Clinical trials: Paracetamol, completed
Multiple Myeloma
A Study of JNJ-54767414 (HuMax CD38) (Anti-CD38 Monoclonal Antibody) in Combination With Backbone Treatments for the Treatment of Patients With Multiple Myeloma
The purpose of this study is to evaluate the safety, tolerability, and dose regimen of daratumumab when administered in combination with various treatment regimens for the treatment of multiple myeloma.
- Trial name
- NCT01998971
- Testing
- Daratumumab, Velcade, Pomalidomide
- Where
- 22 sites in United States, France and 1 more
- Volunteers
- 240 people
- Sponsor
- Janssen Research & Development, LLC
Knee Pain
Genicular Nerve Block for Knee Pain in the ED
Patient with atraumatic knee pain without a large knee effusion on x-ray will be randomized to receive either a genicular nerve block (GNB) or standard of care in the emergency department.
- Trial name
- NCT07158736
- Testing
- Genicular nerve block with bupivacaine and corticosteroids, Standard of Care
- Where
- 4 sites in United States
- Volunteers
- 8 people
- Sponsor
- University of Pennsylvania
Acetaminophen Toxicity
Treatment of APAP Toxicity With IV and Oral NAC 2008-2011
Retrospective chart review of patients who receive N-acetylcysteine for Acetaminophen(APAP) toxicity to assess length of oral vs.
- Trial name
- NCT01465542
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Akron Children's Hospital
Pain Measurement
Comparison Between Dexamethasone and Ibuprofen on Pain Prevention and Control Following Surgical Implant Placement
Background and aim: Postoperative pain is an adverse effect of oral surgeries and may therefore be prevented or minimized. This study compares the efficacy of preemptive ibuprofen and dexamethasone protocols in pain prevention…
- Trial name
- CBDIPPCFSIP (NCT02763059)
- Testing
- Ibuprofen 600 mg, Dexamethasone 4 mg, Acetaminophen 1000 mg
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Post-Dural Puncture Headache
Sphenopalatine Ganglion Block for Management of Post- Dural Puncture Headache in Obstetric Patients
The purpose of this trial is to study the efficacy and efficiency of sphenopalatine ganglion block for management of post dural puncture headache in obstetric patients
- Trial name
- NCT04793490
- Testing
- Sphenopalatine ganglion block, paracetamol
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Post Operative Pain
Effect of Pregabalin on Post Operative Pain in Abdominal Hysterectomy Under Spinal Anesthesia With Intrathecal Morphine
This study aims to compare the effect of pre-operative oral pregabalin on post operative morphine consumption after abdominal hysterectomy with/without salpingo-oophorectomy.
- Trial name
- NCT02285010
- Testing
- Pregabalin
- Where
- Thailand
- Volunteers
- 125 people
- Sponsor
- Mahidol University
Postoperative Pain
Lornoxicam vs. Paracetamol After Lower Abdominal Surgery
Background: The aim of this prospective, randomized, double-blind study is to determine the most effective supplemental analgesic, paracetamol or lornoxicam for postoperative pain relief after lower abdominal surgery.
- Trial name
- NCT01564680
- Testing
- Paracetamol, Lornoxicam
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
Pain, Postoperative Arthroscopy
Effect of Rofecoxib and a Narcotic Analgesic to Treat Pain Following Arthroscopic Surgery (0966-179)(COMPLETED)
Study the effect of rofecoxib 50 mg compared to both placebo, and hydrocodone 7.5 mg with acetaminophen 750 mg, to treat moderate to severe pain following arthroscopic knee surgery.
- Trial name
- NCT00390260
- Testing
- MK0966 / Duration of Treatment: 1 Days, Comparator: acetaminophen (+) hydrocodone bitartrate / Duration of Treatment: 1 Days
- Volunteers
- 420 people
- Sponsor
- Merck Sharp & Dohme LLC
Pain
Preoperative Gabapentin for Acute and Chronic Post-thoracotomy Analgesia
One dose of either gabapentin or placebo will be given to patients prior to thoracotomy. Patients will also receive an epidural infusion, intravenous patient-controlled analgesia with fentanyl, oral acetaminophen and intravenous…
- Trial name
- NCT00588159
- Testing
- Gabapentin, Diphenhydramine
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Michelle Kinney
Perforated Appendicitis
The Impact of IV Acetaminophen on Pain After Appendectomy for Perforated Appendicitis
The objective of this study is to evaluate two standard post-operative pain regimens routinely used after laparoscopic appendectomy for perforated appendicitis.
- Trial name
- NCT02881996
- Testing
- IV tylenol, No IV tylenol, Ketorolac
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Children's Mercy Hospital Kansas City
Pain, Acute, Satisfaction, Patient
Virtual Reality for Pain Management and Patient Satisfaction During Outpatient Hysteroscopy
The investigators conducted a randomized controlled trial in 120 patients undergoing an outpatient hysteroscopy (OH). 60 patients were randomly allocated to the control group and 60 patients were randomly allocated to the study…
- Trial name
- NCT06463210
- Testing
- Virtual reality as a distraction technique
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario 12 de Octubre
Chronic Widespread Pain, Fibromyalgia
Efficacy and Safety of IGN-ES001 in Chronic Widespread Pain With or Without Fibromyalgia
This is a randomized, double-blind, placebo-controlled exploratory trial to investigate efficacy and safety of food supplement IGN-ES001 in patients with chronic widespread pain (CWP) with or without fibromyalgia (FM).
