 160 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Patent Ductus Arteriosus in Preterm Infants
Noninvasive Hemodynamics Assessment of Preterms With Successful Medical Closure of PDA
The aim of our study was to use Electrical Cardiometry EC to monitor hemodynamic alternations during pharmacological closure of hemodynamically significant patent ductus arteriosus (hsPDA) in preterm neonates
- Trial name
- NCT06606015
- Testing
- I.V Paracetamol., Echocardiography., Electrical Cardiometry
- Where
- Egypt
- Volunteers
- 43 people
- Sponsor
- Tanta University
Healthy Subjects
A Study to Compare Two Paracetamol Tablets
This is a single dose pharmacoscintigraphic study investigating the differences in paracetamol absorption between two formulations.
- Trial name
- NCT01381640
- Testing
- Marketed paracetamol, Experimental paracetamol formulation
- Where
- 2 sites in United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Post-surgical Pain
Study of CA-008 (Vocacapsaicin) in Bunionectomy Patients
This is a Phase 2, multi-center, randomized, double-blind, placebo-controlled, parallel design study evaluating a single dose of one of three CA-008 dose levels vs.
- Trial name
- NCT03599089
- Testing
- CA-008, Ketorolac, Acetaminophen
- Where
- 3 sites in United States
- Volunteers
- 147 people
- Sponsor
- Concentric Analgesics
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