- Trial name
- NCT03058224
- Testing
- IGN-ES001, Parol 500 mg Tablets (acetaminophen)
- Where
- 23 sites in Turkey (Türkiye)
- Volunteers
- 230 people
- Sponsor
- IgNova GmbH
Arthritis, Arthralgia
Treatment of Mild to Moderate Joint Pain in Patients With Chronic Plaque Psoriasis Receiving Efalizumab
The purpose of this study is to evaluate tolerability and effectiveness of conventional treatment for mild to moderate arthritic or arthralgic symptoms while subjects are being treated with efalizumab for psoriasis.
- Trial name
- NCT00510536
- Testing
- Acetaminophen, NSAID
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Probity Medical Research
Lung Neoplasms, Pain
Supplementary Epidural Analgesia in Video-Assisted Thoracic Surgery (VATS) - The SEAVATS Study
Whereas it, in the case of conventional thoracotomy, has been demonstrated that thoracic epidural analgesia is more effective than systemic opioids in terms of pain relief and preservation of postoperative pulmonary function, the…
- Conditions
- Lung Neoplasms, Pain, Immune Suppression
- Trial name
- SEAVATS (NCT02359175)
- Testing
- Bupivacaine in epidural catheter, Fentanyl in epidural catheter, Oral Paracetamol
- Where
- Denmark
- Volunteers
- 161 people
- Sponsor
- Odense University Hospital
Locoregional Analgesia in Breast Surgery
Double-blind Study to Assess effectIveness of Pectoral Nerves Block After Breast Surgery on Piritramide Consumption
The aims of this study is to compare the effectiveness of pecs block associated to a general anesthesia in terms of Piritramide consumption compared with a general anaesthesia alone and the chronic pain incidence in patients that…
- Trial name
- DESIGN (NCT02655965)
- Testing
- Ropivacaine, Clonidine, Sodium Chloride
- Where
- Belgium
- Volunteers
- 54 people
- Sponsor
- Jules Bordet Institute
the Use of Radiofrequency Ablation in Form of TECAR(Capacitive and Resistive Transfer Energy) in Chronic Pain of Sickle Cell Disease Patients
The Radiofrequency Therapy in Management of Sickle Cell Disease Chronic Pain RCT Tested the Effect of TECAR Therapy on Sickle Cell Disease Chronic Pain.
The goal of this clinical trial study is to assess effect of radiofrequency on chronic pain of sickle cell disease pain . All SCA participants who fulfilled inclusion and exclusion criteria were 220; only 170 participant agreed…
- Trial name
- RCT/TECAR (NCT07066072)
- Testing
- Tecar therapy (TECAR: Capacitive and Resistive Energy Transfer)., standard pharmacological therapy in sickle cell disease like hydroxyurea,paracetamol,ibubrofen and blood transfusion if needed
- Where
- Egypt
- Volunteers
- 170 people
- Sponsor
- Cairo University
Pain, Fibromyalgia
An Efficacy Study of Combination of Tramadol and Acetaminophen Tablets in the Treatment of Participants With Fibromyalgia Pain
The purpose of this study is to evaluate the analgesic effect of combination of tramadol hydrochloride and acetaminophen in participants for treatment of fibromyalgia pain (chronic widespread pain and presence of tender points).
- Trial name
- NCT00766675
- Testing
- Tramadol hydrochloride, Acetaminophen
- Volunteers
- 80 people
- Sponsor
- Johnson & Johnson Taiwan Ltd
Knee Osteoarthritis
A Sequenced Strategy for Improving Outcomes in People With Knee Osteoarthritis Pain
There is an urgent public health need to reduce reliance on opioids for effective long-term pain management, particularly in knee osteoarthritis (KOA).
- Trial name
- SKOAP (NCT04504812)
- Testing
- Duloxetine, Intra-Articular Injection, Nerve Procedure with long acting blocks
- Where
- 24 sites in United States
- Volunteers
- 1,937 people
- Sponsor
- Johns Hopkins University
Healthy
Bioequivalence Study of Co-codamol 15mg/500mg Capsules vs Co-codamol 30mg/500mg Tablets in Healthy Subjects
The purpose of this study is to compare the bioavailability of co-codamol 15mg/500mg capsules (test product) and co-codamol 30mg/500mg tablets (reference product).
- Trial name
- NCT03280095
- Testing
- co-codamol 15mg/500mg capsule, co-codamol 30mg/500mg tablet
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Galen Limited
Breast Cancer
Metabolomic Profiling of Erector Spinae Plane Block* for Breast Cancer Surgery
Worldwide, breast cancer is the most common cancer among women, and its incidence and mortality rates are expected to increase significantly in the next years. It remains a major health problem.
- Trial name
- ESP (NCT04689945)
- Testing
- Morphine, Erector Spinae Block, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 91 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
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